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Genetic Characteristics and Immunogenicity of Pandemic H1N1 Influenza Virus Isolate from Pig in Korea

  • Hyoung Joon Moon;Jin Sik Oh;Woonsung Na;Minjoo Yeom;Sang Yoon Han;Sung Jae Kim;Bong Kyun Park;Dae Sub Song;Bo Kyu Kang
    • IMMUNE NETWORK
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    • v.16 no.5
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    • pp.311-315
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    • 2016
  • A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/California/04/2009, with >99% sequence similarity in the HA, NA, M, NS, NP, PA, PB1, and PB2 genes. The isolated strain was inactivated and used to prepare a swine influenza vaccine. This trial vaccine, containing the new isolate that has high sequence similarity with the pandemic influenza A (H1N1) virus, resulted in seroconversion in Guinea pigs and piglets. This strain could therefore be a potential vaccine candidate for swine influenza control in commercial farms.

Sustainable construction material using nanosilica and multi-walled carbon nanotubes in cement concrete

  • Breetha Yesudhas Jayakumari;Elangovan Nattanmai Swaminathan;Pachaivannan Partheeban
    • Advances in nano research
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    • v.16 no.5
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    • pp.459-472
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    • 2024
  • Nanotechnology is a popular field in the construction industry due to its multiple functions. It mitigates CO2 emissions and enhances the desirable properties of concrete by replacing small amounts of cement with supplements. This study assess the sustainability impact of using two different nanoparticles partially replacing the cement with 0.3%, 0.6%, 1.0% of nano silica (NS) and 0.03%, 0.045%, 0.06% of Multi-Walled Carbon Nanotubes (MWCNT) in the green concrete mix developement. Nano-sized fragments at the atomic scale tends to modify the properties of concrete. Concrete may increase its strength, durability by adding nanocomposite materials, which will decrease the amount of nano and micropores in structural parts. The strength of the structural elements can be greatly improved and allowing them to withstand higher loads and resist deformation. It improved durability properties by 64.8% in water absorption, 56.4% in acid attack, 78.1% in sulphate attack, and 53.4% in chloride attack. There was an improvement in compressive strength of 37% and split tensile strength of 90%. SEM, FTIR, and XRD investigations have used to look at the microstructural characteristics of nanoconcrete dictated the microstructure characteristics may be made more consistent and dense by adding nanocomposite materials.

TCP-DAD: Dynamically Adjusted Dupthresh Mechanism for Improving the Robustness of TCP against Packet Reordering (TCP-DAD: 중복 응답 임계값의 동적 조절을 통한 TCP의 패킷 재배치 내성 향상 기법)

  • Park, Min-Woo;Lee, Jae-Min;Kim, Jong-Myoung;Han, Young-Ju;Chung, Tai-Myoung
    • Proceedings of the Korea Information Processing Society Conference
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    • 2007.11a
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    • pp.978-981
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    • 2007
  • TCP(Transmission Control Protocol)는 흐름제어와 오류제어 그리고 혼잡제어 등을 통해 목적지까지 효율적으로 데이터를 전송하는 프로토콜이다. 최근 라우터 성능 및 라우팅 알고리즘 등의 발달로 인해 패킷이 비순차적으로 전송되는 패킷 재배치(packet reordering)가 빈번한 발생하여 TCP 성능 저하의 주요 원인이 되고 있다. 패킷 재배치가 TCP 로 하여금 불필요한 재전송(Spurious Retransmission) 및 혼잡제어를 수행하도록 하기 때문이다. 본 논문에서는 TCP 의 신속 재전송(Fast Retransmission)의 중복 응답 임계값(dupthresh)를 동적으로 조절함으로써, 불필요한 재전송 및 혼잡제어의 발생횟수를 효율적으로 줄이는 TCP-DAD(TCP Dynamically Adjusted Dupthresh)기법을 제안한다. 본 논문은 NS-2를 이용한 시뮬레이션을 통해 TCP-DAD 가 다른 TCP 메커니즘보다 평균적으로 약 34%의 성능 향상을 보임을 증명하였다.

Assessment of Nutritional Status before TPN Support of Hospitalized Patients (입원환자의 TPN 투여전 영양상태 평가)

  • Park, Hyoung-Sook;Lee, Soo-Kyeong;Ha, Mi-Jeong
    • Journal of Korean Academic Society of Home Health Care Nursing
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    • v.9 no.2
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    • pp.69-77
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    • 2002
  • The purpose of this study was to assessment of hospitalized patients. Nutritional assessment was performed on 353 hospitalized patients before TPN support by ideal body weight. albumin, total lymphocyte count, cholesterol. The data analysis were performed on frequency, percentage, means and standard deviation. The major findings as follows: 1. Everage NPO duration was $6.77\pm5.39$day and $\geq5$days 48.9%, >5days 51.1%. NPO duration of 1M, NL, GS, Others prolonged. 2. %IBW was everge $94.86\pm17.21%$ 43.1% normal. 37.8% low weight. There were low weight IM 44.8%. TS 47.8%, Others 44.0%. 3. Albumin was everage $2.93\pm0.51$g/dl. moderate malnutrition 45.4%, mild malnutrition 30.9%. All session were malnutrition status. 4. Total lymphocyte count was ever age $960.41\pm721.32cell/mm^2$. severe malnutrition 43.9%. moderate malnutrition 29.0%, mild malnutrition 24.4%, normal 2.7%. All session were malnutrition status. 5. Cholesterol was everage $123.02\pm45.67$mg/dl 58.4% low level. 41.2% normal. 0.4% high level. 1M, GS and TS were low level. NL, NS, DR, Others were normal. It was very poor nutritional status before TPN support of patients. The malnutrition decrease immunity, slowly cure injury, cause abnormality organs, increase the complication and obstruct the recovery. Therefore, Evaluating and correcting are very important.

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Fabrication of a Large-Area $Hg_{1-x}Cd_{x}$Te Photovoltaic Infrared Detector ($Hg_{1-x}Cd_{x}$Te photovoltaic 대형 적외선 감지 소자의 제작)

  • Chung, Han;Kim, Kwan;Lee, Hee-Chul;Kim, Jae-Mook
    • Journal of the Korean Institute of Telematics and Electronics A
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    • v.31A no.2
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    • pp.88-93
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    • 1994
  • We fabricated a large-scale photovoltaic device for detecting-3-5$\mu$m IR, by forming of n$^{+}$-p junction in the $Hg_{1-x}Cd_{x}$Te (MCT) layer which was grown by LPE on CdTe substrate. The composition x of the MCT epitaxial layer was 0.295 and the hole concentration was 1.3${\times}10^{13}/cm^{4}$. The n$^{+}$-p junction was formed by B+ implantation at 100 keV with a does 3${\times}10^{11}/cm^{2}. The n$^{+}$ region has a circular shape with 2.68mm diameter. The vacuum-evaporated ZnS with resistivity of 2${\times}10^{4}{\Omega}$cm is used as an insulating layer over the epitaxial layer. ZnS plays the role of the anti-reflection coating transmitting more than 90% of 3~5$\mu$m IR. For ohmic contacts, gole was used for p-MCT and indium was used for n$^{+}$-MCT. The fabrication took 5 photolithographic masks and all the processing temperatures of the MCT wafer were below 90$^{\circ}C$. The R,A of the fabricated devices was 7500${\Omega}cm^{2}$. The carrier lifetime of the devices was estimated 2.5ns. The junction was linearly-graded and the concentration slope was measured to be 1.7${\times}10^{17}/{\mu}m$. the normalized detectivity in 3~5$\mu$m IR was 1${\times}10^{11}cmHz^{12}$/W, which is sufficient for real application.

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Combined X-ray CT/SPECT System with a Common CZT Detector (CZT검출기를 이용한 CT/SPECT 조합영상시스템)

  • 권수일
    • Progress in Medical Physics
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    • v.13 no.4
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    • pp.229-233
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    • 2002
  • We have tested a combined CT/SPECT system with a single CZT detector for x-ray and gamma-ray medical imaging. The size of detector is 10$\times$10$\times$5 ㎣, and the anodes are pixellated as a 4$\times$4 array with a pixel dimension of $1.5\times$1.5 $\textrm{mm}^2$. The cathode was coated with a continuous Au-plated. We have characterized the system performance by scanning a radiographic resolution phantom and the Hoffman Brain phantom. Pulse counting electronics with very short shaping time (50 ㎱) are used to satisfy high photon rates in x-ray imaging, and response linearity up to 3$\times$10$^{5}$ counts per second per detector element is achieved. Energy resolution of 10.4% and 5.3% FWHM at Tc-99m 140 keV peak are obtained for the 50 ㎱ and 2 $mutextrm{s}$ shaping times, respectively. The spatial resolutions of CT and SPECT are about 1mm and 9mm, respectively. Photopeak efficiency of detector systems are 41.0% for 50㎱ and 72.5% for 2 $mutextrm{s}$ shaping time.

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An Improved Handoff and Resource Reservation Scheme Using Triggers in Wireless Network (이동망에서 트리거를 이용한 향상된 핸드오프 메커니즘 및 자원예약 방안)

  • Lee, Don-Su;Min, Sang-Won
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.32 no.10B
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    • pp.630-637
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    • 2007
  • In this paper, we propose an effective handoff mechanism using events at the layer 2 and a tunnel-based mechanism that is performed by sharing information of a mobile node and anticipated-based handoff. Also, we propose a novel anticipated-reservation mechanism using the events triggered at layer 2 to make easy a resource reservation procedure. Comparing with the existing mobile IPv6 handoff mechanism, our proposed handoff mechanism can reduce an amount of handoff latency and traffic volume between access routers where handoff is performed. In the anticipated-reservation mechanism, the amount of signaling traffics between an mobile node and the correspondent nodes can be reduced and then the allocation of resource can be accomplished. We present the performance of our proposed handoff mechanism in the wireless network environment by ns-2 simulation. Although the anticipated-reservation mechanism including a proxy agent is explained without performance evaluation, we can validate the operation of our proposed model only by the procedure of message flow.

Comparison of Inpatient and Outpatient Preoperative Factors and Postoperative Outcomes in 2-Level Cervical Disc Arthroplasty

  • Hill, Patrick;Vaishnav, Avani;Kushwaha, Blake;McAnany, Steven;Albert, Todd;Gang, Catherine Himo;Qureshi, Sheeraz
    • Neurospine
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    • v.15 no.4
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    • pp.376-382
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    • 2018
  • Objective: The purpose of this study was to evaluate factors associated with inpatient admission following 2-level cervical disc arthroplasty (CDA). A secondary aim was to compare outcomes between those treated on an inpatient versus outpatient basis. Methods: Using data from the American College of Surgeons National Surgical Quality Improvement Program database, multivariate logistic regression analysis was used to assess the independent effect of each variable on inpatient or outpatient selection for surgery. Statistical significance was defined by p-values <0.05. The factors considered were age, sex, body mass index (BMI), smoking status, American Society of Anesthesiologists physical status classification, and comorbidities including hypertension, diabetes, history of dyspnea or chronic obstructive pulmonary disease, previous cardiac intervention or surgery, steroid usage, and history of bleeding. In addition, whether the operation was performed by an orthopedic or neurosurgical specialist was analyzed. Results: The number of 2-level CDA procedures increased from 6 cases reported in 2014 to 142 in 2016, although a statistically significant increase in the number of outpatient cases performed was not seen (p=0.2). The factors found to be significantly associated with inpatient status following surgery were BMI (p=0.019) and diabetes mellitus requiring insulin (p=0.043). There were no significant differences in complication and readmission rates between the inpatient and outpatient groups. Conclusion: Patients undergoing inpatient 2-level CDA had significantly higher rates of obesity and diabetes requiring insulin than did patients undergoing the same procedure in the outpatient setting. With no difference in complication or readmission rates, 2-level CDA may be considered safe in the outpatient setting in appropriately selected patients.

Fracture Pattern and Physical Property of the Granodiorite for Stone Resources in the Nangsan Area (낭산일대에 분포하는 화강섬록암 암석자원의 열극체계 및 물리적 특성)

  • Yun, Hyun-Soo;Hong, Sei-Sun;Park, Deok-Won
    • The Journal of the Petrological Society of Korea
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    • v.16 no.3
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    • pp.144-161
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    • 2007
  • The studied Nangsan area is widely covered by the Jurassic biotite granodiorite, which is mainly light grey in color and medium-grained in texture. Results of the regional fracture pattern analysis for the granodiorite body are as follows. Strike directions of fractures show three dominant sets in terms of frequency order. The sets are in an order of a (1) $N80^{\circ}{\sim}90^{\circ}E$ (1st-order)>(2) $N70^{\circ}{\sim}80^{\circ}E$ (2nd-order)>(3) $NS{\sim}N10^{\circ}E$ (3rd-order). Spacings of the fractures are mostly predominant in less than 200 cm. Therefore, the granodiorite of the area has more potential for non-dimensional stones than dimension ones. And orientations of vertical quarrying planes can be also divided into two groups in terms of frequency $N14^{\circ}W{\sim}N16^{\circ}E$ (1st-order) and (2) $N78^{\circ}E{\sim}N88^{\circ}E$ (2nd-order). The orientations of the two groups are more or less different from those of the regional fracture patterns. These can be mainly attributed to the preferred orientations of microcrack developed in the quarries. Of physical properties, specific gravity, absorption ratio, porosity, compressive strength, tensile strength and abrasive hardness are 2.65, 0.28%, 0.73%, $1,628kg/cm^2,\;100kg/cm^2$ and 31, respectively. Contrary to the porosity, both granites of the Nangsan and Sogrisan areas show almost similar values of the abrasive hardness. These can be explained by the differences of Qz+Af modes, which can be regarded as an index for abrasive resistance. Meanwhile, it is anticipated that comprehensive understanding of the orientations of vertical quarrying planes and characteristics of various physical properties will be utilized as an important information for stone resources.

The identification of non-synonymous SNP in the Enoyl-CoA delta isomerase 2 (ECI2) gene and its Association with Meat Quality Traits in Berkshire pigs (버크셔 돼지 육질 형질과 Enoyl-CoA delta isomerase 2 (ECI2) 유전자 nsSNP의 연관성 분석)

  • Hwang, Jung Hye;An, Sang Mi;Park, Da Hye;Kang, Deok Gyeong;Kim, Tae Wan;Park, Hwa Chun;Ha, Jeongim;Kim, Chul Wook
    • Journal of the Korean Society of International Agriculture
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    • v.30 no.4
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    • pp.277-284
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    • 2018
  • Meat quality has always been one of the most important factors that controls the choice of pork consumers and is of great interest in the pig industry. In this study, we identified a single nucleotide polymorphism (SNP) in the enoyl-CoA delta isomerase 2 (ECI2) gene in Berkshire pigs (n = 430) by analyzed the association between the SNP and meat quality traits. The non-synonymous SNP in the ECI2 gene is located at c.608 C > G and resulted in an amino acid change from threonine to serine. Significant associations between the SNP and meat quality traits, such as redness (CIE a), and the $pH_{24hr}$, were revealed in both the dominant and co-dominant models, whereas carcass weight, drip loss, and fat content and moisture content were significantly associated only with the dominant model. In barrow, the SNP was significantly associated with CIE a, drip loss, and $pH_{24hr}$, whereas in gilt, only a significant relationship with moisture content was observed. GG genotype pigs had a higher $pH_{24hr}$ and lower drip loss. Because $pH_{24hr}$ and drip loss are considered the most important meat quality traits, GG genotype pork is high-quality meat compared to that from other genotypes. In conclusion, the SNP in the ECI2 gene is significantly associated with several meat quality traits. These traits and could be as genetic markers in molecular breeding programs for improving meat quality.