• Journal of the Korea Institute of Information and Communication Engineering
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• v.10 no.6
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• pp.1153-1158
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• 2006

The classification of the background and cell areas is very important research area because of the ambiguous boundary. In this paper, the region of cell is extracted from an image of uterine cervical cytodiagnosis using the region growing method that increases the region of interest based on similarity between pixels. Segmented image from background and cell areas is binarized using a threshold value. And then 8-directional tracking algorithm for contour lines is applied to extract the cell area. First, the extracted nucleus is transformed to RGB color that is the original image. Second, the K-means clustering algorithm is employed to classify RGB pixels to the R, G, and B channels, respectively. Third, the Hue information of nucleus is extracted from the HSI models that is the transformation of the clustering values in R, G, and B channels. The backpropagation algorithm is employed to classify and identify the normal or abnormal nucleus.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.9 no.2
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• pp.110-122
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• 2005

Background: The basic concept of thermographic interpretation is the thermologic equality of both side in normal person. But both sides diseases were limited diagnostic values by thermographic interpretation, and this interpretation does not apply to the case in thermal temperature of each part of body. Nevertheless, the measurement conditions are not standardized. So, for its clinical applications are extended, we think that the measurement conditions are considered the individual variations. Objectives: The purpose of this study is to examine the optimum conditions thermal temperature of the time period and region are not effected by internal and external variables. Methods: After the subjects took off their clothes, the filming were repeatedly five times made on duration of 5minutes during 20minutes. We selected nine regions around acupoints including Yin dang[印堂, HN1], Sugu[水溝, GV26], Ch’ondol[天突, CV22], Chonjung[CV17], Chung-wan[中脘, CV12], Ch’onch'u[天樞 S25], No-gung[勞宮, P8], and calculated based on the utility of R.O.I.(Region of Integer) in our system these points temperature. We measured the optimal time period and region that has little variation of thermal temperature. Results: The results shows that the optimal time period is 20minutes after undressed, and the optimal region is the region around acupoints including Sugu[水溝, GV26]. Conclusions: we obtained the measurement conditions were considered the individual variations. And also, this study offers basic sources for that the measurement conditions would be standardized. Furthermore, based on this results, we expect that clinical applications using thermography would be extended.

• The Transactions of the Korean Institute of Power Electronics
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• v.9 no.5
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• pp.491-497
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• 2004

This paper presents a new rotor position estimation method for brushless DC motors. It is clear that the estimation error of the rotor position provokes the phase shift angle misaligned between the phase current and the back-EMF waveforms, which causes torque ripple in brushless DC motor drives. Such an estimation error can be reduced with the help of the proposed neutral voltage-based estimation method that is structured in the form of a closed loop observer. A neutral voltage appearing during the normal mode of the inverter operation is found to be an observable and controllable measure, which can be dealt with for estimating an exact rotor position. This neutral voltage is obtained from the DC-link current, the switching logic, and the motor speed values. The proposed algorithm, which can be implemented easily by using a single DC-link current and the motor terminal voltage sensors, is verified by simulation and experiment results.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.1
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• pp.13-18
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• 2015

This study presents the structure design of antenna to have the dual band characteristics in a desired frequency band through the structural modification of an antenna structure. For the experiment, a wideband crossed planar monopole antenna was used. The target frequency band was set to ISM 2.45GHz/5.8GHz. To give the properties, an additional antenna element was added to the crossed planar monopole antenna, which is a main body of the antenna. And then structural adjustment parameter was set to change the length(shape) of the antenna. Various simulations were conducted to find the dual band characteristics in the desired frequency band. The simulations brought forth the antenna bandwidth above the normal values for ISM 2.45GHz/5.8GHz. The structural adjustment parameter introduced in this study for structural modification of an antenna can be useful in developing an antenna featured with dual band(multiband) characteristics.

• Korean Journal of Applied Biomechanics
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• v.17 no.3
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• pp.147-154
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• 2007

This study's purpose is to investigate the effects on leg muscle activity caused by perturbation, using a trapdoor system during the support phase of gait for healthy adults (n = 6, height $177.5{\pm}5.5cm$, weight $81.0{\pm}9.5kg$, age $30.0{\pm}3.3yrs$). The trapdoor had the functional ability of causing inversion or eversion. The release time for the trapdoor was specified for two times, 0.3 and 0.5 seconds after heel contact. While altering these variables, EMG was recorded for the leg muscles (rectus femoris, biceps femoris, vastus lateralis, tibialis anterior, gastrocnemius, soleus). The following conclusions were derived. The steptime was longer for the 0.5s eversion than 0.3s inversion condition. So in order to regain stability after the perturbation the unsupporting leg reached forward rapidly. This quick reflex can be observed through the center of pressure (COP) and its rapid change in direction. The gastrocnemius was activated throughout the total experiment. There was a low amount of activity recorded in the rectus femoris, vastus lateralis and tibialis anterior except for the condition of inversion 0.3s. For most of the conditions, the highest average EMG peak values were recorded during the condition of inversion 0.3s. The iEMG patterns were similar for the conditions of inversion 0.3s and eversion 0.3s. To cope with the rapid change in these conditions, the biceps femoris was activated. During the experiment except for the condition of normal gait, the activity of the soleus and gastrocnemius was relatively high. Therefore, to prevent injury from perturbation of the lower leg strengthening of the soleus and gastrocnemius is required. Likewise to prevent injury to the thigh strengthening for the biceps femoris.

• Journal of Korean Society of Steel Construction
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• v.10 no.1 s.34
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• pp.85-99
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• 1998

This paper describes an experimental study to examine collapse causes of the lifting cable due to brittle failure of an fitting anchor under the lifting works. Also, in this study an collapse mechanism that was obtained from stress analysis was compared with an actual collapse procedure. Fractographical analysis as well as chemical component test, tension test and Charpy V-Notch impact test for the fractured steel members were carried out. And then, its results were compared with that of normal steel members. Circumferential surface flaws were developed at internal facets of the fitting anchor before tensile stress occurred. Hence, a higher stress than nominal stress was occurred at flaws by stress concentration at the crack tip. Also, stress intensity factor of members increased by crack size of the potential flaws. Because the stress intensity factor at the crack tip was greater than critical values(fracture toughness), brittle fracture occurred under the lifting works. It is judged that the main collapse of the lifting cable is due to brittle fracture of the fitting anchor.

• Journal of the Korean Vacuum Society
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• v.19 no.6
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• pp.489-494
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• 2010

Enhance signal-to-noise ratio, slow positron coincidence Doppler Broadening method has been applied to study of characteristics of $Nb_3Ge$ superconductor film, which were performed from 20 K to 300 K sample temperature near Tc of it. In this investigation the numerical analysis of the Doppler spectra was employed to the determination of the shape parameter, S, defined as the ratio between the amount of counts in a central portion of the spectrum and the total counts of whole spectrum. The S-parameter values between 0.598 and 0.594 were decreased while the temperature were decreasing, that indicated the voids into the samples. The temperature dependence came from specific positron trapping rate into the vacancy-type defects. It is believed that the positrons annihilate with normal-electrons instead of super-electrons in the Nb3Ge superconductor.

• Toxicological Research
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• v.33 no.4
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• pp.343-350
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• 2017

Lamivudine belongs to the set of antiviral agents effective against hepatitis B virus infection. Given case reports on liver injuries after certain antiviral agent treatments, this study examined the effects of lamivudine on alanine aminotransferase (ALT) and total bilirubin (TB) using a medical system database. A total of 1,321 patients taking lamivudine alone or with others were evaluated using laboratory hits in an electronic medical system at Seoul National University Hospital from 2005 through 2011. The patients were grouped according to prior ALT results: G#1, ALT < 40 IU/L; G#2, 40 IU/L ${\leq}$ ALT < 120 IU/L; G#3, 120 IU/L ${\leq}$ ALT < 240 IU/L; and G#4, ALT ${\geq}$ 240 IU/L. In G#1 and G#2 patients, lamivudine or adefovir treatment decreased ALT and TB compared to prior values. In G#3 and G#4 patients with three times the upper limit of normal (ULN) ${\leq}$ ALT < 15 times the ULN, both ALT and TB were decreased after treatment with lamivudine alone, or adefovir following lamivudine therapy, indicating that lamivudine therapy ameliorated liver functions. However, in G#4 patients who experienced severely advanced hepatitis (ALT ${\geq}$ 15 times the ULN, or ${\geq}$ 600 IU/L), lamivudine augmented TBmax ($6.3{\rightarrow}13.3mg/dL$) despite a slight improvement in ALT ($839{\rightarrow}783IU/L$), indicative of exacerbation of bilirubinemia. Patients who used adefovir after lamivudine also showed a high incidence of hyperbilirubinemia when they experienced severely advanced hepatitis. Treatment with adefovir alone did not show the effect. In conclusion, lamivudine may increase the risk of hyperbilirubinemia in patients with severely advanced hepatitis, implying that caution should be exercised when using lamivudine therapy in certain patient populations.

• Biomolecules & Therapeutics
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• v.3 no.4
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• pp.316-321
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• 1995

All the pharmacological studies of LB17522 described here were carried out with high doses (fifteen to sixty times of the therapeutic dose) to determine an indication of potential side effects in clinical use in terms of the acute clinical signs, cardiovascular and central nervous system. LB10522 does not produce any observable clinical signs except for the symptoms such as moist eye, skin rash, slight salivation, vomitting, and slightly reduced activity. The effects of LB10522 on the hemodynamics and cardiac function of anesthetized beagle dogs are as follows; heart rates and mean arterial blood pressure had a tendency to increase mildly, which is a normal finding in anesthetized dogs. All the animals except for one showed relatively stable respiratory rates throughout the observation period. Each animal treated with LB10522 showed slight increase in the left cardiac work and left ventricular stroke work which are mainly related to corresponding increases in cardiac output. Femoral blood flow were shown to be increased in some animals treated with LB10522. The epileptogenic activities of various cephalosporins were assessed by a direct intracerebral injection of appropriate concentration of test articles. The CD$_{50}$ values (nmol) obtained from the analysis of the dose-response data are as follows; 78.2, 175.3, 156.3, and 53.5 for cefazolin, cephaloridine, ceftazidime, and LB 10522, respectively. LB10522 seems to be equipotent with cefazolin or to be three times more potent than cephaloridine and ceftazidime in causing adverse CNS stimulation. Taken into consideration all the information obtained, LB10522 is not supposed to induce much changes in the functions examined in these studies in man at therapeutic doses.s.

• Korean Journal of Acupuncture
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• v.26 no.2
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• pp.75-89
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• 2009

Objectives: Warm needling combines simultaneously the effects of acupuncture and moxibustion. This study was to investigate whether warm needling could relieve acute knee arthritis induced by carrageenan in rats. Methods: To illuminate the underlying mechanisms of the warm needling-induced antinociception, weight bearing force (WBF) was observed on the acute knee arthritic rat model. Under general anesthesia, ST36, SP9, Hakjung extra point, LI4 were punctured and stimulated with 30 mg moxa ball combustion on top of the needle (${\emptyset}0.18{\times}8mm$). Results: In behavioral test, rats subsequently showed a reduced stepping force of the affected limb 3 hours after the induction of arthritis. Warm needling on the contralateral or ipsilateral ST36 failed to show antinociceptive effect on the acute knee arthritis. Warm needling on the contralateral SP9 or LI4 increased WBF values to normal level in the acute stage of the arthritis. Warm needling on the Hakjung extra-point resulted in the significant antinociceptive effects through acute stage. These effects of warm needling were suppressed by opioids receptor antagonist naltrexone (10 mg/kg, i.p.) and alpha adrenoceptor antagonist phentolamine (5 mg/kg, i.p.). Conclusion: The data suggest that warm needling-induced antinociception is differently mediated by acupoints and accomplished by activating the descending inhibitory systems including endogenous opioids and $\alpha$-adrenoceptors.