• Title/Summary/Keyword: OTM

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DNA Damage Effect of Botanical Insecticides Using Chinese Hamster Lung Cells

  • Kim, Areumnuri;Jeong, Mihye;Park, Kyung-Hun;Chon, Kyongmi;Cho, Namjun;Paik, Min Kyoung
    • Korean Journal of Environmental Agriculture
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    • v.34 no.4
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    • pp.350-354
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    • 2015
  • BACKGROUND: Botanical insecticides, especially Azadirachta Indica extract (AIE) and Sophorae radix extract (SRE) are widely used in Agriculture field. In our previous studies on genotoxicity test of AIE and SRE samples, a suspicious clastogenic properties was shown. Herein, we investigated the DNA damage effect of these botanical insecticide samples through the in vitro comet assay. METHODS AND RESULTS: Chinese hamster lung (CHL) fibroblast cell line was used, and methyl methanesulphonate was as positive control. Respective two samples of AIE and SRE were evaluated using Single Cell Gel Electrophoresis (Comet) assay and measured as the Olive tail moment (OTM). Results from this study indicated that all tested AIE and SRE samples did not show DNA damage in comet assay using CHL cells, compared with control. CONCLUSION: AIE and SRE samples used in this study were not cause genetic toxicity and are suitable for use as organic materials.

Measurement of DNA Damage with Fpg/Endo III FLARE Assay and Real Time RT-PCR in SD Rats Exposed to Cumene

  • Kim, Soo-Jin;Rim, Kyung-Taek;Lee, Seong-Bae;Kim, Hyeon-Yeong
    • Molecular & Cellular Toxicology
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    • v.4 no.3
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    • pp.211-217
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    • 2008
  • To clarify the DNA damage from reactive oxygen species, we measured the DNA damage through Fpg/Endo III FLARE (Fragment Length Analysis with Repair Enzyme) assay and real time RT-PCR. The 80 SD rats assigned to 4 dose groups exposed to cumene vapor for 90 days. With Fpg/Endo III FLARE assay in hepatocytes, we found the OTM (Olive Tail Moment) and TL (Tail Length) significantly increased in no-enzyme treated and Fpg-treated control and 8 ppm groups with 28 days exposure. In Endo III-treated 8 ppm group, significantly increased the values with 90 days exposure. With lymphocytes, it was founded the values significantly increased in no-enzyme treated 800 ppm group in 28 and 90 days. It was significantly increased in Endo III-treated 80 ppm for 28 days and 800 ppm for 90 days. From the above findings, FLARE assay was suggested as being available as a biological marker for DNA damage induced by cumene exposure in SD rats. And we used real time RT-PCR for the OGG1 mRNA expression, it had dose-dependent biologic effects in 1 day exposure, but decrease the levels of rOGG1 mRNA. Our findings provide evidence that cumene exposure may cause suppression of rOGG1 in the rat hepatocytes or lymphocytes.

Trace Mineral Nutrition in Poultry and Swine

  • Richards, James D.;Zhao, Junmei;Harrell, Robert J.;Atwell, Cindy A.;Dibner, Julia J.
    • Asian-Australasian Journal of Animal Sciences
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    • v.23 no.11
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    • pp.1527-1534
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    • 2010
  • Trace minerals such as zinc, copper, and manganese are essential cofactors for hundreds of cellular enzymes and transcription factors in all animal species, and thus participate in a wide variety of biochemical processes. Immune development and response, tissue and bone development and integrity, protection against oxidative stress, and cellular growth and division are just a few examples. Deficiencies in trace minerals can lead to deficits in any of these processes, as well as reductions in growth performance. As such, most animal diets are supplemented with inorganic and/or organic forms of trace minerals. Inorganic trace minerals (ITM) such as sulfates and oxides form the bulk of trace mineral supplementation, but these forms of minerals are well known to be prone to dietary antagonisms. Feeding high-quality chelated trace minerals or other classes of organic trace minerals (OTM) can provide the animal with more bioavailable forms of the minerals. Interestingly, many, if not most, published experiments show little or no difference in the bioavailability of OTMs versus ITMs. In some cases, it appears that there truly is no difference. However, real differences in bioavailability can be masked if source comparisons are not made on the linear portion of the dose-response curve. When highly bioavailable chelated minerals are fed, they will better supply the biochemical systems of the cells of the animal, leading to a wide variety of benefits in both poultry and swine. Indeed, the use of certain chelated trace minerals has been shown to enhance mineral uptake, and improve the immune response, oxidative stress management, and tissue and bone development and strength. Furthermore, the higher bioavailability of these trace minerals allows the producer to achieve similar or improved performance, at reduced levels of trace mineral inclusion.

$CO_2$ Separation in Pre-Combustion using Principles of Gas hydrate Formation (연소전 탈탄소화 적용을 위한 $CO_2/H_2$ 하이드레이트 형성 및 분리 연구)

  • Lee, Hyun-Ju;Lee, Ju-Dong;Lee, Yoon-Seok;Lee, Eun-Kyung;Kim, Soo-Min;Kim, Yang-Do
    • 한국신재생에너지학회:학술대회논문집
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    • 2009.06a
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    • pp.698-698
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    • 2009
  • 화력발전이 많은 비중을 차지하는 전력생산 산업은 온실가스($CO_2$)의 최대 배출 원으로 알려져 있으며 증가하는 전력 수요 뿐 만 아니라 다가오는 기후변화협약에 대응하기 위하여 $CO_2$ 회수 및 공정 개선에 관한 연구가 많이 수행되고 있다. 특히 현재 연구되고 있는 전력분야의 대표적인 $CO_2$ 회수기술은 연소 후 포집(Post-combustion capture), 순산소 연소(Oxy-fuel combustion), 연소전 탈탄소화(Pre-combustion) 3가지로 구분된다. 이중 연소전 탈탄소화 기술은 석탄가스화복합발전(IGCC) 기술과 연계하여 $CO_2$를 회수할 수 있는 방법으로 가스화 된 석탄가스에 Water-Gas Shift 반응과, $CO_2$ 분리로 얻어진 탈 탄소 연료를 통해서 전력을 생산한다. 이 기술의 핵심은 생성된 $CO_2/H_2$ 복합가스로부터 $CO_2$를 분리하는 공정으로 차세대 회수 기술로는 Membrance Reactor, SOFC, Oxygen Ion Transfer Membrane(OTM), 그리고 가스 하이드레이트가 있다. 이중 가스 하이드레이트는 $CO_2$의 회수 뿐 만 아니라 처리 기술에도 적용 가능하지만 우리나라에는 이에 관한 기술이 전무한 형편이다. 본 연구에서는 가스 하이드레이트 형성원리를 이용하여 정온 정압 조건에서 $CO_2/H_2$ 하이드레이트를 제조하였으며 특히, 하이드레이트 형성 촉진제인 THF(Tetrahydrofuran)를 첨가하여 THF 농도에 따른 상평형 및 속도론 실험을 수행 하였다. 이러한 연구는 연소전 탄소화 기술에서의 $CO_2$ 회수 분리에 대한 핵심 연구임과 동시에 탄소배출권 규제에 실질적인 기여를 할 수 있을 것으로 사료된다.

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A New Asynchronous Pipeline Architecture for CISC type Embedded Micro-Controller, A8051 (CISC 임베디드 컨트롤러를 위한 새로운 비동기 파이프라인 아키텍쳐, A8051)

  • 이제훈;조경록
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.40 no.4
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    • pp.85-94
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    • 2003
  • The asynchronous design methods proved to have the higher performance in power consumption and execution speed than synchronous ones because it just needs to activate the required module without feeding clock in the system. Despite the advantage of CISC machine providing the variable addressing modes and instructions, its execution scheme is hardly suited for a synchronous Pipeline architecture and incurs a lot of overhead. This paper proposes a novel asynchronous pipeline architecture, A80sl, whose instruction set is fully compatible with that of Intel 80C51, an embedded micro controller. We classify the instructions into the group keeping the same execution scheme for the asynchronous pipeline and optimize it eliminating the bubble stage that comes from the overhead of the multi-cycle execution. The new methodologies for branch and various instruction lengths are suggested to minimize the number of states required for instructions execution and to increase its parallelism. The proposed A80C51 architecture is synthesized with 0.35${\mu}{\textrm}{m}$ CMOS standard cell library. The simulation results show higher speed than that of Intel 80C51 with 36 MHz and other asynchronous counterparts by 24 times.

Surface Modification of Nano Silica Prepared by Sol-gel Process and Subsequent Application towards Gas-barrier Films (졸-겔 공정으로 제조한 나노 실리카의 표면개질 및 가스차단성 필름으로의 응용)

  • Jang, Hyo Jun;Chang, Mi Jung;Nam, Kwang Hyun;Chung, Dae-won
    • Applied Chemistry for Engineering
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    • v.30 no.1
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    • pp.68-73
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    • 2019
  • We prepared hydrophobic silica particles by a sol-gel process from tetraethyl orthosilicate (TEOS), followed by coupling the reaction with octyltrimethoxysilane (OTMS) or hexadecyltrimethoxysilane (HDTMS) under various reaction conditions. We confirmed the extent of silica surface modification with organic compounds by SEM-EDS, thermogravimetry and elemental analysis. The silica particles obtained after the hydrolysis reaction of TEOS in ethanol at $50^{\circ}C$ for 24 h and the coupling reaction with OTMS for 2 h at the same temperature displayed the optimum performance in terms of the dispersity in an organic solvent and the surface roughness of films composited with epoxy resins. The oxygen permeability of the composite film with modified-silica was 12% lower than that of using the film without modified-silica.

Improvement about Regulatory System of KRX Derivatives Trading: Focusing on Financial Consumer Protection (장내파생상품거래의 제도개선: 소비자보호를 중심으로)

  • Kim, Chisoo;Cheong, Kiwoong
    • International Area Studies Review
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    • v.16 no.3
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    • pp.239-266
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    • 2012
  • The purpose of this paper is to suggest desirable improvement for KRX derivatives market plagued with many problems in spite of its world level of quantitative growth. In order to try to find desirable improvement for KRX derivatives market which has many problems like that, I suggest various ways of improvement for regulatory system in the future in terms of behavioral regulation for investor protection. First of all, in order to relieve speculative tendency of trading, KOSPI200 option market with ATM-oriented option trading needs to be induced from the market in which OTM-oriented option is now trading. So discount or exemption of brokerage fee for ATM trading and the introduction of market-maker for ATM type can be considered. For the protection of individual investors, we suggest feasible plans such as differential regulation between professional and individual investors, consolidation of basic deposit management, and enlargement of opportunities for risk management education & simulation trading.

Scenario-based Future Infantry Brigade Information Distribution Capability Analysis (시나리오 기반의 미래 보병여단 정보유통능력 분석 연구)

  • Junseob Kim;Sangjun Park;Yiju You;Yongchul Kim
    • Convergence Security Journal
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    • v.23 no.1
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    • pp.139-145
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    • 2023
  • The ROK Army is promoting cutting-edge, future-oriented military development such as a mobile, intelligent, and hyper-connected Army TIGER system. The future infantry brigade plans to increase mobility with squad-level tactical vehicles to enable combat in multi-domain operations and to deploy various weapon systems such as surveillance and reconnaissance drones. In addition, it will be developed into an intelligent unit that transmits and receives data collected through the weapon system through a hyper-connected network. Accordingly, the future infantry brigade will transmit and receive more data. However, the Army's tactical information communication system has limitations in operating as a tactical communication system for future units, such as low transmission speed and bandwidth and restrictions on communication support. Therefore, in this paper, the information distribution capability of the future infantry brigade is presented through the offensive operation scenario and M&S.

KOREAN MARS MISSION DESIGN USING KSLV-III (KSLV-III를 이용한 한국형 화성 탐사 임무의 설계)

  • Song, Young-Joo;Yoo, Sung-Moon;Park, Eun-Seo;Park, Sang-Young;Choi, Kyu-Hong;Yoon, Jae-Cheol;Yim, Jo-Ryeong;Choi, Joon-Min;Kim, Byung-Kyo
    • Journal of Astronomy and Space Sciences
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    • v.23 no.4
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    • pp.355-372
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    • 2006
  • Mission opportunities and trajectory characteristics for the future Korean Mars mission have designed and analyzed using KSIV-III(Korea Space Launch Vehicle-III). Korea's first space center, 'NARO space center' is selected as a launch site. For launch opportunities, year 2033 is investigated under considering the date of space center's completion with KSLV series development status. Optimal magnitude of various maneuvers, Trans Mars Injection (TMI) maneuver, Trajectory Correction Maneuver (TCM), Mars Orbit Insertion (MOI) maneuver and Orbit Trim Maneuver(OTM), which are required during the every Mars mission phases are computed with the formulation of nonlinear optimization problems using NPSOL software. Finally, mass budgets for upper stage (launcher for KSIV-III and spacecraft are derived using various optimized maneuver magnitudes. For results, daily launch window from NARO space center for successful Korean Mars mission is avaliable for next 27 minutes starting from Apr. 16. 2033. 12:17:26 (UTC). Maximum spacecraft gross mass which can delivered to Mars is about 206kg, with propellant mass of 109kg and structure mass of 97kg, when on board spacecraft thruster's Isp is assumed to have 290 sec. For upper stage, having structure ratio of 0.15 and Isp value of 280 sec, gross mass is about 1293kg with propellant mass of 1099kg and structure mass of 194kg. However, including 10% margins to computed optimal maneuver values, spacecraft gross mass is reduced to about 148kg with upper stage's mass of 1352kg. This work will give various insights, requiring performances to developing of KSIV-III and spacecraft design for future Korean Mars missions.

An Analysis of Satellite Communications System structure for NCW (NCW대비 군 위성통신 구조 분석)

  • Park, Woo-Chul;Cha, Jae-Ryong;Kim, Jae-Hyun
    • Journal of Satellite, Information and Communications
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    • v.4 no.1
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    • pp.1-7
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    • 2009
  • As the information age comes out, the aspect of future war brings about the many changes in terms of war-fighting environment. Accordingly, information superiority and intelligence-centric warfare have been important and new war-fighting concept such as NCW(network centric warfare) have been turned up. This paper proposed all-weather core-strategy communications systems guaranteeing not only the real-time transmission of the information collected in a battlefield and expansion, automation, and rapidity of a battlefield but also broadband, mobility, survivability, and flexibility. The proposed military satellite communications system is classified into wideband mass capacity link, survivability, and the system supporting OTM(on the move) communication for the real-time transmission of battlefield information. This paper analyzed the essential operation concepts and core schemes of the U.S. Army's next generation system, TSAT(Transformational Satellite Communication System). Base on the analysis results, this paper proposed that the architecture of next generation military satellite communications systems for NCW have to provide the data rate, anti-jamming capability, network control and management capability which are optimally adaptable for the wireless channel environments such as jamming and interference and to support the variety of platforms like high-speed mobile vehicles, micromini devices, super-high speed unmanned aerial vehicles. Finally, this paper also proposed that next generation military satellite communications systems need the technologies such as the adaptable multi-antenna, laser link, and next-generation anti-jamming waveform.

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