• Natural Product Sciences
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• 제24권1호
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• pp.59-65
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• 2018

An isoform of NADPH oxidase (NOX), NOX2 is a superoxide-generating enzyme involved in diverse pathophysiological events. Although its potential as a therapeutic target has been validated, there is no clinically available inhibitor. Herein, NOX2-inhibitory activity was screened with the constituents isolated from Schisandra chinensis, which has been reported to have antioxidant and reactive oxygen species (ROS)-scavenging effects. Among the partitions prepared from crude methanolic extract, a chloroform-soluble partition showed the highest NOX2-inhibitory activity in PLB-985 cell-based NOX2 assay. A total of twenty nine compounds (1 - 29) were identified from the chloroform fraction, including two first isolated compounds; dimethyl-malate (25) and 2-(2-hydroxyacetyl) furan (27) from this plants. Of these constituents, two compounds (gomisin T, and pregomisin) exhibited an NOX2-inhibitory effect with the $IC_{50}$ of $9.4{\pm}3.6$, and $62.9{\pm}11.3{\mu}M$, respectively. They are confirmed not to be nonspecific superoxide scavengers in a counter assay using a xanthine-xanthine oxidase system. These findings suggest the potential application of gomisin T (6) and other constituents of S. chinensis to inhibit NOX2.

• 한국가스학회지
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• 제24권4호
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• pp.39-47
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• 2020

배기가스 재순환(flue gas recirculation, 이하 FGR)은 질소산화물 저감에 효과적인 연소 기법으로 저공해 연소 분야에 다양하게 응용되고 있다. 이전 연구에 이어서 메탄/공기 대향류 예혼합화염에 FGR 기법 적용 시 나타나는 화염의 특성 변화 및 NOx 생성기구를 파악하기 위한 수치해석이 진행되었다. 배출되는 질소산화물(NOx)은 4가지 주요 반응경로(열적 NO, prompt NO, N₂H 및 N₂O)로 구분하여 배기가스 재순환율에 따른 각 NO 생성률을 상대적으로 나타내었다. 그 결과 열적 NO가 전체 NO 형성에 가장 크게 차지한 반면 N₂H의 영향은 미미하였다. 또한, 열적 NO의 기여를 검토하기 위하여 본 연구에 사용된 반응기구(UC San Diego mechanism)를 수정하여 재순환율 증가에 따른 NO 배출지수(EINO)를 비교하였다.

• 조명전기설비학회논문지
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• 제13권4호
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• pp.32-37
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• 1999

본 연구에서는 연소공정에서 발생하는 NOx를 제거하기 위해 연면방전과 AC Corona 방전을 중첩해서 특수설계 제작된 중첩방전 반응기의 방전분해 특성을 연구하였다. 실험은 SPCP, Corona Discharge 및 중첩방전에 대한 NOx의 분해율을 비교 측정하였다. 실험변수는 방전형태, 가스의 농도, 방전주파수, 가스의 유량 등에 대하여 측정하였다. 실험결과 중첩방전에 의한 NOx의 분해율은 SPCP방전고 Corona방전에 의한 분해율보다 10∼15[%] 증가하였고 소모전력도 10[%] 정도 작게 소모되었다. 중첩방전시 상부전극의 주파수의 영향은 주파수가 작을수록 NOx의 분해율이 높았고 하부전극의 SPCP만의 방전시에는 주파수가 높을수록 NOx의 분해율이 증가하였다. 방전형태에 대한 NOx의 최대분해율은 SPCP일 때 방전전력 18[W]에서 80[%] 이었고 AC코로나 방전일 때 방전전력 805[W]에서 10[%] 이었으나 중첩방전의 경우는 14[W]에서 90[%]로 중첩방전의 효과는 10[%]이상 증가하였다.

• IMMUNE NETWORK
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• 제11권3호
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• pp.169-174
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• 2011

Background: NADPH oxidase (NOX) modulates cell proliferation, differentiation and immune response through generation of reactive oxygen species. Particularly, NOX2 is recently reported to be important for regulating Treg cell differentiation of CD4+ T cells. Methods: We employed ovalbumin-induced airway inflammation in wild-type and NOX2-deficient mice and analyzed tissue histopathology and cytokine profiles. Results: We investigated whether NOX2-deficiency affects T cell-mediated airway inflammation. Ovalbumin injection which activates T cell-mediated allergic response increased airway inflammation in wild-type mice, as evidenced by increased immune cell infiltration, allergic cytokine expression, and goblet cell hyperplasia in the lung. Interestingly, NOX2 knockout (KO) mice were more susceptible to allergen-induced lung inflammation compared to wild-type mice. Immune cells including neutrophils, lymphocytes, macrophages, and eosinophils were drastically infiltrated into the lung of NOX2 KO mice and mucus secretion was substantially increased in deficiency of NOX2. Furthermore, inflammatory allergic cytokines and eotaxin were significantly elevated in NOX2 KO mice, in accordance with enhanced generation of inflammatory cytokines interleukin-17 and interferon-${\gamma}$ by CD4+ T cells. Conclusion: These results indicate that NOX2 deficiency favorably produces inflammatory cytokines by T cells and thus increases the susceptibility to severe airway inflammation.

• 한국분무공학회지
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• 제25권4호
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• pp.196-203
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• 2020

Nowadays, urea SCR technology is considered as the most effective NOx reduction technology of diesel engine. However, low NOx conversion efficiency under low temperature conditions is one of its problems to be solved. This is because injection of UWS (Urea Water Solution) is impossible under such a low temperature condition due to the problem of insufficient of urea decomposition and urea deposits. In several previous studies, it has been reported that appropriate control of the amount of ammonia adsorbed on SCR catalyst can improve the NOx conversion efficiency under low temperature conditions. In this study, we tried to find out how much the NOx conversion efficiency increases with respect to the amount of ammonia adsorbed on the catalyst, and what the temperature conditions that the ammonia slip occurs. This study shows the results of 8 times repeated WHTC test with a diesel engine, in which UWS was injected with NH3/NOx mole ratio of '1'. Through this study, it was found that 13% of the NOx conversion efficiency of WHTC increased while the θ (ammonia adsorption rate) increased from "0%" to "22%". In addition, it is found that in cases of high θ value, the significant improvement of NOx conversion efficiency at low temperatures presented during the beginning period of WHTC and at high temperature and transient conditions presented during last part of WHTC test. The NH3 slip occurring condition was 250℃ of catalyst temperature and 10% of θ, and the amount of NH3 slip increased as the temperature and θ are increased.

• Environmental Engineering Research
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• 제20권4호
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• pp.397-402
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• 2015

SCR has been popularly approved as one of the most effective means for NOx emission control in heavy-duty and medium-duty vehicles currently. However, high urea dosing would lead to ammonia slip. And $NH_3$ sensor for vehicle emission applications has not been popularly used in real applications. This paper presents experimental studies on the diesel engine urea-SCR system by using a double NOx sensor system that is arranged in the downstream of the SCR catalyst based on ammonia cross-sensitivity. It was shown that the NOx conversion efficiency rised as $NH_3/NOx$ increases and the ammonia slip started from the $NH_3/NOx$ equal to 1.4. The increase of temperature caused high improvement of the SCR reaction rate while the space velocity had no obvious change. The ammonia slip was in advance as catalyst temperature or space velocity increase and the ammonia storage reduced as catalyst temperature or space velocity increase. The NOx real-time conversion efficiency rised as the ammonia accumulative storage increase and reached the maximum value gradually.

• 대한기계학회논문집B
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• 제26권4호
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• pp.561-569
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• 2002

This paper presents an investigation on $C_2$, CH, OH radicals and NOx emissions in partially premixed flames with acoustic excitation. The radicals are visualized by the digital image technique with optical filters and ICCD camera while NOx emissions are determined by a chemiluminescent detection(NOx analyser). The measurements are made in flames with an overall equivalence ratio (${\phi}_o$) 0.5 and a center tube equivalence ratio(${\phi}_c$) varing from 1.1 to 5.0 for a constant fuel flow rate. In the case of excitation, the visual shape of the flame is changed from laminar to turbulent-like flames. Images of $C_2$, CH, and OH radicals resemble those of the flame appearances as the excitation phase is varied, and the radicals generated at the upstream are convected toward the downstream. It is inferred that the flame characteristics is affected by the flow characteristics of air-fuel mixture. In the case of acoustic excitation, OH radicals are much increased relative to unexcitation. From the radicals and flame visualization under acoustic excitation, the reduction of flame length affects the shorter residence time of center tube mixture, and significantly influences the NOx reduction.

• Journal of Advanced Marine Engineering and Technology
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• 제28권7호
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• pp.1123-1130
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• 2004

Numerical simulations have been carried out to investigate the effect of nozzle hole geometry on the combustion characteristics of the large diesel engine. 6S90MC-C. Spray and combustion phenomena were examined numerically using FIRE code. Wane breakup and Zeldovich models were adopted to describe the atomization characteristics and NOx formation processes. Predictions on the cylinder peak pressure and NOx emission were first verified with the experimental data to confirm the reliability of numerical calculations. The comparison results showed good agreements within the range of 0.64% and 4.6% respectively. Finally, the effects of fuel spray angle and diameter on the engine performance were investigated numerically to find the optimum nozzle hole geometry considering fuel consumption, NOx emission and heat flux of the combustion chamber wall. It was concluded that the combustion gas recirculation in cylinder by changing fuel injection direction is an effective method to reduce NOx emission by about 10% with increasing fuel oil consumption, 1.4% in a large diesel engine.

• Journal of Advanced Marine Engineering and Technology
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• 제27권5호
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• pp.657-665
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• 2003

Combined De-NOx Process in which $NH_3$ SCR (Selective Catalytic Reduction) and non-thermal Plasma Process are simultaneously used, has been investigated with a pilot test facility. The pilot test facility treats the combustion flue gases exhausted from a diesel engine that generates 240 kW of electrical power. Test results show that up to 80 % of NOx (NO and NO2) can be removed at 100 - $200^{\circ}C$. None of conventional De-NOx techniques works under such low temperature range. In addition to NOx. the Pilot test results show that soot can be simultaneously treated with the present non-thermal plasma technique. The present pilot test shows that the electrical power consumption to operate the non-thermal plasma reactor is equivalent to 3 - 4 % of the electrical power generated by the diesel engine.

• 한국대기환경학회지
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• 제14권4호
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• pp.333-342
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• 1998

Plasma process has great possibilities to remove SOx, NOx simultaneously with high treatment efficiency and is expected to be suitable for small or middle plants. It was accomplished to evaluate SO2, NOx control possibility and achieve basic data to control pollutants by use of Surface Discharge Induced Plasma Chemical Process (SPCP) in this study. O3 generation characteristics by discharge of a plate was proportional to O2 concentration and power consumption and inversely proportional to temperature and humidity, In case of dry air, NOx was highly generated by N2 and O2 in air during the plasma discharge process but it was decreased considerably as H2O was added. SO2 removal efficiency was very high, and removal rate was 170,350 mEA at 30,50 watt respectively in flue gas which is usually contain HIO. NOx removal efficiency was about 57% at 40 watt power consumption with 7.5% humidity. It is estimated that H2O has an important role in reaction mechanism with pollutants according to plasma discharge.