• 한국생활과학회지
• /
• 제21권3호
• /
• pp.539-550
• /
• 2012

In-depth knowledge of fabric microstructure is essential for understanding clothing comfort since it plays a significant role in heat and mass transfer between the human body and clothing. In this study, a novel method was employed for investigating 3D surfaces and solid construction characteristics of specific fabrics by using a reverse engineering technique. The surface construction data were obtained by a confocal laser scanning microscope and then manipulated by a 3D analysis program. Triangle mesh was used for connecting each 3D point, with clouds and fabric surface characteristics created by rendering techniques. For generating a 3D solid model, determinants of radius of curvature was used. According to the proposed method, actual surface expression of the real fabric was achieved successfully. The results from this methodology can be applied to the detailed analysis of clothing comfort that is highly influenced by the microstructure of the fabric.

• Journal of Electrical Engineering and Technology
• /
• 제12권1호
• /
• pp.39-44
• /
• 2017

This paper proposes a novel approach to determine symmetrical components of power system by applying method of least squares in time domain. For the modern power system stability, clearance of faults on high voltage transmission lines in zero response time is crucial and important. Symmetrical components have a great attention since last century. They have been found an effective tool for the analysis of symmetrical and unsymmetrical faults in power system. Moreover, magnitude of symmetrical components are also used as a caution about faults in system. With rapid changes in technology, Microprocessor assumed to be fastest machine of the modern era. Hence microprocessor based techniques were developed and implemented for last few decades. The proposed technique apply least square method in the computation of symmetrical components which is suitable as an application in microprocessor based monitoring and controlling power system in order to avoid cascading failures. Simulation of proposed model is carried out in MATLAB/SIMULINK and all results exploit the validity of model.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2003년도 추계학술대회 논문집 전기기기 및 에너지변환시스템부문
• /
• pp.216-219
• /
• 2003

The resonant inverter is widely used for induction heating, electronic ballast and supersonic motor driving circuit. In the meantime, control techniques of PWM, PFM etc.. are mainly applied to control the output power of the resonant inverter. But, in the case of using the half bridge resonant inverter, it is difficult to control the output power by PWM, because its main circuit does not provide the load free-wheeling mode. Therefore, PAM or PFM was usually applied to control output power of half bridge resonant inverter. However, PAM needs a variable DC voltage source, which makes the system structure more complex. On the other hand, in case of PFM, efficiency is declined by operation with poor power factor. This paper Proposed the novel half bridge resonant inverter which can provide the load free-wheeling mode. Also its analysis results for PWM operation with unity fundamental power factor are Presented and compared with other resonant inverters using PWM and PFM.

• ETRI Journal
• /
• 제36권1호
• /
• pp.62-68
• /
• 2014

This paper presents a novel user selection method based on the signal-to-interference-plus-noise ratio (SINR), which is approximated using limited feedback data at the base stations (BSs) of multiple user multiple-input multiple-output (MU-MIMO) systems. In the proposed system, the codebook vector index, the quantization error obtained from the correlation between the measured channel and the codebook vector, and the measured value of the largest singular value are fed back from each user to the BS. The proposed method not only generates precoding vectors that are orthogonal to the precoding vectors of the previously selected users and are highly correlated with the codebook vector of each user but also adopts the quantization error in approximating the SINR, which eventually provides a significantly more accurate SINR than the conventional SINR-based user selection techniques. Computer simulations show that the proposed method enhances the sum rate of the conventional SINR-based methods by at least 2.4 (2.62) bps/Hz when the number of transmit antennas and number of receive antennas per user terminal is 4 and 1(2), respectively, with 100 candidate users and an SNR of 30 dB.

• BMB Reports
• /
• 제40권2호
• /
• pp.226-231
• /
• 2007

Housekeeping genes are widely used as internal controls in a variety of study types, including real time RT-PCR, microarrays, Northern analysis and RNase protection assays. However, even commonly used housekeeping genes may vary in stability depending on the cell type or disease being studied. Thus, it is necessary to identify additional housekeeping-type genes that show sample-independent stability. Here, we used statistical analysis to examine a large human microarray database, seeking genes that were stably expressed in various tissues, disease states and cell lines. We further selected genes that were expressed at different levels, because reference and target genes should be present in similar copy numbers to achieve reliable quantitative results. Real time RT-PCR amplification of three newly identified reference genes, CGI-119, CTBP1 and GOLGAl, alongside three well-known housekeeping genes, B2M, GAPD, and TUBB, confirmed that the newly identified genes were more stably expressed in individual samples with similar ranges. These results collectively suggest that statistical analysis of microarray data can be used to identify new candidate housekeeping genes showing consistent expression across tissues and diseases. Our analysis identified three novel candidate housekeeping genes (CGI-119, GOLGA1, and CTBP1) that could prove useful for normalization across a variety of RNA-based techniques.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제5권4호
• /
• pp.703-719
• /
• 2011

In multi-user wireless communication systems, adaptive modulation and scheduling are promising techniques for increasing the system throughput. However, a mass of wireless recourse will be occupied and spectrum efficiency will be decreased to feedback channel quality indication (CQI) of all users in every subcarrier or chunk for adaptive orthogonal frequency division multiplexing (OFDM) systems. Thus numerous limited feedback schemes are proposed to reduce the system overhead. The recently proposed compressive sensing (CS) theory provides a new framework to jointly measure and compress signals that allows less sampling and storage resources than traditional approaches based on Nyquist sampling. In this paper, we proposed two novel CQI feedback schemes based on general CS and subspace CS, respectively, both of which could be used in a wireless OFDM system. The feedback rate with subspace CS is greatly decreased by exploiting the subspace information of the underlying signal. Simulation results show the effectiveness of the proposed methods, with the same feedback rate, the throughputs with subspace CS outperform the discrete cosine transform (DCT) based method which is usually employed, and the throughputs with general CS outperform DCT when the feedback rate is larger than 0.13 bits/subcarrier.

• Biomolecules & Therapeutics
• /
• 제11권2호
• /
• pp.91-98
• /
• 2003

A new series of highly water soluble platinum(II) complexes[Pt(II)(DL-2-hydroxy-3-methylbutyrate)(trans-l-1,2-dimninocyc1ohexane)] (PC-1) and [Pt(II)DL-2-hydroxy-3-methylbutyrate](cis-1,2-diaminocyclohexane)](PC-2) were synthesized and characterized by their elemental analysis and by various spectroscopic techniques [infrared(IR), $^{13}C$-nuclear magnetic resonance (NMR)]. In vitro antitumor activity of new Pt(II)complexes was tested against MKN-45, MKN/ADM and MKN/CDDP human gastric adenocarcinoma cell lines using colorimetric MTT[3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyltetrazoliumbromide] assay for cell survival and proliferation. PC-1 and PC-2 showed active against MKN-45/P, MKN/ADM and MKN/CDDP human gastric cancer cell lines, and the antitumor activity of these compounds were comparable or superior to that of cisplatin. The nephrotoxicities of PC-1 and PC-2 were found quite less then that of cisplatin using MTT and [$^3H$] thymidine uptake tests in rabbit proximal tubule cells, human kidney cortical cells human renal cortical tissues. Based on these results, these novel platinum(II) complex compounds(PC-1 ＆ PC-2) represent a valuable lead in the development of the new anticancer chemotherapeutic agents capable of improving antitumor activity and low nephrotoxicity.

• 한국자기공명학회논문지
• /
• 제24권3호
• /
• pp.91-95
• /
• 2020

Transthyretin (TTR) is an abundant protein in blood plasma and cerebrospinal fluid (CSF), working as a homo-tetrameric complex to transport thyroxine (T₄) and a holo-retinol binding protein. TTR is well-known for its amyloidogenic property; several types of systemic amyloidosis diseases are caused by aggregation of either wild-type TTR or its variants, for which more than 100 mutations were reported to increase the amyloidogenicity of TTR. The rate-limiting step of TTR aggregation is the dissociation of a monomeric subunit from a tetrameric complex. A wide range of biochemical and biophysical techniques have been employed to elucidate the TTR aggregation processes, among which nuclear magnetic resonance (NMR) spectroscopy contributed much to characterize the structural and functional features of TTR during its aggregation processes. The present review focuses on discussing the recent advances of our understanding to the amyloidosis mechanism of TTR and to the structural features of its monomeric aggregation-prone state in solution. We expect that the present review provides novel insights to appreciate the molecular basis of TTR amyloidosis and to develop novel therapeutic strategies to treat diverse TTR-related diseases.

• Biomolecules & Therapeutics
• /
• 제25권5호
• /
• pp.497-503
• /
• 2017

Recent reports claimed that glucosylsphingosine (GS) is highly accumulated and specifically evoking itch-scratch responses in the skins of atopic dermatitis (AD) patients. However, it was unclear how GS can trigger itch-scratch responses, since there were no known molecular singling pathways revealed yet. In the present study, it was verified for the first time that GS can activate mouse serotonin receptor 2a (mHtr2a) and 2b (mHtr2b), but not 2c (mHtr2c) that are expressed in HEK293T cells. Specifically, effects of GS on all mouse serotonin receptor 2 subfamily were evaluated by calcium imaging techniques. The GS-induced intracellular calcium increase was dose-dependent, and antagonists such as ketanserin (Htr2a antagonist) and RS-127445 (Htr2b antagonist) significantly blocked the GS-induced responses. Moreover, the proposed GS-induced responses appear to be mediated by phospholipase C (PLC), since pretreatment of a PLC inhibitor U-73122 abolished the GS-induced responses. Additionally, the GS-induced calcium influx is probably mediated by endogenous TRPC ion channels in HEK293T cells, since pretreatment of SKF-96365, an inhibitor for TRPC, significantly suppressed GS-induced response. In conclusion, the present study revealed for the first time that GS can stimulate mHtr2a and mHtr2b to induce calcium influx, by utilizing PLC-dependent pathway afterwards. Considering that GS is regarded as a pruritogen in AD, the present study implicates a novel GS-induced itch signaling pathway.

• Steel and Composite Structures
• /
• 제27권5호
• /
• pp.545-554
• /
• 2018

This study presents a novel method of improving the strength and stiffness of cold-formed steel (CFS) beams. Flexural members are primary members in most of the structures. Hence, there is an urgent need in the CFS industry to look beyond the conventional CFS beam sections and develop novel techniques to address the severe local buckling problems that exist in CFS flexural members. The primary objective of this study was to develop new CFS composite beam sections with improved structural performance and economy. This paper presents an experimental study conducted on different CFS composite beams with simply supported end conditions under four point loading. Material properties and geometric imperfections of the models were measured. The test strengths of the models are compared with the design strengths predicted by using Australian/New Zealand Standard for cold-formed steel structures. Furthermore, to ensure high precision testing, a special testing rig was also developed for testing of long span beams. The description of test models, testing rig features and test results are presented here. For better interpretation of results, a comparison of the test results with a hot rolled section is also presented. The test results have shown that the proposed CFS composite beams are promising both in terms of better structural performance as well as economy.