• Journal of Korean society of Dental Hygiene
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• v.9 no.4
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• pp.606-619
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• 2009

Objectives : This study was to examine the state of customized visiting oral health programs in a bid to help facilitate the unified operation of the programs and the development of required guidelines. Methods : The subjects in this study were 49 dental hygienists who were professionals responsible for customized visiting health care programs across the nation. Results : 1. Regarding the form of employment of the dental hygienists were investigated many contract and daily workers. 2. As to the possession of equipment necessary for visiting oral health programs, denture cleaners(12.2%) were most widely possessed in some regions, followed by mobile scalers(10.2%) and mobile suctions(8.2%). In terms of expendable devices and materials, dental mirrors, pincettes and explorers were the most widely possessed dental checkup devices, and the most widely possessed oral hygiene supplies were toothbrushes, interdental brushes and denture cleaners. Those devices and materials were in more possession than the other types of devices and materials. The most widely possessed equipment for educational purpose was laptop computers, followed by beam projectors and screens. The most widely possessed teaching materials were dentiform, followed by CD-ROMs. 3. Those whom they visited the most for oral health care service were elderly people, followed by the disabled and patients with chronic diseases. The dental hygienists who went out to visit those people outnumbered the others who stayed at public health centers. Concerning the types of visiting oral health care service, the most prevalent service provided to the elderly included denture cleaning/management, oral massage and preventive treatment against dental caries. The most dominant service provided to the disabled involved education of the oral health care act, preventive treatment against dental caries and toothbrushing by professionals. The most common service offered to patients with chronic diseases was education of the oral health care act and oral health education. The dental hygienists paid a visit to a mean of 5.8 households a day. The average weekly number of households cared by the dental hygienists was 27.3. It took a mean of 37.1 minutes for them to take care of each household. 4. As for satisfaction level with the implementation of the visiting oral health programs, they expressed the greatest satisfaction at teamwork with professionals($3.56{\pm}0.94$), followed by the professionalism of their work($3.21{\pm}0.94$) and workload($3.08{\pm}0.94$). Their satisfaction level with the work conditions required for creative job performance($2.75{\pm}0.98$) and partnership with other institutions($2.64{\pm}1.03$) was below 3.0. In regard to the impact of their characteristics, marital status made a statistically significant difference to satisfaction level with workload. The unmarried dental hygienists were more pleased with their workload than the married ones(p<0.05). 5. As to needs for education for professionalism improvement, they asked for education about visiting oral health care skills the most, followed by education about oral health care for patients with chronic diseases, education of planning/evaluation and education of oral health care for the disabled. Conclusions : The top priority for the vitalization of the programs was the procurement of budget, followed by the procurement of equipment and educational media and the procurement of human resources.

• Journal of Veterinary Clinics
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• v.22 no.4
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• pp.396-400
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• 2005

A 13-year old, female Maltese dog was presented due to a five-month history of episodic syncope. A diagnosis of sick sinus syndrome (SSS) with mitral valve endocardiosis (MVE) was made based on history takings, physical and cardiac examination, complete blood count (CBC), serum chemistry profiles, radiography, electrocardiography (ECG), atropine response test, hormonal assay, and echocardiography. In this case, SSS was definitely diagnosed by evaluation of ECG recording following atropine administration. Clinical signs were improved with medical management of theophylline (THEOLAN, KunWha Pharm, Seoul, Korea, 20 mg/kg, PO, BID). After 10 more month survival, the dog, died of respiratory distress and shock during the operation of abdominal mass removal in local animal hospital. Unfortunately, we were not able to perform necropsy after death due to owner's decline. This case demonstrates that theophylline can be used in management oF dog with SSS.

• KDI Journal of Economic Policy
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• v.13 no.4
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• pp.155-177
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• 1991

The promotion of economic exchange and cooperation between North and South Korea is significant in two ways. First, the pursuit of economic interest can lead gradually to the unification of the national economies. Second, economic relations can serve as the first stride toward political reunification. There are, however, many difficulties in conceiving a strategy for economic cooperation between North and South Korea because of their differences in ideology and socio-economic system. Under these circumstances, a bid by either the North or the South to consider its specific ideology or socio-economic system absolute and to impose them on the other side would inevitably lead to confrontation and collision and deepen the division of the country. Therefore, steps to expand and develop economic and technological cooperation and comprehensive exchanges between the North and the South, with due regard to the development of bilateral relations, are in full accord with the interests of the both sides. It is clear that North Korea's changing attitude toward its environmental conditions is neither a policy of opening nor an ideological shift toward pragmatism, as has occurred in the Eastern European countries. Instead, it is a temporary tactic for breaking out of the economic stagnation caused by its rigid economic structure. In this light, we must.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.3
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• pp.367-373
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• 2014

In this study, we investigated the anticancer activity of methyl gallate (MG), which is the major biologically active component of Galla Rhois, in RC-58T/h/SA#4 human prostate cancer cells. MG inhibited cell proliferation in a dose-dependent manner. Cell death induced by MG increased the population of cells in sub-G1 phase, formation of apoptotic bodies, nuclear condensation, and DNA fragmentation. Apoptosis induced by MG was associated with activation of initiator caspases-8 and -9 as well as effector caspase-3. Endocrine disruptors such as dioxin and bisphenol A increased growth of RC-58T/h/SA#4 cells in charcoal-treated FBS (cFBS) medium. Cell proliferation was highest upon treatment with 1 nM and $0.1{\mu}M$ dioxin and bisphenol A, respectively. MG also dose-dependently inhibited cell proliferation in RC-58T/h/SA#4 cells treated with endocrine disruptors. These results indicate that MG exerts anticancer effects on RC-58T/h/SA#4 primary human prostate cancer cells.

• Journal of the Korean Society of Food Science and Nutrition
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• v.45 no.6
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• pp.835-842
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• 2016

The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway plays a crucial role in cancer occurrence by promoting cell proliferation and inhibiting apoptosis. In the present study, we evaluated the effect of a PI3K inhibitor, LY294002, on the chemosensitivity of gastric cancer cells to cordycepin, a predominant functional component of the fungus Cordyceps militaris, in AGS human gastric cancer cells and investigated possible underlying cellular mechanisms. Our results revealed that cordycepin inhibited viability of AGS cells in a concentration-dependent manner and induced apoptosis, as determined by apoptotic cell morphologies and fluorescence-activated cell sorting analysis associated with attenuated activation of the PI3K/Akt signaling pathway. Treatment with cordycepin in combination with a subtoxic concentration of LY294002 enhanced cordycepin-induced cytotoxicity and apoptotic potentials in AGS cells. Sensitization of LY294002 to cordycepin-induced apoptosis was accompanied by activation of caspases (caspases-3, -8, and -9) and was concomitant with poly(ADP-ribose) polymerase cleavage. Moreover, LY294002 up-regulated pro-apoptotic Bax and enhanced truncation of Bid in cordycepin-treated AGS cells, which was connected with increased loss of mitochondrial membrane potential and release of cytochrome c from mitochondria to the cytosol. Taken together, these results indicate that inhibition of the PI3K/Akt signaling pathway could augment cordycepin-induced apoptosis in human gastric cancer cells by up-regulating caspase activity through mitochondrial dysfunction.

• Journal of Korean society of Dental Hygiene
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• v.9 no.3
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• pp.426-438
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• 2009

The purpose of this study was to examine the relationship of the general characteristics of dental patients to their total O'Leary index and individual plaque indexes in a bid to check the oral hygiene state of citizens and evaluate their plaque management ability. The subjects in this study were 288 patients at dental hospitals and clinics in Busan and South Gyeongsang Province. A survey was conducted from September to November 2008. The findings of the study were as follows: 1. Overall, the O'Leary index of the patients investigated stood at 72 percent. By age and gender, the O'Leary index was highest among those in their 30s(83%) and among the women(75%)(p<.05). As to the influence of toothbrushing frequency, the patients who did it twice or more a day had the highest O'Leary index(75%)(p<.001). By the use of oral hygiene supplies, the patients who used oral hygiene supplies had a higher O'Leary index(76%) than the others who didn't(p<.01). 2. As for plaque index for each tooth, 28 percent of their teeth were given zero point, and 52 percent were given one mark. 13 percent were given two marks, and 6.3 percent were given three marks. Thus, the teeth that were given one mark were largest in number(p<.001). 3. As for plaque index for labial posterior mandibular, 43 percent of their teeth were given one point, and 36 percent were given zero mark. 14 percent were given three mark, and 5 percent were given three marks(p<.01). 4. As for plaque index for buccal posterior maxilla, 57 percent of their teeth were given one point, and 20 percent were given zero mark. 16 percent were given two mark, and 6.3 percent were given three marks(p<.01). 5. As for plaque index for lingual posterior mandibular, 56 percent of their teeth were given one point, and 27.8 percent were given zero mark. 9 percent were given three mark and 6 percent were given three mark(p<.001).

• Tunnel and Underground Space
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• v.27 no.6
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• pp.343-350
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• 2017

Amid increasingly saturated ground space, development of underground space has been booming throughout the world and excavation has been underway near the structure above or under the ground level. But the ground subsidence caused by improper or poor construction technologies, underground water leakage, sudden changes of stratum and the problem with earth retaining system component has been emerged as hot social issue. To deal with such problems nationwide, establishment of preventive and proactive disaster management and rapid restoration system has been pushed now. In this study, collection of the data on technology development trend to secure the underground safety was made, taking into account of internal change elements (changing groundwater level, damage to underground utilities, etc) and external change elements (vehicle load, earthquake and ground excavation, etc) during excavation. Amid the growing need of ground behavior analysis, ground subsidence evaluation technology, safe excavation to prevent ground subsidence and reinforcement technology, improvement of rapid restoration technology in preparation for ground subsidence and development of independent capability, this study is intended to introduce the technology development in a bid to prevent the ground subsidence during excavation. It's categorized into prediction/evaluation technology, complex detect technology, waterproof reinforcement technology, rapid restoration technology and excavation technology which, in part, has been in process now.

• Biomolecules & Therapeutics
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• v.22 no.3
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• pp.184-192
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• 2014

${\beta}$-lapachone is a naturally occurring quinone that selectively induces apoptotic cell death in a variety of human cancer cells in vitro and in vivo; however, its mechanism of action needs to be further elaborated. In this study, we investigated the effects of ${\beta}$-lapachone on the induction of apoptosis in human gastric carcinoma AGS cells. ${\beta}$-lapachone significantly inhibited cellular proliferation, and some typical apoptotic characteristics such as chromatin condensation and an increase in the population of sub-G1 hypodiploid cells were observed in ${\beta}$-lapachone-treated AGS cells. Treatment with ${\beta}$-lapachone caused mitochondrial transmembrane potential dissipation, stimulated the mitochondria-mediated intrinsic apoptotic pathway, as indicated by caspase-9 activation, cytochrome c release, Bcl-2 downregulation and Bax upregulation, as well as death receptor-mediated extrinsic apoptotic pathway, as indicated by activation of caspase-8 and truncation of Bid. This process was accompanied by activation of caspase-3 and concomitant with cleavage of poly(ADP-ribose) polymerase. The general caspase inhibitor, z-VAD-fmk, significantly abolished ${\beta}$-lapachone-induced cell death and inhibited growth. Further analysis demonstrated that the induction of apoptosis by ${\beta}$-lapachone was accompanied by inactivation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. The PI3K inhibitor LY29004 significantly increased ${\beta}$-lapachone-induced apoptosis and growth inhibition. Taken together, these findings indicate that the apoptotic activity of ${\beta}$-lapachone is probably regulated by a caspase-dependent cascade through activation of both intrinsic and extrinsic signaling pathways, and that inhibition of the PI3K/Akt signaling may contribute to ${\beta}$-lapachone-mediated AGS cell growth inhibition and apoptosis induction.

• Journal of dental hygiene science
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• v.5 no.1
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• pp.19-24
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• 2005

The purpose of this study was to examine the oral health states of elderly people over the age of 65 from the city of Seongnam, including the number of present permanent tooth, dental caries, rate of treatment need, CPITN and use of prosthesis, in a bid to lay the foundation for improving elderly oral health programs. The findings of the study were as follows: 1. The DMF rate of the male senior citizens stood at 98.3 percent, and that of the women numbered 99.0 percent and DMFT index 20.8. 2. The number of present permanent tooth excluded the third molars was 13. 3. Regarding CPITN, $CPITN_1$ was 74.9 percent, and $CPITN_2$ was 56.2 percent. $CPITN_3$ was 8.0 percent. 4. The rate of full denture wearing of the elderly people was 26.1 percent in the upper part and 17.8 percent in the lower part. And their rate of full denture need was 7.4 percent in the upper part and 4.3 percent in the lower part. 5. Establishing an planned abject for Oral health, Seongnam City has reviewed the necessity of development on enhancement of Oral health.

• The Korean Journal of Elementary Counseling
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• v.10 no.1
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• pp.95-108
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• 2011

The purpose of this study was to examine variables affecting the occupational aspiration of elementary school students and the relationship of the variables in a bid to acquire empirical information on influential factors for the development of children's occupational aspiration. Out of the personal characteristics of school children, academic achievement, self-esteem and parental educational level that respectively belonged to the cognitive, affective and environmental domains were selected as the variables that might affect occupational aspiration. And the relationship of the variables to the level of occupational aspiration was selected as a research question of the study. The findings of the study were as follows: in relation to the level of occupational aspiration by gender, the girls were ahead of the boys. There were no statistically significant gaps in that aspect according to grade. And, the academic achievement of the elementary school students had a positive correlation to the level of their occupational aspiration, and there was no statistically significant relationship between self-esteem and the level of occupational aspiration. When academic achievement and self-esteem were selected as predictors, the two variables made a 8.5% prediction of the occupational aspiration of the fourth graders, and made a 12.3% prediction of the occupational aspiration of the sixth graders. There were no statistically significant differences in the level of occupational aspiration according to parental educational level. The fourth and sixth graders were found to have an occupational aspiration in consideration of not only the characteristics of occupations but their own academic achievement, namely their abilities.