• Journal of Computing Science and Engineering
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• v.4 no.4
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• pp.291-312
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• 2010

The last decades a large amount of research has been done in the genomics domain which has and is generating terabytes, if not exabytes, of information stored globally in a very fragmented way. Different databases use different ways of storing the same data, resulting in undesired redundancy and restrained information transfer. Adding to this, keeping the existing databases consistent and data integrity maintained is mainly left to human intervention which in turn is very costly, both in time and money as well as error prone. Identifying a fixed conceptual dictionary in the form of a conceptual model thus seems crucial. This paper presents an effort to integrate the mutational data from the established genomic data source HGMD into a conceptual model driven database HGDB, thereby providing useful lessons to improve the already existing conceptual model of the human genome.

• Journal of Microbiology and Biotechnology
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• v.25 no.10
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• pp.1714-1727
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• 2015

This work describes a new strategy for optimal design of Multiplex-PCR primer sequences. The process is based on the Particle Swarm Optimization-Simplex algorithm (Mult-PSOS). Diverging from previous solutions centered on heuristic tools, the Mult-PSOS is selfconfigured because it does not require the definition of the algorithm's initial search parameters. The successful performance of this method was validated in vitro using Multiplex-PCR assays. For this validation, seven gene sequences of the most prevalent bacteria implicated in urinary tract infections were taken as DNA targets. The in vitro tests confirmed the good performance of the Mult-PSOS, with respect to infectious disease diagnosis, in the rapid and efficient selection of the optimal oligonucleotide sequences for Multiplex-PCRs. The predicted sequences allowed the adequate amplification of all amplicons in a single step (with the correct amount of DNA template and primers), reducing significantly the need for trial and error experiments. In addition, owing to its independence from the initial selection of the heuristic constants, the Mult-PSOS can be employed by non-expert users in computational techniques or in primer design problems.

• BMB Reports
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• v.45 no.4
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• pp.233-238
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• 2012

We present a top down separation platform for yeast ribosomal proteins using affinity chromatography and capillary electrophoresis which is designed to allow deposition of proteins onto a substrate. FLAG tagged ribosomes were affinity purified, and rRNA acid precipitation was performed on the ribosomes followed by capillary electrophoresis to separate the ribosomal proteins. Over 26 peaks were detected with excellent reproducibility (<0.5% RSD migration time). This is the first reported separation of eukaryotic ribosomal proteins using capillary electrophoresis. The two stages in this workflow, affinity chromatography and capillary electrophoresis, share the advantages that they are fast, flexible and have small sample requirements in comparison to more commonly used techniques. This method is a remarkably quick route from cell to separation that has the potential to be coupled to high throughput readout platforms for studies of the ribosomal proteome.

• Journal of the Korean Society of Costume
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• v.57 no.1 s.110
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• pp.1-16
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• 2007

This study is to design costumes of each characters, seen in the film of 'TITANIC' directed by James Cameron in 1997, by analyzing various costumes for each roles in the film. The 'TITANIC' has got the 'Oscar Award' in 1998 in 11 sectors for its' high box office record and the finest of the work, based on successful visualization of the costumes for the contemporary characters by historical research. The social background of 'TITANIC' would be presumed in the year of 1912, of which era was also called by 'La Belle Epoque', to say, 'good period'. This study, therefore, traced the representative art trend for the 1910's, together with political, economical and social backgrounds as 1st step. The 2nd step is the consideration of fashion trends of costume affected by the contemporary trends such as Art Nouveau and Art Deco in the period. The 3rd step is the analysis of costumes in the film of 'TITANIC'. Finally, this work has designed the virtual costumes of the characters, in imaginary scenes, which could denote the nature of the personality. Hopefully, this study could help designers show sustainable development in creating cinema costumes and other related projects, based on the understandings of this work.

• Publications of The Korean Astronomical Society
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• v.19 no.1
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• pp.77-81
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• 2004

A high performance computing cluster for astronomical computations has been built at Korea Astronomy Observatory. The 64 node cluster interconnected with Gigabit Ethernet is composed of 128 Intel Xeon processors, 160 GB memory, 6 TB global storage space, and an LTO (Linear Tape-Open) tape library. The cluster was installed and has been managed with the Open Source Cluster Application Resource (OSCAR) framework. Its performance for parallel computations was measured with a three-dimensional hydrodynamic code and showed quite a good scalability as the number of computational cells increases. The cluster has already been utilized for several computational research projects, some of which resulted in a few publications, even though its full operation time is less than one year. As a major resource of the $K^*Grid$ testbed, the cluster has been used for Grid computations, too.

• Wind and Structures
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• v.25 no.6
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• pp.569-588
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• 2017

The aim of this paper is to present a method to obtain the dynamic response of a wind turbine tower in time domain by means of the generation of time series and to estimate the associated fatigue damage by means of a Rainflow counting algorithm. The proposed method is based on assuming the vortex shedding is a bidimensional phenomena and on following a classical modal superposition method to obtain the structure dynamic response. Four different wind turbine tower geometric configurations have been analyzed in a range of usual wind velocities and covering extreme wind velocities. The obtained results have shown that, depending on the turbulence intensity and the mean wind velocity, there are tower geometric configurations more advantageous from the fatigue load standpoint. Consequently, the presented model can be utilized to define assembly strategies oriented to fatigue damage minimization.

• Smart Structures and Systems
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• v.5 no.3
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• pp.223-240
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• 2009

As in any engineering application, the problem of structural assessment should face the different uncertainties present in real world. The main source of uncertainty in Health Monitoring System (HMS) applications are those related to the sensor accuracy, the theoretical models and the variability in structural parameters and applied loads. In present work, two methodologies have been developed to deal with these uncertainties in order to adopt reliable decisions related to the presence of damage. A simple example, a steel beam analysis, is considered in order to establish a liable comparison between them. Also, such methodologies are used with a developed structural assessment algorithm that consists in a direct and consistent comparison between sensor data and numerical model results, both affected by uncertainty. Such algorithm is applied to a simple concrete laboratory beam, tested till rupture, to show it feasibility and operational process. From these applications several conclusions are derived with a high value, regarding the final objective of the work, which is the implementation of this algorithm within a HMS, developed and applied into a prototype structure.

• ETRI Journal
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• v.32 no.1
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• pp.33-43
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• 2010

The increasing demand for non-sinusoidal currents affects the quality of distribution networks. Harmonic detection is a crucial step in the cancellation of those components by active power filters. In this paper, the discrete cosine transform (DCT) is compared with different implementations based on Fourier transforms, demonstrating their equivalences and the advantages provided by the former. We demonstrate that the phase error in the presence of grid frequency deviations and the transient length are reduced by half in comparison to the discrete Fourier transform. A novel algorithm is developed to provide frequency adaptation to the DCT, taking advantage of its good features. The window width is adjusted in real time according to the actual value of the grid fundamental frequency by means of a phase-locked loop. A technique based on dithering is employed to overcome the limitation caused by the truncation of the window number of samples, so the frequency resolution is enhanced. The theoretical approach is verified by simulated and experimental results.

• Journal of English Language & Literature
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• v.60 no.2
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• pp.211-232
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• 2014

In late Victorian England, a "pervert" meant two things. One meaning designated a person who "turned" or converted from one sect of Christianity to another. In Wilde's time this referred specifically to converts from the established state Church of England to the transnational Roman Catholic Church. The other, newer meaning designated someone who turned from conventional heterosexual relations to a (as yet unnamed) homosexual orientation. In the context of the late Victorian empire, both were considered dangerous. The rising social and political influence of Roman Catholicism appeared threatening as a transnational Church invading a national one. For the Anglican Church of England, this crisis was played out what came to be known as the Oxford Movement, still influential during Wilde's time as a student there from 1874 to 1878. What is interesting in Wilde's life, as in his work, is the way he himself played with the dangerous transgressions inherent in being a "pervert." Sexually, he was converted to same-sex love while still a married man. In terms of religion, he remained fascinated with Catholicism, allegedly converting on his death-bed. But what is provocative is way that Wilde used one "perversion" to play into another: so that in such works as The Picture of Dorian Gray and Salome, his version of a kind of anti-Catholic Catholicism becomes a site of sexual desire, and sexual desire expression for that kind of spirituality, which, as unrequited longing, can ultimately n find no object adequate to its imagination.

• Smart Structures and Systems
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• v.24 no.4
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• pp.447-457
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• 2019

The use of Tuned mass dampers (TMD) has proved to be effective in reducing the effects of vibrations caused by wind loads and far-field seismic action. However, its effectiveness in controlling the dynamic response of structures under near-fault earthquakes is still under discussion. In this case, the uncertainty about the TMD performance arises from the short significant duration of near-fault ground motions. In this work, the TMD effectiveness for increasing the safety margin against collapse of structures subjected to near-fault earthquakes is investigated. In order to evaluate the TMD performance in the proposed scenario, the nonlinear dynamic response of two reinforced concrete (RC) frames was analyzed. TMDs with different mass values were added to these structures, and a set of near-fault records with frequency content close to the fundamental frequency of the structure was employed. Through a series of nonlinear dynamic analysis, the minimum amplitude of each seismic record that causes the structural collapse was found. By comparing this value, called collapse acceleration, for the case of the structures with and without TMD, the benefit produced by the addition of the control device was established.