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한우의 생식세포 보존에 관한 연구 II. PEG 30% FSH 투여가 한우의 체내수정란 생산에 미치는 영향 (Studies on Preservation of Germ Cells in Hanwoo II. Effects of In Vivo Embryos Production by PEG 30% FSH in Hanwoo)

  • 이명식;박정준;전기준;정영훈;우제석;박수봉;임석기;연성흠;손동수
    • 한국수정란이식학회지
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    • 제18권2호
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    • pp.151-156
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    • 2003
  • 한우의 수정란을 보존하기 위하여 고급육계통과 다유계통의 공란우를 선발하여 과배란처리에 따른 황체의 반응, 황체수에 대한 채란된 수정란의 수 그리고 채란 수정란수에 대한 이식가능한 수정란 생산에 미치는 영향을 조사하였다. 다유계통의 공란우는 이유시 체중에 대한 육종가 상위 20%이내, 고급육 계통의 공란우는 육질에 대한 육종가 상위 20%이내의 종빈우를 선발하였다. 과배란처리 방법은 발정후 11일차에 PEG 30% FSH를 견갑부에 피하주사로 1회 투여하고 13일차에 PGF$_2$a 25mg을 투여하였으며 15일차와 16일차에 각각 2회씩 인공수정하였고 23일차에 채란하였다. 과배란처리에 따른 황체의 반응은 좌측난소가 47.1% (242/513), 우측난소가 52.8%(271/513)로써 우측의 반응이 좋게 나타났고 황체의 반응과 비교하여 채란된 수정란의 회수율은 79.9%(410/513)로 나타났다. 회수된 수정란 중에서 이식이 가능한 수정란은 86.5%(355/410)이었고 수정란의 발달단계에 있어서 상실배는 61.6%(219/355), 배반포는 38.3%(136/355)로 나타났으며 두당 이식가능한 생산수는 6.4개였다.

시보건소 결핵등록관리환자들의 치료충실도에 미치는 요인에 관한 조사 -서울특별시 일개 구보건소 등록환자 중심- (A Study on the Factors which Influenced the Faithfulness to Treatment Among the Pulmonary Tuberculosis Patients Registered in a City Health Center)

  • 이영우
    • Journal of Preventive Medicine and Public Health
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    • 제17권1호
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    • pp.127-135
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    • 1984
  • Personal and social characteristics, disease status, reason of delay of receiving drug from City Health Center and knowledge and attitude on the pulmonary tuberculosis were compared between the faithful group in treatment and the unfaithful group among the patients for pulmonary tuberculosis registered in a City Health Center in order to analyze the factors which influenced the faithfulness to treatment. Record as well as interview survey was done toward all patients of 247 who were registered and being cared during over 6 months in a City Health Center from April 1, 1982 to March 31, 1983, and results were as follows; 1. There was no statistically significant difference in sex and age distribution between the faithful group in treatment and the unfaithful group. 2. There was no statistically significant difference in marital status distribution between the faithful group and unfaithful group in treatment. 3. The lower education group comprised higher proportion than the higher education group among the faithful group in treatment. 4. The proportion of the emlployed was higher than unemlpoyed among the unfaithful group in treatment. 5. The proportion of mild case was higher than severe case among the unfaithful group in treatment. 6. As for the onset of delay of receiving drug, 'less than 3 month after starting treatment' was 59.5% among the unfaithful group in treatment. 7. The reasons of delay of receiving drug were 'no time' (42.2%). 'being away from home' (25.0%), 'being sick' (13.8%), and 'forgot the appointed date' (12.0%). 8. There was no statistically significant difference in the knowledge on the communicability of the tuberculosis between the faithful groups in treatment and the unfaithful group. 9. There was no statistically significant difference in the knowlege on B.C.G. as vaccination drug of tuberculosis between the faithful group and the unfaithful group in treatment. 10. There was no statistically significant difference in the satisfaction on the treatment of health center between the group of faithful and unfaithful in treatment. 11. There was no statistically significant difference in the belief on the complete recovery of tuberculosis between the faithful group and the unfaithful group in treatment. 12. The rate of consulting on tuberculosis treatment with life partner was higher among the faithful group in treatment than the unfaithful group.

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Proposed Treatment Protocol for Frostbite: A Retrospective Analysis of 17 Cases Based on a 3-Year Single-Institution Experience

  • Woo, Eun-Kyung;Lee, Jong Wook;Hur, Gi-Yeun;Koh, Jang-Hyu;Seo, Dong-Kook;Choi, Jai-Ku;Jang, Young-Chul
    • Archives of Plastic Surgery
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    • 제40권5호
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    • pp.510-516
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    • 2013
  • Background This paper discusses the treatment protocol for patients with frostbite. Methods We performed a retrospective analysis of a series of 17 patients with second- and higher-degree frostbite who had been treated at our medical institution between 2010 and 2012. Results Our clinical series of patients (n=17) included 13 men and four women, whose mean age was $42.4{\pm}11.6$ years (range, 22-67 years). The sites of injury include the foot in six patients (35.3%), the hand in six patients (35.3%) and the facial region in five patients (29.4%). Seven patients with second-degree frostbite were completely cured with only conservative treatment during a mean period of $12.7{\pm}3.3$ days (range, 8-16 days). Of the five patients with third-degree frostbite, two underwent skin grafting following debridement, and the remaining three achieved a complete cure with conservative treatment during a mean period of $35{\pm}4.3$ days (range, 29-39 days). Five patients with fourth-degree frostbite were treated with surgical procedures including amputation. Conclusions With the appropriate conservative management in the early stage of onset, surgeons should decide on surgery after waiting for a sufficient period of time until the demarcation of the wound. Continuous management of patients is also needed to achieve functional recovery after a complete cure has been achieved. This should also be accompanied by patient education for the avoidance of re-exposure to cold environments.

Rat 의 포유조절이 혈중 Insulin-like Growth Factor- I 수준에 미치는 영향 (Effect of Suckling on Serum Insulin-like Growth Factor- I Levels in the Primiparous Rat)

  • 오석두;성환후;민관식;윤창현
    • 한국가축번식학회지
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    • 제24권1호
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    • pp.35-40
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    • 2000
  • 본 연구는 Wistar계 rat를 이용하여 포유기간 중 제한포유시기와 이유시기를 조절하여, 혈중 IGF- I 수준변화에 대해 검토하였다. NL군 (NL)은 포유자의 수를 8 마리로 조절하였으며, RL군 (RL)과 W군 (W)은 RL0, RL0, RL10, RLl5 및 RL20, 그리고 W0, W5, WI0, W15 및 W20으로 각각 5개 군으로 구분하여, RL군은 각 개시일에 포유자의 수를 8마리에서 4마리로 조절하였으며, W군은 각 개시일에 포유자의 수를 완전히 이유시켜 다음과 같은 결과를 얻었다. 1. NL군의 혈중 IGF-I 농도는 분만직후 (Day 0) 750.59$\pm$3.52ng/$m\ell$ 을 나타내어 15일까지 일정한 수준을 유지하다가 그 후 포유 25일에 1,690.20$\pm$4.42ng/$m\ell$ 까지 증가되었다. 2. 포유초기 RL군 (RL0, RL5)의 IGF- I 농도는 포유 10일에 RL0군과 RL5군에서 각각 1,395.90$\pm$3.45 및 1,351.73$\pm$3.23ng/$m\ell$로서 NL 군의 745.96$\pm$2.24ng/$m\ell$ 보다 유의적 (P<0.05)으로 높게 나타났으나 포유 15일부터는 차이가 없었다. 3. 포유초기 W군의 IGF- I 농도는 이유 후 일주일 정도는 NL군에 비해 높은 수준 (P<0.05)을 나타내다가 10일경에 NL군과 같은 수준으로 감소하였다. 포유자극의 강약은 난소의 생리적 변화와 함께 혈중 IGF- I의 농도를 조절하는 것으로 사료된다.

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사용후핵연료 수송용기에 사용될 수지계 중성자 차폐재 제조 및 특성 (Fabrication and Characteristics of Resin-Type Neutron Shielding Materials for Spent Fuel Shipping Cask)

  • 조수행;도재범;노성기;도춘호
    • 공업화학
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    • 제7권3호
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    • pp.597-604
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    • 1996
  • 사용후핵연료 수송용기 등에 사용되는 수지계 중성자 차폐재, KNS-115A, 115B 및 115C를 제조하였다. 기본물질은 에폭시수지이며, 첨가제로는 폴리프로필렌, 수산화알루미늄 및 탄화붕소이다. 이들 중성자 차폐재들은 유동성이 좋아 수송용기와 같은 복잡한 구조에 사용할 수 있다. 개발된 중성자 차폐재들의 차폐능, 연소특성, 난연성, 열적 및 역학적 성질 등을 평가하기 위해 여러 특성시험을 행하였다. 개발된 중성자 차폐재(수소원자 밀도, $6.1{\sim}6.2{\times}10^{22}atoms/cm^3$)들은 외국산 중성자 차폐재(NS-4-FR, $6.0{\times}10^{22}atoms/cm^3$)보다 수소원자 밀도가 높아 차폐능이 우수할 것으로 예측되며, 조사된 제반 특성들은 열분해온도; $267{\sim}270^{\circ}C$, 열전도도; $0.62{\sim}0.72W/m{\cdot}K$, 연소특성; $800^{\circ}C$ 이하, 평균연소시간; 5초 이하, 평균연소길이; 5mm 이하, 인장강도; $2.3{\sim}3.0kg/mm^2$, 압축강도; $5.3{\sim}13.3kg/mm^2$, 굴곡강도; $4.4{\sim}5.4kg/mm^2$ 등을 나타냈다.

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운동 유발성 알레르기 질환(FDEIA)에 미치는 영향과 기전분석 (Effects of Different Exercise Intensity on FDEIA and Related Mechanisms)

  • 이원준;곽이섭;유병인
    • 생명과학회지
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    • 제21권4호
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    • pp.542-548
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    • 2011
  • 본 연구에서는 우선 운동 강도(저강도, 중강도, 고강도)를 달리하여 훈련한 서로 다른 그룹에서 운동 유발성 알러지 아나필락시스의 차이를 규명하고 운동강도에 따른 운동 유발성 알러지 질환의 기전을 규명하고자 본 연구를 실시 하였다. 본 실험을 위하여 군당 25마리씩 통제군(S; control sensitized, n=25), 저강도 훈련군(S30, n=25), 중강도 훈련군(S50, n=25) 및 고강도 훈련군(S80, n=25)으로 구분하여 수영훈련 강도별 알러지를 유도하였을 때, 알러지 아나필락시스를 조사하고 아울러 비장지수, 림프구의 수, 림프구 증식반응, 싸이토카인(IL-4, INF-${\gamma}$), 항체 및 복강과 비장의 ROS를 함께 측정하였다. 본 연구 결과, 일반 감작군에 비하여 운동 감작군에서 알러지가 더 잘 일어남을 확인하였고, 운동강도의 증가와도 밀접한 것으로 확인되었다. 이는 운동강도가 증가할수록 OVA반응에 대한 림프구 증가가 현저하게 일어나는 원인과 복강활성산소의 증가 및 알러지 면역반응에 중요한 역할을 담당하는 싸이토카인인 IL-4의 증가 때문인 것으로 해석할 수 있다. 특히, 운동강도의 증가에 따라 INF-${\gamma}$의 감소도 의미 있는 결과로 해석된다. 따라서 추후 운동 강도뿐만이 아니라 운동빈도에 따라서도 FDEIA의 변화에 대한 심도 있는 연구가 필요하다고 여겨진다.

마이크로 컴퓨터를 이용한 수학 교수.학습법 개발에 관한 연구 (On the Development of Microcomputer-Assisted Mathematics Teaching/Learning Method)

  • 김창동;이태욱
    • 한국수학교육학회지시리즈A:수학교육
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    • 제27권1호
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    • pp.15-23
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    • 1988
  • We are at the onset of a major revolution in education, a revolution unparalleled since the invention of the printing press. The computer will be the instrument of this revolution. Computers and computer application are everywhere these days. Everyone can't avoid the influence of the computer in today's world. The computer is no longer a magical, unfamiliar tool that is used only by researchers or scholars or scientists. The computer helps us do our jobs and even routine tasks more effectively and efficiently. More importantly, it gives us power never before available to solve complex problems. Mathematics instruction in secondary schools is frequently perceived to be more a amendable to the use of computers than are other areas of the school curriculum. This is based on the perception of mathematics as a subject with clearly defined objectives and outcomes that can be reliably measured by devices readily at hand or easily constructed by teachers or researchers. Because of this reason, the first large-scale computerized curriculum projects were in mathematics, and the first educational computer games were mathematics games. And now, the entire mathematics curriculum appears to be the first of the traditional school curriculum areas to be undergoing substantial trasformation because of computers. Recently, many research-Institutes of our country are going to study on computers in orders to use it in mathematics education, but the study is still start ing-step. In order to keep abreast of this trend necessity, and to enhance mathematics teaching/learning which is instructed lecture-based teaching/learning at the present time, this study aims to develop/present practical method of computer-using. This is devided into three methods. 1. Programming teaching/learning method This part is presented the following five types which can teach/learn the mathematical concepts and principle through concise program. (Type 1) Complete a program. (Type 2) Know the given program's content and predict the output. (Type 3) Write a program of the given flow-chart and solve the problem. (Type 4) Make an inference from an error message, find errors and correct them. (Type 5) Investigate complex mathematical fact through program and annotate a program. 2. Problem-solving teaching/learning method solving This part is illustrated how a computer can be used as a tool to help students solve realistic mathematical problems while simultaneously reinforcing their understanding of problem-solving processes. Here, four different problems are presented. For each problem, a four-stage problem-solving model of polya is given: Problem statement, Problem analysis, Computer program, and Looking back/Looking ahead. 3. CAI program teaching/learning method This part is developed/presented courseware of sine theorem section (Mathematics I for high school) in order to avail individualized learning or interactive learning with teacher. (Appendix I, II)

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에폭시수지계 중성자 차폐재 제조 및 특성 (Fabrication and Characteristics of Epoxy Resin-Type Based Neutron Shielding Materials)

  • 조수행;김익수;도재범;노성기;박현수
    • 한국재료학회지
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    • 제8권5호
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    • pp.457-463
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    • 1998
  • 방사선물질의 수송 및 저장용기 등에 사용되는 에폭시수지계 중섣자 차폐재, KNS-201, KNS-301 및 KNS-601을 제조하였다. 기본물질은 개질 및 수소 첨가된 비스페놀 A형 그리고 노블락형 에폭시수지이며, 첨가제로는 수산화알루미늄 및 탄화붕소이다. 이들 중성자 차폐재들의 열적 및 역학적 성질 및 재방사선성 등을 평가하기 위해 여러 특성시험을 행하였다. 조사된 제반 특성들은 열분해온도;$257~280^{\circ}C$, 열전도도;0.95~1.14W/m.K, 열팽창계수 ;0.77~1.26x$10^{-6}$$^{\circ}$$C^{-1}$, 연소특성;$800^{\circ}C$이하, 평균연소시간;5초 이하, 평균연소길이 ;5mm 이하, 인장강도;2.5~3.2Kg/$\textrm{mm}^2$,압축강도:13.2~15.2kg/$\textrm{mm}^2$ 굴곡강도:5.2~604Kg/$\textrm{mm}^2$ 등을 나타냈다. 전반적으로 개발된 중성자 차폐재들의 관련 특성들이 외국에서 사용되는 중성자 차폐재, NS-4-RF보다 우수한 것으로 나타났다. 또한 KNS-601의 내방사선성이 KNS-201과 KNS-301보다 우수한 것으로 나타났다. 또한 KNS-601의 내방사선이 KNS-201과 KNS-301보다 우수한 것으로 나타났다.

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월경전 불쾌기분장애에 관한 전향적인 연구 (A Prospective Study of Premenstrual Dysphoric Disorder)

  • 김지연;조숙행;곽동일;박용균
    • 정신신체의학
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    • 제5권1호
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    • pp.52-62
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    • 1997
  • This study was designed to determine the frequency of premenstrual dysphoric disorder in gynecological outpatients, and also attempted to compare premenstrual change characteristics, functional impairment due to premenstrual changes and frequency of risk factors reported by women with confirmed premenstrual changes$(PMC^+)$(n=17) and those without confirmed premenstrual changes$(PMC^-)$(n=23). Forty gynecological outpatients who complained of premenstrual discomforts were asked to complete questionnaires on menstrual history, obstetric-gynecological history, and premenstrual change and functional impairment. The women were also asked to complete a daily rating form based on DSM-IV diagnostic criteria for one menstrual cycle. Absolute severity method, effect size method and percent change method were used to assess changes between follicular phase and luteal phase. The results of the study were as follows: 1) The frequency of premenstrual dysphoric disorder according to each of the three methods was 5% for the absolute severity method, 15% for the effect size method, and 27.5% for the percent change method. 2) The frequently reported symptoms were as follow: physical symptoms(64.7%) : lethargy, easy fatigability, or marked lack of energy(41.2%) : decreased interest in usual activities(29.4%) ; and marked affective lability(23.5%). 3) There were no significant differences in onset ages of premenstrual changes, regularities of premenstrual changes and changes of severity and duration of premenstrual symptoms over time between women with and without confirmed premenstrual changes. However, women with confirmed premenstrual changes reported both physical and emotional symptoms as earliest symptoms most frequently, while women without confirmed premenstrual changes reported only physical symptoms most frequently. 4) functional impairment was significantly higher in women with confirmed premenstrual changes than those without confirmed premenstrual changes, but impairment was not severe. 5) No differences were found between women with and without confirmed premenstrual changes in risk factors including demographic data, menstrual and obstetric and gynecological history. These results suggest that the prevalence of premenstrual dysphoric disorder varies with scoring methods. The women with confirmed premenstrual changes reported physical symptoms most frequently(64.7%). functional impairment was significantly higher in women with confirmed premenstrual changes, but impairment was not severe.

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떡노화에 대한 전분분해효소류의 효과 (Effect of Starch Degradation Enzymes on the Retrogradation of a Korean Rice Cakes)

  • 송재철;박현정
    • 한국식품영양과학회지
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    • 제32권8호
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    • pp.1262-1269
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    • 2003
  • 효소류의 떡 노화에 미치는 영향을 검토하였다. DSC 열특성의 검토에서 호화개시온도는 GP(glucoamylase+pullulanase)로 처리한 경우가 71.1$^{\circ}C$로 가장 낮고 그 다음이 $\beta$-amylase, $\alpha$-amylase 순이었다. 또 호화최대온도는 효소 처리한 것이 대조구에 비해서 대부분 낮은 편이었으며 그 중 GP처리한 것이 가장 낮은 것으로 나타났다. 또 떡의 용융 enthalpy는 GP, $\beta$-amylase, $\alpha$-amylase 순으로 증가하였으며 GP의 용융 enthalpy값이 다른 경우보다 많이 낮게 나타났다. 재결정도는 GP의 값이 크게 낮은 것으로 나타났다. Avrami exponent(n)는 0.90 ∼ 1.20 범위에 있었으며 노화속도의 시간상수 1/k은 GP, $\beta$-amylase, $\alpha$-amylase, Control의 순이었다. 효소류를 첨가한 떡의 조직감은 대조구에 비해서 차이를 보였으며 종류별 효과는 GP, $\beta$-, $\alpha$-amylase의 순으로 나타났다. L* 값은 $\beta$-amylase를 제외하고는 모두 감소하고 a* 값은 효소간 5% 수준에서 유의차를 나타내었다. b* 값의 경우는 GP는 청색 방향으로, $\beta$-, $\alpha$-amylase는 반대인 황색 방향으로 변하였다. 효소 처리한 떡의 관능검사는 효소 처리한 것이 대조구보다 다소 높은 값을 나타내어 좋은 관능성을 보여주었다.