• 대한수의학회지
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• 제59권3호
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• pp.165-169
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• 2019

A 6-year-old Dachshund was presented with acute, non-localized pain without neurological dysfunction. Radiography revealed multiple calcifications of intervertebral discs and narrowing of disc space in the thoracolumbar region. Computed tomography and magnetic resonance imaging revealed calcified disc-like material entrapped in the left extraforaminal area and showed a displaced nerve root. Fenestration and removal of the extruded disc material were performed in a routine manner. Histopathological examination showed degenerative disc materials with severe calcification both in the nucleus pulposus and around the annulus fibrosis. Based on imaging, surgical, and histopathologic results, the dog was diagnosed with far lateral lumbar disc extrusion.

• 대한정형도수물리치료학회지
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• 제25권1호
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• pp.77-81
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• 2019

Background: The Purpose of this study was investigated the effects of the Self Sling Suspension on the numbness, radiated pain, visual analogue scale (VAS), Cobb's angle, Jochumsen's depth, neck disabliity index (NDI). Methods: This study was carried out with a 4 forward head posture (FHP) & 4 herniated nucleus pulposus (HNP) survivors. Outcomes such as the Numbness, Radiated Pain, VAS, Cobb's angle, Jochumsen's depth and NDI were measured pre- and post-intervention for both groups. Results: 2 HNP decrease was found numbness & radiated pain. After the intervention, was decreased VAS, NDI and was increased Cobb's angle, Jochumsen's depth. Conclusions: Applying Self Sling Suspension treatment to FHP & HNP patients proved to have a positive effect.

• 폴리머
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• 제31권1호
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• pp.14-19
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• 2007

탈미네랄화된 골분(demineralized bone particle, DBP)은 골/연골 형성의 강력한 유도인자로 사용된다. 본 연구에서는 용매 캐스팅/염 추출법을 이용해 함량별 DBP와 PLGA가 하이브리드화된 다공성 지지체를 실제 디스크 형태와 유사하게 제조하였다. 제조된 지지체의 특성을 분석하기 위하여 다공도, 표면 젖음성 및 물 흡수성을 측정하였다. 디스크 세포인 섬유륜 및 수핵 세포는 토끼로부터 분리하여 제조된 지지체에 각각 파종한 후, 지지체를 재조합하여 배양하였다. 지지체에 파종된 디스크 세포의 생존율과 증식률은 MTT(3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium-bromide) 분석 방법을 이용하였고, 면역결핍 쥐의 피하에 삽입하여 이들의 디스크 조직 형성 정도를 확인하였다. 피하에 이식된 지지체를 적출하여 육안으로 관찰하고 모폴로지의 변화를 확인한 후, 조직을 파라핀으로 고정시켜 슬라이드를 제조하여 hematoxylin과 eosin 염색을 수행하였다. 천연/합성 하이브리드 담체로서의 DBP/PLGA 담체가 PLGA 단독으로 사용하였을 때와 비교하여 볼 때 디스크 조직의 형성이 우수하였으며, 특히 20, 40%의 DBP가 함유된 지지체가 세포의 성장과, 디스크 조직화에 유리함을 확인하였다.

• Journal of Acupuncture Research
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• 제23권3호
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• pp.21-35
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• 2006

Objectives : Herniation of Nucleus Pulposus(HNP) of Cervical is the most important reason that causes Cervical pain. The aim of this study is to investigate the effectiveness of Carthmi-Flos Herbal acua-acupuncture therapy for Cervical disc Herniation patients. Methods : To evaluate the effectiveness of Carthmi-Flos Herbal acua-Acupuncture Therapy, 20 patients were treated by Carthmi-Flos Herbal acua-acupuncture therapy. To estimate the efficacy of treatment, we used Quardruple Visual Analog Scale (QVAS). Results & Conclusion : 1. As a objectivity treatment record, they test treatment record good 35%, fair 35%, excellent 30%. 2. After Carthmi-Flos acua-acupuncture therapy, pain rate changed from 8.80 to 5.40 3. By the results which puts out the statistics in sex , a pain rate of male changed from 8.57$({\pm}1.51)$ to 2.71$({\pm}2.63)$, a pain rate of female 8.92$({\pm}0.95)$ to 3.77$({\pm}2.09)$. Intentional difference is none as a therapy. 4. By the results which puts out the statistics in age, after forties changed from 9.07$({\pm}0.88)$ to 3.80$({\pm}2.43)$ and before forties changed from 8.00$({\pm}1.58)$ to 2.20$({\pm}1.30)$. Intentional difference is none as a therapy. 5. By the results which puts out the statistics in Duration, pain rate of the acutest group changed from 8.36$({\pm}1.12)$ to 2.18$({\pm}1.08)$, pain rate of the subacute group changed from 9.80$({\pm}0.45)$, to 5.20$({\pm}2.68)$, pain rate of the chronic group changed from 8.67$({\pm}1.53)$ to 3.33$({\pm}1.53)$. Intentional difference is none as a therapy. 6. By the results which puts out the statistics in the reading of Lumbar MID, pain rate of the Bulging type changed from 9.00$({\pm}1.05)$ to 4.30$({\pm}2.67)$, pain rate of the Protruded type changed from 8.50$({\pm}1.00)$, to 3.50$({\pm}1.29)$, pain rate of the Extruded type changed from 6.00 to 1.00, pain rate of the Mixed type changed from 9.20$({\pm}0.84)$ to 2.00$({\pm}1.23)$, Intentional difference is none as a therapy.

• The Korean Journal of Pain
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• 제19권2호
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• pp.207-212
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• 2006

Background: The epidural injection technique is a commonly used intervention in the management of chronic spinal pain, which has the advantage of delivering various drugs, such as local anesthetics or steroids, in higher concentrations to the inflamed nerve root. A guidewire-reinforced epidural catheter was introduced through a Tuohy needle during the caudal epidural procedure, with a catheter threaded into the affected nerve roots and the spread-pattern of contrast agents observed under fluoroscopy. Methods: Sixty-seven patients with low back pain, who showed evidence of a herniated nucleus pulposus on magnetic resonance imaging, were included. All patients received fluoroscopically guided caudal epidural injections, with the guidewire-reinforced epidural catheter introduced through a Tuohy needle and threaded either to the right or left side toward the target nerve roots. After confirming the catheter tip position at the affected nerve root, 2 ml increments of contrast agents (up to 6 ml) were injected, and their corresponding AP fluoroscopic views were obtained. Three radiologists reviewed all the radiographic findings and measured the proportion of the area of contrast spread at the side of target nerve roots. Results: Greater proportion of the area of contrast spread was observed at the side of the target nerve roots (P < 0.0001). At each level of contrast injection (2-⁣, 4- ⁣ and 6 ml), more than 70% of the spread of contrast dye was observed at the side of the target nerve roots in 85%, 70%, and 55% of cases, respectively. Conclusions: The combination of a caudal epidural injection and use of a guidewire-reinforced epidural catheter significantly enhances the target specificity, as revealed by the selective spread of contrast dye at the side of target nerves.

• Journal of the Korean Data and Information Science Society
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• 제23권4호
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• pp.727-738
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• 2012

본 연구의 목적은 요추 추간판 탈출증 환자에게 치료적 모달리티와 칵스 신연교정치료 효과에 대하여 알아보고자 한다. 요추 추간판 탈출증 환자 15명 (나이 36.62, 범위 20-50, 남자 7명과 여자 8명)을 대상으로 4주간 적용하였다. 치료적 모달리티와 칵스 신연교정치료를 첫 2주 동안 주 6일, 12회 적용하였으며, 마지막 2주간은 주 3일 6회 적용하였다. 모든 실험대상자에게 4주 동안 18회를 적용하였다. 측정은 오스웨스트리 요통장애지수, 근력, 하지 직거상 검사는 실험 전, 치료 2주 후, 치료 4주 후 변화의 차이를 일요인 반복측정을 이용하였으며, 추간판 탈출지수는 실험 전, 치료 4주 후 변화 차이를 대응표본 t-검정을 이용하여 측정하였다. 치료적 중재 기간에 따라 치료 전, 2주 후, 4주 후 측정결과 오스웨스트리 요통장애 지수, 하지 직거상 검사, 그리고 근력은 치료 2주 후, 치료 4주 후가 치료 전에 비하여 통계학적 유의한 변화가 있었다. 그러나 추간판 탈출지수는 치료 전에 비하여 감소함을 나타냈으나 통계학적으로 유의한 변화는 없었다. 결론적으로 요추 추간판 탈출증 환자에게 치료적 모달리티와 칵스 신연교정치료가 요통장애지수, 하지 직거상 검사, 근력개선에 효과적이란 결론을 얻었다. 이것은 칵스 신연교정치료의 안전성과 효과의 확인, 그리고 요추 추간판 탈출증 환자에게 비수술적 치료법으로서의 근거를 제시하였다.

• Experimental and Molecular Medicine
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• 제50권11호
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• pp.5.1-5.14
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• 2018

Oxidative stress-induced mitochondrial dysfunction is implicated in the pathogenesis of intervertebral disc degeneration (IVDD). Sirtuin 3 (SIRT3), a sirtuin family protein located in mitochondria, is essential for mitochondrial homeostasis; however, the role of SIRT3 in the process of IVDD has remained elusive. Here, we explored the expression of SIRT3 in IVDD in vivo and in vitro; we also explored the role of SIRT3 in senescence, apoptosis, and mitochondrial homeostasis under oxidative stress. We subsequently activated SIRT3 using honokiol to evaluate its therapeutic potential for IVDD. We assessed SIRT3 expression in degenerative nucleus pulposus (NP) tissues and oxidative stress-induced nucleus pulposus cells (NPCs). SIRT3 was knocked down by lentivirus and activated by honokiol to determine its role in oxidative stress-induced NPCs. The mechanism by which honokiol affected SIRT3 regulation was investigated in vitro, and the therapeutic potential of honokiol was assessed in vitro and in vivo. We found that the expression of SIRT3 decreased with IVDD, and SIRT3 knockdown reduced the tolerance of NPCs to oxidative stress. Honokiol ($10{\mu}M$) improved the viability of NPCs under oxidative stress and promoted their properties of anti-oxidation, mitochondrial dynamics and mitophagy in a SIRT3-dependent manner. Furthermore, honokiol activated SIRT3 through the AMPK-PGC-$1{\alpha}$ signaling pathway. Moreover, honokiol treatment ameliorated IVDD in rats. Our study indicated that SIRT3 is involved in IVDD and showed the potential of the SIRT3 agonist honokiol for the treatment of IVDD.

• 대한물리치료사협회지
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• 통권3호
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• pp.11-18
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• 1981

A Clinical Study of physical Therapy on the Low Back Conditions J. B. Rhee, S. K. fang, D. J, Han Low back pain usually is due primarily to a faulty mechanics, ,dis'c disease and other contributing factors .Conservative treatment of low back pain is considered to be useful with applicationes physical therapeutic measures including elimination of gravity, but surgical treatment is alternative to conservative .This study 1s conducted to analyse and evaluate efficiency of physical therapy on the low back pain on 452 cases who were treated at the Korea University Hospital, from January 1, 1978 to December 31. 1978.The results obtained in this study are summarized as follows :1. Sex distribution of total rationㄷs surveyed showed that 5l.3% in male and 487% in female.2 . In the age distrbution. the mest Liedominant age group was 25-54 years with7O.8 % .3 . The most proportion of the cases by occupation was housewife 27.7%, clerical and office workers 2l.7% , students 12.8% and labours 12.2 % respectively .4 . The most common causes of low back conditions classified, the Strain or Trau-rla revealed the highest frequency with 58.4% and thc Herniated Nucleus Pulpe-sus with 29.2 % of the total.5 . The modalities of physical therapy suitable to each cases were applied : 94.0%of all cases were treated with deep thermotherapy, 91.4 % hydrocollator steampack, 86.7% strengthening exercise of the weak muscles, pelvic traction 34.1%.6 . In regard to the duration required for the physical therapy. Herniated Nucleus Pulposus were approximately 4 weeks and strain or trauma were 2 weeks.7 . The improvement by physical therapy on lcw back conditions was classified in-to 41grades and showed following reaulits , excellent 42.5%, good 37.8%, fair 13.7% and poor 6.0% respectively.

• 한방재활의학과학회지
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• 제20권4호
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• pp.131-138
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• 2010

Objectives : Recently work-related musculoskeletal disorders have increased in various workplaces and many reports have been confirming this, but a comparative study on incidence of spinal disease by occupation has not been established yet. So this study was designed to clarify the distinction on incidence of spinal disease between white and blue collar workers. Methods : The subjects who visited with spinal disease to Ja-Seng oriental hospital from January to April in 2020 were selected and divided into white collar workers(n=844) and blue collar workers(n=333). We counted the number of patients with each spinal disease in both groups and carried out comparative analysis in five items(herniated nucleus pulposus(HNP), stenosis, spondylosis, sprain, etc). All data were analyzed by chi-square test. Results and Conclusions : Whit collar workers had higher incidence in HNP(p=0.030), sprain(p=0.016),etc(p=0.035) than blue collar workers, while blue collar workers had higher incidence in stenosis(p=0.002). But we think that the confidence is low in stenosis because the number of cases are very small. There were no significance between two groups with spondylosis.

• 대한기계학회논문집A
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• 제26권2호
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• pp.234-242
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• 2002

A shape optimal design of synthetic intervertebral disc prosthesis is performed using a three-dimensional finite element method. Geometric parameters are introduced to model the cross-sectional geometry of the intervertebral disc. It is assumed that the total strain energy in the intact intervertebral disc is minimized under the normal load conditions, as often cited in other references. To calculate the stain energy density, both the nonlinear material properties and the large deformations are taken into account. The design variables of the annulus fiber angle and the area ratio of the nucleus pulposus are calculated as 31°and 30%, respectively, which complies well with the intact disc. Thus, the same optimization procedure is applied to the design of the synthetic intervertebral disc prosthesis whose material properties are different from the intact disc. For the given synthetic material properties, the values of 67°and 24% for the fiber angle and the area ratio are obtained.