• Korean Journal of Microbiology
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• v.54 no.1
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• pp.9-17
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• 2018

To investigate the role of bkdR, sigL, yplP, and des genes which were known to be involved in fatty acid synthesis and sensitive at low temperature, deletion mutants of Bacillus subtilis CU1065 and JH642 were constructed. To determine the low temperature sensitivity of these genes, we compared the growth curves of cells at $37^{\circ}C$ and $15^{\circ}C$. At $37^{\circ}C$, wild type and deletion mutants showed almost similar growth but only bkdR deletion strain at $15^{\circ}C$ showed very slow growing compared with wild type. At $15^{\circ}C$ sigL and yplP deletions were somewhat slower or similar to those of wild type strain. Double and triple mutants for bkdR, sigL, yplP deletions were constructed and grown at $20^{\circ}C$ in LB agar to investigate cold sensitive growth. Double or triple deletions including bkdR deletion showed cold sensitive growing. In order to identify more clearly cold sensitive growth, the experiments were carried out under cold shock conditions in which the temperature was lowered from $37^{\circ}C$ to $15^{\circ}C$ at the point of 0.4 optical densities at 600 nm. In these cold shock experiments, only bkdR deletion showed significantly lower growing and additional des deletion increases cold sensitivity. The bkdR activates the bkd operon, which catabolized isoleucine, valine and leucine, amino acids and produce precursors for the synthesis of branched fatty acids. At cold shock growing of bkdR deletion strain, isoleucine recovered cold sensitivity of bkdR deletion but valine did not restore cold sensitivity. Isoleucine is used as a precursor for the synthesis of anteiso-branched fatty acids. On the other hand, valine is used as a precursor for the synthesis of iso-branched fatty acids. This indicates that anteiso-branched fatty acid plays an important role at the cold shock condition.

• Journal of The Korean Ophthalmological Society
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• v.59 no.12
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• pp.1152-1159
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• 2018

Purpose: We prospectively investigated clinical changes and long-term outcomes after administration of the drugs recommended by the Age-Related Eye Disease Study-2 to patients with intermediate age-related macular degeneration (AMD). Methods: This prospective multicenter study enrolled 79 eyes of 55 patients taking lutein and zeaxanthin. The primary endpoint was contrast sensitivity; this was checked every 12 months for a total of 36 months after treatment commenced. The secondary endpoints were visual acuity, central macular thickness, and drusen volume; the latter two parameters were assessed using spectral domain optical coherence tomography. Results: The mean patient age was $72.46{\pm}7.16years$. Contrast sensitivity gradually improved at both three and six cycles per degree. The corrected visual acuity was $0.13{\pm}0.14logMAR$ and did not change significantly over the 36 months. Neither the central macular thickness nor drusen volume changed significantly. Conclusions: Contrast sensitivity markedly improved after treatment, improving vision and patient satisfaction. Visual acuity, central retinal thickness, and drusen volume did not deteriorate. Therefore, progression of AMD and visual function deterioration were halted.

• Journal of the Korean Society for Nondestructive Testing
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• v.29 no.5
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• pp.436-441
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• 2009

A fiber optic sensor is prospective to be applied to structural health monitoring. Especially, a fiber Bragg grating(FBG) sensor is one of the most popular sensors for the structural health monitoring. The FBG sensor has several demodulation systems for tracking the shift of the Bragg wavelength. The dynamic bandwidth is dependent on the demodulation system. In this paper, the sensing mechanism is that the slope of the optical spectrum of FBG could be used as its sensitivity when the tunable laser shot the monochromatic laser wavelength at the highest slope point. In this technique, the high sensitivity is guaranteed even though the sensing range is limited. In an example of the application, the composite plate embedding a FBG sensor was manufactured by using an autoclave method and the above sensing mechanism was applied to the composite plate. Firstly, the natural frequencies of the plate were successfully measured by the FBG sensor during the impact hammer test. Secondly, a high-power speaker was used to force the plate to be vibrated at the specific frequency that was one of the natural frequencies. During the shaking, the FBG sensor measures the dynamic characteristics and ESPI was also used to measure the mode shape. From the two dynamic tests, the availability of the FBG sensor system and the ESPI was proven as a technique for measuring the dynamic characteristics of composite structure.

• Journal of the Korean Society of Radiology
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• v.3 no.4
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• pp.35-38
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• 2009

Flat-panel x-ray detectors using a phosphor and photoconductor material have been used for application in various medical modalities. In this study, the monte carlo simulation, optical and x-ray response characteristics were investigated in the conversion structure obtained by a columnar CsI:Na scintillation layer with a photosensitive amorphous selenium layer. Firstly, from the measurement of luminescent spectrum of CsI:Na and absorption spectrum of a-Se layer, the signal conversion characteristics are analysed. And also, the x-ray sensitivity is measured and compared with conventional a-Se($500{\mu}m$) as a function of electrical field. From the experimental result, the x-ray sensitivities of the CsI:Na($180{\mu}m$)/a-Se($30{\mu}m$) detector and the a-Se($500{\mu}m$) detector were $7.31nC/mR-cm^{2}$ and $3.95nC/mR-cm^{2}$at an electric field of $10V/{\mu}m$, respectively.

• Korean Journal of Optics and Photonics
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• v.19 no.2
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• pp.127-131
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• 2008

A refractometric glucose biosensor incorporating a vertically coupled microring resonator in polymers was proposed and realized. The ring was covered with a target analyte of glucose solution with a certain concentration, so that its effective refractive index could be altered and, as a result, the resonance wavelength of the sensor was shifted. Therefore the concentration of the glucose solution can be estimated by observing the shift in the resonance wavelength. Two schemes were exploited for enhancing the sensitivity of the sensor. First, the effective refractive index of the polymeric waveguide used for the resonator sensor was adjusted to approach that of the target analyte as best as possible. Second, the ring waveguide, which serves as a crucial sensing part, was appropriately over-etched to enlarge its contact area with the analyte. The proposed resonator sensor was designed with the beam propagation method. The refractive indices of the core and cladding polymer involved were 1.430 and 1.375 respectively, leading to the waveguide's effective refractive index of ${\sim}1.390$, which is faiirly close to that of the glucose solution of ${\sim}1.333$. The prepared ring resonator with the $400-{\mu}m$ radius exhibited the free spectral range of 0.66 nm, the bandwidth of 0.15 nm, and the quality factor of 10,000. For the sensor operating at 1,550 nm wavelength, the achieved sensitivity was as great as 0.28 pm/(mg/dL), which is equivalent to 200 nm/RIU.

• Journal of the Korean Society of Radiology
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• v.10 no.5
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• pp.321-325
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• 2016

Dose creep is one of clinical errors that arises from the tester's inexperience or carelessness, and according to Task Group #116 of American Association of Physicists in Medicine, its continued occurrence is being reported in the digital method. At this point, the demand for an automatic exposure control device that minimizes the dose creep phenomenon and can improve reproducibility is increasing. In this study is to consider the automatic exposure control device sensor that can is not only easy to produce, but also reduce the dose creep phenomenon by conducting a research on high-efficient semiconductor sensor. As a result, the Intrinsic-type and PIN-type sensors have excellent optical property compared to Ref sensor, would have less shading effect, and have relatively low sensitivity, but would provide accurate feedback signals to automatic exposure control device with its consistent tendency according to exposure condition changes.

• Journal of Sensor Science and Technology
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• v.7 no.3
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• pp.147-153
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• 1998

The strain characteristics of a fiber optic Fabry-Perot pressure sensor with high sensitivity using a $Si_{3}N_{4}/SiO_{2}/Si_{3}N_{4}$ (N/O/N) diaphragm is experimentally investigated. A 600 nm thick N/O/N diaphragm was fabricated by silicon anisotropic etching technology in 44 wt% KOH solution. An interferometric fiber optic pressure sensor has been manufactured by using a fiber optic Fabry-Perot intereferometer and a N/O/N diaphragm. The 2 cm length fiber optic Fabry-Perot interferometers in the continuous length of single mode fiber were produced with two pieces of single mode fiber coated with $TiO_{2}$ dielectric film utilizing the fusion splicing technique. The one end of the fiber optic Fabry-Perot interferometer was bonded to a N/O/N diaphragm. and the other end was connected to an optical setup through a 3 dB coupler. For the N/O/N diaphragm sized $2{\times}2\;mm^{2}$ and $8{\times}8\;mm^{2}$, the pressure sensitivity was measured 0.11 rad/kPa and 1.57 rad/kPa, respectively, and both of the nonlinearities were less than 0.2% FS.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.22 no.1
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• pp.24-32
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• 2008

The ultimate purpose of the study is to develop a discomfort glare forecasting formula that can be practically used in Korea in order to effectively forecast discomfort glare considering the optical characteristics of the Koreans. The study was to examine the relations between discomfort glare and the variables such as luminance, background luminance, solid angle, luminous area and louver. To this end, experiments were conducted in a mock-up office that emulates the lighting environment of an ordinary office. The study was conducted by four steps as follow. First, previous studies on discomfort glare rating to define and rate discomfort glare were analyzed and modified to be applied to the experiments of this study. Second, experiment variables, variable scope, evaluation objects and evaluation points were determined after review on existing discomfort glare evaluation experimental formulas. Third, experiments were conducted in a mock-up office to be able to control variables. Finally, sensitivity of experiment variables were analyzed through examination of the relation between discomfort glare and the variables such as luminance, solid angle, louver, luminous area and subject's position. The result showed that the most influential variables on discomfort glare of an artificial light source is luminance and louver, luminous area and subject's position(solid angle) followed.

• Journal of the Earthquake Engineering Society of Korea
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• v.10 no.6 s.52
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• pp.137-145
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• 2006

Recently, the interests in structural monitoring of civil infrastructures are increased. Especially, as the civil infrastructures such as bridges, tunnels and buildings become large-scale, it is necessary to monitor and maintain the safety state of the structures, which requires smart systems that can supply long-term monitoring during the service time of the structures. In this paper, we investigated the possibilities of fiber optic sensor application to the various structures. We investigate the possibility of using fiber optic Bragg grating sensors to joint structure. The sensors show good response to the structural behavior of the joint while electric gauges lack of sensitivity, durability and long term stability for continuous monitoring. We also apply fiber optic structural monitoring to the composite repaired concrete beam structure. Peel-out effects is detected with optical fiber Bragg grating sensors and the strain difference between main structure and repaired carbon sheets is observed when they separate each other. The real field test was performed to verify the behaviors of fiber Bragg grating sensors attached to the containment structure in Uljin nuclear power plant in Korea as a part of structural integrity test which demonstrates that the structural response of the non-prototype primary containment structures. The optical fiber Bragg grating sensor smart system which is the probable means for long term assessments can be applicable to monitoring of structural members in various civil infrastructures.

• Journal of Korean Society of Environmental Engineers
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• v.28 no.2
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• pp.150-157
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• 2006

Spatially resolved remote identification and quantification of trace gases in the atmosphere is desirable in various fields of scientific research as well as in public security and industrial contexts. Environmental observations investigating causes, extent md consequences of air pollution are of fundamental interest. We present an Imaging-DOAS system, a ground based remote sensing instrument that allows spatially resolved mapping of atmospheric trace gases by a differential optical absorption spectroscopy(DOAS) with sun scattered light as the light source. A passive DOAS technique permits the identification and quantification of various gases, e.g., $NO_2,\;SO_2,\;and\;CH_2O$, from their differential absorption structures with high sensitivity. The Imaging-DOAS system consists of a scanning mirror, a focusing lens, a spectrometer, a 2-D CCD, ad the integral control software. An imaging spectrometer simultaneously acquires spectral information on the incident light in one spatial dimension(column) and sequentially scans the next spatial dimension with a motorized scanning mirror. The structure of the signal acquisition system is described in detail and the evaluation method is also briefly discussed. Applications of imaging of the $NO_2$ contents in the exhaust plumes from a power plant are presented.