• Proceedings of the Korea Water Resources Association Conference
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• 2005.09a
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• pp.117-118
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• 2005

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.1
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• pp.25-30
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• 2012

Under some pathological conditions as bile flow obstruction or liver diseases with the enterohepatic circulation being disrupted, regurgitation of bile acids into the systemic circulation occurs and the plasma level of bile acids increases. Bile acids in circulation may affect the nervous system. We examined this possibility by studying the effects of bile acids on gating of neuronal (N)-type $Ca^{2+}$ channel that is essential for neurotransmitter release at synapses of the peripheral and central nervous system. N-type $Ca^{2+}$ channel currents were recorded from bullfrog sympathetic neuron under a cell-attached mode using 100 mM $Ba^{2+}$ as a charge carrier. Cholic acid (CA, $10^{-6}M$) that is relatively hydrophilic thus less cytotoxic was included in the pipette solution. CA suppressed the open probability of N-type $Ca^{2+}$ channel, which appeared to be due to an increase in (no activity) sweeps. For example, the proportion of sweep in the presence of CA was ~40% at +40 mV as compared with ~8% in the control recorded without CA. Other single channel properties including slope conductance, single channel current amplitude, open and shut times were not significantly affected by CA being present. The results suggest that CA could modulate N-type $Ca^{2+}$ channel gating at a concentration as low as $10^{-6}M$. Bile acids have been shown to activate nonselective cation conductance and depolarize the cell membrane. Under pathological conditions with increased circulating bile acids, CA suppression of N-type $Ca^{2+}$ channel function may be beneficial against overexcitation of the synapses.

• Proceedings of the Korea Water Resources Association Conference
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• 2009.05a
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• pp.678-682
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• 2009

하천의 합류부에서는 홍수시 침수피해가 빈번하게 발생 하거나 하안침식, 강턱붕괴, 하천의 장갑화 등의 악영향이 발생하는데, 이러한 현상의 원인 규명을 위해 본류와 지류의 유량비에 의해 혹은 지류의 유입각에 의해 다양한 흐름 특성을 가정하고 개수로 장치를 이용하거나 수치모형 실험을 통하여 연구되고 있다. 본 연구에서는 미시시피 대학 연구기관인 NCCHE(Natioanl Center for Computational Hydroscience an Engineering)에서 개발한 CCHE2D 2차원 수치모형을 이용하여, 개수로 합류부에서 흐름 및 하상변동 특성을 분석하였다. 수치모의 결과는 "Experiments on Flow at a $90^{\circ}$ Open-Channel Junction", Journal of Hydraulic Engineering, May 2001, Vol. 127, No. 5, 340-350.에 기재되었던 논문의 실내실험 결과와 비교분석하였으며, 유속의 분포는 $0.01{\sim}1.0$ m정도로 개수로 관측치와 비교적 유사하게 모의 되었다. 또한 하상 변동 모의 결과 Biron 등(1996)이 제안한 합류부에서 6구역의 흐름 정의도와 대체적으로 유사하게 모의 되었으며, 최대 유속 구간에서 $-0.2m{\sim}0.03m$의 침식이 발생하고, 정체 구간과 분리구간에서 $0.01{\sim}0.02m$의 퇴적이 발생하였다. 본 연구의 결과는 하천의 물리적 특성을 파악하고 하천공사나 수리구조물 설계의 기초 자료로 활용될 수 있을 것으로 판단된다.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.2B
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• pp.139-144
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• 2006

Using DNS data for turbulent flows in an open-channel with sidewalls, the mechanisms by which secondary flows are generated and by which Reynolds shear stresses are created, are demonstrated. Near the sidewall, secondary flows invading towards the sidewall are observed in the regions of both lower and upper corners, while secondary flows ejecting from the sidewall towards the center of the channel are created elsewhere. The distributions of Reynolds shear stresses near the sidewall are analyzed, connecting their productions with coherent structures. A quadrant analysis shows that sweeps are dominant in two corner regions where secondary flows invading towards the sidewall are generated, but that ejections are dominant in the region where secondary flows ejecting towards the center of the channel are created. Also, conditional quadrant analyses reveal that the productions of Reynolds shear stresses and the patterns of secondary flows are determined by the directional tendencies of coherent structures.

• Journal of Korea Water Resources Association
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• v.40 no.3
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• pp.265-276
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• 2007

An understanding of the hydraulic characteristics in the compound channel with vegetation is important in designing stream restorations or managing the floodplain. A laboratory flume of 16 m long and 0.8 m wide was used for analysis of the hydraulic characteristics in the single section channel and the compound channel with artificial vegetation. Slope of experimental channel is 0.5 %. Discharges are ranged from $0.2\;m^3/s\;to\;$0.4\;m^3/s$. The experiments were done by changing water depth ratio, vegetation density and vegetation location. When water depth ratio in the single section channel with vegetation increase up to 3.5, the results showed that the increment of water depth due to vegetation may be ignored in practice. The maximum increment of water depth was measured up to 6 % in the compound channel with vegetation and the range of velocities increment in the low flow channel was from 25 % to 85 % compared with section average velocities. As the vegetation densities increase and water depth ratios decrease, the velocity of the low flow channel increased. The range of roughness coefficients in the vegetated reaches were estimated from 0.055 to 0.14 in the single section channel and from 0.063 to 0.085 in the compound channel using HEC-RAS and RMA-2 model.

• Journal of Korea Water Resources Association
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• v.51 no.2
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• pp.109-120
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• 2018

In this study, we conducted flume experiments to investigate the three-dimensional flow structures around a half-submerged spur dike in a straight open channel flume. The experiments were carried out under the two different Froude numbers, 0.10 and 0.18. The results were compared with the previous experimental result conducted for non-submerged spur dike. Three-dimensional instantaneous velocities were measured using Acoustic Doppler Velocimetry (ADV) and water elevation data were collected using ultra sonic distance sensor. The results show that submergence conditions of the spur dike largely influence the three-dimensional flow structures around a spur dike.

• 한국방재학회:학술대회논문집
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• 2008.02a
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• pp.401-404
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• 2008

The vegetation in the surrounding area of river is a primary factor to increase water level during flood. The influence of vegetation on the river flow in a bank has been investigated by using a hydraulic experiment. For a hydraulic experiment square-shaped piers are used as a model of unsubmerged rigid vegetation in a open channel. For fully developed uniform flows, the water elevation of the experiment was measured as varying the interval of piers and the porosity which presents the fraction of water flowing area in the cross-sectional area. The Manning's roughness coefficient, which implicates energy losses due to the vegetation, was obtained by using the experimental data. As a result, the energy losses were varied when the distance of piers and the porosity of area were changed, and the Manning's coefficient increased nonlinearly when a water elevation increased.

• Water for future
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• v.21 no.1
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• pp.67-76
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• 1988

Analyzed was the circulation phenomena in the open channel with sudden expansion, by applying the Galerkin's finite element method to the depth-averaged 2-dimensional continuity and momentum equations. Wave tests were done in the simplified channel in order to review the validity of this newly developed model and the computed results were within 0.5% of $L_2$-norm error, and application of this model to the simulation of simplified dam-break gave very close results compared with the analytical solution, thus, it can be concluded that this model is valid and efficient. The main flow in the expanded channel was defined as a new initial condition with given velocity and the flow in the expanded portion was at rest in simulating the circulation, and besides the Neumann's condition the slip boundary condition for lateral wall was found to be proper condition than the no-slip condition. It can be concluded, from the numerical tests in the sudden expension, that the circulating phenomena depend mainly on the convective inertia and the effect of turbulence due to bottom shear and lateral shear is insignificant.

• Journal of Advanced Marine Engineering and Technology
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• v.25 no.5
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• pp.1037-1049
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• 2001

Considerable interest has evolved in the flow of non-Newtonian fluids in channels of noncircular cross section in compact heat exchanges. Analytical solution was developed for prediction of the flow rate and maximum velocity in steady laminar flow of any incompressible, time-independent non-Newtonian fluids in straight closed and open channels of arbitrary, but axially unchanging cross section. The geometric parameters and function of shear describing the behavior of the fluid model were evaluated for fluid flow among a bundle of rods arranged in triangular and square array. Numerical values of dimensionless maximum velocities, mean velocities, pressure-drop-flow parameters and friction factors were evaluated as a function of porosity and pitch-to-radius ratio.

• Journal of Korea Water Resources Association
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• v.33 no.4
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• pp.461-469
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• 2000

An numerical analysis of sediment-laden flow is carried out, and results are compared with the experiments of Coleman(1981, 1986) that included the several cases varying sediment size and quantity in open channel flow. K-$\omega$ turbulence model is selected for the fully turbulent flow field, and the concentration equation considering the fall velocity is adopted for the concentration field. The model of Einstein and Chien(1955) is applied to couple the velocity field and the concentration field. Most of researches have been carried out without considering the bed-load thickness, but it is found that the bed-load thickness cannot be ignored in case of a large amount of sediment or a large size of it. The bed-load thickness and surface roughness are considered in this study. Here, $\beta$ value, which is defined by the reciprocal of turbulent Schmidt number and is related with the concentration profile, is found to be varied according to the sediment size and quantity. Even though most of researchers have insisted that $\beta$ had always larger than 1.0, it may be concluded that $\beta$ can have smaller value than 1.0, that is coincident with the report of recent research.