• Title/Summary/Keyword: North India

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Genetic Variants of CYP11B2 and CYP1A1 Among the North-Indian Punjabi Females with Polycystic Ovary Syndrome

  • Ratneev, Kaur;Mandeep, Kaur;Sukhjashanpreet, Singh;Tajinder, Kaur;Anupam, Kaur
    • Korean Journal of Clinical Laboratory Science
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    • v.54 no.4
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    • pp.316-324
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    • 2022
  • Polycystic ovary syndrome (PCOS) is a complex endocrinopathy in women of reproductive age. The genetics of PCOS is heterogeneous with the involvement of number of genes in the steroid synthesis pathway. The CYP11B2 encodes aldosterone synthase and the genetic variants might increase aldosterone secretion in PCOS cases. CYP1A1 is known to enhance the intraovarian catechol estrogen production and thus the propensity for PCOS. The present case-control study analyzed a total of 619 females for CYP11B2 (rs1799998) and CYP1A1 (rs4646903) polymorphisms. Obesity was examined according to body mass index (BMI) and waist hip ratio (WHR) categorization. Biochemical (lipid profile) analysis was performed in PCOS females. BMI (P=0.0001) and WHR (P=0.0001) revealed a statistically significant difference between PCOS cases and controls. The overall levels of triglycerides were higher in PCOS females. The genotype frequency distribution of CYP11B2 (rs1799998) polymorphism revealed statistically significant difference between PCOS cases and controls (P=0.017). However, CYP1A1 (rs4646903) polymorphism did not showed any association with PCOS. The present case-control association analysis is first from our region for CYP1A1 and CYP11B2 polymorphisms and is suggestive of genetic predisposition of steroidogenic genes among PCOS patients in the North-Indian Punjabi females.

Evaluation of Genetic Variation and Phylogenetic Relationship among North Indian Cattle Breeds

  • Sharma, Rekha;Pandey, A.K.;Singh, Y.;Prakash, B.;Mishra, B.P.;Kathiravan, P.;Singh, P.K.;Singh, G.
    • Asian-Australasian Journal of Animal Sciences
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    • v.22 no.1
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    • pp.13-19
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    • 2009
  • In the present study, genetic analyses of diversity and differentiation were performed on four breeds of Indian zebu cattle (Bos indicus). In total, 181 animals belonging to Ponwar, Kherigarh, Gangatiri and Kenkatha breeds were genotyped for 20 cattle specific microsatellite markers. Mean number of alleles observed per locus (MNA) varied between 5.75 (Kenkatha) to 6.05 (Kherigarh). The observed and expected heterozygosity for the breeds varied from 0.48 (Gangatiri) to 0.58 (Kherigarh) and 0.65 (Kenkatha) to 0.70 (Kherigarh), respectively. $F_{IS}$ estimates of all the breeds indicated significant deficit of heterozygotes being 28.8%, 25.9%, 17.7% and 17.7% for Gangatiri, Ponwar, Kherigarh and Kenkatha, respectively. The $F_{ST}$ estimates demonstrated that 10.6% was the average genetic differentiation among the breeds. Nei's genetic distance DA and Cavalli- Sforza and Edwards Chord distance ($D_C$) and the phylogenetic tree constructed from these reflected the close genetic relationship of Gangatiri and Kenkatha, whereas Ponwar appears to be more distant.

Hepatoprotective and antioxidant activity of Leea asiatica leaves against acetaminophen-induced hepatotoxicity in rats

  • Sen, Saikat;De, Biplab;Devanna, N.;Chakraborty, Raja
    • CELLMED
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    • v.4 no.3
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    • pp.18.1-18.5
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    • 2014
  • Leea asiatica (L.) Ridsdale, a folk medicinal plant is used by the ethnic people of North East India for the treatment of hepatic disorder. In this study, we have investigated the hepatoprotective and antioxidant activity of L. asiatica leaves against acetaminophen induced hepatotoxicity. Methanol extract of L. asiatica (150 and 300 mg/kg/day, p.o.) were administered to rats for three consecutive days followed by single acetaminophen (3000 mg/kg, p.o.) administration on $3^{rd}$ day. After 48 h of acetaminophen administration animals were sacrificed and biochemical estimation of serum, in vivo antioxidant activity using liver tissue were carried out. High levels of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum alkaline phosphatase, total bilirubin, direct bilirubin, total cholesterol and triglycerides were observed in disease control group, which found near to normal in extract treated groups. Higher dose exhibited significant hepatoprotective activity against acetaminophen induced toxicity. Level of superoxide dismutase, catalase, glutathione peroxidase in liver tissue, and reduced glutathione in liver and blood were also significantly increased in extract (300 mg/kg) treated animals compare to disease control group. In this study we found that leaves of L. asiatica exhibited potent hepatoprotective activity against acetaminophen induced hepatic damage in experimental animals which justify the folklore claim, and the possible mechanism of this activity may be due to strong antioxidant activities of extract.

Review for the Current Status of Cancer Complementary and Alternative Medicine in the World (세계 암 보완대체의학의 현황에 대한 연구)

  • Kwon, Hae-Kyoung;Kim, Jung-Sun;Yoo, Hwa-Seung
    • Journal of Korean Traditional Oncology
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    • v.14 no.1
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    • pp.1-11
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    • 2009
  • Objectives: Many countries have been using Complementary and alternative medicine (CAM) for treating cancer and it has been given more weight than before. This study aimed to look into its current status and perspective way to suggest the way which Korean oriental medicine goes to. Methods: We searched internet web sites that are relative with CAM in oncology parts and made lists for this study. We downloaded the essays in the form of electronic files in that web sites and copied the originals consulting to each libraries and relative institution. Results: North America was processing the standardization of CAM based evidences and China was making their traditional medicine representative medicine of CAM. India was developing their traditional medicine because of their domestic need and its results were recognized by National Cancer Institute (NCI). CAM was regulated and studied legally in Europe. Japan was using mushroom for immune therapy clinically. Mexico had a large scale of medical valley in Tijuana area and made it international. Conclusions: The efforts to develop and study CAM for treating cancer are increasing in the world. We need to know the current status of CAM in the world, and make our way that Korean oriental medicine goes to.

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A comprehensive review on Tukhm-e-Karafs (Apium graveolens L.) with special reference to Unani System of Medicine

  • Naushad, Mohd;Zakir, Mohammad;Sahar, Najmus;Kazmi, Munawwar Husain
    • CELLMED
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    • v.10 no.3
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    • pp.20.1-20.6
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    • 2020
  • The Karafs is a dried herb of whole plant of Apium graveolens L. from Apiaceae (carrot family). The seeds (fruits) of Apium graveolens are known as Tukhm-e- Karafs in Unani Medicine. Karafs is known as Celeri in French, Apio in Spanish, Selderiji in Dutch, Syelderey in Russian and Chin in Chinese. It is cultivated in different parts of the world for its seeds as spice and green leaves and root as salad crop. Its seeds are also used for medicinal purposes in complementary and alternative medicines. In Unani it is used as a single drug or as an ingredient in compound formulations used for management in various ailments. The seeds have various pharmacological actions like hepatoprotective, diuretic and lithotriptic etc. It is commonly found in Western Asia, Europe, North Africa and various parts of India like Punjab, Uttar Pradesh and Himachal Pradesh etc. In Unani its actions are described as Mudirr-i-Bawl (Diuretic), Mufattit-i-Hasāh (Lithotriptic), Dafi'-i-Tashannuj (Antispasmodic) and Kāsir-i-Riyāh (Carminative). It is used for the treatment of Hasah al-Kulya (Nephrolithiasis), Nafkh al-Mi'da (Flatulence), Istisqā' (Oedema) and Ihtibās al-Bawl (Retention of urine) etc.

A Survey on the Woody Plants Introduced to the Southern Part of Korea (우리나라 남부지방(南部地方)에 분포(分布)하는 외래수목조사(外來樹木調査))

  • Kim, Sam-Sik
    • Journal of Korean Society of Forest Science
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    • v.26 no.1
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    • pp.31-41
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    • 1975
  • This work was carried out from March 1963 to December 1974 to investigate exotic woody plants in the southern part of Korea. The author enumerated 263 kinds of woody plants; 203 species, 40 varieties, and 17 forms which belong to 136 genera and 63 families. Among 263 sorts of woody plants 99 were introduced from Japan, 87 from China, 32 from the North America, 17 from Europe, 13 from Australia, 8 from India and 8 from central part of Asia, etc. On the use of those trees of today 151 have been used for an ornamental source, 49 for timber, 22 for edible, 16 for medicinal and 22 for the others.

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A Comparative and Analytic Study of Elementary School Mathematics Textbooks between Korea and Japan- Focused on the 5, 6th Grade - (한국과 일본의 초등학교 수학교과서 비교 연구 - 5, 6 학년 수학 교과서를 중심으로 -)

  • Kim, Eun-Mi;Lim, Mun-Kyu
    • Journal of Elementary Mathematics Education in Korea
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    • v.11 no.1
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    • pp.61-80
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    • 2007
  • Korea and Japan are close countries having a mutual influence on history and have similar cultural and educational circumstances. The purpose of this study was to compare and analyze the textbooks for elementary school mathematics between Korea and Japan. First, it established the theoretical backgrounds through the precedent research comparing the mathematic textbooks between South Korea and North Korea, Korea and India, Yanbian in China, Japan( Fraction part in numeral field. The Plane Figures). Next, it compared and analyzed two countries'(Korea and Japan) textbooks regarding the structural system and concept of units on the basis of the theoretical research. And it included more specific and detail contents in comparison of Korean with Japanese mathematic textbooks focused on the 5, 6th grade.

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A Study on 4PL Development to Improve Air Cargo Process (항공물류 프로세스 개선을 위한 4PL 도입 연구)

  • Na, Hyeong-Seok;Jho, Yong-Chul;Lee, Chang-Ho
    • Proceedings of the Safety Management and Science Conference
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    • 2008.04a
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    • pp.383-387
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    • 2008
  • Nowadays, the tendency of world air cargo is noteworthy and air traffic in terms of cargo throughput will no doubt grow significantly in the new Region, with India and China's booming economy and the upcoming Olympics 2008. For example, in the first 11 months of 2006 cargo traffic was increased by 6.3%. First of all, the market of air cargo in Korea grows very quickly and diversifies. It is an essential factor in the process of development of Northeast-Asia as a hub for Air Cargo logistics. However the process of air cargo in Korea is complex as compared with other north-east asia nations. At the same time, it has many problems and causes inconvenience to owners of freight. This paper investigated the process of air cargo in Korea now and analyzed problems of the process. We emphasize that 4PL is the excellent solution from among many alternatives. It is also worthy of notice that EPCglobal network strengthen the role of 4PL. In conclusion, the 4PL system based on EPCglobal network will result in a good success, so it will raise a prestige of air cargo in Korea to a higher position.

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Pharmacognostic Evaluation of Curcuma caesia Roxb. rhizome

  • Verma, Durgesh;Srivastava, Sharad;Singh, Vineet;Rawat, A.K.S.
    • Natural Product Sciences
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    • v.16 no.2
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    • pp.107-110
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    • 2010
  • Curcuma caesia Roxb. (Zingiberaceae) is commonly known as 'Black turmeric'. In India it grows in West Bengal, Madhya Pradesh, Orissa, Bihar, North-East and Uttar Pradesh and is widely used by ethnic communities for various ailments. Rhizomes of the plant are used for sprains and bruises and are also employed in cosmetics. In West Bengal it is an important place in traditional system of medicine and is also used as a substitute for turmeric in fresh stage. Present communication deals with the detailed pharmacognostical evaluation of the rhizome sample. Inner part of the rhizome is bluish-black in colour and emits a characteristic sweet smell, due to the presence of essential oil. On steam distillation the rhizome yields an essential oil rich in camphor. A detailed HPTLC studies has been carried out for quantitative evaluation of active marker component. HPTLC, physico-chemical, morphological and histological parameters presented in this paper may be proposed as parameters to establish the authenticity of C. caesia rhizome and may possibly help to differentiate the drug from its other allied species.

Analysis of Production and Trade of Agro-products in Myanmar (미얀마 주요 농산물의 생산 및 수출입 동향 분석)

  • Yim, Duk-Soon
    • Journal of the Korean Society of International Agriculture
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    • v.23 no.5
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    • pp.485-490
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    • 2011
  • In Southeast Asia, Myanmar is the largest country of the continent with land area 676,577 km2 that is three times higher than Korea. Nonetheless, a lot of diversity in agricultural enterprises is available in Myanmar as different climatic zones are available due to its unique location from north to south and east to west. Agriculture is considered the most important industry in Myanmar that largely relies on rice production. During 2009-10, rice and black gram are also among the major export items of Myanmar. Wheat, maize and sorghum are among the other major crops of the country and cultivation area of wheat and corn has been steadily increasing. Sesame is an important oilseed crop of Myanmar that is cultivated on the largest area. Presently, Myanmar has trade relations with Thailand, India and China.