• Journal of Pharmaceutical Investigation
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• v.20 no.1
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• pp.19-28
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• 1990

Pharmacokinetic parameters of aminoglycosides are dependent on renal function, sex, age, hematocrit, fever, lean body weight (LBW) and disease states, etc. Therefore, the individual pharmacokinetic parameters such as half life $(t^{1/2})$ and volume of distribution(Vd) are needed to achieve optimal therapy. However these parameters had not been determined in Koreans. The purpose of this study was to evaluate the Vd and $t^{1/2}$ of amikacin in Korean patients who had normal renal function, to compare the mean values of study group with that reported in the literature and to compare the measured $t^{1/2}$ with the expected $t^{1/2}$ based on actual body weight (ABW), LBW and ideal body weight (IBW), respectively. Based on data, the Vd was greater than the literature and $t^{1/2}$ was similar to the literature. The predicted $t^{1/2}$ based on IBW was the closest to actual $t^{1/2}$. And postpartum patients had greater Vd than other group and had lower correlation between actual elimination rate constant and calculated creatinine clearance but higher correlation between actual elimination rate constant and Vd than other group.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2003.11a
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• pp.389-394
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• 2003

In this paper, a shape optimization technique is applied to design of an air-conditioner mounting bracket. The mounting bracket is a structural component of an engine, on which bolts attach an air-conditioner compressor. The air-conditioner mounting bracket has a large portion of weight among the engine components. To reduce weight of the bracket, the shape is optimized using a finite element software. The compressor assembly, composed of a compressor and a bracket is modeled using finite elements. An objective function for the shape optimization of the bracket is the weight of the bracket. Two design constraints on the bracket are the first resonant frequency of the compressor assembly and the fatigue life of the bracket. The design variables are the shape of the bracket including thickness profiles of the front and back surfaces of the bracket, radius of outer bolt-holes, and side edge profiles. The coordinates of the FE nodes control the shape parameters. Optimal shapes of the bracket are obtained by using SOL200 of MSC/NASTRAN.

• Journal of Environmental Science International
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• v.30 no.3
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• pp.289-293
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• 2021

This study was conducted to investigate the distribution of duck production in duck housing as a function of the breeding period. The items in duck production distribution included body weight, feed intake, feed conversion ratio, and average duck production. All data were based on eight cycles (June and December, 2017; February, June, August, September, and November, 2018; February, 2019) at Farm Site 1 through 7. The most optimal results in the duck production distribution were observed at Site 1 for weight gain, feed intake, and feed efficiency. This could be explained by the fact that Site 1 was well managed in environmental improvement and sustainability. Based on these data, selective alternatives to improve duck production in duck farms are recommended as follows: first, proper management and recording of litter used as a flooring material are required, and second, continuous management such as temperature, relative humidity and ventilation is needed. Lastly, it is necessary to change duck facilities by introducing environmental management techniques. Furthermore, efforts to improve the overall facilities and management of duck breeding farms through additional field studies are needed in the future.

• The KSFM Journal of Fluid Machinery
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• v.7 no.2 s.23
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• pp.7-13
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• 2004

In an attempt to solve multiobjective optimization problems, weighted sum method is most widely used for the advantage that a designer can consider the relative significance of each object functions by weight values but it can be highly sensitive to weight vector and occasionally yield a deviated optimum from the relative weighting values designer designated because the multiobjective function has the form of simple sum of the product of the weighting values and the object functions in traditional approach. To search the design solution agree well to the designer's weighting values, we proposed new multiobjective function which was the functional of each normalized objective functions and considered to find the design solution comparing the distance between the characteristic line and the ideal optimum. In this study, proposed multiobjective function was applied to design high efficiency and low noise axial flow fan and the result shows this approach is effective for the case that the quality of the design can be highly affected by the designer's subjectiveness represented as weighting values in multiobjective design optimization process.

• ETRI Journal
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• v.39 no.5
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• pp.621-631
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• 2017

Abnormal samples are usually difficult to obtain in production systems, resulting in imbalanced training sample sets. Namely, the number of positive samples is far less than the number of negative samples. Traditional Support Vector Machine (SVM)-based anomaly detection algorithms perform poorly for highly imbalanced datasets: the learned classification hyperplane skews toward the positive samples, resulting in a high false-negative rate. This article proposes a new imbalanced SVM (termed ImSVM)-based anomaly detection algorithm, which assigns a different weight for each positive support vector in the decision function. ImSVM adjusts the learned classification hyperplane to make the decision function achieve a maximum GMean measure value on the dataset. The above problem is converted into an unconstrained optimization problem to search the optimal weight vector. Experiments are carried out on both Cloud datasets and Knowledge Discovery and Data Mining datasets to evaluate ImSVM. Highly imbalanced training sample sets are constructed. The experimental results show that ImSVM outperforms over-sampling techniques and several existing imbalanced SVM-based techniques.

• 유체기계공업학회:학술대회논문집
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• 2003.12a
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• pp.397-403
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• 2003

In an attempt to solve multiobjective optimization problems, weighted sum method is most widely used for the advantage that a designer can consider the relative significance of each object functions by weight values but it can be highly sensitive to weight vector and occasionally yield a deviated optimum from the relative weighting values designer designated because the multiobjective function has the form of simple sum of the product of the weighting values and the object functions in traditional approach. To search the design solution well agree to the designer's weighting values, we proposed new multiobjective function which is the functional of each normalized objective functions and considered to find the design solution comparing the distance between the characteristic line and the ideal optimum. In this study, proposed multiobjective function was applied to design high efficiency and low noise axial flow fan and the result shows this approach will be effective for the case that the qualify of the design can be highly affected by the designer's subjectiveness represented as weighting values in multiobjective design optimization process.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.22 no.1
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• pp.148-159
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• 1998

Spot welding palys a key role in increasing productivity and weight reduction of the final products. This paper proposes a systematic approach on the design of spot weld configuration, dealing with the requried number and location of spot weld joints under the given design parameters, such as the applied loads, lap area, and individual spot weld strength. The optimal design of a spot-welded joint is postulated as a state when the safety factors of all spot weld points (i) are evenly distributed and (ii) reach maximum value. A CAD program is developed to arrange the optimal location of each spot weld based on the derived objective function and constraints. The CAD tool integrates the optimization procedure with Finite Element Analysis (FEA) code through an interface. The interface automatically provides geometrical data and mesh configuration for different spot weld locations to FEA model. It also extracts the transmitted load of each spot weld from the FEA code, and allows the optimization code predict an improved arrangement of spot weld locations. The feasibility of the developed approach is demonstrated by the selected examples.

• Transactions of the Korean Society of Automotive Engineers
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• v.3 no.6
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• pp.96-111
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• 1995

A bellows is a component installed in the automobile exhaust system to reduce the impact from an engine. It's stiffness has a great influence on the natural frequency of the system. Therefore, it must be designed to keep the specified stiffness that requires in the system. This study present the finite element analysis of U-typed bellows using a curved conical frustum element and the shape optimal design with specified stiffness. The finite element analysis is verified by comparing with the experimental results. In the shape optimal design, the weight is considered as the cost function. The specified stiffness from the system design is transformed to equality constraints. The formulation has inequality constraints imposed on the fatigue limit, the natural frequencies, the buckling load and the manufacturing conditions. A procedure for shape optimization adopts a thickness, a corrugation radius, and a length of annular plate as optimal design variables. The external loading conditions include the axial and lateral loads with a boundary condition fixed at an end of the bellows. The recursive quadratic programming algorithm is selected to solve the problem. The result are compared with the existing bellows, and the characteristics of the bellows is investigated through the optimal design process. The optimized shape of the bellows are expected to give quite a good guideline to the practical design.

• Journal of Integrative Natural Science
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• v.11 no.4
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• pp.167-183
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• 2018

Electroencephalogram (EEG) recording provides a new way to support human-machine communication. It gives us an opportunity to analyze the neuro-dynamics of human cognition. Machine learning is a powerful for the EEG classification. In addition, machine learning can compensate for high variability of EEG when analyzing data in real time. However, the optimal EEG electrode location must be prioritized in order to extract the most relevant features from brain wave data. In this paper, we propose an intelligent system model for the extraction of EEG data by training the optimal electrode location of EEG in a specific problem. The proposed system is basically a fuzzy system and uses a neural network structurally. The fuzzy clustering method is used to determine the optimal number of fuzzy rules using the features extracted from the EEG data. The parameters and weight values found in the process of determining the number of rules determined here must be tuned for optimization in the learning process. Genetic algorithms are used to obtain optimized parameters. We present useful results by using optimal rule numbers and non - symmetric membership function using EEG data for four movements with the right arm through various experiments.

• KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
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• v.5B no.3
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• pp.262-266
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• 2005

In this paper, in order to enhance thrust of slotless type Permanent Magnet Linear Synchronous Motor, an optimal design is achieved by combining a genetic algorithm with 3D space harmonic method. In the case of multi-objective functions, the ratio of thrust/weight and thrust/volume are increased by $\7.56[%]l\;and\;7.98\[%]$, respectively. Thus, miniaturization and lightweight were realized at the same time.