• Bulletin of the Korean Chemical Society
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• v.33 no.10
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• pp.3298-3302
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• 2012

Although offline enrichment of phosphorylated peptides is widely used, enrichment for phosphopeptides using $TiO_2$ is often performed manually, which is labor-intensive and can lead to irreproducible results. To address the problems associated with offline enrichment and to improve the effectiveness of phosphopeptide detection, we developed an automated online enrichment system for phosphopeptide analysis. A standard protein mixture comprising BSA, fetuin, crystalline, ${\alpha}$-casein and ${\beta}$-casein, and ovalbumin was assessed using our new system. Our multidimensional system has four main parts: a sample pump, a 20-mm $TiO_2$-based column, a weak anion-exchange, and a strong cation-exchange (2:1 WAX:SCX) separation column with LC/MS. Phosphorylated peptides were successfully detected using the $TiO_2$-based online system with little interference from nonphosphorylated peptides. Our results confirmed that our online enrichment system is a simple and efficient method for detecting phosphorylated peptides.

• Journal of the Ergonomics Society of Korea
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• v.31 no.1
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• pp.101-107
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• 2012

Objective: The aim of this study is to investigate service design cases by online service companies and suggests framework to understand service design of them. Background: Recently, exploratory service design cases by online service companies such as Google, Apple, and NHN has been developed. Service design and online service experience design has been booming among user experience professionals but these two areas are not clearly defined. It is interesting to study the definition and key factors of service design and online service experience design. Moreover, investigating service design cases by online service companies is needed. Method: Due to diversification of service design cases by online service companies, this study has reviewed online resources and literatures about top 5 online service companies in USA and Korea. Furthermore, this study used expert interview who worked for service design at NHN. To understand the attributes of service design cases, this study developed 3 types of service design classifications scheme such as service design as extension of online service, space design and event service design. Finally, this study suggested a new framework for service design cases. Results: This study investigated service design cases by online service companies and suggests key issues and frameworks to uncover service design for online service. Conclusion: Service design cases for online service was analyzed by $2^*2$ matrix(extension, $enrichment^*product$, service) to explain characteristics and attributes. NHN's Knowledge-iN bookshelf at NHN library1 is a unique form of service design as a tool of enrichment of online experience. Application: The results of this study might help to understand service design cases and plan new service design for online service companies with structured framework.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2561-2567
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• 2015

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer death worldwide. Our study aimed to reveal molecular mechanisms. Microarray data of GSE15471 (including 39 matching pairs of pancreatic tumor tissues and patient-matched normal tissues) was downloaded from Gene Expression Omnibus (GEO) database. We identified differentially expressed genes (DEGs) in PDAC tissues compared with normal tissues by limma package in R language. Then GO and KEGG pathway enrichment analyses were conducted with online DAVID. In addition, principal component analysis was performed and a protein-protein interaction network was constructed to study relationships between the DEGs through database STRING. A total of 532 DEGs were identified in the 38 PDAC tissues compared with 33 normal tissues. The results of principal component analysis of the top 20 DEGs could differentiate the PDAC tissues from normal tissues directly. In the PPI network, 8 of the 20 DEGs were all key genes of the collagen family. Additionally, FN1 (fibronectin 1) was also a hub node in the network. The genes of the collagen family as well as FN1 were significantly enriched in complement and coagulation cascades, ECM-receptor interaction and focal adhesion pathways. Our results suggest that genes of collagen family and FN1 may play an important role in PDAC progression. Meanwhile, these DEGs and enriched pathways, such as complement and coagulation cascades, ECM-receptor interaction and focal adhesion may be important molecular mechanisms involved in the development and progression of PDAC.

• The Research Journal of the Costume Culture
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• v.16 no.4
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• pp.634-645
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• 2008

The purpose of this study was to develop cruise look design inspired by the ocean life motif using by computer CAD system. Domestic and international brands were selected for this study researching cruise line collection. A variety of literature and online site for concept of cruise look and sustainable design was studied. Adobe Illustrator CS2 and Adobe Photoshop CS2 program were used for cruise look design through analysis of 07/08 S/S trend. The diffusion of cruise look reflects a societal trend to be changed life pattern. The results of this study are as below. First, as this society has become modernized with advancement of technology, people have been increasingly interested in the pursuit of happiness and the concept of 'quality of life', thereby creating a new trend of consumption culture. As a result, fashion market place changed targeting sensible and self-enrichment customers. Second, as combining rapid technological innovation and mass production, industrial design caused environmental pollution and the problems are being worsen. Fashion design has same problems and led to eco-friendly design by the large. Third, as the change of style influenced by economic and social condition, cruise look re-defined and became more common. The change of various fields led to fashion market place should be changed. The cruise look design using computer program will give more benefits to many designers.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2008.04a
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• pp.349-353
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• 2008

With the development of the internet and the spread of 'digital home', the communities in cyber space have been especially revitalized since the information-oriented society. Apartment houses provided networks that are well equipped with internet websites, which build up the houses as a virtual space unit. This study attempted to conducted the questionnaire research for apartment occupants in order to investigate their recognition of and participation in the virtual community and demand for the classified contents The results are as follows. 1) First of all, some easy-access programs are necessary to be groped while aggressive promotional strategies for virtual community that create interests of residents are required to make progress to increase the participation for virtual community 2) 'Gender', 'the form of ownership' and 'level of using the Internet' show significant differences in the case of 'needs in the like-minded people's association', the participation of residents that is induced by both online and offline can cause positive effects on community activity 3) Needs in community enrichment are generally high so that various contents development related to those are necessary. 4) Effects of virtual community on the residential community are on the whole affirmative.

• Journal of the Korean Society for Library and Information Science
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• v.17
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• pp.339-366
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• 1989

Appearance of full-text online is the most encouraging phenomenon ·during the development of databases. The full-text databases of today is derived from by-product of electronic publication of printed materials. Now, there are also some movements toward electronic production of documents in Korea although not powerful. The present study is designed to examine the characteristics and effective retrieval method of full-text databases now commercially available through various vendors. The outline of this paper IS as follows: First, background and present situation of existing full-text database services through national and worldwide are examined. Second, free-text searching system of full-text databases is compared with controlled vocabulary system. The factors influencing on free-text retrieval performance, searching thesaurus, and hybrid or compromising system, which is using limited controlled vocabulary in conjunction with natural language for the enrichment needed for practical operation of the . system, are examined. Third, user demands through the analysis of preceding studies on 'various types of full-text databases are recognised. Fouth, application of CD-ROM full-text database to the libraries and information centers is examined as prospective resources for them. Finally, some problems and prospect of full-text databases are presented.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.17 no.8
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• pp.2292-2313
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• 2023

With improving computing performance, various digital platforms are being developed to enable easily utilization of high-performance computing environments. EDISON 1.0 is an online simulation platform widely used in computational science and engineering education. As the research paradigm changes, the demand for developing the EDISON 1.0 platform centered on simulation into the EDISON 2.0 platform centered on data and artificial intelligence is growing. Herein, a data framework, a core module for data-centric research on EDISON 2.0 digital platform, is proposed. The proposed data framework provides the following three functions. First, it provides a data repository suitable for the data lifecycle to increase research reproducibility. Second, it provides a new data model that can integrate, manage, search, and utilize heterogeneous data to support a data-driven interdisciplinary convergence research environment. Finally, it provides an exploratory data analysis (EDA) service and data enrichment using an AI model, both developed to strengthen data reliability and maximize the efficiency and effectiveness of research endeavors. Using the EDISON 2.0 data framework, researchers can conduct interdisciplinary convergence research using heterogeneous data and easily perform data pre-processing through the web-based UI. Further, it presents the opportunity to leverage the derived data obtained through AI technology to gain insights and create new research topics.

• Journal of Cadastre & Land InformatiX
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• v.48 no.2
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• pp.109-119
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• 2018

Point of interest (POI) of the city is a special place that has what importance to the user. For example, it is such landmark, restaurants, museums, hotels, and theaters. Because of its role in the social and economic life of us, these have attracted a lot of interest in location-based applications such as social networks and online map. However, while it can easily be obtained through the Web, the basic information of POI such as geographic location, another effort is required to obtain detailed information such as Wi-Fi, accepting credit cards, opening hours, romper room and the assessment and evaluation of other users. To solve these problems, a new method for correcting position error is required to link location-based social network service (LBSNS) data and POIs. This paper attempts to propose a position error correction method of POI and LBSNS data to enrich POI information from the vast information that is accumulated in LBSNS. Through this study, we can overcome the limitation of individual POI information via the information fusion method of LBSNS and POI, and we have discovered the possibility to be able to provide additional information which users need. As a result, we expect to be able to collect a variety of POI information quickly.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.13
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• pp.5325-5330
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• 2014

Background: Chronic myelocytic leukemia is a disease that threatens both adults and children. Great progress has been achieved in treatment but protein-protein interaction networks underlining chronic myelocytic leukemia are less known. Objective: To develop a protein-protein interaction network for chronic myelocytic leukemia based on gene expression and to predict biological pathways underlying molecular complexes in the network. Materials and Methods: Genes involved in chronic myelocytic leukemia were selected from OMIM database. Literature mining was performed by Agilent Literature Search plugin and a protein-protein interaction network of chronic myelocytic leukemia was established by Cytoscape. The molecular complexes in the network were detected by Clusterviz plugin and pathway enrichment of molecular complexes were performed by DAVID online. Results and Discussion: There are seventy-nine chronic myelocytic leukemia genes in the Mendelian Inheritance In Man Database. The protein-protein interaction network of chronic myelocytic leukemia contained 638 nodes, 1830 edges and perhaps 5 molecular complexes. Among them, complex 1 is involved in pathways that are related to cytokine secretion, cytokine-receptor binding, cytokine receptor signaling, while complex 3 is related to biological behavior of tumors which can provide the bioinformatic foundation for further understanding the mechanisms of chronic myelocytic leukemia.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.135-135
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• 2017

The Gramene database (http://www.gramene.org) is a powerful online resource for agricultural researchers, plant breeders and educators that provides easy access to reference data, visualizations and analytical tools for conducting cross-species comparisons. Learn the benefits of using Gramene to enrich your lectures, accelerate your research goals, and respond to your organismal community needs. Gramene's genomes portal hosts browsers for 44 complete reference genomes, including crops and model organisms, each displaying functional annotations, gene-trees with orthologous and paralogous gene classification, and whole-genome alignments. SNP and structural diversity data, available for 11 species, are displayed in the context of gene annotation, protein domains and functional consequences on transcript structure (e.g., missense variant). Browsers from multiple species can be viewed simultaneously with links to community-driven organismal databases. Thus, while hosting the underlying data for comparative studies, the portal also provides unified access to diverse plant community resources, and the ability for communities to upload and display private data sets in multiple standard formats. Our BioMart data mining interface enable complex queries and bulk download of sequence, annotation, homology and variation data. Gramene's pathway portal, the Plant Reactome, hosts over 240 pathways curated in rice and inferred in 66 additional plant species by orthology projection. Users may compare pathways across species, query and visualize curated expression data from EMBL-EBI's Expression Atlas in the context of pathways, analyze genome-scale expression data, and conduct pathway enrichment analysis. Our integrated search database and modern user interface leverage these diverse annotations to facilitate finding genes through selecting auto-suggested filters with interactive views of the results.