• Molecules and Cells
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• v.25 no.1
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• pp.124-130
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• 2008

Astrocyte ion channels participate in ionic homeostasis in the brain. Inward rectifying potassium channels (Kir channels) in astrocytes have been particularly implicated in $K^+$ homeostasis because of their high open probability at resting potential and their increased conductance at high concentrations of extracellular $K^+$. We examined the expression of the Kir2.1 subunit, one of the Kir channel subunits, in the mouse brain by immunohistochemistry. Kir2.1 channels were widely distributed throughout the brain, with high expression in the olfactory bulb and the cerebellum. Interestingly, they were abundantly expressed in astrocytes of the olfactory bulb, while astrocytes in other brain regions including the hippocampus did not show any detectable expression. However, Kir2.1 channel-expressing cells were dramatically increased in the hippocampus by kainic acid-induced seizure and the cells were glial fibrillary acidic protein (GFAP)-positive, which confirms that astrocytes in the hippocampus express Kir2.1 channels under pathological conditions. Our results imply that Kir2.1 channels in astrocyte may be involved in buffering $K^+$ against accumulated extracellular $K^+$ caused by neuronal hyperexcitability under phathophysiological conditions.

• The Korean Journal of Applied Statistics
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• v.28 no.3
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• pp.417-427
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• 2015

Measures in response rate used to measure the representativeness of the sample (the more high response rate) better explain the representativeness of the sample. However, we cannot often explain the representativeness of the sample because there is nonresponse even in the high response rate. Therefore, Schouten et al. (2009) presented a new R-indicator measure that can be described as a representative of the sample. We research the new estimator of the R-indicator in this paper because there are parameters that require estimations. We describe the meanings as representative of the R-indicator; consequently, the bias and efficiency of the proposed estimator for R-indicator are compared to the existing estimator under various simulations. The representativeness of the sample is also explained by applying the proposed estimators in the actual data.

• Journal of the Korea Institute of Military Science and Technology
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• v.18 no.2
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• pp.181-188
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• 2015

This paper present, the result of the guidance and control law for a course correction munitions(CCM) with 2sets of canards positioned in the rotating nose section. The nonlinear simulation model of the CCM was developed based on 7DOF equation of motion. The ability of correcting position was verified by open-loop control input with nonlinear model. The guidance and control command was constructed by reference trajectory which can be obtained with no control. Finally, the performance of the guidance and control law was evaluated through Monte-carlo simulation. The CEP(Circular Error Probability) was obtained by considering the errors in muzzle velocity, aerodynamic coefficient, wind, elevation and azimuth angle and density.

• BMB Reports
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• v.39 no.1
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• pp.91-96
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• 2006

Previously, we have shown that nitric oxide (NO) directly activates the Maxi-K channels. In the present study, we have investigated whether NO has prolonged effects on the Maxi-K channels reconstituted in lipid bilayer. Application of S-nitroso-N-acetyl-D, L-penicillamine (SNAP), a NO donor, induced an immediate increase of open probability (Po) of Maxi-K channel in a dose-dependent manner. When SNAP was removed from the cytosolic solution, the Po did not simply returned to, but irreversibly decreased to a level lower than that of the control Po. At 0.2 mM, (Z)-[N-(3-Ammoniopropyl)-N-(n-propyl)amino] diazen-1-ium-1,2-diolate (PAPA-NO), another NO donor, produced a similar increase of Po and decrease of Po upon washout. The increasing effects of SNAP on Po were not blocked by either 50 U/ml superoxide dismutase (SOD) or 2 mM N-ethylmaleimide (NEM) pre-treatments. However, NEM appears to be ineffective when applied after SNAP. These results suggest that NO can modulate Maxi-K channel via direct interaction and chemical modification, such as S-nitrosylation in the brain.

• Computers and Concrete
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• v.16 no.1
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• pp.99-123
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• 2015

In this study, structural vulnerability of reinforced concrete moment resisting frames (RC-MRFs) by considering the Iran-specific characteristics is investigated to manage the earthquake risk in terms of multicomponent seismic excitations. Low and medium rise RC-MRFs, which constitute approximately 80-90% of the total buildings stock in Iran, are focused in this fragility-based assessment. The seismic design of 3-12 story RC-MRFs are carried out according to the Iranian Code of Practice for Seismic Resistant Design of Buildings (Standard No. 2800), and the analytical models are formed accordingly in open source nonlinear platforms. Frame structures are categorized in three subclasses according to the specific characteristics of construction practice and the observed seismic performance after major earthquakes in Iran. Both far and near fields' ground motions have been considered in the fragility estimation. An optimal intensity measure (IM) called Sa, avg and beta probability distribution were used to obtain reliable fragility-based database for earthquake damage and loss estimation of RC buildings stock in urban areas of Iran. Nonlinear incremental dynamic analyses by means of lumped-parameter based structural models have been simulated and performed to extract the fragility curves. Approximate confidence bounds are developed to represent the epistemic uncertainties inherent in the fragility estimations. Consequently, it's shown that including vertical ground motion in the analysis is highly recommended for reliable seismic assessment of RC buildings.

• Proceedings of the Korea Contents Association Conference
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• 2004.11a
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• pp.314-317
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• 2004

With the advance of network and software infrastructure, Grid-computing technology on a cluster of heterogeneous computing resources becomes pervasive. Grid computing is required a coordinated use of an assembly of distributed computers, which are linked by WAN. As the number of grid system components increases, the probability of failure in the grid computing is higher than that in a traditional parallel computing. To provide the robustness of grid applications, fault detection is critical and is essential elements in design and implementation. In this paper, a OGSA based process fault-detection services presented to provide high reliability under low network traffic environment.

• International Journal of Naval Architecture and Ocean Engineering
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• v.8 no.1
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• pp.110-116
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• 2016

In this study an attempt has been made to study the hydrodynamic performance of pumpjet propulsor. Numerical investigation based on the Reynolds Averaged NaviereStokes (RANS) computational fluid dynamics (CFD) method has been carried out. The structured grid and SST ${\kappa}-{\omega}$ turbulence model have been applied. The numerical simulations of open water performance of marine propeller E779A are carried out with different advance ratios to verify the numerical simulation method. Results show that the thrust and the torque are in good agreements with experimental data. The grid independent inspection is applied to verify accuracy of numerical simulation grid. The numerical predictions of hydrodynamic performance of pumpjet propulsor are carried out with different advance ratios. Results indicate that the rotor provides the main thrust of propulsor and the balance performance of propulsor is generally satisfactory. Additionally, the curve of propulsor efficiency is in good agreement with experimental data. Furthermore, the pressure distributions around rotor and stator blades are reasonable. Beyond that, the existence of tip clearance accounts for the appearance of tip vortex that leads to a further loss in efficiency and a probability of cavitation phenomenon.

• Journal of the Korea Institute of Military Science and Technology
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• v.13 no.2
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• pp.336-341
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• 2010

The burning interruption between the initiator and the delay column in a Zr-Ni K1 delay system used for a K510 fuze occurs with long-time storage. About 10 % failure probability of 15-years stored delay systems shows the failure mode in open literature. This paper shows storage lifetime improvement results for the delay system through changing the single-base delay column into double-base ones and controlling the manufacturing processes especially the initial inclusion of humidity. The double-base delay columns was implemented by inserting one delay column of fast burning rates between the initiator and the previous delay column of slow burning rates. Accelerated aging tests of the delay systems with double-base columns, and then the firing tests were performed to evaluate the improved lifetime. The double-base delay columns shows improved storage lifetime of the delay system through preventing the failure mode.

• The Journal of Engineering Research
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• v.3 no.1
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• pp.85-95
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• 1998

In this study, we consider a recursive procedure to obtain the stationary probability distribution for analyzing Coxian queueing networks with finite queues. This network deals with multiple class customers. Due to the state space representing multiple class customers, the sub-matrices corresponding to states can not be square matrices and can not be inverted. Therefore, we introduce more complex recursive method to avoid the singular problem. The open queueing network that we study consists of 3 parallel first-level sources linked to a single second level queue. We consider two types of schemes for entering a queue. The first scheme is assumed to be the first-blocked-first-enter (FBFE) and the second scheme is the higher-priority-first-enter (HPFE). Arrival and service times are assume to have a Coxian distribution with two phases. Comparison between the resulting using Gauss-Seidel method and recursive procedure will be shown.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.5
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• pp.1881-1903
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• 2015

With the fast-developing of mobile terminals, positioning techniques based on fingerprinting method draws attention from many researchers even world famous companies. To conquer some shortcomings of the existing fingerprinting systems and further improve its performance, we propose a radio map building and updating technique, which is able to customize the spatial and temporal dependency of radio maps. The method includes indoor propagation and penetration modeling and the analysis of human traffic. Based on the combination of Ray-Tracing Algorithm, Finite-Different Time-Domain and Rough Set Theory, the approach of indoor propagation modeling accurately represents the spatial dependency of the radio map. In terms of temporal dependency, we specifically study the factor of moving people in the interest area. With measurement and statistics, the factor of human traffic is introduced as the temporal updating component. We improve our existing indoor positioning system with the proposed building and updating method, and compare the localization accuracy. The results show that the enhanced system can conquer the influence caused by moving people, and maintain the confidence probability stable during week, which enhance the actual availability and robustness of fingerprinting-based indoor positioning system.