• Proceedings of the Korean Information Science Society Conference
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• 2005.07a
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• pp.829-831
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• 2005

실시간 시스템이란 시간적인 제한을 가지고 작업 수행 결과의 정확도가 보장되는 시스템으로 경성 실시간 시스템과 연성 실시간 시스템으로 분류된다. 최근 분산 실시간 분야에서 새로운 패러다임으로써 폭넓게 활용되기 시작한 실시간 객체 모델인 TMO는 Kane Kim과 Kopetz에 의해 처음 제안되었다. TMO 모델은 경성 또는 연성 실시간 응용과 병렬 컴퓨팅 응용 프로그램에서 사용 될 수 있으며, 시스템의 기능적인 면과 시간 조건 수행 모두를 명확히 정의할 수 있다. TMO의 네트워크로 구성되는 실시간 분산 환경에서의 실행을 위해 몇 개의 TMO 실행 엔진이 개발 되었는데, 그 중에서 LTMOS라는 리눅스 기반의 연성 실시간 미들웨어 엔진이 한국외대 RTDCS lab.에서 개발되었다. 하지만 LTMOS의 실시간 시스템 수행 중 작업량의 과부하로 인한 deadline 위반이나, 시스템간의 분산 IPC 통신에 있어서 Channel Traffic이 빈번한 경우 실시간 시스템을 유지할 수 없다는 문제점들을 갖고 있다. 이러한 문제점들을 해결하고 조금 더 효율적인 실시간 시스템을 유지하기 위해서, TMO 프로그램의 resource 정보를 담고 있는 ODS(Object Data Store)만을 다른 노드에 있는 자신의 TMO 프로그램 Replica로 이주해서 실시간 로드 밸런싱을 구현하는 기법을 사용하였다. 이에 본 논문에서는 TMO 프로그램들의 deadline 위반 및 Channel Traffic 부하를 감지할 수 있는 Node Monitor와 최적의 노드를 선별할 수 있는 Migration Manager를 새롭게 추가하였고, 쓰레드들의 스케줄러인 WRMT에 이주 작업을 하기 위한 부가적인 기능을 구현하였다. 2D 이미지의 관측점을 줄여 계산량을 대폭 감소시키는 장점을 갖는다.것으로 조사되었으며 40대 이상의 연령층은 점심비용으로 더 많은 지출을 하고 있는 것으로 나타났다. 4) 끼니별 한식에 대한 선호도는 아침식사의 경우가 가장 높았으며, 이는 40대와 50대에서 높게 나타났다. 점심 식사로 가장 선호되는 음식은 중식, 일식이었으며 저녁 식사에서 가장 선호되는 메뉴는 전 연령층에서 일식, 분식류 이었으며, 한식에 대한 선택 정도는 전 연령층에서 매우 낮게 나타났다. 5) 각 연령층에서 선호하는 한식에 대한 조사에서는 된장찌개가 전 연령층에서 가장 높은 선호도를 나타내었고, 김치는 40대 이상의 선호도가 30대보다 높게 나타났으며, 흥미롭게도 30세 이하의 선호도는 30대보다 높게 나타났다. 그 외에도 떡과 죽에 대한 선호도는 전 연령층에서 낮게 조사되었다. 장아찌류의 선호도는 전 연령대에서 낮았으며 특히 30세 이하에서 매우 낮게 조사되었다. 한식의 맛에 대한 만족도 조사에서는 연령이 올라갈수록 한식의 맛에 대한 만족도는 낮아지고 있었으나, 한식의 맛에 대한 만족도가 높을수록 양과 가격에 대한 만족도는 높은 경향을 나타내었다. 전반적으로 한식에 대한 선호도는 식사 때와 식사 목적에 따라 연령대 별로 다르게 나타나고 있으나, 선호도는 성별이나 세대에 관계없이 폭 넓은 선호도를 반영하고 있으며, 이는 대학생들을 대상으로 하는 연구 등에서도 나타난바 같다. 주 5일 근무제의 확산과 초 중 고생들의 토요일 휴무와 더불어 여행과 엔터테인먼트산업은 더욱 더 발전을 거듭하고 있으며, 외식은 여행과 여가 활동의 필수적인 요소로써 그 역할을 일조하고 있다. 이와 같은 여가시간의 증가는 독신자들에게는 좀더 많은 여유시간을 가족을

• Korean Journal of Food Science and Technology
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• v.34 no.3
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• pp.505-509
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• 2002

In the course of screening program for VHR DS-PTPase (dual-specificity protein tyrosine phosphatase) from natural sources, Gastrodia elata was selected. One compound showing potent inhibitory activity was isolated by the solvent extraction and column chromatography including silica gel, ODS RP-18, Sephades LH-20, and HPLC. This compound was identified as baicalein by several NMR techniques such as $^1H-NMR$, $^{13}C-NMR$, and DEPT. Baicalein showed selective inhibitory activity against VHR DS-PTPase with $IC_{50}=2.4\;{\mu}M$, and showed cytotoxicity against several human cancer cell lines with an $GI_{50}$ of $5.26{\sim}12.93\;{\mu}g/mL$ range, including, melanoma (LOX-IMVI), lung cancer (NCI H23 and A549), colon cancer (HCT 116 and SW 620), prostate cancer (PC-3), and leukemia (MOLT 4F).

• Journal of the Korean Society of Floral Art and Design
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• no.43
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• pp.39-56
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• 2020

This study is on the creation of floral art works based on the intuitive insight acquired by methodological process of ruminating the experienced meaningful events of the artists utilizing sensible perception. The researcher used the narration and visualization techniques. The narration process adopted the writing technique of subjective impression, emotion, stream of consciousness to capture sensations of subconscious state, which were applied in three steps of 'the exploration of experiences', 'the concretion of experiences', and 'the creation of meaning out of experiences'. The visualization process adopted collection, selection, classification, and interpretation of related images, which were applied in three methods of 'the creation of images', 'the utilization of intuition', and 'the perception through remembering'. Finally 5 art works of 'Hammock is Good', 'At the Rooftop with Warm Sunshine', 'Standing at the Waterside Alone', 'Dizziness at Hot Sand Field', and 'Having Good Time at a Botanical Garden'were created through the combination of these two methods mentioned above and complementary research and writing. The meaningfulness of this research lies in presenting methodological approaches of utilizing narration and visualization of experiences in art creation process.

• Journal of the Korea Society of Computer and Information
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• v.28 no.3
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• pp.137-148
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• 2023

The purpose of this study is to classify the potential types of mental health of mothers of multicultural youth by applying Latent Profile Analysis, analyze the influence of predictors, and find out how differences in potential types affect parental efficacy. To this end, panel data for the 9th year (2019) of the Multicultural Youth Panel Survey (MAPS) were used. As a result of the analysis, first, the mental health types of mothers of multicultural adolescents were analyzed in the order of 'middle risk type of mental health'(class3) > 'high risk type of self-esteem'(class1) > 'high risk type of mental health'(class4) > 'cultural adaptation and daily life stress'(class2). Second, compared to the "class 1" group, the lower the family economy level of multicultural youth mothers, the lower the educational background of multicultural youth fathers (husbands) graduate from middle school, the lower the level of Korean, and the lower the level of communication with children, the higher the odds of belonging to the 'mental health medium risk' group (Ods). Third, compared to the 'middle risk type of mental health'(class3) and 'high risk type of mental health'(class4), the 'high risk type of self-esteem'(class1) group was found to have a significant positive (+) effect on parental efficacy.

• Analytical Science and Technology
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• v.19 no.5
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• pp.433-440
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• 2006

A HPLC/UV method was developed and validated for the rapid and simultaneous determination of urinary metabolites of organic solvents, mandelic acid, hippuric acid, phenylglyoxylic acid, ortho-, meta- and para-methylhippuric acid, using a monolithic column. The mobile phase was composed of tetrabutylammonium bromide as ion-pairing reagent with a flow rate of 2.4 mL/min. The total run time was less than 2.5 min for all six analytes. Good linearities were obtained for all the metabolites with correlation coefficients above 0.9993. Intra-day precision, accuracy and inter-day precision was 0.01~7.32%, 83.9~116.3% and 0.01~7.16%, respectively. The method was validated and confirmed by quantification of the quality assurance samples of Industrial Safety and Health Research Institute, Korea Occupational Safety and Health Agency.

• Analytical Science and Technology
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• v.20 no.4
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• pp.323-330
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• 2007

A simple and rapid HPLC method with fluorescence detection(FLD) for quantitation of penciclovir in human plasma using a monolithic column was developed and validated. Penciclovir and ganciclovir(internal standard, I.S.) were separated on a Chromolith column RP-18e ($4.6{\times}100mm$) with a mobile phase consisting of a mixture of (A) methanol/50 mM sodium phosphate buffer containing 200 mg/L sodium dodecyl sulfate (3/97, pH 2.5) and (B) methanol/50 mM sodium phosphate buffer containing 200 mg/L sodium dodecyl sulfate (50/50, pH 2.5) at a flow gradient of $1.6{\sim}4.0mL/min$. The retention times of penciclovir and internal standard were less than 4.0 min. Calibration curve was linear ($R^2=0.9994$) over a concentration range of $0.1{\sim}5{\mu}g/mL$. Intra-day precision, accuracy and inter-day precision were 1.36~8.55 %, 92.8~100.0 % and 0.93~5.62 %, respectively with a limit of quantitation at $0.1{\mu}g/mL$. The present HPLC-FLD method is sensitive, precise and accurate. The method described herein has been successfully used for the bioequivalence study of a famciclovir formulation product after oral administration to healthy Korean volunteers.

• Journal of Life Science
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• v.34 no.4
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• pp.215-226
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• 2024

Aralia continentalis is widely distributed in Far East Asian countries such as Korea, China, and Japan. A. continentalis has traditionally been used as an herbal remedy for various conditions, including analgesia, headache, inflammation, lameness, lumbago, rheumatism, and dental diseases in Korea. Previously, epi-continentalic acid, continentalic acid, and kaurenoic acid as major active biological compounds belonging to the diterpenoid class were identified. To synthesize diterpenoid derivatives with enhanced bioavailability, Fusarium fujikuroi was employed to biotransform diterpenoids due to its known antibacterial activity. This yielded two derivatives of kaurenoic acid, namely 16α-hydroxyent-kauran-2-on-19-oic acid and 2β, 16α-dihydroxy-ent-kauran-19-oic acid, with their chemical structures elucidated via NMR analysis. These derivatives exhibited increased polarity compared to kaur- enoic acid, as evidenced by their retention time on preparative HPLC using the ODS-A column and structural modifications. Evaluation of their antidiabetic activity targeting PTP1B, a negative regulator of the insulin signaling pathway, revealed inhibitory activities of 30.8% and 27.6%, respectively, at a concentration of 4 ㎍/ml. Additionally, both derivatives demonstrated low cytotoxicity, with an IC50 value 18 times higher than kaurenoic acid. Therefore, the augmented water solubility and reduced toxicity of 16α-hydroxy-ent-kauran-2-on-19-oic acid and 2β, 16α-dihydroxy-ent-kauran-19-oic acid, resulting from biotransformation by F. fujikuroi, render them promising candidates for industrial applications.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.23 no.2
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• pp.119-131
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• 2024

Understanding accurate traffic performance is crucial for ensuring efficient highway operation and providing a sustainable mobility environment. On the other hand, an immediate and precise estimation of highway traffic performance faces challenges because of infrastructure and technological constraints, data processing complexities, and limitations in using integrated big data. This paper introduces a framework for estimating traffic performance by analyzing real-time data sourced from toll collection systems and dedicated short-range communications used on highways. In particular, this study addresses the data errors arising from segmented information in data, influencing the individual travel trajectories of vehicles and establishing a more reliable Origin-Destination (OD) framework. The study revealed the necessity of trip linkage for accurate estimations when consecutive segments of individual vehicle travel within the OD occur within a 20-minute window. By linking these trip ODs, the daily average highway traffic performance for South Korea was estimated to be248,624 thousand vehicle kilometers per day. This value shows an increase of approximately 458 thousand vehicle kilometers per day compared to the 248,166 thousand vehicle kilometers per day reported in the highway operations manual. This outcome highlights the potential for supplementing previously omitted traffic performance data through the methodology proposed in this study.

• Journal of Applied Biological Chemistry
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• v.66
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• pp.477-483
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• 2023

The flowers of Carthamus tinctorius (Safflower) were extracted with 80% aqueous methanol (CTex) and the concentrates were partitioned into EtOAc (CTE), n-BuOH (CTB), and H₂O (CTW) fractions. Repeated silica gel (SiO₂) and octadecyl silica gel column chromatographies for the EtOAc and n-BuOH fractions led to isolation of four flavonol glycosides. Nuclear magnetic resornance, infrarad spectroscopy, and mass spectroscopy revealed the chemical structure of the isolated compounds, astragalin (1), isoquercetin (2), nicotiflorin (3), and rutin (4). Quantitative analysis of four isolated compounds in CTex was performed by HPLC. CTex was found to contain 1 at 0.107, 2 at 0.367, 3 at 6.752, and 4 at 0.991 mg/g, respectively. Through this study, an experiment was conducted to evaluate the protective effect on pancreatic islets of the extract, solvent fractions, and all isolated compounds using a zebrafish larvae damaged by alloxan. Pancreatic islet size treated with EtOAc (CTE), n-BuOH (CTB), and H₂O (CTW) fractions and compounds 1-4 significantly increased compared to the alloxan-induced group. These results indicate that C. tinctorius flowers and its isolated compounds are used as potential anti-diabetic agents.

• Korean Journal of Medicinal Crop Science
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• v.15 no.4
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• pp.296-303
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• 2007

Acer tegmentosum (Acereaceae) has been used a source of traditional medicines for the treatment of hepatic disorders in Korea. This research was conducted to determine biofunctional activities of A. tegmentosum stem extract and to identify its bioactive components. Methanolic extract from A. tegmentosum stem was partitioned by using organic solvents, including n-hexane, ethyl acetate, n-butanol, and water. Two compounds were isolated by using an ODS column chromatography from ethyl acetate soluble fraction shown to the strongest antioxidant activity ($RC_{50}=3.15\;{\mu}g/m{\ell}$) among the fractions. The isolated compounds were analyzed by $^1H$ and $^{13}C$ NMR, IR, UV/VIS, MS spectrum data and identified as catechin, ${\rho}-Hydroxyphenethyl$ alcohol $1-O-{\beta}-_D-(6'-O-galloyl)-glucopyranoside$. The compounds have shown strong antioxidant activity, with similar activity to BHA ($RC_{50}=2\;{\mu}g/m{\ell}$). Especially, ${\rho}-Hydroxyphenethyl$ alcohol 1-O-{\beta}-_D-(6'-O-galloyl)-glucopyranoside$ was shown strong anti-lipid peroxidative activity. However, the compounds were not shown antimicrobial activities. In antimicrobial activity assays, ethyl acetate soluble fraction was effective to bacterial inhibition, such as Escherichia coli and Klebsiella pneumonia, with minimum inhibitory concentrations in $125\;{\mu}g/m{\ell}$. Otherwise, antifungal activity against Candida albicans was shown in n-hexane soluble fraction exhibiting $63\;{\mu}g/m{\ell}$ of minimum inhibitory concentration. In anticomplementary activity assays, water soluble fraction was the most effective exhibiting 24% inhibitory activity.