• Nuclear Engineering and Technology
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• 제55권10호
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• pp.3844-3853
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• 2023

Although radiation and chemotherapy methods for cancer therapy have advanced significantly, surgical resection is still recommended for most cancers. Therefore, intraoperative imaging studies have emerged as a surgical tool for identifying tumor margins. Intraoperative imaging has been examined using conventional imaging devices, such as optical near-infrared probes, gamma probes, and ultrasound devices. However, each modality has its limitations, such as depth penetration and spatial resolution. To overcome these limitations, hybrid imaging modalities and tracer studies are being developed. In a previous study, a multi-modal laparoscope with silicon photo-multiplier (SiPM)-based gamma detection acquired a 1 s interval gamma image. However, improvements in the near-infrared fluorophore (NIRF) signal intensity and gamma image central defects are needed to further evaluate the usefulness of multi-modal systems. In this study, an attempt was made to change the NIRF image acquisition method and the SiPM-based gamma detector to improve the source detection ability and reduce the image acquisition time. The performance of the multi-modal system using a complementary metal oxide semiconductor and modified SiPM gamma detector was evaluated in a phantom test. In future studies, a multi-modal system will be further optimized for pilot preclinical studies.

• 한국광학회지
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• 제31권1호
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• pp.13-19
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• 2020

광섬유 사냑 간섭형 센서를 이용해 수중 음향을 측정하기 위하여 링형 탐촉자를 적용하는 경우 민감도를 이론과 실험을 통하여 조사한다. 링형 탐촉자는 단일 모드 광섬유를 지름 5 cm의 링형으로 감아서 접착제로 패키징하였다. 링형 탐촉자는 감지 광섬유의 길이를 46.84 m로 하여 제작한 A형 탐촉자와 감지 광섬유의 길이를 112.22 m로 한 B형 탐촉자를 준비하였다. 수중 음향 시험은 상용 음향 발생기와 1 m 떨어진 거리에서 링형 탐촉자를 사용하여 50, 70, 90 kHz의 주파수에 대하여 20~100 Pa의 음향 압력 범위에서 음향 민감도를 조사하는 실험을 수행하였다. 실험 결과, 링형 탐촉자는 주파수에 대하여 다른 민감도를 나타내었으며, 이론과 비교하기 위하여 평균값을 구하였다. 세 주파수에 대한 평균 민감도는 A 탐촉자와 B 탐촉자에 대하여 각각 25.48 × 10^-5, 60.79 × 10^-5 rad/Pa으로 측정되었으며, 이로부터 영률 보정 계수 c값을 0.35로 결정할 수 있었다.

• 한국해양공학회지
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• 제26권3호
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• pp.61-65
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• 2012

Air-water flow measurements are of importance for the coastal and ocean engineering fields. Although kinematic investigations of the multi-phase flows have been conducted for long time, velocity measurements still are concerned with many researchers and engineers in coastal and ocean areas. In the present study, an imaging technique using shadowgraphy and fiber optic probe for velocity measurements of air bubbles is introduced. The shadow graphy image technique is modified from the typical image velocimetry methods, and optical fibers are used for the well-known intrusive coupled phase-detection probe system. Since the imaging technique is a non-intrusive optical method from the air, it is usually applied for 2D flows. On the other hand, the double fiber optic probes touch flows regardless of flow patterns. The results of the flow measurements by both methods are compared and discussed. The methods are also applied to the measurements of overtopping flows by a breaking wave over the structure fixed on the free surface.

• 한국정밀공학회지
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• 제29권8호
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• pp.845-852
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• 2012

The diaphragm-type stylus probe was developed for ultra-precision on-machine measurement (OMM) application. This probe is equipped with two diaphragms which are parallel and one capacitive sensor is used for detecting the vertical motion of end tip in the stylus when it is contacted to the optical freeform surface. For better performance of proposed probes, several design parameters such as axial stiffness and the lateral deformations were investigated with finite element analysis techniques. To verify the feasibility, the profiles of the master sphere ball were measured on the ultra-precision milling machine. The measurement results show that the proposed probe can calculate the radius of the circle within the accuracy of 0.1 ${\mu}m$ for the ultraprecision optical surface.

• Biomolecules & Therapeutics
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• 제26권1호
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• pp.81-92
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• 2018

It is widely accepted that altered metabolism contributes to cancer growth and has been described as a hallmark of cancer. Our view and understanding of cancer metabolism has expanded at a rapid pace, however, there remains a need to study metabolic dependencies of human cancer in vivo. Recent studies have sought to utilize multi-modality imaging (MMI) techniques in order to build a more detailed and comprehensive understanding of cancer metabolism. MMI combines several in vivo techniques that can provide complementary information related to cancer metabolism. We describe several non-invasive imaging techniques that provide both anatomical and functional information related to tumor metabolism. These imaging modalities include: positron emission tomography (PET), computed tomography (CT), magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS) that uses hyperpolarized probes and optical imaging utilizing bioluminescence and quantification of light emitted. We describe how these imaging modalities can be combined with mass spectrometry and quantitative immunochemistry to obtain more complete picture of cancer metabolism. In vivo studies of tumor metabolism are emerging in the field and represent an important component to our understanding of how metabolism shapes and defines cancer initiation, progression and response to treatment. In this review we describe in vivo based studies of cancer metabolism that have taken advantage of MMI in both pre-clinical and clinical studies. MMI promises to advance our understanding of cancer metabolism in both basic research and clinical settings with the ultimate goal of improving detection, diagnosis and treatment of cancer patients.

• 한국세라믹학회지
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• 제55권5호
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• pp.510-514
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• 2018

Colloidal semiconductor quantum dots (QDs), because of the novel optical and electrical properties that stem from their three-dimensional confinement, have attracted great interest for their potential applications in such fields as bio-imaging, display, and opto-electronics. However, many semiconductors that can be exploited for QD applications contain toxic elements. Herein, we synthesized non-toxic ZnTe/ZnSe (core/shell) type-II QDs by pyrolysis method. Because of the unique type-II character of these QDs, their emission can range over an extended wavelength regime, showing photoluminescence (PL) from 450 nm to 580 nm. By optimizing the ZnSe shell growth condition, resulting ZnTe/ZnSe type-II QDs shows PL quantum yield up to ~ 25% with 35 nm PL bandwidth. Using a simple two step cation exchange reaction, we also fabricated ZnTe/ZnSe type-II QDs with absorption extended over the whole visible region. The visible-light sensitized heavy metal free ZnTe/ZnSe type-II QDs can be relevant for opto-electronic applications such as displays, light emitting diodes, and bio-imaging probes.

• Tribology and Lubricants
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• 제30권4호
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• pp.218-223
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• 2014

This paper presents a method of controlling the stiffness of a tungsten probe for an atomic force microscope (AFM) in order to provide high-quality phase contrast images in accordance with sample characteristics. While inducing sufficient deformation on sample surfaces with commercial Si or $Si_3N_4$ probes is difficult because of their low stiffness, a tungsten probe fabricated by electrochemical etching with appropriately high stiffness can generate relatively large elastic deformation without damaging sample surfaces. The fabrication of the tungsten probe involves two separate procedures. The first procedure involves immersing a tungsten wire with both ends bent parallel to the surface of an electrolyte and controlling the stiffness of the tungsten cantilever by decreasing its diameter using electrochemical etching in the direction of the central axis. The second procedure involves immersing the end of the etched tungsten cantilever in the direction perpendicular to the surface of the electrolyte and fabricating a tungsten tip with a tip radius of 20-50 nm via the necking phenomenon. The latter etching process applies pulse waves every 0.25 seconds to the manufactured tip to improve its yield. Finite element analysis (FEA) of the stiffness of the tungsten probe as a function of its diameter showed that the stiffness of the tungsten probes greatly varies from 56 N/m to 3501 N/m according to the cantilever diameters from $30{\mu}m$ to $100{\mu}m$, respectively. Thus, the proposed etching method is effective for producing a tungsten probe having specific stiffness for optimal use with an AFM and certain samples.

• 대한기계학회논문집A
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• 제36권2호
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• pp.195-201
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• 2012

다양한 소비자의 요구에 따라 가공된 제품을 좀더 신속하고 정확하게 측정할 수 있는 공작기계 내 자동계측장치를 적용하는 사례가 급격히 증가하고 있다. 자동 계측으로 가장 많이 활용되는 접촉식 측정 프로브는 주로 공작물의 가공 원점을 설정하고, 정확한 치수 검사를 통한 불량유무 판정 및 보상가공에 많이 활용된다. 따라서 본 연구에서는 기기상 자동계측장치인 접촉식 측정 프로브를 활용하여 가공된 형상을 신속하고 정확하게 측정하는 방법을 연구하였으며 이를 위하여 가장 많이 활용되는 홀 측정 사이클에 대한 매크로 프로그램을 개발하였다. 또한 측정 시 홀의 진원도 오차에 따라 발생할 수 있는 편심량을 시뮬레이션하여 분석하였으며 본 연구의 신뢰성을 높이기 위하여 기기상에서 개발된 홀 측정 매크로 프로그램을 이용하여 홀플레이트에 대한 측정이 이루어졌으며, 진원도 오차에 따른 편심량을 검증하였다.

• 한국정밀공학회지
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• 제23권3호
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• pp.179-186
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• 2006

Single-walled carbon nanotubes (SWNT) exhibit strong Raman signals as well as fluorescence emissions in the near infrared regions where most biomolecules are transparent. Such signals do not blink or photobleach under prolonged excitation. which is advantageous to optical nano-bio marker applications. In this paper, single walled carbon nanotubes are conjugated with specific types of single-stranded DNA in order to detect oligonucleotides of corresponding complimentary sequences. Dot blotting experiments and comparative Raman spectroscopy observations demonstrated excellent sensitivity and specificity of carbon nanotube-DNA probes. The results show the possibility of using SWNT as generic nano-bio markers for the precise detection of specific kinds of genes.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2006년도 추계학술대회 논문집 Vol.19
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• pp.290-291
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• 2006

We prepared the multilayer with Al doped ZnO (AZO)/Ag/AZO structure. The multilayer were deposited with various thickness of Ag layer on glass substrates at room temperature by using facing targets sputtering (FTS) method. To investigate the electrical, optical and structural properties, we used Hall Effect measurement system, four-point probes. UV-VIS spectrometer with a wavelength of 300 - 100nm, X-ray Diffractometer(XRD) and scanning electron microscopy (SEM). We obtained multilayer thin film with the low resistivity $5,9{\times}10^{-5}{\Omega}cm$ and the average transmittance of 86% m the visible range (400 - 800nm).