• Journal of Aerospace System Engineering
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• v.4 no.1
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• pp.23-26
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• 2010

In this study, it was performed damage assesment of small scale composite aircraft developing. This aircraft adopted the sandwich structure to skin of wing. This study aims to investigate the residual strength of sandwich composites with Nomex honeycomb core and carbon fiber face sheets after the open hole damage by the experimental investigation. The 4-point bending tests were used to find the bending strength, and the open hole was applied to introduce the simulated damage on the specimen. The bending strength test results after open hole was compared with the results of no damaged specimen test. The FEM analysis is assessed via an experimental 4-point bending test.

• Journal of the Korean Society for Precision Engineering
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• v.33 no.2
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• pp.121-128
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• 2016

The mechanical jointing method is very important in the machine parts and structure. They are used by the bolts and rivet because it is very convenient to replace the parts and the structure. However, the mechanical jointing methods using the bolt and rivet needed the open hole. The machine parts life cycle is reduced because this open hole created the stress concentration. Therefore, the measurement methods are needed to evaluate phenomenon of the stress concentration. This paper discusses the development of the measurement algorithm using the digital image correlation methods to measure the strain distribution of the open hole. To implement the measurement algorithm using the DIC, the LabVIEW 2010 programming tool was used. To measure the strain distribution of the open hole, the tensile specimens having an open hole are made by using the aluminum 6061-T6. To secure the reliability of measurement result using the DIC, the DIC measurement results and FEM analysis results were compared.

• Advances in Traditional Medicine
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• v.6 no.3
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• pp.174-178
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• 2006

The ethanolic extract of Leucas aspera root was studied for its effect on the central nervous system (CNS) using pentobarbitone induced sleeping time test, the open field test and the hole cross test in Swiss albino mice. The present investigation revealed that the extract at the doses of 250 and 500 mg/kg, significantly prolonged the pentobarbitone induced sleeping time in mice though the onset of sleep was delayed as compared to control. In open field test the depressing effect was prominent from the second observation period (30 min) and persisted throughout the entire experimental period (240 min). In the hole cross test, the depressing effect was observed significant from the third observation period (60 min) and persisted up to the seventh observation period (240 min) except at fourth observation (90 min) for 250 mg dose group and depressing effect was significant from second observation (30 min) up to seventh observation period (240 min) for 500 mg dose group. These results support the finding that Leucas aspera root may contain biologically active constituent(s) having CNS activity.

• Advances in Traditional Medicine
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• v.4 no.4
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• pp.249-252
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• 2004

The methanol extract of Diospyros peregrina bark was studied for its effect on the central nervous system (CNS) using the pentobarbitone induced sleeping time test, the open field test and the hole cross test in Swiss albino mice. The present investigation revealed that the extract, at the doses of 250 and 500 mg/kg, significantly prolonged the pentobarbitone induced sleeping time in mice though the onset of sleep was delayed as compared to the control. In open field test, the depressing effect was prominent from the second observation period (30 min) and persisted throughout the entire experimental period (240 min). In the hole cross test, the depressing effect was observed from the second observation period (30 min) and persisted up to fifth observation period (120 min) for 250 mg dose group and up to sixth observation period (180 min) for 500 mg dose group. These results support the finding that D. peregrina bark extract at the above doses has CNS depressing effects and indicate that D. peregrina bark may contain biologically active constituent(s) having CNS depressant activity.

• Composites Research
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• v.24 no.4
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• pp.29-35
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• 2011

The characteristic length method used to determine a laminate's strength generally requires the test for un-notched and notched laminates and finite element analysis together. In this paper, the methods used to predict the stress distribution and tensile characteristic length of open-hole laminates using the stress concentration factor and equivalent material properties are proposed. These methods do not require data on the failure load of open-hole laminates or finite element analysis. Once the stress and characteristic length have been determined, the failure load of the open-hole laminate can be calculated. The proposed method considers the effect of the material properties as a parameter and therefore can be applied to a variety of materials. The stress distribution is verified by comparing with a finite element analysis and test results. The predicted failure load shows a maximum deviation of 8% from the test results.

• Composites Research
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• v.27 no.2
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• pp.77-81
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• 2014

In this study, it was performed damage assessment and repair of small scale aircraft adopted on composite. This aircraft adopted the sandwich structure to skin of wing. This study aims to investigate the residual strength of sandwich composites with nomex honeycomb core and carbon fiber face sheets after the open hole damage by the experimental investigation. The 4-point bending tests were used to find the bending strength, and the open hole was applied to introduce the simulated damage on the specimen. The bending strength test results after open hole were compared with the results of no damaged specimen test. In addition, The damaged composite structure was repaired using external patch repair method after removing damaged area. After that, this study presents comparison results of the experimental investigation between the damaged and the repaired specimen. It was found that the bending strength of repaired specimen was recovered up to 95% of undamaged specimen.

• Journal of the Korean Society for Nondestructive Testing
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• v.27 no.6
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• pp.563-575
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• 2007

This contribution contained the classical work of an open-hole tensile plate to demonstrate the performance of grating shearography and to compare with the results obtained by other full-field measurement techniques, The isotropic plate with an open-hole has often appeared in the previous contributions introducing novel full-field method and system. Grating shearography directly provided six quantitative measurands about the specimen's surface kinematics by using a single measurement set: three in-plane strains, in plane rotation, and two out-of-plane slopes. The quasi-plane wavefront of grating metrology led to high signal-to-noise ratio (SNR) and thus neither fitting nor filtering was applied, and the small shearing distance of $101{\mu}m$ could be used. The small shearing distance provided the outstanding spatial resolution of $80{\mu}m$ and sensitivity appropriate for experimental mechanics. Finally, the grating shearography enabled the visualization of the complex surface deformation around the hole and also detected parasitic flexions of the specimen in the micrometer regime during the tensile test.

• Journal of Life Science
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• v.24 no.3
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• pp.290-296
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• 2014

The present experiment investigated putative anxiolytic-like effects of quercetin using an elevated plus-maze (EPM) and hole-board apparatus test in mice. Quercetin is a flavonoid widely distributed in nature. Quercetin (1.25, 2.5, 5, or 10 mg/kg) was orally administered to ICR mice 1 h before a behavioral evaluation in the EPM. Control mice were treated with an equal volume of vehicle, and positive control mice were treated with buspirone (2 mg/kg, i.p.). The mice administered quercetin (5 mg/kg) spent a significantly longer percentage of time in the open arms of the EPM and their percentage of entries into the open arms was significantly increased compared to the vehicle-treated controls (p<0.05). The anxiolytic-like activities of quercetin were antagonized by trans-4-aminocrotonic acid (a $GABA_{A-{\rho}}$ agonist, 20 mg/kg) but not by flumazenil (a $GABA_A$ antagonist, 10 mg/kg) or WAY-100635 (a $5-HT_{1A}$ antagonist, 0.3 mg/kg). Moreover, there were no changes in the locomotor activity or myorelaxant effects in any group compared with the vehicle-treated controls. In the hole-board apparatus test, the number of head-dips increased significantly in the single treatment with quercetin (5 mg/kg) group compared to the vehicle-treated controls (p<0.05). These findings suggest that quercetin can promote anxiolytic-like activity, mediated by the GABAergic nervous system, in mice.

• Biomolecules & Therapeutics
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• v.16 no.3
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• pp.261-269
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• 2008

This experiment was performed to investigate the anxiolytic-like effects of cyclopeptide fraction alkaloids of Zizyphi Spinosi Semen (CFAZ), by using the experimental paradigms of anxiety, and compared with those of a known anxiolytic, diazepam. CFAZ (8.0 mg/kg, p.o.) increased the percentage of time spent on the open arms and the number of open arms entries in the elevated plus-maze test, increased the number of head dips in the hole-board test, and increased the percentage of center zone ambulatory time in the open-field box. However, CFAZ has no effect on the locomotor activity, while diazepam (2.0 mg/kg, p.o.) significantly reduced locomotor activity. CFAZ did not influence the grip force in the grip strength meter test, either. From the molecular experiments, CFAZ increased chloride influx in cultured cerebellar granule cells. In addition, $GABA_A$ receptors $\gamma$-subunit were over-expressed by CFAZ in cultured cerebellar granule cells. It is concluded that CFAZ may have anxiolytic-like effects, and these effects may be mediated by $GABA_A$ receptors.

• Natural Product Sciences
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• v.15 no.3
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• pp.115-120
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• 2009

Woohwangcheongsimwon (WHCSW) is a traditional oriental medicinal fomula which has been clinically used for treating strokes, palpitation, loss of consciousness and anxiety. The purpose of this study was to characterize the putative anxiolytic properties of WHCSW using an elevated plus-maze (EPM) and hole-board test. Control mice were orally treated with an equal volume of vehicle (10% Tween 80 solution), and positive control mice were treated with diazepam (1 mg/kg, i.p.). In the EPM test, WHCSW significantly increased the percentage of time-spent in the open arms (200 mg/kg, P < 0.05) and the percentage of open arm entries (200 and 400 mg/kg, P < 0.05). WHCSW also significantly increased the number of head-dips in the hole-board test (200 mg/kg, P < 0.05). In addition, the anxiolytic properties of WHCSW examined in the EPM test were inhibited by flumazenil (10 mg/kg, i.p.), a GABA$_A$ antagonist. However, no changes in spontaneous locomotor activity or myorelaxant effects were observed versus 10% Tween 80 controls. These results suggested that WHCSW is an effective anxiolytic agent, and that its anxiolytic effects are mediated via GABA$_A$ receptors.