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http://dx.doi.org/10.3746/jkfn.2014.43.3.367

Anticancer Activity of Methyl Gallate in RC-58T/h/SA#4 Primary Human Prostate Cancer Cells  

Kwon, Soon Jae (Dept. of Food Science and Technology, Kyungpook National University)
Lee, Ju Hye (Research Institute of Basic Science, Sunchon National University)
Kim, Jae Yong (Jeonnam Institute of Natural Resources Research)
Moon, Kwang Deog (Dept. of Food Science and Technology, Kyungpook National University)
Yee, Sung Tae (Dept. of Biology, Sunchon National University)
Seo, Kwon Il (Dept. Food and Nutrition, Sunchon National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.43, no.3, 2014 , pp. 367-373 More about this Journal
Abstract
In this study, we investigated the anticancer activity of methyl gallate (MG), which is the major biologically active component of Galla Rhois, in RC-58T/h/SA#4 human prostate cancer cells. MG inhibited cell proliferation in a dose-dependent manner. Cell death induced by MG increased the population of cells in sub-G1 phase, formation of apoptotic bodies, nuclear condensation, and DNA fragmentation. Apoptosis induced by MG was associated with activation of initiator caspases-8 and -9 as well as effector caspase-3. Endocrine disruptors such as dioxin and bisphenol A increased growth of RC-58T/h/SA#4 cells in charcoal-treated FBS (cFBS) medium. Cell proliferation was highest upon treatment with 1 nM and $0.1{\mu}M$ dioxin and bisphenol A, respectively. MG also dose-dependently inhibited cell proliferation in RC-58T/h/SA#4 cells treated with endocrine disruptors. These results indicate that MG exerts anticancer effects on RC-58T/h/SA#4 primary human prostate cancer cells.
Keywords
methyl gallate; anticancer activity; apoptosis; environmental hormone;
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Times Cited By KSCI : 11  (Citation Analysis)
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