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http://dx.doi.org/10.7235/hort.2012.11062

Effect of Concentrated Dangyooja-derived Flavonoids Extract Added to Citrus Beverage on Obesity and Blood Lipids in Rats  

Choi, Young-Hun (Citrus Research Station, National Institute of Horticultural & Herbal Science)
Lee, Young-Jae (College of Veterinary Medicine, Jeju National University)
Lee, Sun-Yi (Citrus Research Station, National Institute of Horticultural & Herbal Science)
Chae, Chi-Won (Citrus Research Station, National Institute of Horticultural & Herbal Science)
Park, Suk-Man (Citrus Research Station, National Institute of Horticultural & Herbal Science)
Kim, Sang-Suk (Citrus Research Station, National Institute of Horticultural & Herbal Science)
An, Hyun-Joo (Planning and Coordination Division, National Institute of Horticultural & Herbal Science)
King, Dale (College of Veterinary Medicine, Jeju National University)
Han, Chang-Hoon (College of Veterinary Medicine, Jeju National University)
Hong, Hyun-Ju (College of Veterinary Medicine, Jeju National University)
Publication Information
Horticultural Science & Technology / v.30, no.2, 2012 , pp. 214-219 More about this Journal
Abstract
This study aimed to develop a new type of functional citrus beverage (Citurs-F) containing flavonoids extracted from the young fruits of satsuma mandarin ($Citrus$ $unshiu$) and matured fruits of Jeju native dangyooja ($C.$ $grandis$). We made beverages that contained 30% of satsuma mandarin extract with different percentages of concentrated dangyooja-derived flavonoid extracts. In sensory evalution, the highest response indices of color, taste and aroma were from the beverages based on the 30% young fruit extracts plus 15% (Citrus-F-15) and 20% (Citrus-F-20) flavonoids extract from the dangyooja using the KILO prep. In the changes of body weight after oral administration of the Citrus-F, the rat group with HF diet plus the Citrus-F decreased the body weight compared to the rat group fed only HF diet. This effect was to be continued for 9 weeks until the end of experiment. In the lipid content in blood, the rat group with oral administration of citrus extractions merely tended to resolve it in serum test. However, all the 0.1% Citrus-F-15 and Citrus-F-20 treated rat groups from the beginning or after 5 weeks appeared the lowest lipid contents in the blood. In the cholesterol contents, the rat group feeding the KILO-prep's extraction from the beginning weren't significantly recognized them in the group but the rat group feeding 0.1% Citrus-F-15 acted to reduce in the cholesterol contents from 5 weeks. The results indicated that the Citrus-F-15 with rich flavonoids might be main source alleviating the vascular diseases and obesity in human diet.
Keywords
cholesterol; citrus extract; diet; KILO prep; satsuma mandarin;
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1 Tripoli, E., M.L. Guardia, S. Giammanco, D.D. Majo, and M. Giammanco. 2007. Citrus flavonoids: Molecular structure, biological activity and nutritional properties: A review. Food Chem. 104:466-479.   DOI
2 Vandercook, C.E. and B. Tisserat. 1989. Flavonoid changes in developing lemons grown in vivo and in vitro. Phytochemistry 28:799-803.   DOI
3 Yusof, S., H.M. Ghazali, and G.S. King. 1990. Naringin content in local citrus fruits. Food Chem. 37:113-121.   DOI
4 Zhang, X., F.Z. Lee, and J.B. Eun. 2008. Physicochemical properties and glucose transport retarding effect of pectin from flesh of Asian pear at different growth stages. Korean J. Food Sci. Technol. 40:491-496.
5 Hertog, M.G., P.C.H. Hollman, M.B. Katan, and D. Kromhout, 1993. Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study. Lancet 342:1007-1011.   DOI
6 Jourdan, P.S., C.A. McIntosh, and R.L. Mansell 1985. Naringin levels in citrus tissues. II. Quantitative distribution of naringin in Citrusparadisi Macfad. Plant Physiol. 77:903-908.   DOI
7 Hodek, P., P. Trefil, and M. Stiborova. 2002. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem. Biol. Interact. 139:1-21.   DOI
8 Horowitz, R.M. and B. Gentili. 1969. Taste and structure in phenolic glycosides. J. Agric. Food Chem. 17:696-700.   DOI
9 Horowitz, R.M. and B. Gentili. 1977. Flavonoids constituents of citrus, p. 397-426. In: S. Nagy, P.E. Shaw, and M.K. Vedhuis (eds.). Citrus science and technology. AVI Publishing, Westport, CT.
10 Kim, H.K., T.-S. Jeong, M.-K. Lee, Y.B. Park, and M.-S. Choi. 2003. Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol feed rats. Clin. Chim. Acta. 327:129-137   DOI
11 Kim, S.S., J.S. Baik, T.-H. Oh, W.-J. Yoon, N.H. Lee, and C.-G. Hyun. 2008. Biological activities of Korean Citrus obovodes and Citrus natsudaidai essential oils against acne-inducing bacteria. Biosci. Biotechnol. Biochem. 72:2507-2513.   DOI
12 Kim, Y.D., W.J. Ko, K.S. Koh, Y.J. Jeon, and S.H. Kim. 2009. Composition of flavonoids and antioxidative activity from juice of Jeju native citrus fruits during maturation. Korean J. Nutr. 42:278-290.   DOI
13 Lee, S., Y.B. Park, K.H. Bae, S.H. Bok, Y.K. Kwon, and E.S. Lee. 1999. Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme a reductase and acyl coenzyme A: Cholesterol acyltransferase in rats. Ann. Nutr. Metabolism 43:173-180.   DOI
14 Ortuno, A., D. Garcia Puig, M.D. Fuster, M.L. Perez, F. Sabater, I. Porras, A. Garcia Lidon, and J.A. Del Rio. 1995. Flavanone and nootkatone levels in different varieties of grapefruit and pummelo. J. Agric. Food Chem. 43:1-5.   DOI
15 Cook, R. 1983. Quality of citrus juices as related to composition and processing practices. Food Technol. 133:68-71.
16 Castillo, J., O. Benavente-Garcia, and J.A. Del Rio. 1992. Naringin and neohesperidin levels during development of leaves, flower buds, and fruits of Citrus aurantium. Plant Physiol. 99:67-73.   DOI
17 Castillo, J., O. Benavente-Garcia, and J.A. Del Rio. 1993. Hesperetin 7-O-glucoside and prunin in Citrus species (C. aurantium and C. paradist). A study of their quantitative distribution in immature fruits and as immediate precursors of neohesperidin and naringin in C. aurantium. J. Agric. Food Chem. 41:1920-1924.   DOI
18 Cook, N.C. and S. Samman. 1996. Flavonoids-Chemistry, metabolism, cardioprotective effects, and dietary sources. J. Nutr. Biochem. 7:66-76.   DOI
19 Del Rio, J.A., A. Ortuno, F.R. Marín, D. Garcia Puig, and F. Sabater. 1992. Bioproduction of neohesperidin and naringin in callus cultures of Citrus aurantium. Plant Cell Rep. 11:592-596   DOI
20 Del Rio, J.A. and A. Ortuno. 1994. Citrus paradisi Macf. (Grapefruit): In vitro culture and the bioproduction of sesquiterpenes nootkatone, valencene and other secondary metabolites, p. 123-138. In: Medicinal and Aromatic Plants VIIYPS Bajaj (ed.). Biotechnology in Agriculture and Forestry Vol. 28. Springer, Heidelberg, Germany.
21 Demonty, I., Y. Lin, Y.E.M.P. Zebregs, M.A. Vermeer, H.C.M. van der Knaap, M. Jakel, and E.A. Trautwein. 2010. The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately. J. Nutr. 140:1615-1620.   DOI
22 Hasewaga, S. and V.P. Maier 1972. Cinnamate hydroxylation and the enzymes leading from phenylpyruvate to p-coumarate synthesis in grapefruit tissues. Phytochemistry 11:1365-1370.   DOI
23 Hasegawa, S. and V.P. Maier. 1981. Some aspects of Citrus biochemistry and juice quality. Proc. Int. Soc. Citric. 2:914-918.
24 Berhow, M.A. and C.E. Vandercook. 1991. Sites of naringin biosynthesis in grapefruit seedlings. J. Plant Physiol. 138:176-179.   DOI
25 Benavente-García, O., J. Castillo, and J.A. Del Rio. 1993. Changes in neodiosmin levels during the development of Citru saurantium leaves and fruits. Postulation of neodiosmin biosynthetic pathway. J. Agric. Food Chem. 41:1916-1919.   DOI