• The Korean Journal of Pain
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• 제25권3호
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• pp.168-172
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• 2012

Background: The aim of the study was to investigate the feasibility of fluoroscopy-guided anterior approach for suprascapular nerve block (SSNB). Methods: Twenty patients with chronic shoulder pain were included in the study. All of the nerve blocks were performed with patients in a supine position. Fluoroscopy was tilted medially to obtain the best view of the scapular notch (medial angle) and caudally to put the base of coracoid process and scapular spine on same line (caudal angle). SSNB was performed by introducing a 100-mm, 21-gauge needle to the scapular notch with tunnel view technique. Following negative aspiration, 1.0 ml of contrast was injected to confirm the scapular notch, and 1 % mepivacaine 2 ml was slowly injected. The success of SSNB was assessed by numerical rating scale (NRS) before and after the block. Results: The average NRS was decreased from $4.8{\pm}0.6$ to $0.6{\pm}0.5$ after the procedure (P < 0.05). The best view of the scapular notch was obtained in a medial angle of $15.1{\pm}2.2$ ($11-19^{\circ}$) and a caudal angle of $15.4{\pm}1.7^{\circ}$ ($12-18^{\circ}$). The average distance from the skin to the scapular notch was $5.8{\pm}0.6$ cm. None of the complications such as pneumothorax, intravascular injection, and hematoma formation was found except one case of partial brachial plexus block. Conclusions: SSNB by fluoroscopy-guided anterior approach is a feasible technique. The advantage of using a fluoroscopy resulted in an effective block with a small dose of local anesthetics by an accurate placement of a tip of needle in the scapular notch while avoiding pneumothorax.

• Computers and Concrete
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• 제22권1호
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• pp.39-51
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• 2018

This study introduces a new algorithm to determine size independent values of fracture energy, fracture toughness, and fracture process zone length in three-point bending specimens with shallow to deep notches. By using the exact beam theory, a concept of equivalent notch length is introduced for specimens with no notches in order to predict the peak loads with acceptable precisions. Moreover, the method considers the variations of fracture process zone length and effects of higher order terms of stress field in each specimen size. In this paper, it was demonstrated that the use of some recently developed size effect laws raises some concerns due to the use of nonlinear regression analysis. By using a comprehensive fracture test data, provided by Hoover and Bazant, the algorithm has been assessed. It could be concluded that the proposed algorithm can facilitate a powerful tool for size effect study of three-point bending specimens with different notch lengths.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2003년도 제20회 춘계학술대회 논문집
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• pp.160-163
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• 2003

본 논문에서는 17-4PH강의 동적파괴인성을 노치시편의 겉보기 동적파괴인성으로부터 평가하고자 한다. 0.1mm∼4mm의 다양한 노치반경을 갖는 시험편을 이용하였다. 임계노치반경 이상에서는 노치 반경이 증가할수록 겉보기 동적파괴인성도 증가하는 결과를 보인다. 노치시편을 이용하여 측정한 겉보기 동적파괴인성으로부터 동적파괴인성을 예측할 수 있다.

• 오토저널
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• 제9권5호
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• pp.41-48
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• 1987

The aerodynamic critical phenomenon of notch-back type automobile-like bodies was investigated experimentally. The aerodynamic forces were measured for the various bodies of different back-light rake angle at R$_{e}$0.8*10$^{5}$ , 1.0*10$^{6}$ and 1.4*10$^{6}$ . Also, surface flow visualization was effected by the oil mixture. It was found that the critical phenomenon for the notch-back type bodies was milder than for the hatch-back type bodies; the drag vs. slant angle curve for the notch-back type bodies exhibiting local maximum was much smoother. Surface oil flow visualization revealed that the flow pattern associated with the critical phenomenon was characterized by the reattachment of the separated flow on the boot. The effect of the forebody on the critical phenomenon was seen to be negligible.e.

• Journal of Welding and Joining
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• 제7권4호
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• pp.38-45
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• 1989

In this study, in order to evaluate the shape and the size of the plastic zone at the notch tip before stable crack growth, a newly developed technique for plastic strain measurement, that is, the recrystallization-etching technique was applied to observe the intense strain zone at the notch tip of weld HAZ. 1) The recrystallized specimens showed that the amount of the intense strain zone, more than 20% plastic zone, was quantitatively observed as the plane strain state during the growth of the plastic zone. 2) The behavior of plastic deformation at midsection are different for parent and weld HAZ. In addition, the micro crack initiation occurs at midsection, parent and weld HAZ when the crack opening displacement(COD) value is .delta.$_{t}$=0.4mm. 3) The plastic zone for parent proceeds in the forward direction at notch tip and for weld HAZ in the right and left direction at the notch tip. 4) The relation between plastic strain energy(Wp) and COD(.delta.$_{t}$) depended on yield stress, gradient and plastic strain size.ize.

• Journal of Genetic Medicine
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• 제19권1호
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• pp.38-41
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• 2022

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a single-gene disease caused by mutations in the neurogenic locus notch homolog protein 3 (NOTCH3) gene. The spectrum of clinical manifestations is broad, ranging from asymptomatic to typical ischemic stroke, and mainly depends on the location of the mutations. We describe the case of a 76-year-old female without apparent neurological deficits. However, brain magnetic resonance imaging revealed confluent lesions in the white matter. Direct sequencing of the NOTCH3 gene revealed a novel pathogenic mutation, c.811T>A, which results in a mild phenotype. Therefore, this report will expand the current knowledge in regards to the mutations that can cause CADASIL.

• 대한기계학회논문집A
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• 제40권5호
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• pp.513-523
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• 2016

단순보와 외팔보의 U-노치 및 균열에 대한 응력집중계수 및 응력확대계수를 유한요소법 및 광탄성실험에 의해 해석하였다. 해석결과를 사용하여 응력집중계수 및 응력확대계수의 추정 그래프를 얻었다. 노치의 응력집중계수해석을 위하여 무차원 노치 길이 H(시편의 높이)/h=1.1~2, 무차원 틈 간격 r(노치선단의 반경)/h=0.1~0.5로 하였다. 여기서 h=H-c, c=노치길이이다. 해석결과 틈 길이가 증가할수록 그리고 틈 간격이 좁아질수록 응력집중계수는 증가 한다. 응력집중계수는 단순보가 외팔보다 더 크게 나타나나, 실제 일정한 하중과 노치길이 및 틈 간격 하에서 최대 응력값은 단순보보다 외팔보에서 크게 발생함을 알 수 있었다. 균열해석을 위하여 무차원 균열길이 a(균열길이)/H=0.2~0.5로 하였다. 균열의 길이가 증가 할수록 무차원 응력확대계수는 증가한다. 일정한 하중과 일정한 균열길이하에 응력확대계수값은 단순보 보다 외팔보에서 크게 발생함을 알 수 있었다.

• Molecules and Cells
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• 제40권1호
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• pp.73-81
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• 2017

The ${\gamma}$-secretase complex represents an evolutionarily conserved family of transmembrane aspartyl proteases that cleave numerous type-I membrane proteins, including the ${\beta}$-amyloid precursor protein (APP) and the receptor Notch. All known rare mutations in APP and the ${\gamma}$-secretase catalytic component, presenilin, which lead to increased amyloid ${\beta}$-peptide production, are responsible for early-onset familial Alzheimer's disease. ${\beta}$-amyloid protein precursor-like (APPL) is the Drosophila ortholog of human APP. Here, we created Notch- and APPL-based Drosophila reporter systems for in vivo monitoring of ${\gamma}$-secretase activity. Ectopic expression of the Notch- and APPL-based chimeric reporters in wings results in vein truncation phenotypes. Reporter-mediated vein truncation phenotypes are enhanced by the Notch gain-of-function allele and suppressed by RNAi-mediated knockdown of presenilin. Furthermore, we find that apoptosis partly contributes to the vein truncation phenotypes of the APPL-based reporter, but not to the vein truncation phenotypes of the Notch-based reporter. Taken together, these results suggest that both in vivo reporter systems provide a powerful genetic tool to identify genes that modulate ${\gamma}$-secretase activity and/or APPL metabolism.

• BMB Reports
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• 제46권4호
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• pp.219-224
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• 2013

The cell-fate specification of the anchor cell (AC) and a ventral uterine precursor cell (VU) in Caenorhabditis elegans is initiated by a stochastic interaction between LIN-12/Notch receptor and LAG-2/Delta ligand in two neighboring Z1.ppp and Z4.aaa cells. Both cells express lin-12 and lag-2 before specification, and a small difference in LIN-12 activity leads to the exclusive expressions of lin-12 in VU and lag-2 in the AC, through a feedback mechanism of unknown nature. Here we show that the expression pattern of lag-1/CSL, a transcriptional repressor itself that turns into an activator upon binding of the intracellular domain of Notch, overlaps with that of lin-12. Site-directed mutagenesis of LAG-1 binding sites in lag-1 maintains its expression in the AC, and eliminates it in the VU. Thus, AC/VU cell-fate specification appears to involve direct regulation of lag-1 expression by the LAG-1 protein, activating its transcription in VU cells, but repressing it in the AC.

• Structural Engineering and Mechanics
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• 제60권3호
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• pp.387-404
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• 2016

In this paper, the response and failure of sharp-notched 6061-T6 aluminum alloy circular tubes with five different notch depths of 0.4, 0.8, 1.2, 1.6 and 2.0 mm subjected to cyclic bending were experimentally and theoretically investigated. The experimental moment-curvature relationship exhibits an almost steady loop from the beginning of the first cycle. And, the notch depth has almost no influence on its relationship. However, the ovalization-curvature relationship exhibits a symmetrical, increasing, and ratcheting behavior as the number of cycles increases. In addition, a higher notch depth of a tube leads to a more severe unsymmetrical trend of the ovalization-curvature relationship. Focusing on the aforementioned relationships, the finite element software ANSYS was used to continue the related theoretical simulation. Furthermore, the five groups of tubes tested have different notch depths, from which five unparallel straight lines can be observed from the relationship between the controlled curvature and the number of cycles required to produce failure in the log-log scale. Finally, a failure model was proposed to simulate the aforementioned relationship. Through comparison with the experimental data, the proposed model can properly simulate the experimental data.