• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.10
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• pp.93-103
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• 2016

This study consisted of descriptive research to determine the prevalence of dry eye disease using the Ocular Surface Disease Index (OSDI) questionnaire targeting workers in hospitals to understand the differences between general and health related characteristics depending on whether people have dry eye disease, and to determine the influencing factors of the disease. The subjects were 502 (Male: 51, Female: 451) general hospital employees in G-city. The data were collected from October 1 to October 31, 2015. Logistic regression was used to analyze the data. The results showed that hospital workers' prevalence of dry eye disease was 76.1%. Factors influencing DED in this population included currently having or adjusting medication (OR: 4.73), among those who felt their eyes dry, those who visited clinics and received medical treatment (artificial tears) (OR: 2.37), those who felt eye dryness (OR: 2.23), and not eating regularly (OR: 0.55). Moreover, 54.0% of those who had dry eye disease reported serious conditions. Accordingly, education to manage the risk factors of the disease and improve lifestyle is needed to prevent and manage dry eye disease.

• Journal of Veterinary Clinics
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• v.28 no.1
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• pp.173-178
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• 2011

Homeopathic Pulsatilla 30C was evaluated in 4 clinical cases of ophthalmic complications with concomitant separation anxiety in dogs. Separation anxiety in dogs is excessive anxiety regarding to the separation from owners and is one of the most common behavioral problems in dog. In addition, ocular diseases is sometimes related with abnormal behaviors. Holistic approach is good alternative method to treat dogs with physical problem associated behavior problem. Homeopathy is one of the complementary and alternative medicines and bases on healing of patients themselves which includes mind healing, not the disease itself. Among the material medical remedy of homeopathy, the Pulsatilla is used as homeopathic remedy for ocular problems, earache, cough, cold, and anxiety from lost attention. These case studies described the successful treatment of ocular diseases and separation anxiety by application of Pulsatilla 30C as homeopathy in 4 dogs. During the homeopathy, these dogs did not receive any other treatments, and were performed the physical exam to check the ocular problems. These dogs were completely cured of physical and behavior problem within 10 days. On following up, any clinical signs were not observed at one month after the last therapy. In addition, as from the treatment the anxiety problem of patients has been much better improved. According to these case studies, we know that an application of homeopathic remedy may be useful therapeutic choice to treat both problems of physical and behavior.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.18 no.3
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• pp.95-98
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• 2018

A striking feature of mitochondrial disorders is the vast heterogeneity in their clinical symptoms that ranges from a single organ to severe multisystem involvement. Though a variety of ocular symptoms such as ptosis, pigmentary retinal degeneration, external ophthalmoplegia, and optic nerve atrophy can occur in association with mitochondrial cytopathies, progressive bilateral cataracts are rare among their ocular findings. A 5-year-old girl with no previous medical history came to our hospital presenting symptoms of seizure. She started showing progressive developmental regression, increased seizure frequency, hypotonia, general weakness, dysphagia and decreased vision. Lactic acidosis was noted in metabolic screening test and we confirmed mitochondrial respiratory chain complex I defect in spectrophotometric enzyme assay using the muscle tissue. Progressive bilateral cataracts then developed and were fully evident at the age of 7. She underwent cataract extraction with posterior chamber lens implantation. We are reporting a case of mitochondrial respiratory chain defect with multiorgan involvements including bilateral progressive cataract, an uncommon ocular manifestation. Ophthalmologic evaluation is highly recommended not to overlook the possible ocular manifestations in mitochondrial disorders.

• Journal of Acupuncture Research
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• v.24 no.4
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• pp.237-245
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• 2007

Objective : The Dry Eye Syndrome is characterized by reduction of the stability of the tearfilm and a set of alterations of the eye surface which could relate to tear quality, normal makeup of tearfilm and alterations in blinking or regular closing of eyelids. We treated 3 patients who was suffering with severe Dry Eye Syndrome and assessed the effectiveness of Oriental Medicine in the treatment of Dry Eye Syndrome. Methods : The patients were treated by acupunture, Gi Guk Yang Hyeol-decoction(Qijuyangxie-decoction). The improvement of the symptom was judged the subjective symptoms by the change of Ocular Surface Disease Index. Result : We observed in 2 cases of the patient significant decrease in the frequency of subjective symptoms, 1 case was not treated. Conclusion: The Oriental Medicine had effective results in Dry Eye syndrome. We need to have more observation and examination of Dry Eye syndrome.

• The Journal of Internal Korean Medicine
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• v.39 no.5
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• pp.929-938
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• 2018

Objectives: To report the clinical application and effects of Rg3 ginseng (ginseng radix) pharmacopuncture in patients with dry eye syndrome. Methods: Six patients who suffered from dry eye syndrome were treated with Rg3 ginseng pharmacopuncture for 4 weeks. The Ocular Surface Disease Index (OSDI) was used twice, at the start and end of treatment, to analyze the results. Results: After treatment with Rg3 ginseng pharmacopuncture, OSDI scores were improved in all six patients. Conclusion: Rg3 ginseng pharmacopuncture is an effective treatment for patients with the symptoms of dry eye syndrome.

• Journal of Korean Medicine Rehabilitation
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• v.21 no.2
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• pp.299-307
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• 2011

This study was performed to report the effectiveness of upper cervical chuna and release of cranial base on patients with dry eye syndrome. The patients diagnosed as dry eye syndrome and treated with upper cervical chuna and release of cranial base. Outcomes were measured by ocular surface disease index(OSDI). After treatments, discomfort and ocular surface disease index decreased. These results suggest that upper cervical chuna and release of cranial base were effective on patients with dry eye syndrome.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.4B
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• pp.630-636
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• 2010

Ocular inspection in oriental medicine, which identifies sickness by patient's skin color, is usually applied by doctor's subjective judgment. In order to reduce the subjectiveness of diagnosis, we propose a method of objective and quantitative analysis for ocular inspection. The most issued features for ocular inspection are how to identify the color of patients' face in various situations, and how to link the relation between color and sickness. For resolving these two issues, the color system of CIE Lab is adopted for analyzing and classifying the color characteristics. The classification of color features is verified by experiments on groups of patients and non-patients. The results of experiments showed that the proposed method can provide an objective means for ocular inspection using patient's skin color.

• Journal of Korean Ophthalmic Optics Society
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• v.15 no.3
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• pp.275-280
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• 2010

Propose: Due to the rapid growth of medical technologies and the increasing population of older people, we investigated clinical status of ocular dimensions and visual acuity for pre and post cataract surgeries of people over age 90. Methods: From March 2007 to February 2009, we investigated eighty-two eyes of forty-eight patients who had undergone cataract surgeries at an ophthalmic clinic (Ansung, Kyungi-do), investigated maximum corrected vision, axial length, anterior chamber depth and accompanied ocular diseases before and after the surgeries based on the collected data. Results: As patients aged, axial length unchanged but anterior chamber depth decreased over all due to the increase of intraocular lens thickness, and men tended to have a higher degree than women. Seventy-one (86.6%) of eighty-two eyes showed improved corrected vision than before surgeries and forty-three (52.4%) eyes could see more than visual acuity of 0.5. Conclusions: Patients with the systemic disease and accompanied ocular disease showed low vision less than 0.5 after cataract surgery compared to same healthy age peoples. But the others improved correction visual acuity more than 0.5, so the cataract surgery was surely necessary for people over 90 years old and also the presence of ocular disease could have a great influence on correction visual acuity.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.8
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• pp.3727-3731
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• 2016

Background: The most common type of ocular lymphoma is non-Hodgkin lymphoma (NHL), categorized into two groups: indolent (slow growing) and aggressive (rapid growing). Differentiating benign reactive lymphoid hyperplasia (RLH) from malignant ocular adnexal lymphoma (OAL) is challenging. Histopathology, immunohistochemistry (IHC) and flow cytometry have been used as diagnostic tools in such cases. Materials and Methods: In this retrospective case series, from 2002 to 2013 at Farabi Eye Center, 110 patients with ocular lymphoproliferative disease were enrolled. Prevalence, anatomical locations, mean age at diagnosis and the final diagnosis of the disease with IHC were assessed. Comparison between previous pathologic diagnoses and results of IHC was made. Immunoglobulin light chains and B-cell and T-cell markers and other immuno-phenotyping markers including CD20, CD3, CD5, CD23, CD10, CYCLIND1 and BCL2 were evaluated to determine the most accurate diagnosis. The lymphomas were categorized based on revised European-American lymphoma (REAL) classification. Results: Mean age ${\pm}$ SD (years) of the patients was $55.6{\pm}19.3$ and 61% were male. Patients with follicular lymphoma, large B-cell lymphoma or chronic lymphocytic leukemia/small cell lymphoma (CLL/SLL) tended to be older. Nine patients with previous diagnoses of low grade B-cell lymphoma were re-evaluated by IHC and the new diagnoses were as follows: extranodal marginal zone lymphoma(EMZL) (n=1), SLL(n=1), mantle cell lymphoma (MCL) (n=3), reactive lymphoid hyperplasia RLH (n=2). Two cases were excluded due to poor blocks. Flow cytometry reports in these seven patients revealed SLL with positive CD5 and CD23, MCLwith positive CD5 and CyclinD1 and negative CD23, EMZL with negative CD5,CD23 and CD10. One RLH patient was negative for Kappa/Lambda and positive for CD3 and CD20 and the other was positive for all of the light chains, CD3 and CD20. Orbit (49.1%), conjunctiva (16.1%) and lacrimal glands (16.1%) were the most common sites of involvement. Conclusions: Accurate pathological classification of lesions is crucial to determine proper therapeutic approaches. This can be achieved through precise histologic and IHC analyses by expert pathologists.

• Clinical and Experimental Pediatrics
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• v.58 no.10
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• pp.374-379
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• 2015

Purpose: Incomplete Kawasaki disease (KD) is frequently associated with delayed diagnosis and treatment. Delayed diagnosis leads to increasing risk of coronary artery aneurysm. Anterior uveitis is an important ocular signs of KD. The purpose of this study was to assess differences in laboratory findings, including echocardiographic measurements, clinical characteristics such as fever duration and treatment responses between KD patients with and those without uveitis. Methods: We conducted a prospective study with 110 KD patients from January 2008 to June 2013. The study group (n=32, KD with uveitis) was compared with the control group (n=78, KD without uveitis). Laboratory data were obtained from each patient including complete blood count (CBC), erythrocyte sedimentation rate (ESR), platelet count, and level of alanine aminotransferase, aspartate aminotransferase, serum total protein, albumin, C-reactive protein (CRP), and N-terminal probrain natriuretic peptide (NT-pro BNP). Echocardiographic measurements and intravenous immunoglobulin responses were compared between the two groups. Results: The incidence of uveitis was 29.0%. Neutrophil counts and patient age were higher in the uveitis group than in the control group. ESR and CRP level were slightly increased in the uveitis group compared with the control group, but the difference between the two groups was not significant. No significant differences in coronary arterial complication and treatment responses were observed between the two groups. Conclusion: Uveitis is an important ocular sign in the diagnosis of incomplete KD. It is significantly associated with patient age and neutrophil count.