• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.6B
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• pp.573-581
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• 2006

This paper presents a turbulence modeling of the open-channel flows over smooth-rough bed strips. A Reynolds stress model is used for the turbulence closure. The simulated mean flow and turbulence structures are compared with the previously reported experimental data. Comparisons reveal that the developed Reynolds stress model successfully predicts the mean flow and turbulence structures of open-channel flows over smooth-rough bed strips. The computed flow vectors show cellular secondary currents, of which the upflow occurs over the smooth bed strip and the downflow over the rough bed strip. It is found that the cellular secondary currents affect the mean flow and turbulence structure. A budget analysis of the streamwise vorticity equation is also carried out to investigate the mechanism by which the secondary currents are generated.

• Journal of Korean Society of Water and Wastewater
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• v.18 no.4
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• pp.500-507
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• 2004

This study was conducted to evaluate the equity of the flow distribution from rapid mixing basin to the flocculation basins. Also, several types of inlet structures of the open channel affecting the flow pattern and distribution trend were studied using Computational Fluid Dynamics (CFD) simulation. For investigating the factual phenomena in distribution channel, we selected a certain domestic water treatment plant with capacity of $361,000m^3/d$. From the measurements of flow discharge, it is investigated that this existing inlet geometry resulted in significant inequitable distribution. The both largest deviations in the basins and rows were over 10%. In order to reduce the these deviation, this study suggested installing a baffle against the influent, and showed the effectiveness which the largest deviation was less than 3%. Also, it was concluded that the existing design method of open channel could be improved by three-dimensional hydrodynamic analysis for optimizing the even flow.

• Journal of Korean Society of Water and Wastewater
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• v.21 no.5
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• pp.571-579
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• 2007

This study was conducted to qualify the equality of the flow distribution from open channel between rapid mixing basin and flocculation basins in a domestic full-scale water treatment plant, and suggest a remedy for improving the equality. In order to evaluate the feasibility of the suggested remedy, computational fluid dynamics (CFD) technique are used, and for verifying the CFD simulation results wet tests were carried out for the pilot scale channel based on geometric similarity. From the results of CFD simulation and wet tests, it was investigated that the modification of hydraulic structure in the distribution channel, which is to install the longitudinal orifice baffle in flow direction, could improve the equality of the flow distribution. Also, in the case that Froude number is relatively small (Froude number <<0.03), the open ratio of orifices on the installed baffle hardly affects the equality of flow distribution.

• Archives of Pharmacal Research
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• v.28 no.3
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• pp.269-273
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• 2005

A furocoumarin derivative, psoralen (7H-furo[3,2-g][1]benzopyran-7-one), was isolated from the n-hexane fraction of Heracleum moellendorffii Hance. We examined the effects of psor-alen on a human Kv1.5 potassium channel (hKv1.5) cloned from human heart and stably expressed in Uk- cells. We found that psoralen inhibited the hKv1.5 current in a concentration-, use- and voltage-dependent manner with an IC$_{50}$ value of 180 $\pm$ 21 nM at +60 mV. Psoralen accelerated the inactivation kinetics of the hKv1.5 channel, and it slowed the deactivation kinetics of the hKv1.5 current resulting in a tail crossover phenomenon. These results indicate that psoralen acts on the hKv1.5 channel as an open channel blocker. Furthermore, psoralen prolonged the action potential duration of rat atrial muscles in a dose-dependent manner. Taken together, the present results strongly suggest that psoralen may be an ideal antiarrhythmic drug for atrial fibrillation.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2003.04a
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• pp.69-73
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• 2003

A open section thick composite beam model is suggested in this study. In the model, the primary and secondary warping and transverse shear effects are incorporated. The rigidities associated with thick channel composite beam and thin channel composite beam are obtained and compared. The results show that the difference among rigidities of the thick and thin composite beams increase as the wall thickness increases.

• International Journal of Control, Automation, and Systems
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• v.2 no.1
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• pp.23-38
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• 2004

We proposed the infinity control principle to evaluate the Biological function. The H infinity control was applied to the Sodium (Na) ion selective gating channel on the excitable cellular membrane of the neural system. The channel opening, closing and inactivation processes were expressed by movements of three gates and one inactivation blocking particle in the channel pore. The rate constants of the channel state transition were set to be voltage dependent. The temporal changes in amounts per unit membrane area of the channel states were expressed by means of eight differential equations. The biochemical mimetic used to complete the Na ion selective channel was regarded as noise. The control inputs for ejecting the blocking particle with plugging in the channel pore were set for the active transition from inactivated states to a closed or open state. By applying the H infinity control, we computed temporal changes in the channel states, observers, control inputs and the worst case noises. The present paper will be available for evaluating the noise filtering function of the biological signal transmission system.

• Journal of Korean Medical classics
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• v.32 no.2
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• pp.33-47
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• 2019

Objectives : To review the meaning of Open-Close-Pivot and its transition over time. Methods : Annotations and explanations in chapters where the theory of Open-Close-Pivot originated from in the "Suwen(素問)" and "Lingshu(靈樞)" were examined, followed by philological examination of key physicians. Results & Conclusions : Yang Shang Shan(楊上善) compared the 'Open-Close-Pivot' to a door. Wang Bing(王冰) explained it's movement and stillness to be the principle behind the Three-Yin-Three-Yang's threefold division. Wang Ji(汪機), in "XuSuwenChao(續素問鈔)" explained its physiological function as the entering and exiting of Ying Wei(營衛), and its scope to be exterior, interior, and center. Ma Shi(馬蒔) stratified it similar to "Shanghanlun(傷寒論)"'s six stages, while Wu Kun(吳崑) categorized Shaoyang(少陽) as being in-between exterior and interior. Zhang Jing Yue(張景岳) suggested a standard for the entering-exiting and exterior-interior-center concepts of the Open-Close-Pivot. Zhang Zhi Cong(張志聰) argued a theory of Open-Close-Pivot that emphasized the meaning of Three-Yin-Three-Yang, while Gao Shi Zong(高士宗) explained the relationship between Open, Close, Pivot and the functioning process. Shi Shou Tang(石壽棠) explained the physiology and pathology in the actions among Open-Close-Pivot with a focus on Pivot. Ke Qin(柯琴) applied Open-Close-Pivot to "Shanghanlun(傷寒論)" and used it as the basic principle to the Six Channel Ground Theory(六經地面說), also clinically applying it in the identification and treatment of the Six Channel patterns. Conclusions : Counting based word embedding methods seems to be more effective than.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.2
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• pp.165-175
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• 2001

Background: Recent in vivo experimental evidence suggests that isoflurane-induced cardioprotection may involve $K_{ATP}$ channel activation. However, it was demonstrated that isoflurane inhibited $K_{ATP}$ channel activities in the inside-out patch mode. To explain this discrepancy, the present investigation tested the hypothesis that a metabolite of isoflurane, trifluoroacetic acid (TFA), contributes to isoflurnae-induced cardioprotection via $K_{ATP}$ channel activation during myocardial ischemia and reperfusion. Methods: Single ventricular myocytes were isolated from rabbit hearts by an enzymatic dissociation procedure. Patch-clamp techniques were used to record single-channel currents. $K_{ATP}$ channel activities were assessed before and after the application of TFA with the inside-out patch mode. Results: TFA enhanced channel activity in a concentration-dependent fashion. The concentration of TFA for half-maximal activation and the Hill coefficient were 0.03 mM and 1.2, respectively. TFA did not affect the single channel conductance of $K_{ATP}$ channels. Analysis of open and closed time distributions showed that TFA increased burst duration and decreased the interburst interval without changes in open and closed time distributions shorter than 5 ms. TFA diminished ATP sensitivity of $K_{ATP}$ channels in a concentration-response relationship for ATP. Conclusions: TFA, a metabolite of isoflurane, enhanced $K_{ATP}$ channel activity in a concentration-dependent fashion. These results imply that TFA could mediate isoflurane-induced cardioprotection via $K_{ATP}$ channel activation during myocardial ischemia and reperfusion.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.1
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• pp.25-30
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• 2012

Under some pathological conditions as bile flow obstruction or liver diseases with the enterohepatic circulation being disrupted, regurgitation of bile acids into the systemic circulation occurs and the plasma level of bile acids increases. Bile acids in circulation may affect the nervous system. We examined this possibility by studying the effects of bile acids on gating of neuronal (N)-type $Ca^{2+}$ channel that is essential for neurotransmitter release at synapses of the peripheral and central nervous system. N-type $Ca^{2+}$ channel currents were recorded from bullfrog sympathetic neuron under a cell-attached mode using 100 mM $Ba^{2+}$ as a charge carrier. Cholic acid (CA, $10^{-6}M$) that is relatively hydrophilic thus less cytotoxic was included in the pipette solution. CA suppressed the open probability of N-type $Ca^{2+}$ channel, which appeared to be due to an increase in (no activity) sweeps. For example, the proportion of sweep in the presence of CA was ~40% at +40 mV as compared with ~8% in the control recorded without CA. Other single channel properties including slope conductance, single channel current amplitude, open and shut times were not significantly affected by CA being present. The results suggest that CA could modulate N-type $Ca^{2+}$ channel gating at a concentration as low as $10^{-6}M$. Bile acids have been shown to activate nonselective cation conductance and depolarize the cell membrane. Under pathological conditions with increased circulating bile acids, CA suppression of N-type $Ca^{2+}$ channel function may be beneficial against overexcitation of the synapses.

• The Korean Journal of Physiology and Pharmacology
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• v.7 no.6
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• pp.333-339
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• 2003

It has been demonstrated that an unidentified cytosolic factor(s) reduces $K_{ACh}$ channel function. Therefore, this study attempted to elucidate the cytosolic factor. Fresh cytosol isolated from normal heart (FC) depressed the $K_{ACh}$ channel activity, but cytosol isolated from the ischemic hearts (IC) did not modulate the channel function. Electrophorectic analysis revealed that a protein of ${\sim}80 kDa was markedly reduced or even lost in IC. By using peptide sequencing analysis and Western blot, this 80 kDa protein was identified as transferrin (receptor-mediated $Fe^{3+}$ transporter, 76 kDa). Direct application of transferrin (100 nM) to the cytoplasmic side of inside-out patches decreased the open probability ($P_o$, 12.7${\pm}6.4%, n=4) without change in mean open time (${\tau}_o$, $98.5{\pm}1.3$%, n=4). However, the equimolar apotransferrin, which is free of $Fe^{3+}$, had no effect on the channel activity (N*$P_o$, $129.1{\pm}13.5$%, n=3). Directly applied $Fe^{3+}$ (100 nM) showed results similar to those of transferrin (N*$P_o$: $21.1{\pm}3.9$%, n=5). However $Fe^{2+}$ failed to reduce the channel function (N*$P_o$, $106.3{\pm}26.8$%, n=5). Interestingly, trivalent cation La3+ inhibited N*$P_o$ of the channel ($6.1{\pm}3.0$%, n=3). Taken together, these results suggest that $Fe^{3+}$ bound to transferrin can modulate the $K_{ACh}$ channel function by its electrical property as a polyvalent cation.