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Methanol Extract of Agaricus blazei Murill Reduces Hepatic Damage Induced by $CCl_4$ and High Fat and Improves Liver Lipid Profile in Rats

  • Jung, Myung-Eun;Kwon, Hyuck-Se;Shin, Se-Gye;Jin, Yong-Xie;Han, Eun-Kyung;Ham, Seung-Shi;Kang, Il-Jun;Chung, Cha-Kwon
    • Nutritional Sciences
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    • v.9 no.4
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    • pp.267-272
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    • 2006
  • The effect of methanol extract from Agaricus blazei Murill on the hepatotoxicity was investigated $CCl_4$ is one of the oldest and most widely used toxins for the induction of hepatic damages and fibrosis in experimental animals. In this study, male Sprague-Dawley(SD) rats were randomly divided into 6 groups of the control(C), $CCl_4(T),\;CCl_4$ and high fat group(TL) with matching sub-groups of Agaricus blazei Murill extract-fed groups of CA, TA and TLA. Methanol extracts of Agaricus blazei Murill were fed 50 mg/kg B.W daily via drinking water. A 1.2 mL of $CCl_4/kg$ body weight was administered by oral intubation twice a week for total of six times. The levels of total-cholesterol, TG, LDL and LDL-phospholipids were elevated by $CCl_4$ treatment as compared to the control(C). However, Agaricus blazei Murill methanol extract feeding in the group of TA and TLA significantly(p<0.05) decreased TG by 53.1 % and 17.9% compared to the internal control of T and TL, respectively. Triglyceride of TL was increased by 3.33 times(p<0.05) compared to the control(C) with $CCl_4$ and high fat administration from 3.78 mg/g to 12.60 mg/g liver. The extract(CA) also reduced kidney weight compared to the control(C). With the administration of high fat and $CCl_4$(TLA), the extract reduced the organ weight of both liver and kidney and further, significantly reduced TG, total cholesterol and GTP activity. Hepatoprotective effects of Agaricus blazei Murill on GOT, GPT, AP and LDH activities were enhanced by the extract feeding. Electronmicrograph showed that $CCl_4$ deteriorated the structure of cytoplasmic matrix with its uneven distribution. However, the extract reconstituted the damaged cytoplasm and stimulated mitochondriogenesis. The above results suggest that Agaricus blazei Murill may have a possible protective effect against chemically induced liver damage and further help to reduce the symptoms of fatty liver.

Counter Measures by using Execution Plan Analysis against SQL Injection Attacks (실행계획 분석을 이용한 SQL Injection 공격 대응방안)

  • Ha, Man-Seok;Namgung, Jung-Il;Park, Soo-Hyun
    • Journal of the Institute of Electronics and Information Engineers
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    • v.53 no.2
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    • pp.76-86
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    • 2016
  • SQL Injection attacks are the most widely used and also they are considered one of the oldest traditional hacking techniques. SQL Injection attacks are getting quite complicated and they perform a high portion among web hacking. The big data environments in the future will be widely used resulting in many devices and sensors will be connected to the internet and the amount of data that flows among devices will be highly increased. The scale of damage caused by SQL Injection attacks would be even greater in the future. Besides, creating security solutions against SQL Injection attacks are high costs and time-consuming. In order to prevent SQL Injection attacks, we have to operate quickly and accurately according to this data analysis techniques. We utilized data analytics and machine learning techniques to defend against SQL Injection attacks and analyzed the execution plan of the SQL command input if there are abnormal patterns through checking the web log files. Herein, we propose a way to distinguish between normal and abnormal SQL commands. We have analyzed the value entered by the user in real time using the automated SQL Injection attacks tools. We have proved that it is possible to ensure an effective defense through analyzing the execution plan of the SQL command.

Analysis of Present Status for the Monitoring of land Use and Land Cover in the Korean Peninsula (한반도 토지이용 및 토지피복 모니터링 위한 현안 분석)

  • Lee, Kyu-Sung;Yoon, Yeo-Sang;Kim, Sun-Hwa;Shin, Jung-Il;Yoon, Jong-Suk;Kang, Sung-Jin
    • Korean Journal of Remote Sensing
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    • v.25 no.1
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    • pp.71-83
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    • 2009
  • This paper is written to analyze possible problems encountered with the existing data for the monitoring of land use and land cover change over the Korean peninsula and, further, to provide technical alternatives for the future land monitoring over the area. The oldest type of non-spatial data related to the land use change are cadastral statistics obtained since 1911. Annual statistics of cadastral data in early years (before 1942) can be used to assess land use change over the area. However, the cadastral statistics after the Korean War are not very appropriate for land use monitoring since the land class in cadastral data does not always correspond with actual land cover status. Majority of spatial data available for land monitoring over the area are land cover maps classified from satellite imagery since early 1970's. To analyze the suitability of land cover maps that were produced by two separate institutes with about 10 years interval, we conducted simple change detection analysis using these maps. These maps were not quite ready to be compared each other, in which they did not have the same class definition, classification method, and geometric registration. To achieve continuous and effective monitoring of land use and land cover change, particularly over North Korea, we should have a standard scheme in type and season of satellite imagery, image classification procedure, and class definition, which also should correspond to international standards.

Changes in The Amount of Air Respirator Consumed by Field Fire-fighting Activities (현장 소방활동에 따른 공기호흡기 소모량의 변화)

  • Jeon, Jai-In;Kong, Ha-Sung
    • The Journal of the Convergence on Culture Technology
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    • v.5 no.4
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    • pp.93-98
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    • 2019
  • The purpose of this study was to identify and analyze the rate of change of air respirator consumption based on field fire fighting activities, The results of the experiment are as follows. The mean air consumption of the Five subjects was $15.56{\ell}/min$ when standing still, $32.43{\ell}/min$ when walking with normal pace, $43.07{\ell}/min$ when the fire hoses was expanded and arranged, $55.28{\ell}/min$ when climbing stairs, The situation of running up the stairs and hitting the hammer continuously increases to $127.14{\ell}/min$, which means that the consumption of air increases according to the energy consumption. Despite being the oldest, Experimental subject A was $13.23{\ell}/min$ when standing still, $29.33{\ell}/min$ when walking normally, and $41.08{\ell}/min$ when the fire hose was deployed and arranged. This is a result of familiarity with deep and slow breathing methods. The average respiratory use rate of subjects D was $63.58{\ell}/min$. The reason for this is that obesity seems to increase the air consumption, and it is considered that the physical strength is exhausted by the action of the hammer, which has a greater influence on the increase of air consumption. The subject E had significantly lower air respiratory use rate of $49.90{\ell}/min$. The reason for this is that the age of E is the youngest among the subjects, and it is presumed that it possesses strong physical strength.

The Age of the Earth: Reappraisal (지구의 나이: 재평가)

  • Kwon, Sung-Tack
    • The Journal of the Petrological Society of Korea
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    • v.23 no.3
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    • pp.273-277
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    • 2014
  • This paper presents a brief historical review of various attempts to estimate the age of the Earth, and reappraises the study of Patterson (1956) which revealed for the first time that the age of the Earth is $4550{\pm}70Ma$ by measuring Pb isotope ratios of several meteorites and a marine sediment. The standard model for the planetary formation of early solar system is: formation of solid particles condensed from the cooling of hot nebular gas -> formation of planet-sized bodies by accretion of those solid particles. The Moon is supposed to have formed from the accretion of the relicts produced by the collision of proto-Earth with Mars-sized body. It is not easy to pinpoint the age of the Earth, considering the series of events related to the formation of the Earth. So, I propose that the collision age as that of the Earth, since the present status of the Earth is thought to be the direct product of the collision. According to the previous studies, the collision age can be broadly constrained between the age ($4567.30{\pm}0.16Ma$) of the earliest condensates (CAI, calcium-aluminum rich inclusion) of the nebula gas, i.e., the age of the solar system, and the oldest age ($4,456{\pm}40Ma$) among rocks and minerals of the Earth and the Moon. We need more precise estimation of the collision age, since it is important in estimating time scale for the formation of planet-size body and in revealing thermal evolution of magma oceans of the Earth and the Moon presumably developed right after the collision.

SHRIMP U-Pb Zircon Ages of the Yeongju and Andong Granites, Korea and their Implications (영주화강암과 안동화강암의 SHRIMP U-Pb 저어콘 연대와 그 의미)

  • Yoon, Rina;Song, Yong-Sun;Yi, Keewook
    • The Journal of the Petrological Society of Korea
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    • v.23 no.3
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    • pp.209-220
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    • 2014
  • SHRIMP zircon U-Pb age dating is carried out for the Yeongju and Andong granite batholiths intruding the Precambrian metamorphic complex and Paleozoic sedimentary formations within the NE Yeongnam Massif, Korea. Dating of zircons from a hornblende-biotite tonalite and an equigranular biotite granodiorite in the Yeongju granite has yielded ages of ca. 187 Ma and ca. 186 Ma, respectively. Also, dating of zircons from a biotite granodiorite and a very coarse-grained biotite granite in the Andong granite has yielded ages of ca. 182Ma and ca. 186Ma, respectively. These data indicate that the main intrusions of the Yeongju and Andong granite batholiths occur almost at the same age. The oldest age of ca. 194 Ma has been determined on zircons from a hornblende gabbro in the Andong granite, and the youngest age of 175 Ma is obtained from the Chunyang granite pluton, mainly consisting of fine-grained two-mica granite, of the Yeongju batholith. These results indicate that Jurassic Daebo magmatism in the Yeongju-Andong area, NE Yeongnam massif, started early at the Early Jurassic with an intrusion of mafic magma, and followed by an emplacement voluminous granite magma during the middle of the Early Jurassic, and was finalized with the emplacement of relatively small amount of much evolved granite magma at the end of Early Jurassic.

Relationship between Naming Abilities, Hearing Handicap, and Depression in Community-Dwelling Elderly (지역사회 노인의 연령에 따른 이름대기 능력, 청력장애, 우울 수준의 관계)

  • Lee, Hyun Jung
    • Journal of the Korea Convergence Society
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    • v.12 no.10
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    • pp.97-104
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    • 2021
  • The purpose of the study was to investigate whether there are differences in confrontation naming ability, generative naming ability, hearing handicap, and depression in community-dwelling elderly by age group, and whether there is any correlation among them, and to find out what factors explain the two naming abilities (confront and generative) of the elderly. Sixty-five community-dwelling elderly people participated: 65~74 years were classified into young-old; 75~84 years into old-old; and 85 years and over into oldest-old. K-BNT-15 for the confrontation naming ability, animal naming test for the generative naming ability, K-HHIE for the subjective hearing handicap, and GDS for the subjective depression were administered. First, there was a statistically significant difference in confrontation naming and depression levels according to age groups. Second, there was a positive correlation between chronological age and subjective depression level and between subjective hearing handicap level and subjective depression level, and a negative correlation between education level and subjective depression level. Third, the confrontation naming score was explained by age, and the generative naming score was explained by subjective depression level. The results show that naming abilities, subjective hearing handicap, and subjective depression level are not simply the result of normal aging and that a convergence approach is needed in various fields to solve the issue.

A Study on Jin Tai Quan Zhuan (金臺全傳): A Narration in the Form of a Xylographic Book (한국 소장 『김대전전(金臺全傳)』의 판본과 서사 연구)

  • Kim, Myung-Sin
    • Cross-Cultural Studies
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    • v.41
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    • pp.85-112
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    • 2015
  • This article studies The Complete Story of JinTai(金臺全傳), a Korean and Chinese xylographic book, and wishes to makes a case for the value of this work. The Complete Story of JinTai, is an anonymous Xia-Yi (俠義) novel from the late Qing Dynasty. The oldest edition is at Nanjing Rare Book Library. This work was published in 1881 when Emperor Guangxu (光緖) ruled China. Currently, a copy of this book is at the Kookmin University Rare Book Library, however, it is somewhat different in form from that in the Nanjing Library. But it is almost the same story. The Complete Story of JinTai narratives the life story of the hero, Jintai (金臺). Jintai's appearance, alliance, ordeal, contribution, and return proceed sequentially, thus, the story gradually explicates Jintai's heroic aspects. Jintai is a young hero. Exceptionally, he married an official dancing girl. He values honor, hangs out with friends, slays a wicked villain, to the defense of the country, and eventually becomes a king. The hero of more than 500 is categorized as conductor, strategist, activist, intuitive type. They are from Geumsan Mountain, took a pledge of brotherhood, and try to resolve a national crisis. The remarkable Jintai fights wicked enemies and does battle with the villains in many conflicts.

Age-related Changes in Word Defining Abilities in Concrete and Abstract Nouns with Normal Elderly (노화에 따른 구체명사와 추상명사의 단어정의하기 능력 변화)

  • Kim, Soo Ryon;Kim, HyangHee
    • 재활복지
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    • v.21 no.3
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    • pp.187-207
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    • 2017
  • The purpose of this study was to explore the characteristics of defining concrete and abstract nouns for the elderly. A total of 382 elderly participated in this study and they were classified into four age groups (i.e., over 55 to under 64, over 65 to under 74, over 75 to under 84, and over 85 year-old group). They performed the word definition task, composed of five concrete and five abstract nouns. The total scores and numbers and ratio of core/supplementary meanings were compared among four elderly groups. The frequency and ratio of error types were also examined. The results showed that all four groups had statistically significant differences in total scores, numbers and ratio of core and supplementary meaning of concrete noun definition task. In addition, abstract noun definition performances revealed group differences except the two groups (over 75 to under 84 and over 85-year-old group). The oldest group showed a sharp increase in error production. The highest ratio of error types were personal experience in over 55 to under 64-year-old group, and over 65 to under 74 year-old groups; and for the target word repetition in over 75 to under 84 year-old group; and no response in over 85 year-old group. In conclusion, both concrete and abstract word defining abilities had age-related deterioration. This decline results from impairment in spreading semantic knowledge within semantic network, which is vulnerable to aging. Characteristics of word definition for elderly can provide basic information to understand various neurolinguistic disorders associated with age.

A Study on Measures for Strengthening Intelligence-Led Policing Using HUMINT (휴민트를 이용한 정보지향적 경찰활동 강화방안)

  • Shin, Jae-Hun;Kim, Sang-Woon
    • The Journal of the Korea Contents Association
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    • v.19 no.2
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    • pp.112-120
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    • 2019
  • This study conducts survey on currently working police officers to examine the actual utilization of HUMINT and suggest measures for strengthening the effective intelligence police activity, Intelligence Led Policing. For the completeness of study, this study presented evidences based on survey data from police officers at sites and this study also suggested improvement measures. in regulating the scope of duty, "Act on the Performance of Duties by Police Officers" regulates that 'Gathering, preparation, and distribution of public safety information' is the duty of police officer and defines the information gathering activity of police as the unique work of police officer. Thus, in accordance with "Act on the Performance of Duties by Police Officers", police officers gather various information to prevent crimes and maintain orders. Among the information gathering methods used by police officer, HUMINT is the oldest measure and it is still utilized. HUMINT has the advantages of low expense, high accuracy, and critical impact on the other. Nevertheless, due to limitations in data objectification, measurement, and responses to double attack, HUMINT is underappreciated. With awareness on such HUMINT issues, this study conducted survey on in-service police officers and examined the actual state of HUMINT. Based on the survey result, this study suggested Intelligence-Led Policing as the effective application method.