• Journal of Radiopharmaceuticals and Molecular Probes
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• v.8 no.2
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• pp.95-101
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• 2022

Microfluidic radioimmunoassay (RIA) platform called µ-RIA spends less reagent and shorter reaction time for the analysis compared to the conventional tube-based radioimmunoassay. This study reported the design of µ-RIA chips optimized for the gamma counter which could measure the small samples of radioactive materials automatically. Compared with the previous study, the µ-RIA chips developed in this study were designed to be compatible with conventional RIA test tubes. And, the automatic gamma counter could detect radioactivity from the ¹²⁵I labeled anti-PSA attached to the chips. Effects of the multi-layer microchannels and two-phase flow in the µ-RIA chips were investigated in this study. The measured radioactivity from the ¹²⁵I labeled anti-PSA was linearly proportional to the number of stacked chips, representing that the radioactivity in µ-RIA platform could be amplified by designing the chips with multi-layers. In addition, we designed µ-RIA chip to generate liquid-gas plug flow inside the microfluidic channel. The plug flow can promote binding of the biomolecules onto the microfluidic channel surface with recirculation in the liquid phase. The ratio of liquid slug and air slug length was 1 : 1 when the ¹²⁵I labeled anti-PSA and the air were injected at 1 and 35 µL/min, respectively, exhibiting 1.6 times higher biomolecule attachment compared to the microfluidic chip without the air injection. This experimental result indicated that the biomolecular reaction was improved by generating liquid-gas slugs inside the microfluidic channel. In this study, we presented a novel µ-RIA chips that is compatible with the conventional gamma counter with automated sampler. Therefore, high-throughput radioimmunoassay can be carried out by the automatic measurement of radioactivity with reduced radiowaste generation. We expect the µ-RIA platform can successfully replace conventional tube-based radioimmunoassay in the future.

• Journal of the Korean Society of Propulsion Engineers
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• v.13 no.3
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• pp.27-33
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• 2009

A computational study has been performed out to evaluate the effect of a vertical porous barrier on the pressure oscillations in a supersonic cavity. The porous barriers with different perforations were vertically installed into a rectangular cavity at Mach numbers 1.50, 1.83 and 2.50. TVD finite difference MUSCL scheme was employed to solve the two-dimensional, unsteady, compressible Navier-Stokes equations. The present vertical porous barrier considerably altered the characteristics of the time-dependent shear layers that occur at the upstream edge of cavity and remarkably reduced the pressure oscillations inside the supersonic cavity. The present results showed that the effectiveness of passive control using the present porous vertical barrier is dependent on Mach number and the perforation of the porous barrier.

• Parasites, Hosts and Diseases
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• v.23 no.1
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• pp.47-58
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• 1985

An experimental study was performed to observe the in vivo effects of praziquantel on the light and scanning electron microscopic morphology of Fibricola seoulensis. The metacercariae were obtained from the snakes and 1, 000 in each number was orally given to total 15 albino rats; 5 controls and 10 treatment group. Seven days later the 10 rats were treated with 10 mg/kg praziquantcl and sacrificed 1~24 hours later to search for the worms from their small intestines. The major light microscopic changes in the drug-exposed worms were early contraction followed by relaxation of especially their forebody, vacuolization of the tegument and subtegumental parenchymal layers, and narrowing of the intestinal lumens. The scanning electron microscopic findings were characterized by formation of numerous blebs followed by rupture and subsequent destruction of their whole teguments. These results show that the change in worm body is not confined to the tegument but extends to deeper parenchymal portions and also occurs in their intestines. It is suggested that the drug uptake by the worms should be either through their tegument or through the digestive tract.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.17 no.5 s.122
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• pp.405-414
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• 2007

In recent years, experimental and theoretical studies show that turbulent flows looking disordered have a definite structure produced repetitively with visible order. As a core structure of turbulence, hairpin vertices are believed to play a major role in developing and sustaining the turbulence process in the near wall region of turbulent boundary layers and may be regarded as the simplest conceptual model that can account for the essential features of the wall pressure fluctuations. In this work, fully developed typical hairpin vortices are focused and the associated surface pressure distributions and their corresponding spectra are estimated. On the basis of the attached eddy model, the overall surface pressure spectra are represented in terms of the eddy size distribution. The model is validated by comparison of predicted wavenumber spectra with existing empirical models, the results of direct numerical simulation (DNS) and also spatial correlations with experimental measurements.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.7
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• pp.726-733
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• 2017

A magnetic shutter gear is a device that transfers mechanical power by synchronizing the magnetic field between permanent magnet layers facing circumferentially through a harmonic modulator. However, magnetic gears uses many rare-earth permanent magnets to guarantee comparable torque density to that of mechanical reducer. Hence, we propose a novel axial magnetic gear with a dramatically reduced number of permanent magnets and a closed magnetic path. The torque of the system was compared to that of an existing shutter gear through a harmonic analysis of the air-gap magnetic field. The modulator thickness and open ratio were considered as the primary design parameters, and the cogging effect was analyzed for variation of the reduction ratio. A dynamic model between the high-speed side and low-speed side was derived, and position control was performed for a constructed hardware implementation.

• Journal of Korea Multimedia Society
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• v.15 no.3
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• pp.299-311
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• 2012

Recently, H.264 SE(scalable extension) has become a standard of next generation multimedia service which is one source, multi-user service in the telecommunication environment of different kinds of networks and terminal equipments. But existing DRM schemes for multimedia service are not fit for H.264 SE system. Because the amount of transmitted multimedia data is changed considering network environment and terminal equipments' performance by the system, but in the existing DRM schemes, the amount of handled multimedia data are not variable according to network environment and terminal equipments' performance. In this paper, an information security scheme combined video watermarking and encryption is presented for H.264 SE. Amount of watermarks and embedding positions are calculated by the frame number of enhancement layers which are created according to the state of networks and terminal equipments. In order to minimize delayed time by video watermarking and encryption, the video data are watermarked and encrypted in the H.264 SE compression process. In the experimental results, we confirmed that proposed scheme is robust against video compression, general signal processing and geometric processing.

• The Transactions of the Korea Information Processing Society
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• v.7 no.8
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• pp.2543-2554
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• 2000

Packet schedulers for real-time communication must provide bounded delay and efficient use of network resources such as bandwidth, buffers and so on. In order to satisfy them, a large number of packet scheduling methods have been proposed. Among packet scheduling methods, an EDF (Earliest Deadline First) scheduling is the optimal one for a bounded delay service. A disadvantage of EDF scheduling is that queued packets must be sorted according to their deadlines, requiring a search operation whenever a new packet arrives at the scheduler. Although an RPQ (Rotating Priority Queue) scheduler, requiring large size of buffers, does not use such operation, it can closely approximate the schedulability of an EDF scheduler. To overcome the buffer size problem of an RPQ scheduler, this paper proposes a new scheduler named MRPQ (Multiple Rotating Priority Queue). In a MRPQ scheduler, there are several layers with a set of Queues. In a layer, Queues are configured by using a new strategy named block Queue. A MRPQ scheduler needs nearly half of buffer size required in an RPQ scheduler and produces schedulability as good as an RPQ scheduler.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.37 no.7
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• pp.683-693
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• 2013

In this study, the mixing characteristics in lid-driven cavity flows were studied numerically by using a hybrid lattice Boltzmann method (HLBM). First, we compared the numerical results from single-relaxation-time (LB-SRT) and multi-relaxation-time (LB-MRT) models to examine their reliability. In most of the cavity flow, the results from both the LB-SRT and the LB-MRT models were in good agreement with those using a Navier-Stokes solver for Re=100-5000. However, the LB-MRT model was superior to the LB-SRT model for the simulation of higher Reynolds number flows having a geometrical singularity with much lesser spatial oscillations. For this reason, the LB-MRT model was selected to study the mass transport in lid-driven cavity flows, and it was demonstrated that mass transport in the fluid was activated by a recirculation zone in the cavity, which is connected from the top to the bottom surfaces through two boundary layers. Various mixing characteristics such as the concentration profiles, mean Sherwood (Sh) numbers, and velocity were computed. Finally, the detailed transport mechanism and solutions for the concentration profile in the cavity were presented.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.9
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• pp.1227-1233
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• 2010

In the hot section of a gas turbine, the turbine blades were protected from high temperature by providing a thermal barrier coating (TBC) as well as by cooling air flowing through internal passages within the blades. The cooling air then passed through discrete holes on the blade surface, creating a film of cooling air that further protects the surface from the hot mainstream flow. The holes are subjected to stresses resulting from the lateral growth of thermally grown oxide, the thermal expansion misfit between the constituent layers, and the centrifugal force due to high-speed revolution; these stresses often result in cracking. In this study, the deformation and cracks occurring near a hole on a heat-resistant alloy subjected to thermo-mechanical cycling were investigated. The experiment showed that cracks formed around the hole depending on the applied stress level and the number of cycles. These results could be explained by our analytic solution.

• Journal of the Korea institute for structural maintenance and inspection
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• v.14 no.6
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• pp.85-92
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• 2010

Recently the earthquake occurrences in Korea are likely to increase. Therefore, the facilities such as bridges and tunnels under the unexpected earthquakes need to be enhanced. Especially most of the subways previously built before 1988 have not been seismically designed, so their seismic safety requirements are required to be inspected and/or reinforced. In this study, the seismic reinforcement using FRP-ductile material layered composites was proposed to reinforce for the subway columns. Material properties of FRP-ductile material layered composites were calculated by laboratory tests considering the laminated conditions of the composites. Numerical simulations were performed using the experimental results of the specimens and the calculated properties of the composites. Seismic performance varied according to the types of composites: ductile material, number of layers, fiber orientations.