• 제목/요약/키워드: On-line University

검색결과 14,042건 처리시간 0.044초

Efficacy of First-line Chemotherapy Affects the Second-Line Setting Response in Patients with Advanced Non-Small Cell Lung Cancer

  • Cao, Wa;Li, Ai-Wu;Ren, Sheng-Xiang;Chen, Xiao-Xia;Li, Wei;Gao, Guang-Hui;He, Ya-Yi;Zhou, Cai-Cun
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권16호
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    • pp.6799-6804
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    • 2014
  • Background: Chemotherapy is the mainstay of treatment for the majority of patients with advanced non-small cell lung cancer (NSCLC) without driver mutations and many receive therapies beyond first-line. Second-line chemotherapy has been disappointing both in terms of response rate and survival and we know relatively little about the prognostic factors. Materials and Methods: One thousand and eight patients with advanced NSCLC who received second-line chemotherapy after progression were reviewed in Shanghai Pulmonary Hospital, China, from September 2005 to July 2010. We analyzed the effects of potential prognostic factors on the outcomes of second-line chemotherapy (overall response rate, ORR; progression free survival, PFS; overall survival, OS). Results: The response and progression free survival of first-line chemotherapy affects the ORR, PFS and OS of second-line chemotherapy (ORR: CR/PR 15.4%, SD 10.1%, PD2.3%, p<0.001; PFS: CR/PR 3.80 months, SD 2.77 months, PD 2.03 months, p<0.001; OS: CR/PR 11.60 months, SD 10.33 months, PD 6.57 months, p=0.578, p<0.001, p<0.001, respectively). On multivariate analysis, better response to first-line therapy (CR/PR: HR=0.751, p=0.002; SD: HR=0.781, p=0.021) and progression within 3-6 months (HR=0.626, p<0.001), together with adenocarcinoma (HR=0.815, p=0.017), without liver metastasis (HR=0.541, p=0.001), never-smoker (HR=0.772, p=0.001), and ECOG PS 0-1 (HR=0.745, p=0.021) were predictors for good OS following second-line chemotherapy. Conclusions: Patients who responded to first-line chemotherapy had a better outcome after second-line therapy for advanced NSCLC, and the efficacy of first-line chemotherapy, period of progression, histology, liver metastasis, smoking status and ECOG PS were independent prognostic factors for OS.

On-line 시스템 모델과 파라메터 최적화 기법을 이용한 AVR의 최적 파라메터 튜닝 (AVR Parameter tuning with On-line System model using Parameter optimization technique)

  • 김중문;문승일
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 1999년도 하계학술대회 논문집 C
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    • pp.1242-1244
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    • 1999
  • AVR parameter tuning for voltage control of power system generators has generally been done with the open-circuit model of the synchronous generator. When the generator is connected on-line and operating at rated load conditions, the AVR operates in an entirely different environment from the open-circuit conditions. This paper describes a new method for AVR parameter tuning using optimization technique with on-line linearized system model. As this method considers not only the on-line models but also the off-line open-circuit models, AVR parameters tuned by this method can give the sufficiently stable performance at the open-circuit commissioning phase and give the desired performance at the operating conditions. Also this method estimates the optimum parameters for desired performance indices that are chosen for satisfying requirements in some practical applications, the performance of the AVR can satisfy the various requirements.

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The Study on the Effect of Waiting Line on Consumers' Perceived Quality and Emotional State

  • Li, Nan;Song, Jae-Do
    • Asia Marketing Journal
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    • 제21권2호
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    • pp.21-49
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    • 2019
  • This study examines a model which simultaneously contains two paths between waiting line and purchase intention: one tested the positive effect of waiting line through consumers' perceived quality, whereas another one go through consumers' emotional state to test the negative effect of waiting line on purchase intention. To further understand perceived quality, the study divided perceived quality into perceived product quality and perceived service quality. The study used restaurants in the experiment. Results indicated that although long waits in line will directly increase both consumers' product quality perception and negative emotions, the total indirect effects on purchase intention are still significantly positive. For consumers' perceived service quality, long waiting situations have no such effect on it. Significant results from a moderation analysis also shown that consumers in low-level knowledge settings are more influenced by waiting lines than those in high-level knowledge settings when they make the product's quality-related judgment. However, the level of consumer knowledge does not moderate the relationship between waiting lines and service quality.

무전해 Ni 도금을 위한 양극 산화막위에 스크린 인쇄된 Ag 페이스트 패턴의 정밀도 개선 (Accuracy Improvement of Screen Printed Ag Paste Patterns on Anodized Al for Electroless Ni Plating)

  • 이연승;나사균
    • 한국재료학회지
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    • 제27권8호
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    • pp.397-402
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    • 2017
  • We used an etching process to control the line-width of screen printed Ag paste patterns. Ag paste was printed on anodized Al substrate to produce a high power LED. In general, Ag paste spreads or diffuses on anodized Al substrate in the process of screen printing; therefore, the line-width of the printed Ag paste pattern increases in contrast with the ideal line-width of the pattern. Smudges of Ag paste on anodized Al substrate were removed by neutral etching process without surface damage of the anodized Al substrate. Accordingly, the line-width of the printed Ag paste pattern was controlled as close as possible to the ideal line-width. When the etched Ag paste pattern was used as a seed layer for electroless Ni plating, the line width of the plated Ni film was similar to the line-width of the etched Ag paste pattern. Finally, in pattern formation by Ag paste screen printing, we found that the accuracy of the line-width of the pattern can be effectively improved by using an etching process before electroless Ni plating.

제주도 연안 연속식 갈치채낚기 조획시스템의 개량에 관한 기초적 연구 (A basic study on the improvement of the continuous type fishing system for largehead hairtail hand line in coastal area of Jeju island, Korea)

  • 김병엽;이창헌
    • 수산해양기술연구
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    • 제45권1호
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    • pp.14-21
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    • 2009
  • This experimental study was carried out to obtain the base data for saving the man power in the fishing operation of largehead hairtail hand line by using the continuous type hand line system with a rotary device which could make a main line move automatically. In order to solve the twists and entangling on the main line happened during operating test, the resistance board was suspended at the end of the main line at sea. As the result, there were no problems of tangling and so on due to up and down moving of a main line. According to the control of a fixed angle of guide roller, it was possible to prevent the main line to be separated from a side roller and a guide roller. In addition, PVC tube between a guide roller and a side roller enabled a main line to be moved smoothly without any entanglement.

Basic RF Characteristics of Fishbone-Type Transmission Line Employing Comb-Type Ground Plane (FTLCGP) on PES Substrate for Use in Flexible Passive Circuits

  • Yun, Young;Jeong, Jang-Hyeon;Kim, Hong Seung;Jang, Nakwon
    • ETRI Journal
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    • 제37권1호
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    • pp.128-137
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    • 2015
  • In this work, a fishbone-type transmission line employing a comb-type ground plane (FTLCGP) was fabricated on polyethersulfone (PES) substrate, and its RF characteristics were thoroughly investigated. According to the results, it was found that the FTLCGP on PES showed periodic capacitance values much higher than other types of transmission lines due to a coupling capacitance between the signal line and ground, which resulted in a reduction of wavelength and line width. Using the theoretical analysis, we also extracted the bandwidth characteristic of the FTLCGP on PES. According to the result, the FTLCGP structure showed a cut-off frequency of 280 GHz.

Hybrid Induction Motor Control Using a Genetically Optimized Pseudo-on-line Method

  • Lee, Jong-seok;Jang, Kyung-won;J. F. Peters;Ahn, Tae-chon
    • Journal of Power Electronics
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    • 제4권3호
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    • pp.127-137
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    • 2004
  • This paper introduces a hybrid induction motor control using a genetically optimized pseudo-on-line method. Optimization results from the use of a look-up table based on genetic algorithms to find the global optimum of an unconstrained optimization problem. The approach to induction motor control includes a pseudo-on-line procedure that optimally estimates parameters of a fuzzy PID (FPID) controller. The proposed hybrid genetic fuzzy PID (GFPID) controller is applied to speed control of a 3-phase induction motor and its computer simulation is carried out. Simulation results show that the proposed controller performs better than conventional FPID and PID controllers. The contribution of this paper is the introduction of a high performance hybrid form of induction motor control that makes on-line and real-time control of the drive system possible.

Meshless equilibrium on line method (MELM) for linear elasticity

  • Sadeghirad, A.;Mohammadi, S.;Kani, I. Mahmoudzadeh
    • Structural Engineering and Mechanics
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    • 제35권4호
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    • pp.511-533
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    • 2010
  • As a truly meshfree method, meshless equilibrium on line method (MELM), for 2D elasticity problems is presented. In MELM, the problem domain is represented by a set of distributed nodes, and equilibrium is satisfied on lines for any node within this domain. In contrary to conventional meshfree methods, test domains are lines in this method, and all integrals can be easily evaluated over straight lines along x and y directions. Proposed weak formulation has the same concept as the equilibrium on line method which was previously used by the authors for enforcement of the Neumann boundary conditions in the strong-form meshless methods. In this paper, the idea of the equilibrium on line method is developed to use as the weak forms of the governing equations at inner nodes of the problem domain. The moving least squares (MLS) approximation is used to interpolate solution variables in this paper. Numerical studies have shown that this method is simple to implement, while leading to accurate results.

서울시 대규모 환승역의 지하철 호선별 PM2.5에 대한 오염현황 연구 (Comparison of PM2.5 Pollution Status at a Major Transit Subway Station in Seoul)

  • 유정길;김재혁;김경필;정수영;나규인;조효재;설경화;김기현
    • 한국대기환경학회지
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    • 제31권3호
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    • pp.201-208
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    • 2015
  • We investigated the pollution levels of $PM_{2.5}$ at Wangsimni station at which four subway lines (Line 2, Line 5, the Jungang line, and the Bundang Line) are simultaneously under the operation. The analysis of $PM_{2.5}$ was made for the period of 1~ 11 Nov. 2014. The results of our field campaign were analyzed to assess the effects of various factors and conditions on the $PM_{2.5}$ pollution (such as installation of the screen door, density of floating population, weekdays and weekend, and the depth of platforms). The mean concentrations of $PM_{2.5}$ in each subway line of the Wangsimni station was measured as: the line 2 ($22.5{\mu}g/m^3$) ; the line 5 ($18.3{\mu}g/m^3$) ; the Jungang line ($31.8{\mu}g/m^3$); and the Bundang line ($32.2{\mu}g/m^3$). Based on the detailed analysis of $PM_{2.5}$ pollution at four subway lines, we aimed to provide some perspectives on reducing the concentration of ultrafine particles in a highly populated urban area.

인대의 허리 기준선 설정에 따른 입체 패턴 비교 연구 (A Comparative Study of the Draping Pattern based on Setting Waist Base Line of Dress Form)

  • 양정은;김양원;이은경;이해영
    • 한국생활과학회지
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    • 제16권5호
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    • pp.969-977
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    • 2007
  • The research thesis has been intended to make a comparative analysis on the basic bodice pattern and basic skirt pattern changing on the basis of setting waist line of dress form in an effort to set reasonable standards in selecting the standard lines of drees form. The thesis has made the wearing evaluation by producing the sample of upper and lower dress based on A pattern and B pattern. In details, A pattern functions to keep waist line flatly down from lateral waist-right to posterior waist in a little curved state, paralleling bust line and hipline with waistline. And, B pattern functions to keep waistline, bust line and hipline horizontal paralleling with ground surface. SPSS win 10.1 program was used for the analysis of evaluation and t-test. The result is as follows: For basic bodice-front of upper dress, A and B patterns have made little significant difference. With regard to basic bodice-back, B pattern has got the higher evaluation than A pattern, in the pattern stability and appearance. For basic skirt pattern, A pattern has got the lower evaluation in the aspect of total back appearance, back dart, hip line, and waist line, and front drape. Basic bodice pattern of A pattern, which takes on the different horizontal standard lines of dress form depending on the selection of waistline, and basic skirt pattern has scored less in terms of pattern stability and appearance.