• Asian Pacific Journal of Cancer Prevention
• /
• 제15권21호
• /
• pp.9295-9300
• /
• 2014

Interleukin-17A (IL-17A) is a multifunctional cytokine which plays a crucial role in the initiation and progression of cancer. To date, several studies have investigated associations between IL-17A -197G>A (rs2275913) polymorphism and digestive cancer risk, but the results remain conflicting. We here aimed to confirm the role of this single nucleotide polymorphism (SNP) in susceptibility to digestive cancer through a systemic review and meta-analysis. Ten eligible case-control studies were identified by searching electronic databases, involving 3,087 cases and 3,815 controls. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to estimate the strength of the association. The results of overall analyses indicated that the variant A allele was associated with an increased risk of digestive cancer (AA vs GG: OR=1.51, 95%CI=1.18-1.93; AA vs GG+GA: OR=1.45, 95%CI=1.12-1.87; A vs G: OR=1.21, 95%CI=1.05-1.39). In subgroup analysis stratified by specific cancer type, elevated risk among studies of gastric cancer was found (AA vs GG: OR=1.68, 95%CI=1.24-2.28; AA vs GG+GA: OR=1.62, 95%CI=1.16-2.26; A vs G: OR=1.23, 95%CI=1.04-1.46). According to ethnicity, there was evidence in the Asian populations for an association between this polymorphism and cancer risk (GA vs GG: OR=1.19, 95%CI=1.05-1.36; AA vs GG: OR=1.56, 95%CI=1.15-2.12; AA+GA vs GG: OR=1.28, 95%CI=1.13-1.44; AA vs GG+GA: OR=1.42, 95%CI=1.01-2.00; A vs G: OR=1.24, 95%CI=1.08-1.44), while in the Caucasian populations an association was found in the recessive model (AA vs GG+GA: OR=1.62, 95%CI=1.17-2.24). In conclusion, the results of this meta-analysis suggest that the IL-17A -197G>A polymorphism contributes to an increased risk of human digestive cancer, both in the Asian and Caucasian populations and especially for gastric cancer.

• 한국강구조학회 논문집
• /
• 제20권2호
• /
• pp.333-345
• /
• 2008

프리캐스트 콘크리트 바닥판 교량의 적용이 2거더 교량이나 개구제형 강박스 교량으로 확대되고 있다. 소수거더교에 프리캐스트 바닥판 교량의 적용에서 가장 어려운 점은 완전합성을 확보하기 위해 필요한 전단연결재의 배치이다. 좁은 영역에 많은 연결재를 배치해야 하기 때문에 프리캐스트 바닥판의 단면 손실이 커서 철근의 배치가 어렵게 된다. 이 논문에서는 현재 설계 기준에서 제시하고 있는 스터드 전단연결재의 최소 간격보다 좁은 연결재 간격을 가질 경우의 극한 강도 특성을 정적 실험을 통해 평가하였다. 실험결과로부터 최소 간격보다 좁은 간격으로 배치할 경우에 현재의 설계기준 강도보다 낮은 극한 강도를 발현하는 것으로 나타났고 프리캐스트 슬래브의 보강 혹은 포켓부의 부분보강의 효과로 인해 강도 증진이 나타났다. 그룹 스터드 전단연결부의 설계는 연결재 전단강도와 콘크리트 슬래브의 강도의 상대적인 비로부터 파괴모드를 예측하고 연결재 파괴를 유도할 수 있도록 이루어져야 한다. 실험결과로부터 스터드 간격을 고려한 그룹 스터드 전단연결부의 극한강도에 대한 경험식을 제안하였다. 피로실험을 수행한 결과로부터 이 연구의 실험범위내에서는 그룹스터드 전단연결부의 피로강도 감소가 나타나지 않는 것으로 밝혀졌다. 연구결과를 활용하여 프리캐스트 바닥판의 상세를 개선하였다.

• 농촌의학ㆍ지역보건
• /
• 제27권2호
• /
• pp.27-33
• /
• 2002

섬진강 유역 순창 지역 주민의 간흡충 관리를 위하여 2,591명을 대상으로 효소면역측정법(ELISA)을 실시하여 유병률을 파악하고 ELISA 양성자를 대변검사로 간흡충 감염을 확진한 대상을 상대로 설문조사를 실시하고 95명의 조사 결과를 통계적으로 분석하여 역학적 특성을 파악한 결과는 아래와 같다. 1. 순창군 간흡충 유병률은 평균 16.1% 이었고 각 면 단위별로 33.6%에서 7.0% 범위를 보였다. 2. 면소재 마을별 유병률은 최고 39.2%, 최저 0.0% 범위를 보였으며, 섬진강변에 위치한 면 또는 마을 지역이 강으로부터 먼 지역보다 유병률이 높았다. 3. OR 값은 남자와 여자에서 2.76, 음주군과 비음주군에서 2.14, 민물고기 생식군과 비생식군에서 2.40, 자신이 건강하다고 생각하는 사람과 그렇지 않은 군에서 2.44, 간흡충에 대해 잘 아는 사람과 그렇지 않은 군에서 5.23, 약물치료후 민물고기를 재생식한 사람과 그렇지 않은 군에서 3.32이었다. 이상의 결과에서, 섬진강 상류에 위치한 순창 지역은 간흡충 감염이 유행하고 있었고, 간흡충 유행의 여러 관련요인이 작용하고 있는 역학적 특성을 나타내어 간 흡충 질환이 이 지역의 보건학적 문제가 되고 있음을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권9호
• /
• pp.3645-3651
• /
• 2015

Background: Previous studies evaluating the association between the xeroderma pigmentosum group G (XPG) Asp1104His polymorphism and head and neck cancer susceptibility have proven controversial. This meta-analysis of the literature was performed to obtain a more precise estimation of the relationship. Materials and Methods: We systematically searched PubMed, Embase and Web of Science with a time limit of Dec 18, 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of any association. Results: We performed a meta-analysis of eight published case-control studies, including 3,621 cases and 5,475 controls. Overall, no significant association was found between the XPG Asp1104His polymorphism and head and neck cancer susceptibility under all genetic models. In the subgroup analysis by ethnicity, the XPG Asp1104His polymorphism had statistically significant association with elevated head and neck cancer risk under CC vs GG (OR=1.24, 95% CI=1.00~1.54) and the recessive model (OR=1.22, 95%CI=1.01~1.46) in Asian populations. A similar result was found under CC vs GG (OR =1.22, 95%CI=1.01~1.47) in the population based subgroup by source of control. When performed by tumor site, the XPG Asp1104His polymorphism had statistically significant association with elevated laryngeal cancer under all genetic models (CC vs GG: OR=1.59, 95% CI=1.16~2.19; GC vs GG: OR=1.38, 95%CI=1.10~1.72; dominant model: OR=1.42, 95% CI=1.15~1.74; recessive model: OR=1.36, 95% CI=1.02~1.81). Conclusions: This meta-analysis suggested that the XPG Asp1104His polymorphism is a risk factor for head and neck cancer susceptibility, especially for laryngeal cancer and in Asian populations.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권18호
• /
• pp.7639-7644
• /
• 2014

Background: Results from previous studies concerning the association of ERCC4 rs1800067 polymorphism with risk of cancer were inconsistent. To explore the exact relation with susceptibility, we conducted the present meta-analysis. Materials and Methods: Literature of electronic databases including PubMed, Web of Science, EMBASE, Wanfang and Chinese National Knowledge Infrastructure (CNKI) were systematically searched. ORs and their 95%CIs were used to assess the strength of associations between ERCC4 polymorphism and cancer risk. Results: There was no significant association between ERCC4 rs1800067 AA or AG genotypes and overall risk of cancer (AA vs. GG: OR=0.998, 95%CI=0.670-1.486, P=0.992; AG vs. GG: OR=0.970, 95%CI=0.888-1.061, P=0.508). A dominant genetic model also did not demonstrate significant association of (AA+AG) genotype carriers with altered risk of overall cancer (OR=0.985, 95%CI=0.909-1.068, P=0.719). In addition, no significant association was observed between A allele of ERCC4 rs1800067 A/G polymorphism and altered cancer risk compared with G allele (OR=0.952, 95%CI=0.851-1.063, P=0.381). Subgroup analysis suggested that AA genotype carriers were significantly associated with decreased risk of glioma compared with wild-type GG genotype individuals (OR=0.523, 95%CI=0.275-0.993, P=0.048). For subgroup of lung cancer, A allele of ERCC4 rs1800067 A/G polymorphism was significantly associated with decreased risk of lung cancer compared with G allele (OR=0.806, 95%CI=0.697-0.931, P=0.003). Conclusions: This meta-analysis indicated that ERCC4 rs1800067 A/G polymorphism might not be associated with risk of overall cancer. However, individuals with the AA genotype were associated with significantly reduced risk of glioma compared with wild-type GG genotype; The A allele was associated with significantly reduced risk of lung cancer compared with G allele. Future large-scale studies performed in multiple populations are warranted to confirm our results.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권7호
• /
• pp.4243-4247
• /
• 2013

The relationship between the X-ray repair cross-complementing group 3 (XRCC3) Thr241Met polymorphism and gliomas remains inclusive or controversial. For better understanding of the effect of XRCC3 Thr241Met polymorphism on glioma risk, a meta-analysis was performed. All eligible studies were identified through a search of PubMed, Elsevier Science Direct, Excerpta Medica Database (Embase) and Chinese Biomedical Literature Database (CBM) before May 2013. The association between the XRCC3 Thr241Met polymorphism and gliomas risk was conducted by odds ratios (ORs) and 95% confidence intervals (95% CIs). A total of nine case-control studies including 3,533 cases and 4,696 controls were eventually collected. Overall, we found that XRCC3 Thr241Met polymorphism was significantly associated with the risk of gliomas (T vs. C: OR=1.10, 95%CI=1.01-1.20, P=0.034; TT vs. CC: OR=1.30, 95%CI=1.03-1.65, P=0.027; TT vs. TC/CC: OR=1.29, 95%CI=1.01-1.64, P=0.039). In the subgroup analysis based on ethnicity, the significant association was found in Asian under four models (T vs. C: OR=1.17, 95%CI=1.07-1.28, P=0.00; TT vs. CC: OR=1.79, 95%CI=1.36-2.36, P=0.00; TT vs. TC/CC: OR=1.75, 95%CI=1.32-2.32, P=0.00; TT/TC vs. CC: OR=1.11,95% CI=1.02-1.20). This meta-analysis suggested that the XRCC3 Thr241Met polymorphism is a risk factor for gliomas, especially for Asians. Considering the limited sample size and ethnicities included in the meta-analysis, further large scale and well-designed studies are needed to confirm our results.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권9호
• /
• pp.4247-4250
• /
• 2016

Background: Pax8 and peroxisome proliferator-activated receptor gamma 1 gene (Pax8-$PPAR{\gamma}1$) are important factors in tumors. Several studies have suggested that follicular thyroid cancer may arise from Pax8- $PPAR{\gamma}1$ rearrangement. In order to have a better understanding of the association between Pax8-$PPAR{\gamma}1$ rearrangement and follicular thyroid cancer, we conducted the presenmt meta-analysis. Materials and Methods: The information was extracted from PubMed, EMBASE and Web of Science. Statistic analysis was performed with Stata12.0 software. Odds ratios (ORs) were calculated using a fixed-effects model. We also performed heterogeneity and publication bias analyses. Results: Nine studies including 198 follicular thyroid cancer patients and 268 controls were considered eligible. The frequency of Pax8-$PPAR{\gamma}1$ rearrangement was significantly higher in the follicular thyroid cancer group than in the control group, with a pooled OR of 6.63 (95%CI=3.50-12.7). In addition, through subgroup analysis, the OR between Pax8-$PPAR{\gamma}1$ rearrangement and follicular thyroid cancer was 6.04 (95%CI = 3.18-11.5) when using benign tumor tissues as controls. The OR for the method subgroup was 9.99 (95% CI =4.86-20.5) in the RT-PCR. Conclusions: The final results demonstrated that Pax8-$PPAR{\gamma}1$ rearrangement has significant association with follicular thyroid cancer.

• 치위생과학회지
• /
• 제17권4호
• /
• pp.298-305
• /
• 2017

본 연구는 한국 성인 여성의 수면시간과 치주염과의 관련성을 확인하기 위해 국민건강영양조사 제 6기 2차년도(2014) 자료를 바탕으로, 만 19세 이상의 한국 성인 여성 총 3,292명을 대상으로 연구를 수행하였다. 대상자의 일반적 특성(연령, 교육수준, 소득수준, 당뇨, 고혈압, 비만)에 따라 치주염의 차이를 확인할 수 있었으며, 흡연과는 관련성이 없는 것으로 나타났다. 수면시간이 7시간 이상인 대상자에 비해 7시간 미만인 대상자의 치주염 위험도가 1.37배(crude OR, 1.37; 95% CI, 1.13~1.65) 높았다. 그러나 대상자의 일반적 특성(연령, 교육수준, 소득수준, 당뇨, 고혈압, 비만)을 보정한 후의 수면시간이 치주염에 미치는 영향력은 더 이상 유의하지 않았다. 따라서 후속연구에서는 두 요인의 직접적인 인과관계를 밝힐 수 있는 전향적 코호트 연구가 수행되어야 하며, 성인 여성의 적절한 수면습관을 도모하고 아울러 구강건강 증진을 위한 포괄적 건강증진 프로그램의 시행이 필요하다고 생각된다.

• Safety and Health at Work
• /
• 제10권4호
• /
• pp.470-475
• /
• 2019

Background: There is a lack of statistical analysis investigating the relationship between sleep problems and commute time in Korea. We aimed to analyze the association between representative health symptoms, sleep disturbances, and commute time according to working hours in Korea. Methods: The 4th Korean Working Conditions Survey data were used for analysis, and unpaid family workers and workers who work fewer than three days in a week were excluded. Commute time, working hours, and sleep hours were assessed using self-reported questionnaires. Odds ratios (ORs) with 95% confidence intervals (CIs) for sleep problems were calculated using a multivariate logistic regression model with ≤10 min commute time as the reference group. Results: Among a total of 28,804 workers (men = 14,945, women = 13,859), 2.6% of men and 3.2% of women experienced sleep problems. In both sexes, long commute time (51-60 minutes and >60 minutes) showed an increased OR [men, 2.03 (CI = 1.32-3.13) and 2.05 (CI = 1.33-3.17); women, 1.58 (CI = 1.05-2.39) and 1.63 (CI = 1.06-2.50), respectively]. In stratification analysis of working hours, long commute time (51-60 and > 60 minutes) showed an increased OR in men working >40 hours/week [2.08 (CI = 1.16-3.71) and 1.92 (CI = 1.08-3.41), respectively]. Furthermore, long commute time (41-50, 51-60, and >60 minutes) showed an increased OR in women working >40 hours/week [2.40 (CI = 1.27-4.55), 2.28 (CI = 1.25-4.16), and 2.19 (CI = 1.17-4.16), respectively]. Moreover, commute time >60 minutes showed an increased OR in women working ≤40 hours/week [1.96 (CI = 1.06-3.62)]. Conclusion: This large cross-sectional study highlights that long commute time is related to sleep problems in both sexes. Shorter commute times and decreased working hours are needed to prevent sleep problems in workers.

• Toxicological Research
• /
• 제24권2호
• /
• pp.109-112
• /
• 2008

The G184C and G134A single nucleotide polymorphisms(SNPs) of the CYP1A1 gene result in Ala62Pro and Gly45Asp substitutions, respectively. Here, we tested whether these SNPs are associated with an alteration in lung cancer incidence. We examined 80 Korean subjects with lung cancer and 240 age- and sex-matched controls. For each subject, the CYP1A1 gene was PCR amplified and sequenced. We observed that the odds ratio(OR) for lung cancer was 3.37 higher in subjects with the G184C polymorphism than in controls(95% confidence interval(CI), $0.89{\sim}12.73$, P=0.07). In contrast, the OR for lung cancer was 1.23 in subjects with the G134A polymorphism compared to controls(95% CI, $0.68{\sim}2.20$, P=0.49). The G184C polymorphism exacerbated the effects of smoking on lung cancer development. Gene-smoking interaction analyses revealed that past or present smokers with the G184C polymorphism had a higher incidence of lung cancer(OR, 24.72; 95% CI, $4.48{\sim}136.31$; P<0.01) than control smokers(OR, 6.65; 95% CI, $2.72{\sim}16.28$; P<0.01). However, there was only a slight difference in the ORs for lung cancer between control smokers and smokers with the G134A polymorphism. These findings suggest that the G184C polymorphism, but not the G134A polymorphism, is associated with an increased risk of lung cancer.