• Korean Journal of Pharmacognosy
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• v.1 no.3
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• pp.93-99
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• 1970

There have been reported by several workers for the isolation and determination of the amine derivatives as Metbylephedrine Hydrochloride and Ephedrine Hydrochloride adopting neutralization method, steam distillation method, non-aqous titration method, ion-exchange resin method, titration method after acetylation, colorimetric method, gravimetric method, iodine titration method and gas chromatography. Those methods mentioned in above, can be practically applied for the sample which is not mixed one mith the other amine compounds. Presently, it has not shown on the isolative determination of the mixed sample of amine derivatives. In this paper, it is discussed on the isolative determination of Methylephedrine Hydrochloride as the tertiary amine compound and Ephedrine Hydrochloride as the secondary amine compound. According to the results of the experiment, it could be summarized as follows: 1. There is no time-variation on the color reaction of Methylephedrine Hydrochloride and Ephedrine Hydrochloride with the color reagent, bromcresolgreen. And Methylephedrine Hydrochloride and Ephedrine Hydrochloride, respectively, can be determined spectrophotometrically by means oft his color reaction. 2. For the isolation of Methylephedrine Hydrochloride and Ephedrine Hydrochloride from the mixed sample, Methylephedrine Hydrochloride can be eluted by chloroform, while Ephedrine Hydrochloride by the mixed solvent of chloroform and ethylalcohol (2:1), from the celite column adsorbed at pH6.4 followed by extraction with ether undersodium hydroxide alkali re action. 3. When the sample is mixed with quinine hydrochloride, dihydrocodeine bitartate, and noscapine, these mixed compounds can be eliminated by means of stram distillation. 4. When the sample is mixed with chlorpheniramine maleate, dextromethorphan hydrobromide and diphenhydramine hydrochloride, the mixed compounds can be eliminated by means of steam distillation and celite adsorption column chromatography, In conclusion, the isolative determination method for Methylephedrine Hydrochloride and Ephedrine Hydrochloride studied in this paper, indicates with the excellent reproducibility and accuracy.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.20 no.6
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• pp.591-600
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• 1987

To evaluate the detection rate and the density of Vibrio vulnificus by the sample, sampling area and date, 240 sea water samples and marine invertebrates were collected from coastal area of Korea including Pohang, Chungmu, Yeosu, Kunsan, Sihwa and Pusan from March to October, 1986. Eighty two strains oft of 1087 strains isolated from the submitted samples were identified as V. vulnificus. Forty seven of total 240 samples were positive in V. vulnificus which were constituted by 31 out of 138 sea water samples and 16 out of 102 marine invertebrates. Detection rate of V. vulnificus among the invertebrates was high in the crab, Portunus trituberculatus and the ark shell, Anadara broughtonii samples. The samples collected at Kunsan area showed the highest in detection rate of the bacterium as $67\%$ during the study period and the density of V. vulnificus was high in the sea water which was low in salinity.

• Culinary science and hospitality research
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• v.22 no.5
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• pp.82-94
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• 2016

This study on CRM oftKorean restaurant guests to test the emotional response and behavioral intention. Three kinds of variables(service quality, information quality, system quality) from Korean restaurant guests were set to test the CRM. Results of the multiple regression analysis revealed a positive significant relationship with respect to quality of service, quality information, and quality system with all customer emtional reaction. Second, the results also found that the three independent variables of quality of service (${\beta}=.104$, P<.01), information quality (${\beta}=.215$, P<.001), and system quality (${\beta}=.682$, P<001) had a significant positive effect on the dependent variable for customer behavior (+). Third, CRM quality of service, quality information, and quality of the restaurant system are shown to influence the behavior and it also showed that both the part-mediated effects.

• Journal of the Korea Society of Computer and Information
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• v.13 no.4
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• pp.87-95
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• 2008

In this paper, we developed a selectable observation Point test architecture and test procedure for clocked 4-bit synchronous counter circuit based on boundary scan architecture. To develope, we analyze the operation of Sample/Preload instruction on boundary scan architecture. The Sample/Preload instruction make Possible to snapshot of outputs of CUT(circuit under test) at the specific time. But the changes of output of CUT during normal operation are not possible to observe using Sample/Preload in typical scan architecture. We suggested a selectable observation point test architecture that allows to select output of CUT and to observe of the changes of selected output of CUT during normal operation. The suggested a selectable observation point test architecture and test procedure is simulated by Altera Max 10.0. The simulation results of 4-bit counter shows the accurate operation and effectiveness of the proposed test architecture and procedure.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.43 no.12 s.354
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• pp.9-15
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• 2006

In this paper, signal processing techniques for noncoherent impulse-radio-based UWB (IR-UWB) communication system are proposed to provide system implementation of low power consumption and low complexity. The proposed system adopts a simple modulation technique of OOK (on-oft-keying) and noncoherent signal detection based on signal amplitude. In particular, a technique of a novel high speed digital sampler using a stable, lower reference clock is developed to detect nano-second pulses and recover digital signals from the pulses. Also, a 32 bits Turyn code for data frame synchronization and a convolution code as FEC are applied, respectively. To verify the proposed signal processing techniques for low power, low complexity noncoherent IR-UWB system, the proposed signal processing technique is implemented in FPGA and then a short-range communication system for wireless transmission of high quality MP3 data is designed and tested.

• The Journal of the Acoustical Society of Korea
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• v.16 no.2
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• pp.71-79
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• 1997

In this paper, a codeword-dependent distance normalization(CDDN) and an instar-formed fuzzy smoothing of output distribution are proposed for robust estimation of output probabilities in the FVQ(fuzzy vector quantization)-DHMM(discrete hidden Markov model). The FVQ-DHMM is a variant of DHMM in which the state output probability is estimated by the sum oft he product of the output probability and its weighting factor for each codeword on an input vector. As the performance of the FVQ-DHMM is influenced by weighting factor and output distribution from a state, it is required to get a method to get robust estimation of weighting factors and output distribution for each state. From experimental results, the proposed CDDN method has reduced 24% of error rate over the conventional FVQ-DHMM, and also reduced 79% of error rate when the smoothing of output distribution is also applied to the computation of an output probability. These results indicate that the use of CDDN and the fuzzy smoothing of output distribution to the FVQ-DHMM lead to improved recognition, and therefore it may be used as an alternative to the robust estimation of output probabilities for HMMs.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.26 no.1
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• pp.93-106
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• 2000

One phase liquid crystal formula was developed by using of nonionic surfactants, polyols, water and oils and its physical property was investigated. At the system oft to 1 ratio of POE octyldodecyl ether series, which have Y type (branch type) hydrophobic group, and POE glyceryl monostearate series, Y type hydrophilic group, it was examined that the formula at 7:3, 6:4, and 5:5 ratio of nonionic surfactant : polyols, shows L$\alpha$ , a pattern which is a typical characteristic of liquid crystal structure under the cross microscope polarized film. As results of L$\alpha$ phase diagram study, the formula which had high hydrophilic nonionic surfactant and the 7:3 ratio of nonionic surfactant : polyol appeared to increase the amount of oil containment and to be capable of the lamella formation. Besides it was examined that lamellar liquid crystal formula could contain about 25-40% water between lamella layers and it was transformed into w/o emulsion following as water content increased. When the lamella gel was applied into a human skin, it was investigated that it had effectiveness in increasing transepidermal water content of the skin.

• Korean Journal of Acupuncture
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• v.38 no.3
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• pp.162-174
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• 2021

Objectives : We aimed to identify the antidepressant effect of liver tonification acupuncture treatment (ACU (LT); KI10, LR8, LU8, LR4) and four gate acupuncture treatment (ACU (FG); LI4, LR3) and its brain neural activity in the normal and chronic restraint stress (CRS)-induced mouse model. Methods : Firstly, normal mice were given ACU (LT) or ACU (FG) and the c-Fos expressions in each brain region were analyzed to examine brain neural activity. Secondly, CRS was administered to mice for 4 weeks, then ACU (LT) or ACU (FG) was performed for 2 weeks. The depression-like behavior was evaluated using open field test (OFT) before and after acupuncture treatment. Then, the c-Fos expressions in each brain region were analyzed to examine brain neural activity. Results : In normal mice, ACU (FG) regulated brain neural activities in the hypothalamus, hippocampus, and periaqueductal gray. ACU (LT) changed more brain regions in the prefrontal cortex, insular cortex, striatum, and hippocampus, including those altered by ACU (FG). In CRS-induced model, ACU (LT) alleviated depression-like behavior more than ACU (FG). Also, brain neural activities in the motor cortex area 2 (M2), agranular ventral part and piriform of insular cortex (AIV and Pir), and cornu ammonis (CA) 1 and CA3 of hippocampus were changed by ACU (LT), and those of AIV and CA3 were also changed by ACU (FG). As in normal mice, ACU (LT) resulted in changes in more brain regions, including those altered by ACU (FG) in CRS model. M2, Pir, and CA1 were only changed by ACU (LT) in depression model, suggesting that these brain regions reflect the specific effect of ACU (LT). Conclusions : ACU (LT) relieved depression-like behavior more than ACU (FG), and this acupuncture effect was associated with modulation of brain neural activities in the motor cortex, insular cortex, and hippocampus.

• Biomolecules & Therapeutics
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• v.27 no.2
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• pp.160-167
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• 2019

Depression is a major mood disorder. Abnormal expression of glial glutamate transporter-1 (GLT-1) is associated with depression. Schisantherin B (STB) is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine for thousands of years. This paper was designed to investigate the effects of STB on depressive mice induced by forced swimming test (FST). Additionally, we also assessed the impairment of FST on cognitive function in mice with different ages. FST and open field test (OFT) were used for assessing depressive symptoms, and Y-maze was used for evaluating cognition processes. Our study showed that STB acting as an antidepressant, which increased GLT-1 levels by promoting PI3K/AKT/mTOR pathway. Although the damage is reversible, short-term learning and memory impairment caused by FST test is more serious in the aged mice, and STB also exerts cognition improvement ability in the meanwhile. Our findings suggested that STB might be a promising therapeutic agent of depression by regulating the GLT-1 restoration as well as activating PI3K/AKT/mTOR pathway.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2019.10a
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• pp.85-85
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• 2019

Objective: In this study, the anti-stress effects of extract of Hydrangeae Dulcis Folium (EHDF) or ethalonic extract of Opuntiaficus-indica (EOF) of natural extracts from Jeju Island were investigated. Methods: We performed measurement of whole-body cortisol level and behavioral experiments including the novel tank test (NTT) or the open field test (OFT) to assess stress responses in zebrafish. To induce physical stress, we used the net handling stress (NHS). Fish were treated with EOF or EHDF for 6 min before they were exposed to stress. And then, we sacrificed fish for collecting body fluid from whole-body or conducted behavioural tests, including novel tank test and open field test, were evaluated to observe anxiety-like behaviours and locomotion. We used the cortisol enzyme-linked immunoassay kit to measure the amount of cortisol in each zebrafish sample. Results: The results indicate that increased anxiety-like behaviours in novel tank test and open field test under stress were prevented by treatment with both EOF and EHDF (P < 0.05). Moreover, compared with the unstressed group, which was not treated with NHS, the whole-body cortisol level was significantly increased by treatment with NHS. Compared with the NHS-treated stressed control group, pre-treatment with each EHDF and EOF for 6 min significantly prevented the NHS-increased whole-body cortisol level (P < 0.05). Conclusions: In conclusion these results suggest that both EOF and EHDF pretreatment may prevent stress responses and that its mechanism of action may be related to its positive effects on cortisol release.