• The Journal of Internal Korean Medicine
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• v.38 no.6
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• pp.863-876
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• 2017

Objectives: The aim of this experimental study was to evaluate the anti-neoplastic and anti-inflammatory effects of single and mixed extracts of Ulmus davidiana (UD) and Oldenlandia diffusa (OD) on azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colonic neoplasms in mice. Methods: AOM/DSS induces colitis-associated colonic neoplasms in mice. Mice were divided into seven groups: normal-no inducement and no treatment; control-colonic neoplasms with no treatment; UD-colonic neoplasms and treatment with UD; OD-colonic neoplasms and treatment with OD; UD1+OD1-colonic neoplasms and treatment with UD1 and OD1. UD1+OD2-colonic neoplasms and treatment with UD1 and OD2; UD2+OD1-colonic neoplasms and treatment with UD2 and OD1. Single and mixed preparations of UD and OD were applied to mice for six weeks. The colon length and weight and histopathologic changes of colon tissue were observed. Serum pro-inflammatory cytokines, including tumor necrosis factor-alpha ($TNF-{\alpha}$) and interleukin-6 (IL-6), were determined by enzyme-linked immunosorbent assay. The mRNA expression levels of Bax, Bcl-2, and interferon-gamma ($INF-{\gamma}$) were measured by RT-PCR. Results: The colon length was significantly increased in OD, UD1+OD2, and UD2+OD1 mice, and the colon weight was significantly decreased in OD and UD1+OD2 mice. The morphological change of colon epithelial cells was more suppressed in complex-treatment groups than in single-treatment groups. The inhibitory effect on inflammatory cell invasion was especially shown in UD1+OD2 mice. The serum level of the pro-inflammatory $TNF-{\alpha}$ was decreased in all complex-treatment groups, and the IL-6 level was decreased in UD1+OD1 mice. Single-treatment groups had an increase in the mRNA expression of the pro-apoptosis regulator Bax, and UD2+OD1 decreased the mRNA expression of the anti-apoptosis regulator Bcl-2. The mRNA expression of $INF-{\gamma}$ associated with inflammation was decreased in OD and UD1+OD2 mice. Conclusions: This study suggests that single and mixed extracts of Ulmus davidiana and Oldenlandia diffusa have anti-neoplastic and anti-inflammatory effects on AOM/DSS-induced colonic neoplasms in mice. Therefore, we conclude that UD, OD, and a mixture of UD and OD are potential therapeutic agents for colitis-associated colonic neoplasms.

• Journal of Korean Society of Transportation
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• v.21 no.1
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• pp.53-63
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• 2003

The Origin-Destination(OD) matrix is very important in describing transport movements in a region. The OD matrix can be estimated using traffic counts on links in the transport network and other available information. This information on the travel is often contained in a target OD matrix and traffic counts in links. To estimate an OD matrix from traffic counts, they are the major input data which obviously affects the accuracy of the OD matrix estimated, Generally, the quality of an estimated OD matrix depends much on the reliability of the input data, and the number and locations of traffic counting points in the network. Any Process regarding the traffic counts such as the amount and their location has to be carefully studied. The objective of this study is to select of the optimal location of traffic counting points for the OD matrix estimation. The model was tested in nationwide network. The network consists of 224 zones, 3,125 nodes and 6,725 links except to inner city road links. The OD matrix applied for selection of traffic counting points was estimated to 3-constrained entropy maximizing model. The results of this study follow that : the selected alternative to the best optimal counting points of six alternatives is the alternative using common links of OD matrix and vehicle-km and traffic density(13.0% of 6,725 links), however the worst alternative is alternative of all available traffic counting points(44.9% of 6,725 links) in the network. Finally, it should be concluded that the accuracy of reproduced OD matrix using traffic counts related much to the number of traffic counting points and locations.

• Journal of Korean Society of Transportation
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• v.23 no.4 s.82
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• pp.57-69
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• 2005

The goal of this paper is to develop freeway Origin-Destination (OD) demand estimation model using real-time traffic data collected from Freeway Traffic Management System (FTMS). In existing research, the micro-simulation models had been used to get a link distribution proportion by time process. Because of hi-level problem between the traffic flow model and the optimal OD solution algorithm, it is difficult for the existing models to be loaded at FTMS. The formulation of methodology proposed in this paper includes traffic flow technique to be able to remove the bi-level problem and optimal solution algorithm using a genetic algorithm. The proposed methodology is evaluated by using the real-time data of SOHAEAN freeway, South Korea.

• Journal of Korean Society of Transportation
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• v.22 no.7 s.78
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• pp.17-23
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• 2004

교통정책을 평가하기 위해 기본적으로 요구되는 Data 중 가장 근본이 되는 것이 OD이다. 기존의 교통정책을 평가함에 있어서 일반적으로 사용되고 있는 OD는 AADT(Annual Average Daily Traffic) OD이다. 계절별 평일/주말 교통량의 분산이 매우 크다는 것은 기존 조사나 연구로 익히 알려진 사실이며, 또한 사회 경제적인 여건의 변화 및 주 5일제 근무제의 시행 등으로 여가통행의 비중이 높아짐에 따라 평일과 주말의 교통량의 분산은 더욱 커질 것으로 예상된다. 따라서 교통정책을 평가하는 방법도 AADT OD의 일률적인 적용이 아닌 교통량의 계절별 평일/주말의 분산을 적용시킨 OD를 가지고 교통정책을 평가하는 방법이 교통정책을 결정함에 있어 오류를 범할 가능성을 적게 될 것으로 예상된다. 기존 연구에서는 이러한 교통량의 분산의 보정을 지점교통량에 한정하여 보정하고 있어 실질적인 네트워크 분석에 적용하기에는 무리가 있다. 이에 본 연구에서는 관측된 TCS Data를 이용하여 계절별 평일/주말의 OD 교통 패턴을 분석하여 계절별 평일/주말의 OD 교통패턴을 반영할 수 있는 보정계수를 산출하고 산출된 보정계수에 따라 AADT OD를 보정하여 네트워크 분석의 기초 자료를 구축하였다. 수정된 OD 교통량의 검증을 위하여 기존의 AADT OD의 인구당 통행발생비율과 계절별 평일/주말 OD의 통행발생량을 비교하였다. 그 결과 소수점 두 자리수에서 오차가 발생하여 비교적 합리적인 OD가 추정되었다. 또한 기존의 AADT OD를 이용하여 정책 결정을 할 때의 오류 가능성을 보이기 위하여 각 계절별 평일/주말 OD 교통량과 기존의 AADT OD를 입력 자료로 각각의 네트워크 분석 후 총통행시간의 차이를 분석하였다. 그 결과 정책 결정에 영향을 미칠 수 있을 정도의 차이가 있는 것으로 분석되었다.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.3D
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• pp.355-361
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• 2011

In order to properly evaluate ITS services exposed in SMART Highway project, a confident dynamic origin-destination (OD) is inevitably needed. This paper used WAVE communication information as a part of call and response (C&R) communication which constitutes core part of the technology for constructing OD. This information includes node information and vehicle information (e.g., latitude and longitude) as well as trajectory data and sample path volume date calculated using node information and vehicle information. A procedure developed to construct a dynamic OD and to validate OD is consist of 1) making toy network and one-hour 00 (random distribution), 2) collecting link information and vehicle information, 3) constructing five-minute OD, and 4) validating estimated OD result using traffic volume and travel time simultaneously. The constructed OD is about 84.79% correct within less than 20% error range for 15min traffic volume, and about 85.42%, within less than 20% error rate of 15 min travel time. Some limitations and future research agenda have also been discussed.

• Journal of Korean Society of Transportation
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• v.18 no.6
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• pp.89-99
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• 2000

To cope with the limits of conventional O-D trip matrix collecting methods, several approaches have been developed. One of them is bilevel Programming method Proposed by Yang(1995), which uses Sensitivity Analysis Based(SAB) algorithm to solve Generalized Least Square(GLS) problem. However, the SAB a1gorithm has revealed two critical short-comings. The first is that when there exists a significant difference between target O-D matrix and true O-D matrix, SAB algorithm may not produce correct solution. This stems from the heavy dependance on the historical O-D information, in special when gravel Patterns are dramatically changed. The second is the assumption of iterative linear approximation to original Problem. Because of the approximation, SAB algorithm has difficulty in converging to Perfect Stackelberg game condition. So as to avoid the Problems. we need a more robust and stable solution method. The main purpose of this Paper is to show the problem of the dependency of Previous models and to Propose an alternative solution method to handle it. The Problem of O-D matrix estimation is intrinsically nonlinear and nonconvex. thus it has multiple solutions. Therefore it is necessary to require a method for searching globa1 solution. In this paper, we develop a solution algorithm combined with genetic algorithm(GA) , which is widely used as probabilistic global searching method To compare the efficiency of the algorithm, SAB algorithm suggested by Yang et al. (1992,1995) is used. From the results of numerical example, the Proposed algorithm is superior to SAB algorithm irrespective of travel patterns.

• Journal of Audiology & Otology
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• v.23 no.2
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• pp.103-111
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• 2019

Background and Objectives: Dizzy patients with abnormal otolith function tests, despite a normal caloric response, are defined as having specific (isolated) otolith organ dysfunction. This study was performed to compare the differences in clinical presentation between isolated otolith dysfunction (iOD) patients with lab- and Sx-based iOD group and lab-based iOD symptoms. Subjects and Methods: The medical records of 23 iOD patients with normal caloric response but abnormal cervical vestibular evoked myogenic potential (VEMP), ocular VEMP, or subjective visual vertical were reviewed. Non-spinning vertigo was considered as otolith-related symptoms. The patients' age, onset of dizziness, Numeric Rating Scale on the severity of dizziness, and concomitant vestibular disorders were analyzed. Results: Patients in the lab-based iOD group were significantly older than those in the lab- and Sx-based iOD group. Known vestibular disorders were significantly more common in the lab-based iOD group (83.3%) compared to the lab- and Sx-based iOD group (18.2%). Despite the normal caloric response, catch-up saccade was found in the video head impulse test in more than half (54.5%) of the lab-based iOD group patients. There was no catch-up saccade in the lab- and Sx-based iOD group. There were no significant differences in gender ratio, frequency of dizziness attacks, and duration of illness. Conclusions: We propose new definitions of definite iOD (lab- and Sx-based iOD) and probable iOD (lab- or Sx-based iOD). These new definitions may help researchers to identify patients who are more likely to have true iOD, and facilitate comparisons of results between different studies.

• Korean Journal of Audiology
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• v.23 no.2
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• pp.103-111
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• 2019

Background and Objectives: Dizzy patients with abnormal otolith function tests, despite a normal caloric response, are defined as having specific (isolated) otolith organ dysfunction. This study was performed to compare the differences in clinical presentation between isolated otolith dysfunction (iOD) patients with lab- and Sx-based iOD group and lab-based iOD symptoms. Subjects and Methods: The medical records of 23 iOD patients with normal caloric response but abnormal cervical vestibular evoked myogenic potential (VEMP), ocular VEMP, or subjective visual vertical were reviewed. Non-spinning vertigo was considered as otolith-related symptoms. The patients' age, onset of dizziness, Numeric Rating Scale on the severity of dizziness, and concomitant vestibular disorders were analyzed. Results: Patients in the lab-based iOD group were significantly older than those in the lab- and Sx-based iOD group. Known vestibular disorders were significantly more common in the lab-based iOD group (83.3%) compared to the lab- and Sx-based iOD group (18.2%). Despite the normal caloric response, catch-up saccade was found in the video head impulse test in more than half (54.5%) of the lab-based iOD group patients. There was no catch-up saccade in the lab- and Sx-based iOD group. There were no significant differences in gender ratio, frequency of dizziness attacks, and duration of illness. Conclusions: We propose new definitions of definite iOD (lab- and Sx-based iOD) and probable iOD (lab- or Sx-based iOD). These new definitions may help researchers to identify patients who are more likely to have true iOD, and facilitate comparisons of results between different studies.

• Restorative Dentistry and Endodontics
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• v.31 no.6
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• pp.437-444
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• 2006

This study was aimed to elucidate the biological function of OD314 (Apin protein), which is related to ameloblast differentiation and amelogenesis. Apin protein, calcifying epithelial odontogenic (pindborg) tumors (CEOTs)-associated amyloid, were isolated from CEOTs, and has similar nucleotide sequences to OD314. We examined expression of the OD314 mRNA using in-situ hybridization during tooth development in mice. Expression of OD314 and several enamel matrix proteins were examined in the cultured ameloblast cell line up to 28 days by reverse transcription-polymerase chain reaction (RT-PCR) amplification. After inactivation and over-expression of the OD314 gene in ameloblast cell lines using U6 vectordriven RNA interference and CMV-OD314 construct, RT-PCR were performed to evaluate the effect of the OD314 during amelogenesis. The results were as follows: 1. In in-situ hybridization, OD314 mRNAs were more strongly expressed in ameloblast than odontoblast. 2. When ameloblast cells were cultured in the diffcrentiation and mineralization medium for 28 days, the tuftelin mRNA expression was maintained from the beginning to day 14, and then gradually decreased to day 28. The expressions of amelogenin and enamelin were gradually decreased according to the ameloblast differentiation. 3. Inactivation of OD314 by U6-OD314 siRNA construct down-regulated the expression of OD314, MMP-20, and tuftelin, whereas over-expression of OD314 by CMV-OD314 construct up-regulated the expression of OD314 and MMP-20 without change in tuftelin. These results suggest that OD314 is considered as an ameloblast-enriched gene and may play the important roles in ameloblast differentiation and mineralization.

• Journal of Korean Society of Transportation
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• v.20 no.4
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• pp.83-93
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• 2002

To improve the performance of estimation, the research that uses additional information addition to traffic count and target OD with additional survey cost have been studied. The purpose of this paper is to improve the performance of OD estimation by reducing the feasible solutions with cost-efficiently additional information addition to traffic counts and target OD. For this purpose, we Propose the OD estimation method with sample link use proportion as additional information. That is, we obtain the relationship between OD trip and link flow from sample link use proportion that is high reliable information with roadside survey, not from the traffic assignment of target OD. Therefore, this paper proposes OD estimation algorithm in which the conservation of link flow rule under the path-based non-equilibrium traffic assignment concept. Numerical result with test network shows that it is possible to improve the performance of OD estimation where the precision of additional data is low, since sample link use Proportion represented the information showing the relationship between OD trip and link flow. And this method shows the robust performance of estimation where traffic count or OD trip be changed, since this method did not largely affected by the error of target OD and the one of traffic count. In addition to, we also propose that we must set the level of data precision by considering the level of other information precision, because "precision problem between information" is generated when we use additional information like sample link use proportion etc. And we Propose that the method using traffic count as basic information must obtain the link flow to certain level in order to high the applicability of additional information. Finally, we propose that additional information on link have a optimal counting location problem. Expecially by Precision of information side it is possible that optimal survey location problem of sample link use proportion have a much impact on the performance of OD estimation rather than optimal counting location problem of link flow.