• 제목/요약/키워드: Obesity indices

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The Associations of Percent Body Fat with Dietary Intake, Plasma Lipids, Lipoprotein(a), and PAI-1 in Middle Aged Korean Adults

  • Kim Rim, Jean-Chinock;Kang, Soon-Ah;Hiojung Wee
    • 대한지역사회영양학회지
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    • 제3권5호
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    • pp.695-706
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    • 1998
  • This study was designed to investigate the associations of the percent body fat dietary intake, plasma lipoprotein profile, lipoprotein(a), and plasminogen activator inhibitor-1(PAI-1) concentrations of 1982 Korean subjects(men : 1000 and women : 982) between the ages of 40 and 59 years. The dietary assessment consisted of twenty-four hour dietary records and food frequency questionnaires. The subjects were identified into one of the five rating groups of % body fat : lean, underweight, normal, overweight and obese groups. The biochemical assessment included measurements of plasma total cholesterol(TC), HDL-cholesterol(HDL-C), LDL-cholesterol(LDL-C), triglyceride(TG), lipoprotein(a)(Lp(a)), and PAI-1. With respect to the ratio of percent energy intake of carbohydrate : protein : fat of the normal group of the women was 62% : 17% : 20%, respectively. Women apparently had a higher intake of carbohydrates than men(52% : 17 : 20%) did. There was a linear relationship between energy intake and % body fat in both mean and women(with the exception of the underweight group of women). The relationship of % body fat of men to the protein and fat intake was higher than that of the carbohydrate intake. Of the men in the study, intakes of energy, protein and alcohol were positively correlated to % body fat. In women, energy, carbohydrate and protein intake were positively correlated to % body fat, however, the fat, cholesterol and alcohol intake did not show any correlation to the % body fat in women. This study showed that % body fat was positively correlated with plasma TC, LDL-C, PAI-1 levels, and TG, but the % body fat was negatively correlated with plasma HDL-C level in both men and women. These results indicated that the high energy intake of obese or overweight subjects might contribute to several of the biochemical indices fo coronary heart disease(CHD) risk. In conclusion, increased energy intake is associated with overweight or obesity in middle aged Korean people. There was no relationship between % energy intake of fat and % body fat in the study, in middle-aged Korean men and women. The plasma lipid profile and PAI-1 level thought to be the risk factors of CHD were positively associated with percent body fat in middle aged Korean people.

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농촌 국민학교 아동의 혈압, 짠맛에 대한 역치, 최적 염미도, 뇨 중 배설성분 및 혈압에 관한 영양지식 (Blood Pressure, Salt Threshold, Salt Preference, Urinary Excretions and Nutrition Knowledge About Blood Pressure of Elementary School Children in Rural Area)

  • 김은경
    • Journal of Nutrition and Health
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    • 제26권5호
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    • pp.625-638
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    • 1993
  • The purpose of this study was to observe the relationship of dietary factors to blood pressure in 5th and 6th grade school children. Salt threshold, salt preference and nutrition knowlege about blood pressure were tested. Twenty-four hour urines were collected for the measurements of the volume and concentrations of sodium, potassium, chloride, calcium, phosphorus, creatinine and urea nitrogen. 1) Mean systolic and diastolic blood pressure of elementary school children were 106.8/67.6mmHg in males and 108.7/69.5mmHg in females. Seven children(4%) of total subjects were found to be hypertensive. Their mean blood pressure was 130.0/86.4mmHg. 2) Urinary excretions of creatinine and urea nitrogen during twenty-four hours were 621.1mg and 1524mg, respectively. The mean daily urinary sodium excretion was 2940mg, which is equivalent to 7.37g NaCl. 3) The daily urinary excretions of other minerals were as follows; potassium was 1301mg, chloride, 4991mg, calcium, 55.7mg and phosphorus, 700.03mg. 4) Salt preference of hypertensive children90.473$\pm$0.275) was significantly higher than those of normotensive children(0.473$\pm$0.213%), but salt threshold was lower in hypertensives(0.105$\pm$0.04%) than normotensives(0.081$\pm$0.022%) (p<0.05). INdices for assessing obesity, such as body weight, triceps skinfold, weight for heigth and body surface area, were high in hypertensive children than normotensive children(p<0.05). But there was no significant difference in energy and nutrient intakes between two groups. 5) Various anthropometric measurements had positive correlations with blood pressure, but body muscle mass(%) had a negative correlation with blood pressure. And daily energy and nutrient intakes were not related to blood pressure. 6) Blood pressures-both systolic and diastolic-were significantly correlated with urinary excretions of potassium and chloride. Daily sodium excretion was related to systolic blood pressure, but no related to diastolci blood pressure. There was no relationship of salt threshold to salt preference, and neither threshold nor preference was related to blood pressure. Results of this study suggest that nutrition education program for children including the information about desirable food habits for the prevention of hypertension should be developed.

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고지방식이를 섭취하는 흰쥐에서 가르시니아캄보지아 껍질추출물, 대두펩타이드 및 L-카르니틴 조성물 섭취와 규칙적인 트레드밀운동이 체중감량에 미치는 영향 (Effect of Treadmill Exercise Training and Dietary Intake of Garcinia Cambogia Extract, Soypeptide and L-Carnitine Mixture on Body Weight Reduction in Rats Fed High-Fat Diet)

  • 김연정;전혜승;박인선;김민선;이진희;이강표;박태선
    • Journal of Nutrition and Health
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    • 제38권8호
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    • pp.626-636
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    • 2005
  • This study was undertaken to examine effects of dietary intake of garcinia cambogia extract, soy peptide and L-carnitine mixture on body weight gain and obesity-related bio-markers in rats fed high-fat diet for 9 weeks with or without regular treadmill exercise. Forty 5-week-old male Sprague-Dawley rats were randomly divided into four groups; sedentary control group (SC), exercised control group (EC), sedentary formula-fed group (SF), and exercised formula-fed group (EF). The SC and EC rats were fed high-fat control diet (fat comprises$40\%$ of total caloris), and SF and EF rats were fed high-fat formula (composed of garcinia cambogia, soy peptide and L-carnitine) supplemented diet. Statistical analyses by two-way ANOVA indicated that the regular treadmill exercise significantly lowered cumulative body weight gain, total visceral fat mass, and epididymal, perirenal and retroperitoneal fat pad weights, and serum concentrations of total cholesterol and LDL + VLDL cholesterol, insulin, c-peptide and leptin. Feeding the formula also resulted in significant reductions in cumulative body weight gain and visceral fat pad weights, along with other related parameters including serum total and LDL + VLDL cholesterol levels, and hepatic enzyme activities involved in fatty acid synthesis. Statistical analyses by one-way ANOVA revealed that the formula consumption significantly improved body weight gain ($18\%$ reduction), total visceral fat weight ($20\%$ reductions), and serum total ($43\%$ reduction) and LDL + VLDL cholesterol ($54\%$ reduction) levels, as well as serum levels of insulin ($49\%$ reduction), and c-peptide ($41\%$ reduction) in sedentary rats, but failed to exhibit significant reductions in these indices in animals under treadmill exercise program. Taken together, these results suggest that the treadmill exercise per n exhibited significant improvements in body fat reduction and other related bio-markers, and so the formula consumption did not achieve a further significant reductions in these bio-markers in exercised rats. Nevertheless, animals fed the formula with regular exercise showed the most efficient weight reduction compared to other groups either fed formula without exercise or received regular exercise without dietary supplementation.

Cardiometabolic Index, Triglyceride-glucose Index를 이용한 대사증후군 진단 예측지수에 대한 고찰: 부산지역 건강검진대상자 중심으로 (Consideration of Predictive Indices for Metabolic Syndrome Diagnosis Using Cardiometabolic Index and Triglyceride-glucose Index: Focusing on Those Subject to Health Checkups in the Busan Area)

  • 안현;윤현서;박충무
    • 대한방사선기술학회지:방사선기술과학
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    • 제46권5호
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    • pp.367-377
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    • 2023
  • This study investigates the utility of the Triglyceride-glucose(TyG) index and Cardiometabolic Index(CMI) as predictors for diagnosing metabolic syndrome. The study involved 1970 males, 1459 females, totaling 3429 participants who underwent health checkups at P Hospital in Busan between January 2023 and June 2023. Metabolic syndrome diagnosis was based on the presence of 3 or more risk factors out of the 5 criteria outlined by the American Heart Association/National Heart, Lung, and Blood Institute(AHA/NHLBI), and participants with 2 or fewer risk factors were categorized as normal. Statistical analyses included independent sample t-tests, chi-square tests, Pearson's correlation analysis, Receiver Operating Characteristic(ROC) curve analysis, and logistic regression analysis, using the Statistical Package for the Social Sciences(SPSS) program. Significance was established at p<0.05. The comparison revealed that the metabolic syndrome group exhibited attributes such as advanced age, male gender, elevated systolic and diastolic blood pressures, high blood sugar, elevated triglycerides, reduced LDL-C, elevated HDL-C, higher Cardiometabolic Index, Triglyceride-glucose index, and components linked to abdominal obesity. Pearson correlation analysis showed strong positive correlations between waist circumference/height ratio, waist circumference, Cardiometabolic Index, and triglycerides. Weak positive correlations were observed between LDL-C, body mass index, and Cardiometabolic index, while a strong negative correlation was found between Cardiometabolic Index and HDL-C. ROC analysis indicated that the Cardiometabolic Index(CMI), Triglyceride-glucose(TyG) index, and waist circumference demonstrated the highest Area Under the Curve(AUC) values, indicating their efficacy in diagnosing metabolic syndrome. Optimal cut-off values were determined as >1.34, >8.86, and >84.5 for the Cardiometabolic Index, Triglyceride-glucose index, and waist circumference, respectively. Logistic regression analysis revealed significant differences for age(p=0.037), waist circumference(p<0.001), systolic blood pressure(p<0.001), triglycerides(p<0.001), LDL-C(p=0.028), fasting blood sugar(p<0.001), Cardiometabolic Index(p<0.001), and Triglyceride-glucose index (p<0.001). The odds ratios for these variables were 1.015, 1.179, 1.090, 3.03, and 69.16, respectively. In conclusion, the Cardiometabolic Index and Triglyceride-glucose index are robust predictive indicators closely associated with metabolic syndrome diagnosis, and waist circumference is identified as an excellent predictor. Integrating these variables into clinical practice holds the potential for enhancing early diagnosis and prevention of metabolic syndrome.

당유자 유래 Flavonoids 농축액이 첨가된 감귤 음료의 쥐 비만 및 혈중 지질에 미치는 영향 (Effect of Concentrated Dangyooja-derived Flavonoids Extract Added to Citrus Beverage on Obesity and Blood Lipids in Rats)

  • 최영훈;이영재;이선이;채치원;박석만;김상숙;안현주;;한창훈;홍현주
    • 원예과학기술지
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    • 제30권2호
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    • pp.214-219
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    • 2012
  • 본 연구에서는 제주산 청과즙과 제주 재래귤인 당유자 과즙 내의 기능성 성분을 대량 추출하여 새로운 타입의 고기능성 감귤 음료를 개발코자 기능성 연구를 실시하였다. 관능 검사를 통해 청과 착즙액 30%에 KILO Prep을 이용하여 얻은 당유자 유래 플라보노이드 농축액 15%를 포함하는 Citrus-F 음료를 제조하였다. 새롭게 제조된 Citrus-F를 경구 투여하여 쥐 체중의 변화를 관찰한 결과 HF diet(고지방사료)와 Citrus-F를 병행하여 급이한 군의 경우 급이 7주차부터 HF diet만 단독으로 급이한 군에 비하여 뚜렷하게 체중이 감소되어 그 효과는 실험이 끝나는 9주째까지 지속되었다. 또한 Citrus-F가 혈중지질에 미치는 영향을 알아보기 위해 경구 투여한 쥐를 대상으로 한 혈청검사에서 혈중 지방 함량은 Citrus-F 처리군에서 감소하는 경향을 보였다. 특히 급이 시점을 초기부터 시작한 경우에는 triglycerid의 수치는 감소하였지만 total cholesterol과 HDL-cholesterol의 수치에는 별다른 영행을 미치지 못했다. 그러나 5주 후부터 0.1% Citrus-F를 급이한 처리군에서 triglyceride, total cholesterol과 HDL-cholesterol의 수치가 모두 감소함을 확인할 수 있었다. 본 연구 결과 당유자 유래 플라보노이드 농축액을 15% 포함하는 고기능성 Citrus-F 음료는 비만 및 각종 혈중 지질 관련 질병의 예방에 효과가 있을 것으로 사료된다.

학령 전 아동의 식습관, 신체 발달 및 영양 섭취상태에 관한 연구 (A Study on the Dietary Behaviors, Physical Development and Nutrient Intakes in Preschool Children)

  • 유경희
    • Journal of Nutrition and Health
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    • 제42권1호
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    • pp.23-37
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    • 2009
  • 유아교육 기관에서의 체계적이고 과학적인 영양관리의 중요성이 부각됨에 따라 어린이의 올바른 식생활 형성, 관리 및 영양교육을 위한 영양관리프로그램 개발의 기초자료 마련을 위해 울산시 보육 시설에 다니는 $3{\sim}6$세 어린이를 대상으로 신체계측 및 식습관, 식품섭취빈도, 영양섭취조사를 한 결과는 다음과 같았다. 1) 어린이가 식사를 잘하지 않는 이유로는 '많은 간식으로 인하여'라는 답이 가장 높은 비율 (50.4%)을 차지하였으며, 규칙적 아침 식사에 있어서는 1주에 $3{\sim}4$번 하는 어린이가 17.9%, $1{\sim}2$번 하는 어린이가 6.2%로 아침 결식률이 높았다. 2) 간식의 빈도로 세 번 이상 주는 경우가 22.8%로 나타났으며 생우유 섭취량이 하루 3컵 이상 마시는 어린이도 11.7%였다. 3) 어린이의 식습관에서 흔히 나타나는 문항을 5점 척도로 식습관을 평가하였다. '식사 시간이 규칙적'이라는 문항에 대해서 평균 $3.5\;{\pm}\;0.9$점으로 가장 높은 점수를 나타내었으며 다음으로 '적당양을 섭취한다'의 문항으로 평균 $3.4\;{\pm}\;1.0$, '음식 투정을 하지 않는다' $3.1\;{\pm}1.0$, '음식을 골고루 섭취한다' $3.0\;{\pm}\;1.0$로 나타났으며 마지막으로 '식사를 빨리 끝낸다'의 문항에 대해서는 $2.7\;{\pm}\;0.9$의 낮은 점수로 평가되었다. 또한 5문항 전체 평가에 있어서는 식습관이 우수하다고 판정되는 어린이가 9.0%에 불과했으며 대부분 식습관이 보통인 것으로 평가되었으나 식습관이 불량하다고 판정되는 경우도 6.2%로 유치원에서부터 어린이의 식습관 개선을 위한 영양교육이 필요하다고 보여진다. 4) 어린이의 식품군별 섭취빈도 점수를 점수화하여 비교 분석한 결과 가장 낮은 섭취를 나타낸 식품군은 녹황색 채소류로 평가 점수가 $1.8\;{\pm}\;0.9$였으며, 다음이 미역, 김 등의 해조류의 식품이 $2.1\;{\pm}\;1.1$, 과일류가 $2.5\;{\pm}\;1.2$의 순으로 평가되었다. 어육류, 계란, 콩 등 단백질 식품은 $2.6\;{\pm}\;1.1$, 우유 및 유제품의 경우는 $3.3\;{\pm}\;1.1$로 가장 자주 섭취하는 식품군으로 나타났으며, 튀김 음식의 경우 어린이의 32.4%가 주에 $1{\sim}2$번 정도로 거의 섭취하지 않는다고 답하여 평점 $3.0\;{\pm}\;0.9$로 식습관의 진단에는 양호한 결과를 보였다 4) 어린이의 건강 상태를 5점 척도로 평가한 결과 감기 증상이 $3.1\;{\pm}\;1.0$로 가장 낮은 점수를 나타내었으며 알레르기 증상이 $3.7\;{\pm}\;1.3$로 낮은 결과를 보여 영양소 섭취 부족에 의한 임상 증상들에 비해 면역에 대한 질환의 위험도가 높은 것으로 조사되었다. 어린이의 건강 점수는 50.3%가 양호한 것으로 나타났으며 47.6%가 보통, 2.1%가 건강 위험이 큰 것으로 나타났다. 5) 대상 어린이의 신장은 평균 $103.6\;{\pm}\;6.4\;cm$였으며 남아의 경우 $104.5\;{\pm}\;6.3\;cm$, 여아의 경우 $102.6\;{\pm}\;6.4\;cm$로 연령 간에는 유의한 차이 (p < 0.05)가 있었으며 남녀 어린이 간에는 유의한 차이가 없었다. 체중은 평균 $17.8\;{\pm}\;3.0\;kg$였고, 남아 평균 $18.4\;{\pm}\;3.2\;kg$, 여아 평균 $17.1\;{\pm}\;2.7\;kg$였다. 연령 간에는 4세에는 유의한 차이가 없었으나 5세, 6세에는 유의한 차이가 있었으며, 남녀 어린이 간에는 4세에만 유의한 차이가 있었다. 6) WLI를 기준으로 비만율을 판정한 결과 저체중율은 11.1%, 과체중 이상의 어린이 비율이 17.4%로 나타났다. Rohrer지수의 경우 비만도의 평가는 저체중율은 전혀 없었으며, 과체중 이상의 어린이가 86.8%로 높게 나타났다. Kaup 지수에 의한 비만율은 저체중율이 2.8%, 과체중 이상의 경우는 29.2%로 나타나 WLI에 의한 빈도보다는 조금 높았으며, 비만 지수 (Obesity Index)를 이용한 경우 저체중율이 2.1%, 과체중 이상 어린이가 20.8%로 판정되었다. 본 연구 어린이의 성장의 특징은 모든 지표에서 3세에 유의하게 비만지수가 높게 나타났으며 연령이 증가하면서 비만 지수가 낮아지는 경향이었고, 다른 연구 결과에 비해 저체중 비율이 낮았다. 7) 조사 대상 어린이의 영양소 섭취 상태를 조사한 결과에너지 섭취는 한국인영양섭취기준보다 낮은 수준으로 에너지필요추정량 (EER)의 85.7% 수준이었다. 에너지적정섭취비율 (Acceptable Macronutrient Distribution Ranges:AMDR)은 탄수화물:단백질:지방의 비율이 62.6:21.5:15.7로 한국인 영양섭취기준에서 제시하는 $55{\sim}70:7{\sim}20:15{\sim}30$과 비교 시 지방의 섭취 비율은 낮은 편이며 단백질의 섭취비율이 높은 것으로 나타났다. 단백질의 섭취는 권장섭취량의 3배가 넘는 수준으로 높은 섭취를 나타내었다. 비타민 A의 경우 권장섭취량의 133%를 섭취하였으며, 어린이에서 가장 섭취율이 낮은 것으로 알려진 칼슘의 경우 권장섭취량의 98.9%를 섭취하였고 무기질과 비타민 중 엽산을 제외한 모든 영양소에서 권장섭취량을 초과 섭취하는 것으로 나타났다. 8) 열량섭취 부족의 어린이는 33.3%, 지방의 섭취가 부족한 어린이의 비율은 42.7%로 조사되었으며, 특히 엽산은 어린이의 85.5%가 부족한 것으로 나타났다. 비타민 A, 나이아신, 비타민 C의 경우 각각 어린이의 29.1%, 35.0%, 47.0%가 섭취 부족인 것으로 조사되었다. 반대로 영양소 과잉 섭취 어린이의 비율은 나이아신의 경우는 24.8%, 비타민 A의 경우 4.3%, 철분은 1.7%로 나타났다. 울산 지역 미취학 아동을 대상으로 실시한 이상의 연구결과를 종합해보면 식사를 잘하지 못하는 이유로 간식섭취가 높기 때문이라고 답한 비율이 높고 실제로 어린이의 간식 섭취 빈도나 우유 및 유제품 섭취량 또한 다른 연구와 비교 시 높은 것으로 판단되어 균형잡힌 식습관에 문제가 있을 것으로 판단되어진다. 또한 다른 지역 연구에 비해 저체중으로 판단되는 어린이의 비율이 낮고 과체중 이상 비만으로 판단되는 어린이의 비율이 높게 나타난 점, 영양소섭취에 대한 조사결과 대부분의 영양소에서 한국인영양섭취기준의 권장섭취량을 초과 섭취 하는 것으로 나타난 점등을 고려할 때 본 연구 어린이에 대해 과잉 영양소 섭취에 대한 좀 더 세밀한 관심과 영양교육이 필요하다고 보여 진다. 따라서 본 연구 결과를 바탕으로 지역사회의 건강증진사업을 담당하고 있는 보건소 및 대학, 유아기관 등에서 어린이의 식습관에 대한 교육프로그램 개발에 힘써야 할 것이며, 부모와 어린이의 식생활지도를 통한 교육 프로그램이 활성화 될 수 있도록 지속적인 관심을 가져야 할 것이다.

어린이의 식습관(食習慣)이 체위(體位)에 미치는 영향(影響)에 관한 연구(硏究) (The Influence of Food Habits on Body Stature of Children)

  • 이미숙;모수미
    • Journal of Nutrition and Health
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    • 제9권1호
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    • pp.7-15
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    • 1976
  • The Purpose of this study was to determine every possible correlation between food habits and body statures of primary school children, aged ten years old. This study was conducted from July to October of 1975. In July, prepared questionaires concerning life style, anthropometry, food preference, and food behavior were distributed through school teachers to 425 children; 219 boys and 206 girls, in the 5th grade of three elementary schools in the city of Seoul. Then, in October, when subjects had been classified into underweight/obese by statistical analysis, mothers of obese or underweight children were interviewed by the authors to determine weaning history, daily food consumption of their children, and opinions of various snacks for children. Analysis of results in terms of correlation coefficient, chisquare test and percentage calculations, are as follows: 1. Physical growth and development Boys Girls Height (cm) $134.8{\pm}5.74\;134.4{\pm}5.97$ Weight (kg) $30.0{\pm}4.27\;29.5{\pm}5.16$ Chestgirth (cm) $64.1{\pm}3.59\;63.3{\pm}3.81$ Arm circumference (cm) $18.3{\pm}1.61\;18.2{\pm}1.70$ Triceps skinfold thickness (mm) $10.9{\pm}5.13\;12.7{\pm}4.86$ Various indices of nutrition such as relative weight, relative chestgirth, $R{\ddot{o}}hrer's$ index, Kaup index, Vervaeck index were determined. 2. Food habits 1) Food $preference{\cdots}{\cdots}A$ varying number of foods were selected from 60 items were accepted. It was found that the food which children liked best was fruit and snacks were popular one. Lowest ranking among LIKED foods were from strongly flavored vegetables and organ meat. In general, girls had more food dislikes than did boys. Selected as liked foods were fruits, rice noodle soup, biscuits, and peanuts. Disliked foods were liver, green onions, onions, green pepper, mushrooms, oysters, shellfish, and pork. Items which children never ate before were liver, mushrooms, fish cake, boiled rice mixed with sorghum, mayonnaise, and fresh water firsh. Reasons which children gave for dislike were undesirable flavor and odor. 2) Food $behavior{\cdots}{\cdots}It$ was found that boys liked sweet and salty flavors more than did the girls who more often liked sour flavor. The majority of children enjoyed evening meals more than lunch and breakfast. A number of children skipped breakfast because of lack of appetite or lack of time before going to school. Snacks were the most popular food, especially among girls. Their snacking habits were formed by the encouragement of the mother, and the relieve boredom. Educational backgrounds of mothers and family economical levels of children were remarkable correlated with mothers' attitudes toward feeding of children. There were several interesting findings relating body stature to some other responses; such as that the obese child has a small number of brothers, higher birth order, higher educated mothers and higher family cultural background. It was also discovered that food perference, except for fat and oil group foods was not related to body stature. Sweet taste was liked best and pepperly taste was mostly disliked. Sour taste was popular in the group of underweight. Underweight children were more finicky, disliked snacking, and didn't get much attention from their mothers. 3) Correlation between body stature and nutrition during their infancy. The majority of children, both from obese and underweight, were breast fed as infant. Twenty five per cent of obese children and 17.4 per cent of underwight children started weaning at $1{\sim}6$ months old. The most popular supplemental food of weaning was cereal gruel for the obese group, while boiled white rice and cereal gruel were most common for the underweight group. Highly significant relationships were found between stature of parents and their children. In the obese group 47.8 per cent of fathers and 45.9 per cent of mothers were overweight; however, none of the fathers and only one mother was found to be underweight. In daily food consumption patterns, meals consisting of bread or noodle were popular in the obese group but disliked by the underweight group. The study found clear contrast in that the obese group liked meat and fish while the underweight group liked fruits and vegetables, especially kimchee. The obese children desired to eat cereal foods, milk and milk products, and fat foods while the underweight group desired to eat fruits and vegetables. Frequency of snacks per day was much greater in the obese group. Foods which mothers believed to be good for the health were carrots, cucumbers, fruits, milk, potatoes, sweet potatoes, and breads, while sweet foods such as candies, drinks. chocolate were considered not good for the teeth. Watching television was not significantly related to statures of children. Most significant relationships were found beween frequencies of family guest meals/and eating-out, and children's statures. Nutritional problems which have been considered for the malnourished children in addition to those of children who have a tendency toward obesity, must be taken into consideration in the development of proper nutrition education through the channels of regular school teaching and teaching by parents in the homes. Korean standards of anthropometric measurements for children should be revised, current measurements show much higher figures than present Korean standards.

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형질전환 비만모델 수컷 hGHTg rats에서 경신해지환(輕身解脂丸)이 혈중 항비만지표에 미치는 영향 (The effects GeongshinhaeGihwan 1(GGT1) has on the hGHTg (human growth hormone transgenic) obese male rats' blood-antiobestic index)

  • 정양삼;총배금;최승배;김경철;신순식
    • 대한한의학방제학회지
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    • 제13권2호
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    • pp.1-16
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    • 2005
  • Objectives: To find out the effects GGTl, an antiobestic drug widely used in clinics, has on the blood-antiobestic index and the toxicity index using the data from the hGHTg obese male rats. We looked closely into both of the two indices because GGTl antiobestic effect can happen not only by pharmacological action, but also by its toxicity. Also, we verified the difference in effect between GGTl and reductil (sibutramine), which has been approved by the FDA of the United States. Methods: After performing the experiments for 8 weeks on the hGHTg obese male rats divided into three groups: the control group, the GGTl group, and the reductil (RD) group, we anesthetized the rats with Diethyl ether and took a 3ml blood sample from the heart. Then, after coagulating the blood in room temperature by using the plasma separator, we centrifuged it for 25 minutes in 3,000rpm using the high-speed refrigerated centrifuge. We kept the separated plasma in a deep freezer at $-80^{\circ}C$, and repeatedly measured the antiobestic index and the toxicity index twice using the hematology biochemistry analyzer. Also, in order to judge the indirect toxicity index, we separated liver from kidney and observed them. Results: When we looked at the results of the analysis of covariance on the measuring elements related to the antiobestic index (TC, HDL, LDL, TG, and GLU), there was no significant difference among the groups in all measuring elements. Also, the results of the analysis of covariance on the two roups (RD group and GGTl group) showed that the p-values had no significant difference under the level of significance 0.05. When we looked at the result of the analysis of covariance on the measuring elements related to the toxicity index (GOT, GPT, GGT, CREA, UA, ALB, and TP), we could see that the p-values in GPT, ALB, and TP have a significant difference among the groups. Also, the results of the analysis of covariance about the measuring elements related to the toxicity index on both groups, RD group and GGTl group, showed no significant difference in the p-values of all of the measuring elements in the two groups, RD and GGTl group. Conclusions: In conclusion, through this experiment, the safety of GGTl has been approved, and although the verification on its medical effect has not been clearly approved, when we consider the fact that it belongs to the same group as reductil, an antiobestic drug approved by the FDA of the United States, we could indirectly verify that GGTl has an antiobestic effect. We believe that when doing a sample design for a future experiment, it needs to be performed on a greater sample size based on the power analysis that needs to be performed primarily in experiments, and a more accurate verification is needed through more systematic experiment plans.

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폐쇄성 무호흡의 치료시 지속적 기도 양압치의 예측 (Prediction of Continuous Positive Airway Pressure Level for Treatment of Obstructive Sleep Apnea)

  • 이관호;정진홍;이현우
    • Tuberculosis and Respiratory Diseases
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    • 제43권5호
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    • pp.755-762
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    • 1996
  • 연구배경: 지속적 기도 양압 치료는 폐쇄성 수면 무호흡증 환자의 가장 효과적인 내파적 치료법으로 알려져 있다. 폐쇄성 무호흡증 환자에 사용되는 지속적 기도 양암 치료는 양압이 상기도에서 단순히 물리적인 공기 부목과 같은 역할로 작용한다. 폐쇄성 무호흡 환자에서 지속적 기도 양암 치료시 최적 양압의 결정에 영향을 미치는 변수를 파악하고 이러한 변수들로 다중 선형 회귀 분석을 하여 최적압치를 예측해 보기위하여 이 연구를 하였다. 방법: 폐쇄성 수면 무호흡증이 있는 72명의 환자를 대상으로 이틀동안 진단 및 치료적 수면 다원 검사를 실시하였다. 이들 중 지속적 기도 양압 최적지가 $5cmH_2O$ 이하였던 35명과 최적치가 $10cmH_2O$이상이었던 37명의 환자에서 나이, 키, 몸무게, body mass index(BMI)와 수면 다원 검사의 각 변수의 차이를 분석하고 이러한 변수들로 지속적 기도 양압의 최적치를 다중선형 회귀분석하였다. 결과: 지속적 기도 양압의 최적치가 $10cmH_2O$이상이었던 환자에서 body mass index(BMI)가 의의있게 더 높았고 무호흡 지수와 무호흡 저호흡 지수도 의의있게 더 높았으며 최저 산소 포화도는 의의있게 낮았다. 이러한 변수들로 구한 최소의 지속적 기도 양압의 공식은 CPAP titer = 8.382 + 0.064 x BMI + 0.077 x AI - 0.004 x AHI - 0.077 x lowest $SaO_2$였다. 수면 다원 검사로 실제로 측정한 지속적 기도 양압의 최적압은 평균 $7.93{\pm}4.00cmH_2O$였으며 다중 선형 회귀분석하여 공식으로 구한 예측 최적압치는 $7.80{\pm}2.96cmH_2O$로 이들 두 수치사이의 의의있는 차이는 없었다. 결론: 폐쇄성 수면 무호흡의 치료시의 지속적 기도 양압의 최적압은 신체의 비만도, 무호흡의 심한 정도와 최저 산소 포화도와 관계가 있었으며 이러한 변수들로 비교적 정확하게 최적압치를 예측할 수 있었다.

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db/db 마우스에서 Ceriporia lacerata 균사체 배양액이 GLUT4 발현에 미치는 영향 (Effect of submerged culture of Ceriporia lacerata mycelium on GLUT4 protein in db/db mouse)

  • 신은지;김지은;김지혜;박용만;윤성균;장병철;이삼빈;김병천
    • 한국식품저장유통학회지
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    • 제22권6호
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    • pp.893-900
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    • 2015
  • 최근 경제가 급속히 성장하면서 세계적으로 당뇨병이 심각한 대사성 질환으로 대두되고 있으며 이에 따라 혈당조절에만 초점을 맞춘 경구용 당뇨병 치료제가 아니라 당뇨병을 근본적으로 치료할 수 있는 혈당 강하 소재를 개발하기 위한 연구가 늘어나고 있다. 본 연구에서는 선행 연구에서 항당뇨 효능이 확인된Ceriporia lacerata 균사체 배양물건조물(CL01)을 제 2형 당뇨병 동물 모델인db/db 마우스에 경구투여하여 CL01이 혈액학적 지표 및 인슐린 신호 전달기전 상의 유관 단백질과 mRNA 발현에 미치는 영향을 평가하였다. CL01을 4주간 투여했을 때 혈당이 지속적으로 감소하였고, 혈청 인슐린, c-peptide 농도도 각각 음성대조군의 55.8%, 40% 수준으로 감소하였다(p<0.05). 인슐린 저항성을 반영하는 지표인 HOMA-IR 수치를 계산한 결과, CL01 투여군에서 인슐린 저항성이 음성대조군 대비 약 62% 개선되었다(p<0.05). 또한 인슐린 신호 전달에 관여하는 pIR, pAkt, pAMPK, GLUT4 단백질 및 Akt2, IRS1, GLUT4 mRNA 발현이 증가하였다. 이들 결과를 통해 CL01이 당 대사 및 인슐린 신호 전달에 관여하는 유관 단백질 및 유전자 발현에 영향을 미치며 이에 따라 인슐린 저항성을 개선하여 혈당을 효과적으로 감소시키는 것을 알 수 있다. 제 2형 당뇨병 환자의 90% 이상이 인슐린 저항성으로 인한 고인슐린혈증, 당내성 장애, 고혈압, 비만 등의 대사 이상이 생길 확률이 증가하기 때문에 CL01의 섭취를 통해 GLUT4 발현을 증가시켜 인슐린 저항성을 낮추는 것이 제 2형 당뇨병의 근본적인 치료에 이용될 수 있을 것으로 사료되며 이 연구가 당뇨병 치료의 추가적인 기전 연구를 위한 기초 증거로 활용될 수 있을 것이다.