• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5507-5512
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• 2013

Objective: To investigate the correlation between ERCC1 expression levels in tumor tissue and peripheral blood lymphocytes (PBL) from patients with gastric cancer and assess the relationship between PBL DNA repair rate (DRR) and the efficacy of platinum chemotherapy. Methods: A total of 53 patients with gastric cancer receiving surgery and 20 controls were studied. ERCC1 protein expression in tumour tissue and PBL were determined by immunohistochemical staining. The PBL DRRs of 47 advanced patients and 20 controls were estimated by comet assay. Results: The positive expression rates of ERCC1 were 67. 9%, 56. 6% and 10.0% in tumour tissues, PBLs of gastric cancer patients, and PBLs of the control group. PBL ERCC1 expression correlated with that in tissue (${\chi}^2$=15. 463, p=0.000). Pearson contingency coefficient=0.475). DRRs of cancer patients by tail length (TL) (Z=4. 662, p=0.000) and tail moment (TM) (Z=3. 827, p=0.000) were significantly lower than that of control group. When TL was applied as an indicator, the correlation between DRR and chemotherapy efficacy was significant (Spearman rank correlation r=0.327, p=0.032). Patients with low levels of DRR in PBL presented better short-term efficacy of chemotherapy than those with high levels of DRR. Conclusions: The ERCC1 expression in PBLs may indirectly reflect ERCC1 expression in gastric cancer tissues. Compared with non-cancer populations, patients with gastric cancer may have lower DNA repair capacity. DRR in PBL may predict the short-term efficacy of platinum-based chemotherapy for patients with advanced gastric cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5293-5299
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• 2013

Purpose: High levels of bone morphogenetic protein (BMPs) have been reported in patients with lung cancer. This study was conducted to assess correlations between serum BMP-2 levels and prognostic outcome in patients with non-small-cell lung cancer (NSCLC). Methods: Blood samples from 84 patients with advanced NSCLC and 42 healthy controls were analyzed and quantitated for serum BMP-2 levels before and after two cycles of chemotherapy using a commercially available ELISA kit. Results: The median level of BMP-2 was 146.9 pg/ml in patients with NSCLC vs. 87.7 pg/ml in healthy controls (P<0.01). A significant correlation was observed between pretreatment serum BMP-2 level and ECOG PS, disease stage and number of organs with metastases (P<0.05). Serum BMP-2 level decreased significantly in patients who achieved objective response after two cycles of chemotherapy. Multivariate analysis showed that increased BMP-2 level and advanced clinical stage were significantly correlated with poor prognosis. Conclusion: Thes erum BMP-2 level is positively correlated with clinical stage, ECOG PS and metastatic burden and may serve as an independent negative predictor for prognosis. Decreased BMP-2 after chemotherapy could be a reliable marker for efficacy of treatment.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.43 no.4
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• pp.239-246
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• 2017

Objectives: This paper proposes Han's ratio as an objective and quantitative comparative result obtained from pre and postoperative data in patients with a mandibular angle reduction. Materials and Methods: Thirty patients, 12 men and 18 women, who visited the Department of Oral and Maxillofacial Surgery with the chief complaints of skeletal mandibular prognathism and prominent mandibular angle were selected. The subjects were classified into 3 groups according to the types of surgical procedures involved. Group A consisted of patients who underwent mandibular angle resection and mandibular setback. Group B was comprised of patients with mandibular angle resection, mandibular setback and genioplasty. Group C consisted of patients with mandibular angle resection, mandibular setback, Le Fort I osteotomy, and genioplasty. The landmarks placed in pre and postoperative frontal photographs were used to obtain the Han's ratio in each group. The Han's ratios were compared pre- and postoperation and according to the surgical techniques applied. Results: Of the 3 groups who had undergone a mandibular angle resection, all showed a statistically significant increase in Han's ratio. On the other hand, there was no statistically significant difference based on the surgical techniques used. Conclusion: The ratio of the lateral lower face proposed in this study is a potential indicator of postoperative esthetic enhancement in mandibular angle reduction surgery.

• Journal of Navigation and Port Research
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• v.32 no.3
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• pp.199-205
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• 2008

Currently, ITs(Information Technologies} performances have been recognized as an essential tool for terminal operations. However, there have been little research that analyze level of ITs performance on port operation. Thus, the aim of this research is to analyze current level of ITs performance of major container terminals in Busan and Gwangyang. To achieve this objective, we developed HFP-based index that improve pervious indicator for evaluation of ITs performance. And then, level of ITs performance of four major container terminals were measured by the collected data through face to face interviews. Finally, through this analysis, some findings including weaknesses of ITs performance and implications were discussed.

• Korean Journal of Construction Engineering and Management
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• v.2 no.3 s.7
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• pp.45-57
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• 2001

Knowledge management was introduced as a new strategy in many construction companies aiming at paradigm shift since Asian financial Crisis. However, intensive focusing on acquiring and sharing knowledge couldn't keep pace with the primary goal. Increasing financial profits. That is because clear strategic process and performance measurement are absent in time of the introduction of knowledge management. Based on case analysis in domestic construction industry, this research work presents an alternative plan on Balanced Scorecard(BSC) model. The objective of this study is to develop a model of strategic performance measurement in knowledge management by sorting and grasping core operational knowledge, which can draw key performance indicators accompanied by knowledge map from case study.

• Environmental and Resource Economics Review
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• v.17 no.2
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• pp.349-379
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• 2008

Otters which are the nearly extinct feral animal as well as indicator species of ecological balance of river have a wide variety of public value. The objective of this paper is to estimate non-market value of preservation of otters' habitats in Cheongju Si and Cheong won Gun. In this research, the one-and-one-half bound dichotomize choice method as a contingent valuation methods is used to derive willingness to pay for the preservation of otters' habitats. 311 residents were surveyed to determine their recognition and willingness to pay for preservation of otters' habitats. The results show that the value of preservation of otters' habitats is 5,904 won per house and month.

• Journal of the Korea Convergence Society
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• v.6 no.5
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• pp.303-314
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• 2015

In This paper we study the interrelationship between firm's strategies, MCS (Management Control System), and financial and non-financial performance. And also the objective of this study is to advance the understanding of mediating effect of management accountant on these relationships. This is a suggestion on the study of contemporary settings as little contingency work was carried out on balanced scorecard, target costing, life cycle costing, which come under the broad array of non-financial performance indicators. The result of this study finds that the higher the unpredictability of the business, the more necessary it is to secure a controller within the business. This strongly implies that the controllers must be the main subject of continued growth as they perform an active role within the overall management control process of performance indicator development, performance measurement, feedback, and reward, starting from the very beginning stages of the strategy development within the business.

• The Journal of the Korea Contents Association
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• v.19 no.11
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• pp.549-557
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• 2019

The purpose of this study is to investigate the parallelism and volatility with Korea by using the Export Volume Index of Korea, Canada, Brazil, UK and Australia. The analysis period was prepared for indicator analysis, numerical analysis and model analysis using annual data for a total of 28 years from 1990 to 2017. In the correlation analysis, Korea showed high correlation in Canada, UK and Brazil, but low in Australia. In the coefficient of regression analysis, Brazil, Canada and UK are moving in a positive direction with their dependent variables (Korea), but appear to be almost unaffected by Australia. In order to increase Korea's exports in the future, Australia, Brazil, India, Vietnam and Singapore are emerging as new markets, which requires continuous attention. Although this study selected Canada, UK, Brazil, and Australia, it is expected that an objective and reliable study will be produced if more diverse countries are selected and analyzed in the future.

• Korean Journal of Applied Biomechanics
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• v.27 no.1
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• pp.45-52
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• 2017

Objective: The aim of this study was to investigate the periodicity of the lower extremity joint flexion/extension angle to compare the local stability between young and elderly women during walking on a treadmill. Method: Eighteen young women (mean $age=21.2{\pm}1.6y$; mean $mass=57.1{\pm}6.1kg$; mean $height=1.61{\pm}0.04m$) and 18 elderly women (mean $age=66.4{\pm}1.2y$; mean $mass=55.4{\pm}8.3kg$; mean $height=1.56{\pm}0.04m$) participated in this study. Approximate entropy (ApEn) was used to determine the periodicity in the lower limb joint angles. Results: The ApEn values of the two groups were statistically greater in the surrogate data test than in the original time series data (p<.05). The periodicity of the hip and ankle flexion/extension angles decreased in the elderly women group compared with the young women group (p<.05). The periodicity of the lower extremity joint flexion/extension angle showed that the ankle joint increased dominatingly in both groups (p<.05); the hip joint decreased compared with the knee joint in the young women group; and the knee joint decreased compared with the hip joint in the elderly women group (p<.05). Conclusion: These results suggest that the lower extremity joint flexion/extension angles of the young and elderly women during walking contained random noises as well as biological signals. In addition, the differences in the periodicity in the lower extremity joint between the young and elderly women may provide some insight in predicting potential falls and be used as a characteristic indicator for determining local stability in elderly women during walking.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.3
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• pp.546-550
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• 2011

The aim of this study was to evaluate oriental medicine pattern identification in patients with stroke on the basis of plasma fibrinogen levels and platelet counts. 555 patients diagnosed with stroke between November 2006 and February 2010 were divided in several ways according to the plasma fibrinogen levels and platelet counts on admission. And comparative analysis of the distribution ratio of oriental medicine pattern identification was done between the groups. The mean value of the plasma fibrinogen levels of whole population was 449.18 mg/dL, and it was higher than normal range. The mean value of the platelet counts of whole population was 244.29 /mL, and it was lower but in normal range. Oriental medicine pattern identifications were not characteristic between groups divided according to the serum levels of fibrinogen and platelet counts. In this study, there was not significant correlation between Oriental medicine pattern identifications and the thrombotic factor like plasma fibrinogen levels and platelet counts. This study could be the steppingstone for the next study to develope the objective indicator for the Oriental medicine pattern identifications.