• 항공우주시스템공학회지
• /
• 제4권1호
• /
• pp.23-26
• /
• 2010

In this study, it was performed damage assesment of small scale composite aircraft developing. This aircraft adopted the sandwich structure to skin of wing. This study aims to investigate the residual strength of sandwich composites with Nomex honeycomb core and carbon fiber face sheets after the open hole damage by the experimental investigation. The 4-point bending tests were used to find the bending strength, and the open hole was applied to introduce the simulated damage on the specimen. The bending strength test results after open hole was compared with the results of no damaged specimen test. The FEM analysis is assessed via an experimental 4-point bending test.

• 한국정밀공학회지
• /
• 제33권2호
• /
• pp.121-128
• /
• 2016

The mechanical jointing method is very important in the machine parts and structure. They are used by the bolts and rivet because it is very convenient to replace the parts and the structure. However, the mechanical jointing methods using the bolt and rivet needed the open hole. The machine parts life cycle is reduced because this open hole created the stress concentration. Therefore, the measurement methods are needed to evaluate phenomenon of the stress concentration. This paper discusses the development of the measurement algorithm using the digital image correlation methods to measure the strain distribution of the open hole. To implement the measurement algorithm using the DIC, the LabVIEW 2010 programming tool was used. To measure the strain distribution of the open hole, the tensile specimens having an open hole are made by using the aluminum 6061-T6. To secure the reliability of measurement result using the DIC, the DIC measurement results and FEM analysis results were compared.

• Advances in Traditional Medicine
• /
• 제6권3호
• /
• pp.174-178
• /
• 2006

The ethanolic extract of Leucas aspera root was studied for its effect on the central nervous system (CNS) using pentobarbitone induced sleeping time test, the open field test and the hole cross test in Swiss albino mice. The present investigation revealed that the extract at the doses of 250 and 500 mg/kg, significantly prolonged the pentobarbitone induced sleeping time in mice though the onset of sleep was delayed as compared to control. In open field test the depressing effect was prominent from the second observation period (30 min) and persisted throughout the entire experimental period (240 min). In the hole cross test, the depressing effect was observed significant from the third observation period (60 min) and persisted up to the seventh observation period (240 min) except at fourth observation (90 min) for 250 mg dose group and depressing effect was significant from second observation (30 min) up to seventh observation period (240 min) for 500 mg dose group. These results support the finding that Leucas aspera root may contain biologically active constituent(s) having CNS activity.

• Advances in Traditional Medicine
• /
• 제4권4호
• /
• pp.249-252
• /
• 2004

The methanol extract of Diospyros peregrina bark was studied for its effect on the central nervous system (CNS) using the pentobarbitone induced sleeping time test, the open field test and the hole cross test in Swiss albino mice. The present investigation revealed that the extract, at the doses of 250 and 500 mg/kg, significantly prolonged the pentobarbitone induced sleeping time in mice though the onset of sleep was delayed as compared to the control. In open field test, the depressing effect was prominent from the second observation period (30 min) and persisted throughout the entire experimental period (240 min). In the hole cross test, the depressing effect was observed from the second observation period (30 min) and persisted up to fifth observation period (120 min) for 250 mg dose group and up to sixth observation period (180 min) for 500 mg dose group. These results support the finding that D. peregrina bark extract at the above doses has CNS depressing effects and indicate that D. peregrina bark may contain biologically active constituent(s) having CNS depressant activity.

• Composites Research
• /
• 제24권4호
• /
• pp.29-35
• /
• 2011

전통적인 특성길이 방법을 이용하여 원공이 있는 복합재 적층판의 강도를 예측하기 위해서는 원공이 있는 적층뿐만 아니라 원공이 없는 적층판에 대한 시험 결과와 유한요소해석이 필요하였다. 본 논문에서는 응력집중계수와 재료상수를 이용하여 유한요소해석 없이 복합재 적층판 원공 주위의 응력분포 및 인장특성길이를 추정하고, 이를 바탕으로 원공이 있는 복합재 적층판의 인장강도를 예측할 수 있는 방법을 제안하였다. 또한 새로운 방법에서는 재료의 효과가 변수로 고려되므로 다양한 재료에 대한 적용이 가능하며 원공이 있는 복합재 적층판에 대한 시험도 생략할 수 있다. 적층판 주위의 응력분포는 유한요소해석과의 비교를 통해 검증하였고, 최종적으로는 USN125 탄소/에폭시 적층판을 제작하여 파손하중 예측 결과와 시험 결과를 비교하였다. 원공이 있는 다양한 형상의 복합재 적층판의 파손강도 예측 결과는 최대 8% 이내의 오차로 시험 결과와 잘 일치함을 확인하였다.

• Composites Research
• /
• 제27권2호
• /
• pp.77-81
• /
• 2014

본 연구에서는 전기체 복합재가 적용되어 설계된 소형 항공기의 손상 평가 및 유지 보수 연구를 수행하였다. 본 연구에서 개발 중인 항공기의 스킨 부위는 샌드위치 구조가 적용되었다. 본 연구에서는 노멕스 허니컴코어와 카본 면재가 적용된 샌드위치 복합재 구조에 대해 구멍 손상 이후의 잔류 강도 평가에 대한 연구를 수행하였다. 4점 굽힘 시험을 통해 시편의 굽힘 강도를 확인하고, 시편에 손상을 모사하기 위하여 시편의 중앙 부위에 구멍 손상을 가하였다. 손상된 시편을 손상 전 시편과 동일한 시험을 통해 손상 전의 강도와 비교하였다. 또한 손상된 복합재 구조는 손상 부위 제거 후 패치 수리 기법을 적용하고 손상된 시편과 보수된 시편의 굽힘 강도 시험결과를 비교하였다. 샌드위치 복합재 구조 시편의 유지 보수 후 굽힘 강도 시험 결과 손상 전 시편의 강도와 비교하여 강도의 95%까지 회복되는 것으로 분석되었다.

• 비파괴검사학회지
• /
• 제27권6호
• /
• pp.563-575
• /
• 2007

This contribution contained the classical work of an open-hole tensile plate to demonstrate the performance of grating shearography and to compare with the results obtained by other full-field measurement techniques, The isotropic plate with an open-hole has often appeared in the previous contributions introducing novel full-field method and system. Grating shearography directly provided six quantitative measurands about the specimen's surface kinematics by using a single measurement set: three in-plane strains, in plane rotation, and two out-of-plane slopes. The quasi-plane wavefront of grating metrology led to high signal-to-noise ratio (SNR) and thus neither fitting nor filtering was applied, and the small shearing distance of $101{\mu}m$ could be used. The small shearing distance provided the outstanding spatial resolution of $80{\mu}m$ and sensitivity appropriate for experimental mechanics. Finally, the grating shearography enabled the visualization of the complex surface deformation around the hole and also detected parasitic flexions of the specimen in the micrometer regime during the tensile test.

• 생명과학회지
• /
• 제24권3호
• /
• pp.290-296
• /
• 2014

이 연구의 목적은 mice를 이용하여 elevated plus-maze (EPM) test와 hole-board test를 통해 quercetin의 잠재적인 항불안 작용을 확인하고자 함이다. Quercetin을 1.25, 2.5, 5나 10 mg/kg의 용량으로 각각 행동시험을 측정하기 1 시간 전에 ICR mice에 경구투여하였다. 대조군은 동일한 양의 10% Tween 80을 투여하였고 양성대조군으로 buspirone 2 mg/kg을 투여하였다. Quercetin을 단회 투여하여 EPM test를 실시한 결과, 5 mg/kg 용량에서 open arm에 머문 시간 및 진입한 횟수의 백분율이 control group과 비교하여 통계적으로 유의성 있게 증가하였다(p<0.05). 또한 quercetin을 투여하여 hole-board test를 실시한 결과, 5 mg/kg 용량에서 구멍에 머리를 넣은 횟수가 control group과 비교하여 통계적으로 유의성 있게 증가하였다(p<0.05). 또한 quercetin와 flumazenil ($GABA_A$ antagonist), WAY-100635 ($GABA_{A-{\rho}}$ antagonist) 또는 trans-4-aminocrotonic acid ($GABA_{A-{\rho}}$ agonist)를 병용투여하여 elevated plus-maze를 실험을 하여 신경계와의 관계를 확인한 결과, trans-4-aminocrotonic acid에서만 quercetin의 항불안 작용이 차단되었음을 확인 할 수 있었다. 결론적으로, 본 연구의 결과에서 quercetin이 elevated plus-maze 및 hole-board test, horizontal wire test, open field test를 통하여 locomotor activity 및 근육이완이나 진정 등의 부작용이 없으면서 우수한 항불안 작용을 가지는 소재라고 생각되며 이러한 작용이 특히 GABA 신경계와 관련이 있음을 시사하고 있다.

• Biomolecules & Therapeutics
• /
• 제16권3호
• /
• pp.261-269
• /
• 2008

This experiment was performed to investigate the anxiolytic-like effects of cyclopeptide fraction alkaloids of Zizyphi Spinosi Semen (CFAZ), by using the experimental paradigms of anxiety, and compared with those of a known anxiolytic, diazepam. CFAZ (8.0 mg/kg, p.o.) increased the percentage of time spent on the open arms and the number of open arms entries in the elevated plus-maze test, increased the number of head dips in the hole-board test, and increased the percentage of center zone ambulatory time in the open-field box. However, CFAZ has no effect on the locomotor activity, while diazepam (2.0 mg/kg, p.o.) significantly reduced locomotor activity. CFAZ did not influence the grip force in the grip strength meter test, either. From the molecular experiments, CFAZ increased chloride influx in cultured cerebellar granule cells. In addition, $GABA_A$ receptors $\gamma$-subunit were over-expressed by CFAZ in cultured cerebellar granule cells. It is concluded that CFAZ may have anxiolytic-like effects, and these effects may be mediated by $GABA_A$ receptors.

• Natural Product Sciences
• /
• 제15권3호
• /
• pp.115-120
• /
• 2009

Woohwangcheongsimwon (WHCSW) is a traditional oriental medicinal fomula which has been clinically used for treating strokes, palpitation, loss of consciousness and anxiety. The purpose of this study was to characterize the putative anxiolytic properties of WHCSW using an elevated plus-maze (EPM) and hole-board test. Control mice were orally treated with an equal volume of vehicle (10% Tween 80 solution), and positive control mice were treated with diazepam (1 mg/kg, i.p.). In the EPM test, WHCSW significantly increased the percentage of time-spent in the open arms (200 mg/kg, P < 0.05) and the percentage of open arm entries (200 and 400 mg/kg, P < 0.05). WHCSW also significantly increased the number of head-dips in the hole-board test (200 mg/kg, P < 0.05). In addition, the anxiolytic properties of WHCSW examined in the EPM test were inhibited by flumazenil (10 mg/kg, i.p.), a GABA$_A$ antagonist. However, no changes in spontaneous locomotor activity or myorelaxant effects were observed versus 10% Tween 80 controls. These results suggested that WHCSW is an effective anxiolytic agent, and that its anxiolytic effects are mediated via GABA$_A$ receptors.