• Korean Journal of Clinical Pharmacy
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• v.31 no.3
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• pp.205-215
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• 2021

Background: The treatment of primary open-angle glaucoma (POAG) or ocular hypertension (OHT) for intraocular pressure (IOP) reduction is recommended to proceed with the use of the compound. Therefore, this study aimed to evaluate the efficacy and safety of brinzolamide combination therapy on POAG and OHT following the subgroup analysis among types of brinzolamide combined medications. Methods: By June 2019, PubMed, EMBASE and Cochrane Library were searched to find a study that met our inclusion criteria. Based on randomized control trials (RCTs), we collected studies that tested the brinzolamide combination therapy in POAG and OHT patients, and analyzed the literature identified by the results of the study on IOP reduction and adverse reactions. Results: A total of 13 literature was collected to conduct an analysis including 2,197 patients. The intervention included brinzolamide combination therapies, combined with timolol, brimonidine, PGA or combined with both brimonidine and PGA. The analysis showed significant decreasing tendency for values at morning and end treatment per day in the use of brinzolamide combination therapy in the absolute IOP change (mean difference (MD) -1.41; 95% CI -1.92, -0.90; p<0.001 vs. MD -1.46; 95% CI -2.03, -0.89; p<0.00001, respectively). We could see higher adverse reactions in the brinzolamide combination group using intervention (odds ratio 1.43; 95% CI 1.20, 1.71; p<0.0001). Conclusion: Regarding IOP reduction in POAG and OHT patients, brinzolamide combination therapy is more effective but less safe than control treatment, which diverse among types of combined medications. Thus, more individualized therapy should be applied in real-world practice.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.14 no.6
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• pp.512-519
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• 2004

This paper described the free vibration characteristics of Optimized H Type (OHT) spacer grids (SG) supporting the PWR fuel rod. The vibration test and the finite element (FE) analysis are performed under the free boundary condition and the clamped at two points (or three points) in the bottom which is the same one as the experimental condition for the dummy rod continuously supported by spacer grids. A modal test is conducted by the impulse excitation method using an impulse hammer and an accelerometer, and the TDAS module of the I-DEAS software is used to acquire and analyze the sensor signals. The softwares related to the FE analysis are the I-DEAS for the geometrical shape modeling and meshing, and the ABAQUS for solving. The fundamental frequency of the OHT SG by experiment under a clamped condition at two points is 175.18 Hz, and shows a bending mode. We think there is no resonance between the fuel rod and the SG because the SG's frequency is higher than that of the fuel rod existing in the range from 30 to 120 Hz. The fundamental frequency of the SG under the free boundary condition is 349.2 Hz showing a bending mode, and the results between the test and the analysis have a good agreement with maximum 7 ％ in error It is also found that the FE analysis model of the OHT SGs to analyze an impact, a buckling and vibration et al. has been generated with reliability.

• Food Science of Animal Resources
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• v.40 no.2
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• pp.274-285
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• 2020

In this study, ovalbumin (OVA) hydrolysates were prepared using various proteolytic enzymes and the anti-inflammatory activities of the hydrolysates were determined. Also, the potential application of OVA as a functional food material was discussed. The effect of OVA hydrolysates on the inhibition of nitric oxide (NO) production was evaluated via the Griess reaction, and their effects on the expression of inducible NO synthase (inducible nitric oxide synthase, iNOS) were assessed using the quantitative real-time PCR and Western blotting. To determine the mechanism by which OVA hydrolysates activate macrophages, pathways associated with the mitogen-activated protein kinase (MAPK) signaling were evaluated. When the OVA hydrolysates were added to RAW 264.7 cells without lipopolysaccharide (LPS) stimulation, they did not affect the production of NO. However, both the OVA-Protex 6L hydrolysate (OHPT) and OVA-trypsin hydrolysate (OHT) inhibited NO production dose-dependently in LPS-stimulated RAW 264.7 cells. Especially, OHT showed a strong NO-inhibitory activity (62.35% at 2 mg/mL) and suppressed iNOS production and the mRNA expression for iNOS (p<0.05). Also, OHT treatment decreased the phosphorylation levels of Jun amino-terminal kinases (JNK) and extracellular signal-regulated kinases (ERK) in the MAPK signaling pathway. These findings suggested that OVA hydrolysates could be used as an anti-inflammatory agent that prevent the overproduction of NO.

• Fisheries and Aquatic Sciences
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• v.4 no.4
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• pp.180-185
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• 2001

Al and Cd-induced inhibition of vitellogenin (VTG) production was examined at the estrogen receptor (ER) level in rainbow trout Oncorhynchus mykiss hepatocytes. The binding of $[^3H]$ $estradiol-17\beta\;(E_2)$ to hepatocytes reached a plateau 3 days after addition of $E_2\;(2\times\;10^{-6} M)$to the medium. The binding activity was linearly reduced with the increased concentrations $(-10^{-5}\;M)$ of 4-hydroxy-tamoxifen (4-OHT) and specific binding linearly increased with the increased doses of $[^3H]\;E_2$, indicating that the radioligand bound to ER. Al $(-10^{-4}\;M)$and Cd $(10^{-6}\;M)$ as well as 4-OHT $(10^{-6}\;M)$ significantly reduced the $[^3H]\;E_2$-binding activity by $30­40\%$, while they completely inhibited VTG production. Al and Cd had no effect on $E_2-human$ $ER\alpha$ binding activity at any concentrations used $(-10^5\;nM\;each)$. These results suggested that Al and Cd inhibited VTG production in part by interfereing with the ER level. Inhibitory effects of these metals on the $E_z-dependent$ upregulation of ER activity are also discussed.

• Fisheries and Aquatic Sciences
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• v.5 no.4
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• pp.251-257
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• 2002

Effects of bisphenol-A (BPA) on vitellogenin (VTG) synthesis and estrogen-estrogen receptor $(E_2- ER)$ binding activity were examined in primary hepatocyte cultures of rainbow trout, Oncorhynchus mykiss. Hepatocytes were precultured for 2 days and then $estradiol-17\beta\;(E_2,\;2\times10^{-6}M)\;BPA\;(10^{-5}-10^{-8}M)$ and/or 4-hydroxy-tamoxifen $(4-OHT,\;10^{-6} M)$ were simultaneously added to the incubation medium. Hepatocytes were cultured for 5 more days and then spent medium was analyzed by SDS-PAGE for VTG production. The addition of BPA to the incubation medium had no effect on the viability of hepatocytes in the culture. On the other hand, BPA increased VTG production in a concentration-dependent way and a significant increment occurred at BPA concentrations greater than $10^{-6}$M. Although VTG was increased by the addition of $E_2\;(2\times10^{-6}\;M)\;or\;BPA\;(10^{-5}M)$, its were reduced by a simultaneous 4-OHT $(10^{-6}\;M)$ addition. BPA inhibited $E_2-human$ ER binding activity by $72\%$ at $10^{-5}$ M of BPA. These results suggested that BPA induced VTG synthesis by BPA-ER binding activity in the hepatocyte of rainbow trout.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.3
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• pp.424-431
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• 2003

The spacer grid is one of the main structural components in the fuel assembly, which supports the fuel rods and maintains coolable geometry from an external load. A vibration test and a finite element analysis using ABAQUS on a dummy fuel rod continuously supported by Optimized H type(OHT) and New Doublet (ND) spacer grids arc performed to obtain the vibration characteristics such as natural frequencies and mode shapes an(1 to verify a finite element model. The results from the test and the finite element analysis are compared by modal assurance criteria (MAC) values. It is resulted that MACs for the first, the third and the fifth mode shapes are relatively good as compared with those of the second an(1 fourth ones. The natural frequency differences between two methods as well as the mode comparison results for the rod with OHT spacer grid are better than those with ND spacer grid. It is judged that the FE model for the ND spacer grid spring should be modified to consider the long contact length which actually happen when the spring supports the rod.

• The KIPS Transactions:PartD
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• v.11D no.2
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• pp.461-470
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• 2004

As the semiconductor industrials change 200㎜-sized semiconductor wafer production process to 300㎜-sized one, it requires to develop the software for monitoring and simulating the robot which transfers a 300㎜-sized semiconductor wafer. Because such a software don't run at standalone but communicate MCS(Material Control System) and Its subsystem a robot, its architecture is very complex. Therefore, in order to develop such a software systematically, we must utilize an object-oriented development methodology. UML. This paper presents an UML process application developing the software for monitoring and simulating the robot which transfers a semiconductor wafer on the production process.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.10a
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• pp.1042-1047
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• 2004

Urethane is a high polymeric and elastic material useful in designing mechanic parts that cannot be molded in rubber or plastic material. Especially, urethane is high in mechanical strength and anti-abrasive. Hereby, an urethane coated aluminum wheel is used for supporting of OHT vehicle moving back and forth to transport products. For the sake of verifying the safety of the vehicle, structural safety for applied maximum dynamic load on a urethane wheel needs to be carefully examined while driving. Therefore, we have performed the dynamic simulation on the OHT vehicle model. Although the area definition of applied load can be obtained from the previous study of Hertzian and Non-Hertzian contact force model when having exact properties of contact material, static analysis is simulated, since the proper material properties of urethane have not been guaranteed, after we have performed the actual contact area test for each load. In case of this study, the method of distributing load for each node is included. Finally, in comparison with result of analysis and load-displacement curve obtained from the compression test, we have defined the material properties of urethane. In the analysis, we have verified the safety of the wheel. After all, we have performed a mode analysis using the obtained material properties. With the result, we have the reliable finite element model.

• Journal of the Korean Wood Science and Technology
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• v.44 no.3
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• pp.457-476
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• 2016

This was investigated on the major issues and research trends regarding the heat-treatment of woods through literature reviews. The principal heat-treatment technologies utilized for industrial purposes include the Plato-process (Netherlands), the Retification process (France), the OHT-process (Germany), and the Thermowood Process (Finland). Factors that mainly influence the heat-treatment process are the wood species, process temperature, processing time, and the heating medium (air, steam, vacuum, N2, oil, etc.). Researches on investigating the optimal conditions with these process conditions being the variables stand as the mainstream. Heat-treated woods present dimensional stability improvement, but mass loss and strength reduction, a wide variations for decaying inhibition, and insufficient resistance against mold, wood borer, and termites. For further improvement in respects of durability or resistance to biological degradation, necessity to search for more suitable heat treatment process and processing conditions fit for each wood species has been suggested. Exploiting new ways to utilize heat-treated wood and extending its range of use have been considered to be important matters that need more effort put into for the sustainable and sound environment as well as saving the wood resources.

• Journal of the Korean Society for Precision Engineering
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• v.22 no.10 s.175
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• pp.114-120
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• 2005

Urethane is a high polymeric and elastic material useful in designing mechanic parts that cannot be molded with rubber or plastic material. In particular, urethane is high in mechanical strength and anti-abrasive. Hereby, a urethane coated aluminum wheel is used to support of the OHT vehicle moving back and forth to transport products. For the sake of verifying the safety of the vehicle, structural safety fur applied maximum dynamic load on a urethane wheel must be examined carefully while driving. Therefore, we performed a dynamic simulation on the OHT vehicle model and we determined the driving load. The area definition of applied load may be obtained from the previous study of Hertzian and Non-Hertzian contact force model having exact properties of contact material. But the static analysis is simulated after we have performed the actual contact area test for each load since the proper material properties of urethane have not been guaranteed. In this study, the method of distributing loads for each node is included. Finally, in coMParison with the results of analysis and load-displacement curve obtained from the compression test, we have defined the material properties of urethane. In the analysis, we verified the safety of the wheel. Finally, we performed a mode analysis using the obtained material properties. With these results, we presented a reliable finite element model.