• Reproductive and Developmental Biology
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• v.29 no.1
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• pp.43-48
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• 2005

To search of a new porcine pheromonal odorants for biostimulation control system technologies to offer a potentially useful and practical way to improve reproductive efficiency in livestock species, the holographic quantitative structure activity relationship (HQSAR) model between odorants, 2-phenoxytetrahydrofurane (A), 2-cyclohexyl-oxytetrahydrofurane (B), derivatives and binding affinity constants (p[Od.]/sub 50/) for porcine odorant-binding protein (pOBP) as receptor of pig pheromones were derivated and disscused. The binding affinity constants of cyclohexyl substituents (A) for pOBP were higher (A>B) than that of phenyl substituents (B). It was revealed that the optimum HQSAR model XI using PLS analyses had a fragment length (5∼8) with chirality at 5 components and hologram length 97 bin, which had a cross-validated q²(predictablities) of 0.916, and a conventional correlation coefficient r² (fitness) of 0.988, respectively. From the atomic contribution, the C3 and C5 atom in 2-oxyfuryl group contributed to binding affinity constants, whereas the central carbon atom in tert-butyl group on the cyclohexyl ring and the C4 atom of furyl group parts showed no contribution.

• Journal of Life Science
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• v.26 no.3
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• pp.346-352
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• 2016

Aroma inhalation therapy has traditionally been used not only in alternative medicinal treatment but also in psychotherapy. In the first stage of the study, the in silico molecular binding affinity of the major ingredients of Smart-Wave (SW) on the active site of the odorant-binding protein (OBP) was compared with that of citrate anions. The binding affinity of the chemical mixture formula of the major ingredients of SW on the OBP was relatively higher than that of citrate anions. In addition, nasal inhalation of SW had a positive effect upon changes in brain waves. Eighteen healthy volunteers participated in the experiment. The study consisted of measurements of the brain’s meditation level recordings in the pre- and post-SW inhalation periods as compared with negative (EV) and positive (HB) control groups. After SW inhalation, all the subjects stated that they felt “fresher” and that the SW trial group had significantly changed the brain’s meditation in a positive way. SW inhalation also converted EV-induced unstable brain meditation wave patterns into more stable patterns. Collectively, the results of this empirical study strongly suggest that the SW mixture activates the OBP and controls the mental state by regulating brain waves. The results provide scientific evidence that the SW formula has potential as an effective mental-stress controller.

• Proceedings of the Korean Society of Life Science Conference
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• 2003.10a
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• pp.38-42
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• 2003

• Biotechnology and Bioprocess Engineering:BBE
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• v.5 no.2
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• pp.150-152
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• 2000

The investigation of electroantennogram (EAG) using insect antennad has been primarily focused on the measurement of insect pheromone. Insect has highly specialized olfactroy receptors inside their antennae. In this paper, EAG was applied to detect general oborants and the feasibility of this system for the olfactroy biosensor was investigated. Electroantennogram measurement was carried out using the antennae of male silkworm moth, bombyx mori, and ammonia gas as the model odorant. EAG parametres including peak ampiltude increased linearly with the ammonia concentration and the reproducible electrical signals were generated at least for 2 hrs after the antenna was cut off from the sulkworm moth.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2000.04a
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• pp.235-239
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• 2000

본 연구는 화상 시뮬레이터 상에서 고속 주행(160km/h)으로 긴장감을 유발시킨 후, 향이 긴장감의 증감에 미치는 영향을 알아보고자 한다. 실험에 사용된 향은 100%의 Jasmineabs, Lavender oil france(KIMEX co. Ltd)이다. 10명의 신체 건강한 피험자를 대상으로 하여 Simulator sickness와 생리 반응을 측정하였다. 측정된 생리 신호는 심전도, 피부온도, 피부저항, 맥파와 같은 자율신경계 반응을 측정하였다. 또한 Simulator Sickness가 실험에 미치는 영향을 분석하였다. 실험 결과, 고속 주행 시 향을 제시하지 않았을 때보다 2가지 향을 제시하였을 때 긴장감이 모두 이완되는 경향을 나타내었다. 따라서 고속 주행으로 유발되는 신체의 긴장감이 향 자극으로 인해 감소된다는 사실을 자율신경계의 반응을 통해 관찰할 수 있었다.

• Proceedings of the KIEE Conference
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• 1994.07b
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• pp.1457-1459
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• 1994

A surface acoustic wave(SAW) sensor for the detection of odorants has been constructed by depositing various phospholipids and fatty acids onto the surface of the SAW device. Applying the Langmuir-Blodgett technique, it was possible to deposit the optimal number of layers which was found to be between 10 and 20. Menthone, amylacetate, acetoin, and other organic gases showed different affinities to the coated lipids. An explanation is given for different odorant affinities based on the monolayer properties of phospholipids.

• Journal of Microbiology and Biotechnology
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• v.10 no.6
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• pp.885-888
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• 2000

Electroantennogram(EAG) can be applied to detect odorants since insects have highly specialized olfactory receptors inside their antennae. The characteristics of EAG parameters were investigated for the quantitative measurement of a general odorant using ammonia as a model odorant. The antennae of male silkworm moth, Bombyx mori, were used for the EAG. The electical signal curves generated from a pair of antennae originating from the same silkworm moth were never identical; however, they exhibited a typical type I or type II characteristic curve pattern for every pair of antennae. The correlation between the EAG parameters and the ammonia concentration was analyzed for the type I and type II antennae. The stability of each parameter was also investigated for each type of antenna. The results show the possibility of the quantitative measurement of general odorants using the EAG technique.

• Biomolecules & Therapeutics
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• v.32 no.2
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• pp.192-204
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• 2024

Generally, odorant molecules are detected by olfactory receptors, which are specialized chemoreceptors expressed in olfactory neurons. Besides odorant molecules, certain volatile molecules can be inhaled through the respiratory tract, often leading to pathophysiological changes in the body. These inhaled molecules mediate cellular signaling through the activation of the Ca²⁺-permeable transient receptor potential (TRP) channels in peripheral tissues. This review provides a comprehensive overview of TRP channels that are involved in the detection and response to volatile molecules, including hazardous substances, anesthetics, plant-derived compounds, and pheromones. The review aims to shed light on the biological mechanisms underlying the sensing of inhaled volatile molecules. Therefore, this review will contribute to a better understanding of the roles of TRP channels in the response to inhaled molecules, providing insights into their implications for human health and disease.

• 한국가스학회:학술대회논문집
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• 1997.09a
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• pp.195-200
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• 1997

• Journal of the Korean Institute of Gas
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• v.23 no.6
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• pp.25-32
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• 2019

In many mass-consumption gas facilities, natural gas is not supplied through the pipeline of the gas corporation. LNG is supplied from the gas corporation through the tank lorry to be vaporized. In order to prevent human or property damage due to gas leakage at these facilities, a study was conducted to analyze the concentration of odorant injected at the initial and consumption points. An analysis was performed to confirm the change in odorant concentration according to the pipe position in the gas facility when a constant flow rate flowed. For this study the gas samples were taken with aluminium cylinders(4.5 L) which were created a vacuum at the pressure regulator in which the odorants was injected and the points using the gas. Odorant levels of the samples were analyzed by Gas chromatography(Main Body : Agilent 7890A, Detector : ANTEC 7090).We suggest that the small facilities using LNG need to make the management system by the types of facilities for maintaining the odorization system.