• The Korean Journal of Pain
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• v.25 no.3
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• pp.168-172
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• 2012

Background: The aim of the study was to investigate the feasibility of fluoroscopy-guided anterior approach for suprascapular nerve block (SSNB). Methods: Twenty patients with chronic shoulder pain were included in the study. All of the nerve blocks were performed with patients in a supine position. Fluoroscopy was tilted medially to obtain the best view of the scapular notch (medial angle) and caudally to put the base of coracoid process and scapular spine on same line (caudal angle). SSNB was performed by introducing a 100-mm, 21-gauge needle to the scapular notch with tunnel view technique. Following negative aspiration, 1.0 ml of contrast was injected to confirm the scapular notch, and 1 % mepivacaine 2 ml was slowly injected. The success of SSNB was assessed by numerical rating scale (NRS) before and after the block. Results: The average NRS was decreased from $4.8{\pm}0.6$ to $0.6{\pm}0.5$ after the procedure (P < 0.05). The best view of the scapular notch was obtained in a medial angle of $15.1{\pm}2.2$ ($11-19^{\circ}$) and a caudal angle of $15.4{\pm}1.7^{\circ}$ ($12-18^{\circ}$). The average distance from the skin to the scapular notch was $5.8{\pm}0.6$ cm. None of the complications such as pneumothorax, intravascular injection, and hematoma formation was found except one case of partial brachial plexus block. Conclusions: SSNB by fluoroscopy-guided anterior approach is a feasible technique. The advantage of using a fluoroscopy resulted in an effective block with a small dose of local anesthetics by an accurate placement of a tip of needle in the scapular notch while avoiding pneumothorax.

• Computers and Concrete
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• v.22 no.1
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• pp.39-51
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• 2018

This study introduces a new algorithm to determine size independent values of fracture energy, fracture toughness, and fracture process zone length in three-point bending specimens with shallow to deep notches. By using the exact beam theory, a concept of equivalent notch length is introduced for specimens with no notches in order to predict the peak loads with acceptable precisions. Moreover, the method considers the variations of fracture process zone length and effects of higher order terms of stress field in each specimen size. In this paper, it was demonstrated that the use of some recently developed size effect laws raises some concerns due to the use of nonlinear regression analysis. By using a comprehensive fracture test data, provided by Hoover and Bazant, the algorithm has been assessed. It could be concluded that the proposed algorithm can facilitate a powerful tool for size effect study of three-point bending specimens with different notch lengths.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2003.05a
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• pp.160-163
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• 2003

In this study, intrinsic dynamic fracture toughness of 17-4PH casting steel is evaluated from the apparent dynamic fracture toughness of notched specimen. Notch radius of notched specimen is manufactured from 0.1mm to 4mm. The results shows that dynamic fracture toughness decreases with decreasing of notch root radius above critical notch roof radius. The true dynamic fracture toughness can be predicted from test results of apparent dynamic fracture toughness measured by using notched specimen.

• Journal of the korean Society of Automotive Engineers
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• v.9 no.5
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• pp.41-48
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• 1987

The aerodynamic critical phenomenon of notch-back type automobile-like bodies was investigated experimentally. The aerodynamic forces were measured for the various bodies of different back-light rake angle at R$_{e}$0.8*10$^{5}$ , 1.0*10$^{6}$ and 1.4*10$^{6}$ . Also, surface flow visualization was effected by the oil mixture. It was found that the critical phenomenon for the notch-back type bodies was milder than for the hatch-back type bodies; the drag vs. slant angle curve for the notch-back type bodies exhibiting local maximum was much smoother. Surface oil flow visualization revealed that the flow pattern associated with the critical phenomenon was characterized by the reattachment of the separated flow on the boot. The effect of the forebody on the critical phenomenon was seen to be negligible.e.

• Journal of Welding and Joining
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• v.7 no.4
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• pp.38-45
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• 1989

In this study, in order to evaluate the shape and the size of the plastic zone at the notch tip before stable crack growth, a newly developed technique for plastic strain measurement, that is, the recrystallization-etching technique was applied to observe the intense strain zone at the notch tip of weld HAZ. 1) The recrystallized specimens showed that the amount of the intense strain zone, more than 20% plastic zone, was quantitatively observed as the plane strain state during the growth of the plastic zone. 2) The behavior of plastic deformation at midsection are different for parent and weld HAZ. In addition, the micro crack initiation occurs at midsection, parent and weld HAZ when the crack opening displacement(COD) value is .delta.$_{t}$=0.4mm. 3) The plastic zone for parent proceeds in the forward direction at notch tip and for weld HAZ in the right and left direction at the notch tip. 4) The relation between plastic strain energy(Wp) and COD(.delta.$_{t}$) depended on yield stress, gradient and plastic strain size.ize.

• Journal of Genetic Medicine
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• v.19 no.1
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• pp.38-41
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• 2022

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a single-gene disease caused by mutations in the neurogenic locus notch homolog protein 3 (NOTCH3) gene. The spectrum of clinical manifestations is broad, ranging from asymptomatic to typical ischemic stroke, and mainly depends on the location of the mutations. We describe the case of a 76-year-old female without apparent neurological deficits. However, brain magnetic resonance imaging revealed confluent lesions in the white matter. Direct sequencing of the NOTCH3 gene revealed a novel pathogenic mutation, c.811T>A, which results in a mild phenotype. Therefore, this report will expand the current knowledge in regards to the mutations that can cause CADASIL.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.40 no.5
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• pp.513-523
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• 2016

The stress concentration factors and stress intensity factors for a simple beam and a cantilever are analyzed by using finite element method and phtoelasticity. Using the analyzed results, the estimated graphs on stress concentration factors and stress intensity factors are obtained. To analyze stress concentration factors of notch, the dimensionless notch length H(height of specimen)/h=1.1~2 and dimensionless gap space r(radius at the notch tip)/h=0.1~0.5 are used. where h=H-c and c is the notch length. As the notch gap length increases and the gap decreases, the stress concentration factors increase. Stress concentration factors of a simple beam are greater than those of a cantilever beam. However, actually, the maximum stress values under a load, a notch length and a gap occur more greatly in the cantilever beam than in the simple beam. To analyze stress intensity factors, the normalized crack length a(crack length)/H=0.2~0.5 is used. As the length of the crack increases, the normalized stress intensity factors increase. The stress intensity factors under a constant load and a crack length occur more greatly in the cantilever beam than in the simple beam.

• Molecules and Cells
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• v.40 no.1
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• pp.73-81
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• 2017

The ${\gamma}$-secretase complex represents an evolutionarily conserved family of transmembrane aspartyl proteases that cleave numerous type-I membrane proteins, including the ${\beta}$-amyloid precursor protein (APP) and the receptor Notch. All known rare mutations in APP and the ${\gamma}$-secretase catalytic component, presenilin, which lead to increased amyloid ${\beta}$-peptide production, are responsible for early-onset familial Alzheimer's disease. ${\beta}$-amyloid protein precursor-like (APPL) is the Drosophila ortholog of human APP. Here, we created Notch- and APPL-based Drosophila reporter systems for in vivo monitoring of ${\gamma}$-secretase activity. Ectopic expression of the Notch- and APPL-based chimeric reporters in wings results in vein truncation phenotypes. Reporter-mediated vein truncation phenotypes are enhanced by the Notch gain-of-function allele and suppressed by RNAi-mediated knockdown of presenilin. Furthermore, we find that apoptosis partly contributes to the vein truncation phenotypes of the APPL-based reporter, but not to the vein truncation phenotypes of the Notch-based reporter. Taken together, these results suggest that both in vivo reporter systems provide a powerful genetic tool to identify genes that modulate ${\gamma}$-secretase activity and/or APPL metabolism.

• BMB Reports
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• v.46 no.4
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• pp.219-224
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• 2013

The cell-fate specification of the anchor cell (AC) and a ventral uterine precursor cell (VU) in Caenorhabditis elegans is initiated by a stochastic interaction between LIN-12/Notch receptor and LAG-2/Delta ligand in two neighboring Z1.ppp and Z4.aaa cells. Both cells express lin-12 and lag-2 before specification, and a small difference in LIN-12 activity leads to the exclusive expressions of lin-12 in VU and lag-2 in the AC, through a feedback mechanism of unknown nature. Here we show that the expression pattern of lag-1/CSL, a transcriptional repressor itself that turns into an activator upon binding of the intracellular domain of Notch, overlaps with that of lin-12. Site-directed mutagenesis of LAG-1 binding sites in lag-1 maintains its expression in the AC, and eliminates it in the VU. Thus, AC/VU cell-fate specification appears to involve direct regulation of lag-1 expression by the LAG-1 protein, activating its transcription in VU cells, but repressing it in the AC.

• Structural Engineering and Mechanics
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• v.60 no.3
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• pp.387-404
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• 2016

In this paper, the response and failure of sharp-notched 6061-T6 aluminum alloy circular tubes with five different notch depths of 0.4, 0.8, 1.2, 1.6 and 2.0 mm subjected to cyclic bending were experimentally and theoretically investigated. The experimental moment-curvature relationship exhibits an almost steady loop from the beginning of the first cycle. And, the notch depth has almost no influence on its relationship. However, the ovalization-curvature relationship exhibits a symmetrical, increasing, and ratcheting behavior as the number of cycles increases. In addition, a higher notch depth of a tube leads to a more severe unsymmetrical trend of the ovalization-curvature relationship. Focusing on the aforementioned relationships, the finite element software ANSYS was used to continue the related theoretical simulation. Furthermore, the five groups of tubes tested have different notch depths, from which five unparallel straight lines can be observed from the relationship between the controlled curvature and the number of cycles required to produce failure in the log-log scale. Finally, a failure model was proposed to simulate the aforementioned relationship. Through comparison with the experimental data, the proposed model can properly simulate the experimental data.