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Ecotoxicity Evaluation of PFCs using Marine Invertebrate, Sea Urchin (Mesocentrotus nudus) (둥근성게(Mesocentrotus nudus)를 이용한 과불화화합물의 생태독성평가)

  • Choi, Hoon;Lee, Ju-Wook;Lee, Seung-Min;Jeon, Hyung-Ju;Heo, Seung;Hwang, Un-Ki
    • Journal of Marine Life Science
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    • v.6 no.2
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    • pp.80-87
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    • 2021
  • In this study, the toxic effects of PFOA and PFOS potassium salt on Mesocentrotus nudus using 10 min-fertilization rate and 48 h-normal embryogenesis were confirmed through the calculation of toxicity values such as Non-observed effective concentration, Low-observed effective concentration, and 50% of effective concentration. The case of 10 min-fertilization rate and 48 h-normal embryogenesis showed the concentration-dependent reduction pattern when exposed to PFOA and PFOS potassium salt, in tested concentration, respectively. The EC50 values of 10 min-fertilization rates for PFOA and PFOS potassium salt were 1346.43 mg/l and 536.18 mg/l, respectively, and the EC50 values of 48 h-normal embryogenesis were 42.67 mg/l and 17.81 mg/l, respectively. Both toxicity test methods showed high toxicity sensitivity to PFOS potassium salt. Recent studies have shown that the concentration of PFOA and PFOS in the marine environment has continuously decreased, and it is not enough to show acute toxicity to sea urchin. However, PFOA and PFOS have a very long half-life and can accumulate throughout the life of marine life, so it is still observed at a high concentration in shellfish. Therefore, a study on chronic toxicity through the whole-life cycle of marine organisms in coastal environments should be needed.

A Study on the Quantative Analysis of a Ship's Collision Avoding Action by Using the Maneuvering Indices (조종성지수에 의한 충돌회피동작의 양적 파악에 관한 연구)

  • 윤점동
    • Journal of the Korean Institute of Navigation
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    • v.1 no.1
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    • pp.27-44
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    • 1977
  • The Maneuvering Indices of a ship are the values that decide the quantity of her motion in turning when her rudder is turned over to an angle to the starboard or the port. They consist of two kinds of indices, one of which is called index K and the other, index T. Index K decides a ship's turning ability and index T does the length of time delay of a normal turning motion after her rudder has finished the turn of an ordered angle. Generally, the values of the indices are calculated through some mathematic formulas with figures of her heading degrees recorded at a fixed time intervals during her Z test. The values of the same kind index of a ship appear differently according to the ship'sspeed, trim, rudder angle and loaded condition, etc. In this paper, the author analyzed all the amthematic formulas required to calculate the values of the indices in their forming process and examined them from the point of mathematics and dynamics and also actually figured out the values of maneuvering indices of the M.S. "HANBADA", the training ship of Korea Merchant Marine College through her Z test. The author supposed a case in which two same typed ships as the "HANBADA" in size, shape and conditions were approaching each other in meeting end on situation and each ship turned her rudder hard over to the starboard respectively when they approached to the distance of 3 times as long as the ship's length. The author worked out mathematic formulas calculating forward and transverse ship's motions within the above mentioned situation for the quantative analysis of the collision avoding action to certify whether they are in collision status or not. Applying the calculated values of the maneuvering indices of the "HANBADA" to the motion calculating formulas, the author found out the two ships were passing over each other with the clearing distance o 39m between their port quarters. With the above mentioned examinations and explanations, the author demonstrated that a ship's motion in any collision avoiding action can be shown with quantities of time and distance within reliable limit.istance within reliable limit.

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Effects of administration of Lactobacillus acidophilus-fermented milk on hematological values and histopathological changes of kidney in cadmium-treated rats (Lactobacillus acidophilus 발효유가 cadmium투여된 흰쥐의 혈액상과 신장조직에 미치는 영향)

  • Cho, Young-chae;Jun, Moo-hyung;Chang, Kyung-soo
    • Korean Journal of Veterinary Research
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    • v.34 no.4
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    • pp.833-842
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    • 1994
  • To elucidate the protective effects of Lactobacillus acidophilus-fermented milk against cadmium toxicity, the effects of administration of L acidophilus-fermented milk on hematological values and histopathological changes in cadmium-treated rats were investigated. The experimental rats were divided into 2 groups that were consisted of the one group administered with cadmium alone, and the other group administered with cadmium mixed with the fermented milk. Each group was orally administered with different doses of cadmium such as $1.7{\mu}g/g$ bw/day, $3.4{\mu}g/g$ bw/day, $6.8{\mu}g/g$ bw/day, and $13.6{\mu}g/g$ bw/day, respectively, for 1 to 8 weeks. Hematological values and enzyme activities, histopathological changes of kidney tissues were examined for the experimental groups. The values of RBC, WBC, and Hb in the groups administered with cadmium mixed with the fermented milk showed no significant differences to those of the groups administered with cadmium alone, but Hct showed significant reducing values. The activities of glutamic oxaloacetic transaminase(GOT) and glutamic pyruvic transaminase (GPT) in serum were significantly reduced than those of the groups administered with cadmium alone, at the low dose of cadmium treated groups. But alkaline phophatase(ALP) and lactate dehydorgenase(LDH) were significantly reduced at the high dose of cadmium treated groups. In histopathological study, a severe acute tubular necrosis of the convoluted tubules and distalation of tubules were showed in the groups administered with cadmium alone, but the kidney tissues of the groups administered with cadmium mixed with the fermented milk were similar to those of the normal group. In conclusion, the above results would suggest that L acidophilus-fermented milk has reducing effects on cadmium toxicity, at the low dose of cadmium administration.

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Determination of Equilibrium Moisture Content of Outdoor Woods by Using Hailwood-Horrobin Equation in Korea (Hailwood-Horrobin 방정식을 이용한 한국의 야외 목재평형함수율 결정)

  • Ra, Jong-Bum
    • Journal of the Korean Wood Science and Technology
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    • v.42 no.6
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    • pp.653-658
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    • 2014
  • This research was carried out to investigate equilibrium moisture content (EMC) of wood in outdoor locations in Korea. EMC was calculated using Hailwood-Horrobin equation for 73 different locations in Korea using the 1981 to 2010 climate normal data obtained from the Korea Meteorological Admnistration (KMA). Daegu showed the lowest values of EMC (11.5), and the highest EMC values (15.8) was found in Heuksando. Considering the season effect, summer (June, July, August) showed the highest values 15.3, followed by autumn (September, October, November) 13.7, winter (December, January, February) 12.2, and spring (February, March, April) 12.0. Monthly EMC showed the lowest values 11.6 in April and July showed the highest EMC values 16.1. The smallest changes in monthly EMC were found in Jeju island and Heuksando showed the largest values 8.7. A proper wood drying based on average EMC is more required in the regions with larger variation in EMC.

Effectiveness of Clinical Examination for Detection of Respiratory Tuberculosis (호흡기 결핵 환자에서 임상 검사의 유용성)

  • Choi, Woo-Soon;Choo, Sang-Kyu
    • Korean Journal of Clinical Laboratory Science
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    • v.38 no.1
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    • pp.54-58
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    • 2006
  • To find out the effectiveness of clinical examination for the diagnosis of respiratory tuberculosis, a 78 respiratory tuberculosis patient,s group was matched by sex and age with 78 control healthy subjects. In the result of blood chemistry, mean values of $123.5{\pm}62.04mg/dL$ in glucose, $429.01{\pm}150.77IU/L$ in LDH, and $44.51{\pm}43.76IU/L$ in ${\gamma}$-GTP, were higher than that of the controls (healthy subjects), and $3.51{\pm}0.68mg/dL$ in albumin was lower than that of the controls. In the result of the haematology examination, mean values of $12.52{\pm}3.27g/dL$ in hemoglobin, $36.72{\pm}7.28%$ in hematocrit, and $24.61{\pm}12.36%$ in lymphocyte, were lower than that of the controls, $9.23{\pm}5.25%$ in monocyte $78.30{\pm}37.35mm/hr$ in ESR, and $48.45{\pm}35.15U/L$ in ADA were higher than that of the controls. For the comparisons of the tuberculosis patients values from normal reference values, 22.2% in glucose, 22.4% in LDH, 25.0% in ${\gamma}$-GTP, 35.4% in albumin, 88% in ESR, and 88.6% in ADA, showed abnormal values. We concluded that the values of glucose, ${\gamma}$-GTP, albumin, WBC, RBC, hemoglobin, hematocrit, lymphocyte, monocyte, ADA, and the ESR were useful in tuberculosis diagnosis.

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Comparison of three types of analyzers for urine protein-to-creatinine ratios in dogs

  • Ji, Sumin;Yang, Yeseul;Jeong, Yeji;Hwang, Sung-Hyun;Kim, Myung-Chul;Kim, Yongbaek
    • Journal of Veterinary Science
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    • v.22 no.1
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    • pp.14.1-14.11
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    • 2021
  • Background: Quantitation of urine protein is important in dogs with chronic kidney disease. Various analyzers are used to measure urine protein-to-creatinine ratios (UPCR). Objectives: This study aimed to compare the UPCR obtained by three types of analyzers (automated wet chemistry analyzer, in-house dry chemistry analyzer, and dipstick reading device) and investigate whether the differences could affect clinical decision process. Methods: Urine samples were collected from 115 dogs. UPCR values were obtained using three analyzers. Bland-Altman and Passing Bablok tests were used to analyze agreement between the UPCR values. Urine samples were classified as normal or proteinuria based on the UPCR values obtained by each analyzer and concordance in the classification evaluated with Cohen's kappa coefficient. Results: Passing and Bablok regression showed that there were proportional as well as constant difference between UPCR values obtained by a dipstick reading device and those obtained by the other analyzers. The concordance in the classification of proteinuria was very high (κ = 0.82) between the automated wet chemistry analyzer and in-house dry chemistry analyzer, while the dipstick reading device showed moderate concordance with the automated wet chemistry analyzer (κ = 0.52) and in-house dry chemistry analyzer (κ = 0.53). Conclusions: Although the urine dipstick test is simple and a widely used point-of-care test, our results indicate that UPCR values obtained by the dipstick test are not appropriate for clinical use. Inter-instrumental variability may affect clinical decision process based on UPCR values and should be emphasized in veterinary practice.

Analysis of the Mean and Standard Deviation due to the Change of the Probability Density Function on Tidal Elevation Data (조위의 확률밀도함수 변화에 따른 평균 및 표준편차 분석)

  • Cho, Hong-Yeon;Jeong, Shin-Taek;Lee, Khil-Ha;Kim, Tae-Heon
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.22 no.4
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    • pp.279-285
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    • 2010
  • In the process of the probabilistic-based design on the coastal structures, the probability density function (pdf) of tidal elevation data is assumed as the normal distribution function. The pdf shape of tidal elevation data, however, is better-fitted to the double-peak normal distribution function and the equivalent mean and standard deviation (SD) estimation process based on the equivalent normal distribution is required. The equivalent mean and SD (equivalent parameters) are different with the mean and SD (normal parameters) estimated in the condition that the pdf of tidal elevation is normal distribution. In this study, the difference, i.e., estimation error, between equivalent parameters and normal parameters is compared and analysed. The difference is increased as the tidal elevation and its range are increased. The mean and SD differences in the condition of the tidal elevation is ${\pm}400cm$ are above 100 cm and about 80~100 cm, respectively, in Incheon station. Whereas, the mean and SD differences in the condition of the tidal elevation is ${\pm}60cm$ are very small values in the range of 2~4 cm, in Pohang station.

Cerebral Blood Flow as Measured by TCD in Hyperlipidemic Group (TCD를 이용한 정상군과 고지혈증군의 혈류측정에 관한 비교연구)

  • Park, Sun-Mi;Kim, Young-Kyun;Kwon, Jung-Nam;Shin, Woo-Jin;Son, Yeon-Hui;Jeong, Hyun-Yun;Han, Hyun-Young;Park, Ga-Young
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.23 no.6
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    • pp.1513-1520
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    • 2009
  • The purpose of this study was to compare cerebral blood flow between hyperlipidemic patient group and normal healthy aldult group using transcranial doppler ultrasonography(TCD). I investigated cerebral blood flow of 63 hyperlipidemic patients and 42 healthy adults. To evaluate the cerebral blood flow, I measured the systolic peak velocity(Vs) and mean flow velocity(Vm) of the milddle cerebral artery(MCA), anterior cerebral artery(ACA), posterior cerebral artery(PCA), basilar artery(BA), internal carotid artery(ICA) in the two groups using TCD. In normal healthy adults, subjects showed a decerease in Vs and Vm with advancing in age. There was a significant difference in the Vm of ICA. There was no significant differences in the Vm of ACA and ICA. In normal healthy adults, females showed high velocities of all examined vessel. There was a significant difference in the Vs of ICA. There was a significant differences in the Vm of MCA and ICA. Normal healthy adults higher than hyperlipidemic patients in the Vs of MCA, ACA, PCA. There was no significant difference in the Vs of all exmined vessels. Hyperlipidemic patientsincrease higher than normal healthy adults in the Vm of ACA. There was a significant difference in the Vs of BA. In the patients aged under 50's, normal healthy adults higher than hyperlipidemic patients in the Vs and Vm except BA. But there was no significant difference in all exmined vessels. In the patients aged over 50's, hyperlipidemic patients higher than normal healthy adults in all examined vessel expect PCA. There was a significant difference in the Vs of BA and ICA. And hyperlipidemic patients higher than that normal healthy adults in all exmined vessels. There was a significant difference in BA and ICA. In this study, visible differences in blood flow between hyperlipidemic patient group and normal healthy aldult group were shown. However, these results do not come up to the previous values that were reported and known worldwide.

Iterative identification methods for ill-conditioned processes

  • Lee, Jietae;Cho, Wonhui;Edgar, Thomas F.
    • 제어로봇시스템학회:학술대회논문집
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    • 1997.10a
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    • pp.1762-1765
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    • 1997
  • Some ill-conditioned processes are very sensitive to small element-wise uncertainties arising in classical element-by-element model identifications. For such processes, accurate identification of simgular values and right singular vectors are more important than theose of the elements themselves. Singular values and right singular vectors can be found by iteraive identification methods which implement the input and output transformations iteratively. Methods based on SVD decomposition, QR decomposition and LU decomposition are proposed and compared with the Kuong and Mac Gregor's method. Convergence proofs are given. These SVD and QR mehtods use normal matrices for the transformations which cannot be calculated analytically in general and so they are hoard to apply to dynamic processes, whereas the LU method used simple analyitc transformations and can be directly applied to dynamic processes.

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Optimal Weights for a Vector of Independent Poisson Random Variables

  • Kim, Joo-Hwan
    • Communications for Statistical Applications and Methods
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    • v.9 no.3
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    • pp.765-774
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    • 2002
  • Suppose one is given a vector X of a finite set of quantities $X_i$ which are independent Poisson random variables. A null hypothesis $H_0$ about E(X) is to be tested against an alternative hypothesis $H_1$. A quantity $\sum\limits_{i}w_ix_i$ is to be computed and used for the test. The optimal values of $W_i$ are calculated for three cases: (1) signal to noise ratio is used in the test, (2) normal approximations with unequal variances to the Poisson distributions are used in the test, and (3) the Poisson distribution itself is used. The above three cases are considered to the situations that are without background noise and with background noise. A comparison is made of the optimal values of $W_i$ in the three cases for both situations.