• Title/Summary/Keyword: OECD Classification

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A Study on GHS Classification of 3-Methylpentane by Subacute Inhalation Toxicity (아급성흡입독성시험을 이용한 3-Methylpentane의 GHS 분류·표시)

  • Chung, Yong Hyun;Han, Jeong Hee;Shin, Seo Ho
    • Journal of the Korean Institute of Gas
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    • v.21 no.1
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    • pp.6-17
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    • 2017
  • Objectives : The purpose of this study was to obtain information regarding Globally Harmonized System(GHS) classification and health hazards that may result from a 4 weeks inhalation exposure of 3-Methylpentane in Sprague-Dawley rats. Methods : The testing method was conducted in accordance with OECD guidelines for the testing of chemicals No. 412(Subacute Inhalation Toxicity). The Rats were divided into 4 groups(5 male and 5 female rats in each group) and exposed to 0 ppm, 284 ppm, 1,135 ppm, 4,540 ppm 3-Methylpentane in each exposure chamber for 6 h/day, 5 days/week, for 4 weeks. After two weeks, the test animals were autopsied and carried out blood test and biochemical tests and histopathological examination. We used PRISTIMA (Toxicology data management system) to confirm the system and to have confidence of the raw data. Results : No death and particular clinical presentation including weight change and change of feed rate was observed. Relationship between dose, gender and response was also not significantly changed in hematologic examination, biochemical examination of blood and blood coagulation time. The histopathologic lesions caused by the test substance did not appear. Conclusions : NOAEL(No Observable Adverse Effect Level) of 3-Methylpentane is more than 4,540 ppm in male group and female group and the Ministry of Employment and Labor Guidance Announcement No. 2013-37(criteria for the classification marks and Safety of Chemicals) Specific target organ toxicity(repeated exposure) was determined with a substance that is not the separator material.

An Exploratory Study on the Effect of LCZ Type on Particulate Matter (LCZ 유형이 미세먼지에 미치는 영향에 관한 탐색적 연구)

  • Yeonju Kim;Hansol Mun;Juchul Jung
    • Journal of Environmental Impact Assessment
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    • v.32 no.5
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    • pp.338-352
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    • 2023
  • As of 2019, Korea's fine dust is the most severe among 38 OECD countries, and in the same year, 「the Framework on Disaster and Safety Management」 was revised to define fine dust as a social disaster. Currently, the government is working to achieve its emission reduction goals by preparing a comprehensive fine dust management plan (2022-2023) consisting of a total of five areas, 42 tasks, and 177 detailed tasks. However, it is necessary to come up with measures in consideration of the various spatial characteristics of the city, not just as a source of emission. Therefore, in this study, the shape of the city was classified using the LCZ (Local Climate Zone) classification system into 17 types by building type and land cover type in Busan, and the average annual PM10 and PM2.5 concentration were mapped using the IDW technique. In addition, Fragstats and Moving Window were used to quantify the LCZ classification system. Finally, correlation analysis and regression analysis were conducted to analyze the relationship between the LCZ classification system and PM10 and PM2.5. As a result, it was confirmed that the type of low height of the building and the type of green space with trees had a positive effect on the concentration of PM10 and PM2.5. Therefore, this study is expected to be used as basic data to establish fine dust reduction policies based on efficient spatial planning.

Technological Intensity and Export Specialization in Asia: A Comparative Analysis of Japan, Korea, China and Taiwan

  • Movshuk, Oleksandr
    • Asia-Pacific Journal of Business
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    • v.3 no.2
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    • pp.42-48
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    • 2012
  • This paper examined structural changes in export specialization of Japan, South Korea, Taiwan, and China at different levels of technological intensity. The study found significant differences across these Asian economies, with most pronounced changes for exports with high technological intensity. To account for the changing export specialization, the study applied the classical Ricardian model of comparative advantages to export patterns of Japan and South Korea. We found that the export specialization of Japan was mainly determined by differences in fixed effects across industrial sectors, with changes in relative labor productivity much less important. In contrast, changes in productivity turned out an essential factor for explaining the recent export specialization of South Korea.

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The Characteristics of Water Quality in Mokpo Harbour(II) - Centering on eutrophication summer - (목포항의 수질특성 - 하계의 부영양화를 중심으로 -)

  • 김광수
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.3 no.S1
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    • pp.77-90
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    • 1997
  • the observations in situ and the seawater analyses were conducted in July and August, 1996 for the purpose of evaluating the characteristics of seawater quality centered on eutrophication in Mokpo harbour. By applying the OECD standards of trophic classification to the parameters such as secchi depth, total inorganic nitrogen, phosphate phosphorus and chlorophyll-a, the trophic level of seawater in Mokpo harbour was evaluated to be in eutrophic state in summer. By the estimation of pollution index with relation to eutrophication, the seawater quality of Mokpo harbour was evaluated to be under the regular grades and this evaluation was found to be different from the results of evaluation obtained by the environmental index of single parameter, chemical oxygen demand. By the estimation of eutrophication index, the seawaters of Mokpo harbour were shown to have the high potentiality of red tide occurrence.

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The Characteristics of Water Quality in Mokpo Harbour(II) -Centering on eutrophication in summer- (목포항의 수질특성(II) - 하계의 부영양화를 중심으로 -)

  • 김광수
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.3 no.2
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    • pp.51-61
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    • 1997
  • The in situ observations and the seawater analyses were conducted in July and Auguse, 1996 for the purpose of evaluating the characteristics of seawater quality centered about eutrophication in Mokpo harbour. By applying the OECD standards of trophic classification to the parameters such as secchi depth, total inorganic nitrogen, phosphate phosphorus and chlorophyll-a, the trophic level of seawater in Mokpo harbour was evaluated to be in eutrophic state in summer. The estimation of pollution index by eutrophication showed the seawater quality of Mokpo harbour to deteriorate and fall under the regular grades. The results of eutrophic index estimation showed the high otentiality of red tide occurrence in Mokpo harbour.

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Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats

  • Kim, Yong-Soon;Baek, Min-Won;Sung, Jae-Hyuck;Ryu, Hyun-Youl;Kim, Jin-Sik;Cho, Hyun-Sun;Choi, Byung-Gil;Song, Min-Sub;Song, Moon-Yong;Baik, Eun-Ju;Choi, Young-Kuk;Kim, Jong-Kyu;Yu, Il-Je;Song, Kyung-Seuk
    • Toxicological Research
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    • v.25 no.3
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    • pp.132-139
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    • 2009
  • The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 mg/kg body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 mg/kg body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 mg/kg body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.

Innovation and Intangible Capital for Economic Growth (혁신과 무형자본을 통한 경제성장)

  • Kim, Nari
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.9
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    • pp.454-464
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    • 2018
  • The OECD estimates that a high concentration of intangible capital is in the richest countries of the world. Studies show that intangibles have a positive relation with economic growth. However, different types of intangibles can have different impacts on economic performance. Therefore, this paper attempts to distinguish the differences within the intangibles in influencing economic growth by analyzing three different characteristics of the intangibles. Three main types of intangibles (computerized information, innovative property and economic competencies) are analyzed based on the degree of tacitness, the process of creation and diffusion, and the level of embedded value-added. This research uses Polanyi's classification of tacitness of knowledge, the Nonaka-Takeuchi Model and the "smiling curve" to find that not only investing more in intangible capital but also developing more "tacit" type of intangibles are important for economic growth.

Seasonal Variations of Marine Water Quality and Eutorphication Index in Mokpo Harbour (목포항의 수질 및 부영양도의 계절 변화)

  • Kim Kwang Soo
    • Journal of the Korean Society for Marine Environment & Energy
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    • v.4 no.3
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    • pp.3-15
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    • 2001
  • The in situ observations and the seawater analyses were conducted for 3 years from August 1996 to August 1999 in order to elucidate and evaluate seasonal variations of marine water quality and trophic state in Mokpo harbour of Korea. Compared the seasonal seawater qualities of Mokpo harbour with the OECD standards of trophic classification in parameters such as Secchi depth, dissolved inorganic nitrogen, phosphate phosphorus and chlorophyll-a, the trophic level of seawater in Mokpo harbour was evaluated to be in mesotrophic or eutrophic state through all 4 seasons and to be in eutrophic state, particularly In summer. The estimation of pollution index by eutrophication showed the seawater quality of Mokpo harbour to deteriorate and fall under the regular grades through all 4 seasons, although the seawater quality of Mokpo harbour was evaluated to be equivalent to the second or third class of the Korean seawater quality standards in view of COD values. The results of eutrophication index estimation showed the high potentiality of red tide occurrence In Mokpo harbour, particularly in summer or fall. In the light of the average atomic ratio of N/P in seawater, the limiting nutrient factor against the growth of phytoplankton was concluded to be phosphorus rather than nitrogen in Mokpo Harbour.

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Comparative Analysis of Factors in Country Risk between Cambodia and Vietnam (캄보디아와 베트남의 국가위험도 영향요인 비교 분석)

  • Lee, Changkeun;Choo, Yongsik
    • Journal of the Korean Regional Science Association
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    • v.34 no.2
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    • pp.65-77
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    • 2018
  • The purpose of this study is to compare and analyze factors in country risk between Cambodia and Vietnam. OECD and the Export-Import Ban of Korea assess country risk of Cambodia more highly than Vietnam. As results of the parametric tests for evaluation factors on the basis of country risk classification, the economic growth rate, the foreign trade index, and the foreign exchange reserves among the economic risks with the corruption index as the political and social risk have statistically significant effect on the difference between country risks of two countries. However, discriminant factor analysis indicates that the economic growth rate, the foreign exchange reserves, and the corruption index are key variables, which represent the difference between country risks of Cambodia and Vietnam. Consequently, the government of Cambodia needs to try to root out the corruption and to expand trade through increasing export for lowering the country risk to the level of Vietnam. Vietnam would also need to focus on attaining the sustainable high economic growth rate and increasing the foreign exchange reserves.

Evaluation of Acute Toxicity of Pomace Schisandra chinensis Extracts Using SD-rats (SD-rats를 이용한 오미자박 추출물의 급성경구독성 평가)

  • Seokho, Kim;Bo Ra, Yoo;Young-Suk, Kim;Jong-Min, Lim;Bon-Hwa, Ku;Kyeong Tae, Kwak;Byeong Yeob, Jeon
    • Herbal Formula Science
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    • v.30 no.4
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    • pp.281-291
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    • 2022
  • Objectives : In this study, acute oral toxicity test of pomace Schisandra chinensis extracts was conducted in order to up-cycling to a high value-added industry using by-products discarded in the production process of Schisandra chinensis products and active ingredients such as dibenzocyclooctadiene lignans in Schisandra chinensis. Methods : Pomace Schisandra chinensis extracts were orally administered to SD-rats(female, n=3) without a control group according to the 'OECD guidelines'. After, mortality and clinical signs were observed, and the deceased animals were subjected to an autopsy. In addition, acute oral toxicity test was sequentially performed in step I (300 mg/kg), step II(300 mg/kg), step III(2,000 mg/kg), and step IV(2,000 mg/kg) according to the mortality. Results : There were no abnormalities caused by pomace Schisandra chinensis extracts in step I and step II. However, one animal each died in step III and step IV. In addition, clinical signs(salivation, decrease in food intake, prone position, decrease of locomotor activity, loss of locomotor activity, convulsion, hypothermia, lacrimation, staining around mouth, soiled perineal region, reddish urine, chromaturia, decrease of fecal volume, lying on side, blackish stool, no stool, compound-colored stool, refusal to feed, excitement, hypersensitivity, rigidity, dorsal position, etc.) were observed. But, no clinical signs were observed from 5th day, and experiment animals recovered completely. Conclusions : As a result of this study, pomace Schisandra chinensis extracts may exhibit acute toxicity at concentrations of 2,000 to 5,000 mg/kg, and the GHS classification was designated as 'Category 5'.