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Synthesis of T2-weighted images from proton density images using a generative adversarial network in a temporomandibular joint magnetic resonance imaging protocol

  • Chena, Lee;Eun-Gyu, Ha;Yoon Joo, Choi;Kug Jin, Jeon;Sang-Sun, Han
    • Imaging Science in Dentistry
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    • v.52 no.4
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    • pp.393-398
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    • 2022
  • Purpose: This study proposed a generative adversarial network (GAN) model for T2-weighted image (WI) synthesis from proton density (PD)-WI in a temporomandibular joint(TMJ) magnetic resonance imaging (MRI) protocol. Materials and Methods: From January to November 2019, MRI scans for TMJ were reviewed and 308 imaging sets were collected. For training, 277 pairs of PD- and T2-WI sagittal TMJ images were used. Transfer learning of the pix2pix GAN model was utilized to generate T2-WI from PD-WI. Model performance was evaluated with the structural similarity index map (SSIM) and peak signal-to-noise ratio (PSNR) indices for 31 predicted T2-WI (pT2). The disc position was clinically diagnosed as anterior disc displacement with or without reduction, and joint effusion as present or absent. The true T2-WI-based diagnosis was regarded as the gold standard, to which pT2-based diagnoses were compared using Cohen's ĸ coefficient. Results: The mean SSIM and PSNR values were 0.4781(±0.0522) and 21.30(±1.51) dB, respectively. The pT2 protocol showed almost perfect agreement(ĸ=0.81) with the gold standard for disc position. The number of discordant cases was higher for normal disc position (17%) than for anterior displacement with reduction (2%) or without reduction (10%). The effusion diagnosis also showed almost perfect agreement(ĸ=0.88), with higher concordance for the presence (85%) than for the absence (77%) of effusion. Conclusion: The application of pT2 images for a TMJ MRI protocol useful for diagnosis, although the image quality of pT2 was not fully satisfactory. Further research is expected to enhance pT2 quality.

A Case of Choroidal Melanocytoma with Optic Nerve Involvement in a Dog

  • Jinseon Chang;Dajeong Jeong;Seonmi Kang;Kangmoon Seo
    • Journal of Veterinary Clinics
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    • v.40 no.4
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    • pp.283-287
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    • 2023
  • A 10-year-old spayed female beagle dog presented with a 2-month history of third-eyelid elevation in the left eye (OS). Ophthalmic examination revealed slightly diminished corneal and palpebral reflexes along with exophthalmos in the OS. Schirmer's tear test and intraocular pressure values were within the normal range for the OS. Slit-lamp biomicroscopy revealed protrusion of the third eyelid and corneal opacity in the OS. Fundoscopy revealed a prominent black mass in the OS covering the optic nerve. Tapetal hyper-reflectivity was also observed around the mass. Ocular ultrasonography showed a 0.74 × 0.67 cm echogenic posterior segment mass around the optic nerve protruding into the retrobulbar space. Computed tomography revealed a contrast-enhanced soft tissue lesion in the posteromedial aspect of the left eyeball protruding into the retrobulbar region, and the optic nerve was suspected to be involved. No evidence of osteolytic changes in the adjacent bone or distant metastasis was observed. Enucleation was performed to prevent potential metastasis or local invasion of the mass and to relieve discomfort due to exposure to keratopathy resulting from lagophthalmos. Histopathological examination revealed a central choroidal melanocytoma extending into the optic nerve. No local recurrence was detected until 16 months postoperatively.

Design and test results of a Rogowski coil for measurement of current distribution characteristics in 4-parallel superconducting coils (사병렬 초전도코일의 전류분류 측정을 위한 Rogowski 코일의 제작 및 특성 실험)

  • Cho, Dae-Ho;Yang, S.E.;Kim, M.J.;Ahn, M.C.;Park, D.K.;Bae, D.K.;Seok, B.Y.;Ko, T.K.
    • Progress in Superconductivity and Cryogenics
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    • v.9 no.3
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    • pp.37-40
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    • 2007
  • Large critical current is one of the prerequisites for the design of superconducting electrical equipments with large power capacity. To enlarge the critical current. multiple parallel connection is inevitable. In multiple parallel superconducting coils. the difference in normal resistance of each shunt leads to unequal current distribution. which may yield burnout. Therefore. uniform current distribution is required for a stable operation of multiple parallel superconducting coils. In this paper, Rogowski coils were fabricated to measure each shunt current of a 4-parallel superconducting coil. Four Rogowski coils were installed at the copper bars, which are used as current leads in superconducting coils. As a result, linearity of the Rogowski coils was ascertained and coefficients of each coil, the ratio of voltage and current, were derived. The coefficients were compared with theoretically calculated values. Based on the coefficients, each shunt current was calculated in a 4-parallel superconducting coil, where uniform current. distribution was confirmed. This paper verified the feasibility of the fabricated Rogowski coils as well as operational stability of the 4-parallel superconducting coil in 77K.

Protective Effect of Vasopurus on Atherosclerosis Induced by Dietary Cholesterol in LDL $r^{-/-}$ Mice (Vasopurus의 LDL $r^{-/-}$ Mice에서 항동맥경화 효능)

  • HwangBo, Mi-Hyang;Kim, Hyun-Jeong;Lee, In-Seon;Chung, Tae-Ho;Kim, In-Kyeom;Shin, Heung-Mook
    • The Korea Journal of Herbology
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    • v.24 no.4
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    • pp.49-53
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    • 2009
  • Objectives : The protective effect of Vasopurus, a mixture of three medicinal plants, on atherosclerosis induced by dietary cholesterol in low density lipid (LDL) receptor deficient mice was studied. Methods : Experimental groups were divided into three groups of six animals each; a normal group (N); a high cholesterol group (HC), a high cholesterol plus Vasopurus group (HCVA). The experimental groups were fed for 6 months. Results : Vasopurus supplementation significantly lowered plasma total cholesterol and LDL cholesterol conc entrations compared with the high.cholesterol (HC) diet group. In addition, supplementation with Vasopurus significantly increased fecal cholesterol contents compared to mice fed a HC diet. Mice whose diet was supplemented by Vasopurus showed considerably fewer atherosclerotic plagues in the aortic values of heart and aortas compared to mice receiving the HC diet. Conclusions : These results indicate that Vasopurus has efficacy in anti.atherosclerosis medication.

Chronic Toxicity of a Combined Preparation of Ticlopidine and Ginkgo Biloba Extract (EGb 761) Orally Administered to Rats for 13 Consecutive Weeks

  • Kim, Sang K.;Kim, Sung Y.;Yoon, Mi Y.;Oh, Soo J.;Kim, Hye S.;Lee, Ja Y.;Kang, Sung A.;Lee, Kyung H.;Kim, Young C.
    • Toxicological Research
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    • v.16 no.4
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    • pp.293-301
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    • 2000
  • Toxicity of a combined preparation of ticlopidine and ginkgo biloba extract (EGb 761) in a ratio of 10: 4 was examined in male and female Sprague-Dawley rats. Rats were treated with the test substance intragastrically at a dose of 0 mg/kg, 17 mg/kg, 52 mg/kg or 156 mg/kg for 91 consecutive days. No death or abnormal clinical sign was observed throughout the administration period. There was no difference in body weight gain, food intake or water consumption among different dose groups. Test sub-stance-related differences were not observed in urinalysis. In hematological results mean corpuscular hemoglobin (MCH) of low and high dose male group was increased. Prothrombin time of medium and high dose female group was decreased. A significant increase in serum total cholesterol was observed in both sexes of rats treated with a daily dose of 156 mg/kg, but all the other values obtained in serum chemistry appeared to be within normal ranges. A dose dependent increase in the relative liver and kidney weights was observed in both male and female rats. There were no gross pathological findings at terminal sacrifice. Microscopic histopathological examination did not show any lesion associated with administration of the test substance. The results suggest that under the conditions employed in this study no observable effect level (NOEL) of the test substance be greater than 17 mg/kg/day, but less than 52 mg/kg/day.

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Thermal Analysis for Dry Transport of a Shipping Cask (수송용기의 건식수송에 대한 열해석)

  • Lee, J.C.;Kang, H.Y.;Yoon, J.H.;Chung, S.H.;Kwack, E.H.
    • Nuclear Engineering and Technology
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    • v.25 no.2
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    • pp.248-254
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    • 1993
  • The purpose of this study is to evaluate the thermal safety for dry transport of a shipping cask. Analysis condition was based on an ambient temperature of 38$^{\circ}C$ for normal heat condition. The cask was designed to carry 4PWR spent fuel assemblies with a burnup of 38,000 MWD/MTU and 3 years of cooling time. Thermal analysis was carried out by using the COBRA-SFS code. The fuel cavity was considered to be filled with air, nitrogen or helium gas for dry transport. The results of analysis showed that the maximum temperatures of fuel rod cladding in air and helium cavity would be 277$^{\circ}C$ and 226$^{\circ}C$, respectively, for 3 years of cooling time. These values were less than the specified temperature to maintain the thermal integrity of fuel assembly for dry transport.

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Energy-efficient intrusion detection system for secure acoustic communication in under water sensor networks

  • N. Nithiyanandam;C. Mahesh;S.P. Raja;S. Jeyapriyanga;T. Selva Banu Priya
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.17 no.6
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    • pp.1706-1727
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    • 2023
  • Under Water Sensor Networks (UWSN) has gained attraction among various communities for its potential applications like acoustic monitoring, 3D mapping, tsunami detection, oil spill monitoring, and target tracking. Unlike terrestrial sensor networks, it performs an acoustic mode of communication to carry out collaborative tasks. Typically, surface sink nodes are deployed for aggregating acoustic phenomena collected from the underwater sensors through the multi-hop path. In this context, UWSN is constrained by factors such as lower bandwidth, high propagation delay, and limited battery power. Also, the vulnerabilities to compromise the aquatic environment are in growing numbers. The paper proposes an Energy-Efficient standalone Intrusion Detection System (EEIDS) to entail the acoustic environment against malicious attacks and improve the network lifetime. In EEIDS, attributes such as node ID, residual energy, and depth value are verified for forwarding the data packets in a secured path and stabilizing the nodes' energy levels. Initially, for each node, three agents are modeled to perform the assigned responsibilities. For instance, ID agent verifies the node's authentication of the node, EN agent checks for the residual energy of the node, and D agent substantiates the depth value of each node. Next, the classification of normal and malevolent nodes is performed by determining the score for each node. Furthermore, the proposed system utilizes the sheep-flock heredity algorithm to validate the input attributes using the optimized probability values stored in the training dataset. This assists in finding out the best-fit motes in the UWSN. Significantly, the proposed system detects and isolates the malicious nodes with tampered credentials and nodes with lower residual energy in minimal time. The parameters such as the time taken for malicious node detection, network lifetime, energy consumption, and delivery ratio are investigated using simulation tools. Comparison results show that the proposed EEIDS outperforms the existing acoustic security systems.

Spatio-temporal potential future drought prediction using machine learning for time series data forecast in Abomey-calavi (South of Benin)

  • Agossou, Amos;Kim, Do Yeon;Yang, Jeong-Seok
    • Proceedings of the Korea Water Resources Association Conference
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    • 2021.06a
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    • pp.268-268
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    • 2021
  • Groundwater resource is mostly used in Abomey-calavi (southern region of Benin) as main source of water for domestic, industrial, and agricultural activities. Groundwater intake across the region is not perfectly controlled by a network due to the presence of many private boreholes and traditional wells used by the population. After some decades, this important resource is becoming more and more vulnerable and needs more attention. For a better groundwater management in the region of Abomey-calavi, the present study attempts to predict a future probable groundwater drought using Recurrent Neural Network (RNN) for future groundwater level prediction. The RNN model was created in python using jupyter library. Six years monthly groundwater level data was used for the model calibration, two years data for the model test and the model was finaly used to predict two years future groundwater level (years 2020 and 2021). GRI was calculated for 9 wells across the area from 2012 to 2021. The GRI value in dry season (by the end of March) showed groundwater drought for the first time during the study period in 2014 as severe and moderate; from 2015 to 2021 it shows only moderate drought. The rainy season in years 2020 and 2021 is relatively wet and near normal. GRI showed no drought in rainy season during the study period but an important diminution of groundwater level between 2012 and 2021. The Pearson's correlation coefficient calculated between GRI and rainfall from 2005 to 2020 (using only three wells with times series long period data) proved that the groundwater drought mostly observed in dry season is not mainly caused by rainfall scarcity (correlation values between -0.113 and -0.083), but this could be the consequence of an overexploitation of the resource which caused the important spatial and temporal diminution observed from 2012 to 2021.

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Updating Korean Disability Weights for Causes of Disease: Adopting an Add-on Study Method

  • Dasom Im;Noor Afif Mahmudah;Seok-Jun Yoon;Young-Eun Kim;Don-Hyung Lee;Yeon-hee Kim;Yoon-Sun Jung;Minsu Ock
    • Journal of Preventive Medicine and Public Health
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    • v.56 no.4
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    • pp.291-302
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    • 2023
  • Objectives: Disability weights require regular updates, as they are influenced by both diseases and societal perceptions. Consequently, it is necessary to develop an up-to-date list of the causes of diseases and establish a survey panel for estimating disability weights. Accordingly, this study was conducted to calculate, assess, modify, and validate disability weights suitable for Korea, accounting for its cultural and social characteristics. Methods: The 380 causes of disease used in the survey were derived from the 2019 Global Burden of Disease Collaborative Network and from 2019 and 2020 Korean studies on disability weights for causes of disease. Disability weights were reanalyzed by integrating the findings of an earlier survey on disability weights in Korea with those of the additional survey conducted in this study. The responses were transformed into paired comparisons and analyzed using probit regression analysis. Coefficients for the causes of disease were converted into predicted probabilities, and disability weights in 2 models (model 1 and 2) were rescaled using a normal distribution and the natural logarithm, respectively. Results: The mean values for the 380 causes of disease in models 1 and 2 were 0.488 and 0.369, respectively. Both models exhibited the same order of disability weights. The disability weights for the 300 causes of disease present in both the current and 2019 studies demonstrated a Pearson correlation coefficient of 0.994 (p=0.001 for both models). This study presents a detailed add-on approach for calculating disability weights. Conclusions: This method can be employed in other countries to obtain timely disability weight estimations.

Activity concentrations and radiological hazard assessments of 226Ra, 232Th, 40K, and 137Cs in soil samples obtained from the Dongnam Institute of Radiological & Medical Science, Korea

  • Jieun Lee;HyoJin Kim;Yong Uk Kye; Dong Yeon Lee;Wol Soon Jo;Chang Geun Lee;Jeung Kee Kim;Jeong-Hwa Baek;Yeong-Rok Kang
    • Nuclear Engineering and Technology
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    • v.55 no.7
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    • pp.2388-2394
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    • 2023
  • The radioactivity concentration of environmental radionuclides was analyzed for soil and sand at eight locations within a radius of 255 m centered on the Dongnam Institute of Radiological & Medical Science (DIRAMS), Korea. The average activity concentrations of 40K, 137Cs, 226Ra, and 232Th were 661.1 Bq/kg-dry, 0.9 Bq/kg-dry, 21.9 Bq/kg-dry, and 11.1 Bq/kg-dry, respectively. The activity of 40K and 137Cs was lower than the 3-year (2017-2019) average reported by the Korea Institute of Nuclear Safety, respectively. Due to the nature of granite-rich soil, the radioactivity of 40K was 0.6-fold higher than in other countries, while 137Cs was in the normal fluctuation range (15-30 Bq/kg-dry) of the concentration of radioactive fallout from nuclear tests. The activity of 226Ra and 232Th was lower than in Korean soils reported by the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). The average activity concentrations of 232Th and 40K for the soil and sand samples from DIRAMS were within the range specified by UNSCEAR in 2000. The radium equivalent activity and internal and external hazard index values were below the recommended limits (1 mSv/y). These radionuclide concentration (226Ra, 232Th, 40K, and 137Cs) data can be used for regional environmental monitoring and ecological impact assessments of nuclear power plant accidents.