• Nuclear Engineering and Technology
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• v.53 no.12
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• pp.4067-4071
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• 2021

The ¹³C (α,n)¹⁶O reaction cross-section is important data for nuclear physics, astrophysical, and neutrino physics experiments, however, they exhibit uncertainties due to the discrepancies in the experimental data. In this study, using the Nedis-2m program code, the energy spectrum of α-induced neutrons in a thin carbon target was calculated and the corresponding reaction cross-section was refined in the alpha particle energy range of 5-8 MeV. The results were used to calculate the intensity and energy spectrum of background neutrons produced in the liquid scintillator of KamLAND. The results will be useful in a variety of astrophysical and neutrino experiments especially those based on LS or Gd-LS detectors.

• Nuclear Engineering and Technology
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• v.41 no.1
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• pp.1-10
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• 2009

The safe and reliable performance of fusion and fission plants depends on the choice of suitable materials and an assessment of long-term materials degradation. These materials are degraded by their exposure to extreme conditions; it is necessary, therefore, to address the issue of long-term damage evolution of materials under service exposure in advanced plants. The empirical approach to the study of structural materials and fuels is reaching its limit when used to define and extrapolate new materials, new environments, or new operating conditions due to a lack of knowledge of the basic principles and mechanisms present. Materials designed for future Gen IV systems require significant innovation for the new environments that the materials will be exposed to. Thus, it is a challenge to understand the materials more precisely and to go far beyond the current empirical design methodology. Breakthrough technology is being achieved with the incorporation in design codes of a fundamental understanding of the properties of materials. This paper discusses the multi-scale, multi-code computations and multi-dimensional modelling undertaken to understand the mechanical properties of these materials. Such an approach is envisaged to probe beyond currently possible approaches to become a predictive tool in estimating the mechanical properties and lifetimes of materials.

• Journal of Ginseng Research
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• v.47 no.3
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• pp.440-447
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• 2023

Background: The human hair follicle undergoes cyclic phases-anagen, catagen, and telogen-throughout its lifetime. This cyclic transition has been studied as a target for treating hair loss. Recently, correlation between the inhibition of autophagy and acceleration of the catagen phase in human hair follicles was investigated. However, the role of autophagy in human dermal papilla cells (hDPCs), which is involved in the development and growth of hair follicles, is not known. We hypothesized that acceleration of hair catagen phase upon inhibition of autophagy is due to the downregulation of Wnt/β-catenin signaling in hDPCs, and that components of Panax ginseng extract can increase the autophagic flux in hDPCs. Methods: We generated an autophagy-inhibited condition using 3-methyladenine (3-MA), a specific autophagy inhibitor, and investigated the regulation of Wnt/β-catenin signaling using the luciferase reporter assay, qRT-PCR, and western blot analysis. In addition, cells were cotreated with ginsenoside Re and 3-MA and their roles in inhibiting autophagosome formation were investigated. Results: We found that the unstimulated anagen phase dermal papilla region expressed the autophagy marker, LC3. Transcription of Wnt-related genes and nuclear translocation of β-catenin were reduced after treatment of hDPCs with 3-MA. In addition, treatment with the combination of ginsenoside Re and 3-MA changed the Wnt activity and hair cycle by restoring autophagy. Conclusions: Our results suggest that autophagy inhibition in hDPCs accelerates the catagen phase by downregulating Wnt/β-catenin signaling. Furthermore, ginsenoside Re, which increased autophagy in hDPCs, could be useful for reducing hair loss caused by abnormal inhibition of autophagy.

• The Korean Journal of Nuclear Medicine
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• v.39 no.2
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• pp.69-74
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• 2005

Ever since it was first introduced as a method of scintigraphically measuring regional myocardial perfusion, myocardial perfusion study has been widely used in patients diagnosed or suspected with coronary artery diseases, and continuously improved upon. In addition to the technological enhancement of nuclear medicine equipments, the innovation of radiopharmaceuticals used in the cardiac exams were important contributors to such improvement. Besides the cardiac perfusion studies, new radiopharmaceuticals that visualize fat metabolism or receptors of the sympathetic nervous system have successfully been applied to clinical practice. More information can be collected before diagnosing coronary vascular disease, evaluating the patient's condition, or assessing therapeutic effects. In this review article, the clinical efficacy and characteristics of radiopharmaceutical products tailored for cardiac SPECT that are commonly used in Korea currently, plus the ones not being used yet but have proven value are briefly described.

• Nuclear Engineering and Technology
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• v.55 no.3
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• pp.1015-1020
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• 2023

A multi-layer design is applied to mitigate single event effect (SEE) in a 28 nm System-on-Chip (SoC). It depends on asymmetric multiprocessing (AMP), redundancy and system watchdog. Irradiation tests utilized 70 and 90 MeV proton beams to examine its performance through comparative analysis. Via examining SEEs in on-chip memory (OCM), compared with the trial without applying the multi-layer design, the test results demonstrate that the adopted multi-layer design can effectively mitigate SEEs in the SoC.

• Nuclear Medicine and Molecular Imaging
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• v.43 no.3
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• pp.174-178
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• 2009

Many radiopharmaceuticals have been developed and wildy used in the imaging cardiac function. Myocardial perfusion imaging (MPI) is a well established noninvasive method of assessing coronary blood flow and has been widely used in patients diagnosed or suspected with coronary artery diseases. The innovation of radiopharmaceuticals used in the cardiac imaging is one of the most important contributors to the development of nuclear cardiology. Thallium-201 and various technetium-99m agents have been globally used for myocardial perfusion SPEG, and N-13 ammonia (13NH3), rubidium-82 (82Rb), 0-15 water (H2150) for myocardial perfusion PET. As well as the cardiac perfusion studies, new radiopharmaceuticals that visualize fat metabolism or receptors of the sympathetic nervous system have successfully been applied to clinical practice. Useful information can be obtained for diagnosing coronary artery disease, evaluating patients' condition, or assessing therapeutic effects. In this review, we describe the characteristics and clinical usefulness of radiopharmaceuticals used for cardiac SPEG and PET.

• Korean Journal of Pharmacognosy
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• v.46 no.4
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• pp.295-302
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• 2015

Cynanchi wilfordii Radix roots have been utilized as traditional medicine for variety of diseases including diabetes mellitus, aging progression and scavenging free radicals, enhancing immunity, reducing high serum cholesterol, and anti-tumor activity. However, the mechanisms underlying this effect remain poorly understood. The principal objective of this study was to determine the effect of cynandione A on osteoclast cells. Thus, we was isolated cynandione A from Cynanchi wilfordii Radix roots and evaluated the effect of cynandione A on receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL)-induced osteoclast differentiation. We found that cynandione A significantly inhibited osteoclast differentiation stimulated-RANKL in RAW 264.7 cells. Cynandione A conspicuously inhibited the mRNA and protein expression of matrix metallopeptidase 9 (MMP-9), tartrate-resistant acid phosphatase (TRAP) in cynandione A treated with RANKL. Taken together, our results demonstrated that Cynanchi Wilfordii Radix may be useful treatment option of bone-related disease such as osteoporosis leads to fracture of bone and rheumatoid arthritis.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2002.05b
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• pp.221-228
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• 2002

In viewing R&D as a series of activities of problem solving in the course of technological learning in developing countries, national R&D is very likely to play an pivotal role in incubating and improving industrial technology and competitiveness, especially for S&T-intensive industries, such as nuclear fuel industry. To this end, the national R&D needs to be primarily designed to reinforce technological capabilities of the country including government research institutes (GRIs), industrial firms, etc., from the initial stage of absorption as well as at the innovation stage. Based on this strategic role, national R&D performed by GRIs should provide scientific knowledge and core technologies which are required for the absorbption of foreign technology and development of indigenous technological capabilities with which domestic technological efforts are made to successfully achieve not only technological imitation but also innovation in global sense.

• Journal of Korea Technology Innovation Society
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• v.20 no.4
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• pp.1057-1088
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• 2017

This research has attempted to conduct meta-analysis on 605 published papers in the field of socio-nuclear studies from 1957 to 2016 in Korea through network analysis of author-provided keywords. The findings lead to several straightforward conclusions. First, socio-nuclear studies including policy research have mostly been conducted by universities, while technology developments have been led by public organizations. Second, it is apparent that the Fukushima accident has provoked major engagement among social scientists in nuclear issues as the remarkable growth of the knowledge network after 2011 signify. Third, the research topics have been diversified as a result of growing multi-disciplinary research projects. Finally, there is between sub communities in the socio-nuclear knowledge network in terms of network properties. This article provides a stepping stone for future researchers with a wealth of information concerning the status of socio-nuclear studies. For policy makers, this meta-analysis is likely to provide guidance on what we need and do not need. It remains to be seen whether the socio-nuclear knowledge network in Korea is well-structured or not. provide an impetus for comparative studies with overseas cases in order to evaluate the network and its soundness.

• Nuclear industry
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• v.37 no.6
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• pp.49-65
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• 2017

본고는 지난 6월 12일 미 캘리포니아 버클리에서 열린 미국원자력학회(ANS) Annual Meeting(6.12~15)에서 Michael Shellenberger 회장이 강연한 내용이다. 이날 기조강연자는 Shellenberger 회장이 유일했다. Shellenberger 회장은 강연 서두에서 "원자력의 평화적 이용을 전파하기 위해 전력을 다하고 있는 한국과 대만을 위시하여 미국의 오하이오와 펜실베이니아, 독일과 프랑스의 원자력 휴머니스트 여러분들께 오늘의 이 말씀을 전하고 싶다."고 밝혔다.