• 제목/요약/키워드: Normal state

검색결과 2,326건 처리시간 0.036초

Reliability index for non-normal distributions of limit state functions

  • Ghasemi, Seyed Hooman;Nowak, Andrzej S.
    • Structural Engineering and Mechanics
    • /
    • 제62권3호
    • /
    • pp.365-372
    • /
    • 2017
  • Reliability analysis is a probabilistic approach to determine a safety level of a system. Reliability is defined as a probability of a system (or a structure, in structural engineering) to functionally perform under given conditions. In the 1960s, Basler defined the reliability index as a measure to elucidate the safety level of the system, which until today is a commonly used parameter. However, the reliability index has been formulated based on the pivotal assumption which assumed that the considered limit state function is normally distributed. Nevertheless, it is not guaranteed that the limit state function of systems follow as normal distributions; therefore, there is a need to define a new reliability index for no-normal distributions. The main contribution of this paper is to define a sophisticated reliability index for limit state functions which their distributions are non-normal. To do so, the new definition of reliability index is introduced for non-normal limit state functions according to the probability functions which are calculated based on the convolution theory. Eventually, as the state of the art, this paper introduces a simplified method to calculate the reliability index for non-normal distributions. The simplified method is developed to generate non-normal limit state in terms of normal distributions using series of Gaussian functions.

Human Intersectin 2 (ITSN2) binds to Eps8 protein and enhances its degradation

  • Ding, Xiaofeng;Yang, Zijian;Zhou, Fangliang;Hu, Xiang;Zhou, Chang;Luo, Chang;He, Zhicheng;Liu, Qian;Li, Hong;Yan, Feng;Wang, Fangmei;Xiang, Shuanglin;Zhang, Jian
    • BMB Reports
    • /
    • 제45권3호
    • /
    • pp.183-188
    • /
    • 2012
  • Participates in actin remodeling through Rac and receptor endocytosis via Rab5. Here, we used yeast two-hybrid system with Eps8 as bait to screen a human brain cDNA library. ITSN2 was identified as the novel binding factor of Eps8. The interaction between ITSN2 and Eps8 was demonstrated by the in vivo co-immunoprecipitation and colocalization assays and the in vitro GST pull-down assays. Furthermore, we mapped the interaction domains to the region between amino acids 260-306 of Eps8 and the coiled-coil domain of ITSN2. In addition, protein stability assays and immunofluorescence analysis showed ITSN2 overexpression induced the degradation of Eps8 proteins, which was markedly alleviated with the lysosome inhibitor NH4Cl treatment. Taken together, our results suggested ITSN2 interacts with Eps8 and stimulates the degradation of Eps8 proteins.

Normal State EPR Study of the n-type High-Tc Superconductors

  • Lee, Cheol-Eui;Kim, W.S.;Noh, S.J
    • Journal of Magnetics
    • /
    • 제3권2호
    • /
    • pp.39-40
    • /
    • 1998
  • Normal state EPR signals have been studied for the n-type$ high-T_c$ superconductors $Nd_{1.85}Ce_{0.15}CuO_{4-x} and Nd_2CuO_{3.6-x}F_{0.4-y}.$ Since EPR signals were observed only in quenched non-superconducting samples and were absent in furnace-cooled samples, our results suggest that no normal state EPR signals come from pure phase n-type hihg-Tc superconductors. Our observation is consistent with previously reported absence of nomal state EPR signals in the p-type high-Tc superconductors.

  • PDF

K-means 군집화 기법을 이용한 개폐장치의 부분방전 패턴 해석 (Analysis of Partial Discharge Pattern of Closed Switchgear using K-means Clustering)

  • 변두균;김원종;이강원;홍진웅
    • 한국전기전자재료학회논문지
    • /
    • 제20권10호
    • /
    • pp.901-906
    • /
    • 2007
  • In this study, we measured the partial discharge phenomenon of inside the closed switchgear, using ultra wide band antenna. The characteristics of $\Phi-q-n$ in the normal state are stable, and confirmed at less than 0.01, but in proceeding states, about 2 times larger. And in the abnormal state, it grew hundreds of times larger compared with normal state. According to K-means analysis, if slant of discharge characteristics is a straight line close to "0" and standard deviation is small, it is in a normal state. However if we can find a peak from K-means clusters and standard deviation to be large, it is in an abnormal state.

청신화담전 투여가 경련방생시 뇌조직 중 경련 및 산화 관련물질에 미치는 영향 (Anticonvulsant, Antioxidant Effect of Cheongsinhwadam-Jeon(청신화담전))

  • 김락형;권보형;이광규;오찬호
    • 대한한의학회지
    • /
    • 제25권1호
    • /
    • pp.188-197
    • /
    • 2004
  • Objective and Methods : This study was performed to evaluate the anticonvulsant, antioxidant effect of modified formulas Korean traditional medicine Cheongsinhwadam-Jeon(CSHDJ). The extract of CSHDJ was administered (p.o.) to mice for 14 days in anticonvulsant and antioxidant tests. Results : The pretreatment of CSHDJ extract prohibited pentylenetrazol (PTZ)-induced convulsion. In PTZ-induced convulsion, lowered level of brain ${\gamma}$-aminobutyric acid(GABA) was restored normal state by the pretreatment of CSHDJ. Increased level of brain glutamic acid was lowered to normal state by CSHDJ, and increased activity of brain ${\gamma}-aminobutyric$ acid transaminase(GABA-T) was reduced to normal state by CSHDJ. In PTZ-induced convulsion, increased level of brain lipid peroxide was lowered to normal state by the pretreatment of CSHDJ. Increased activity of brain xanthine oxidase(XOD) was lowered by CSHDJ, and increased activity of brain aldehyde oxidase lowered to normal state by CSHDJ. In PTZ-induced convulsion, increased activities of superoxide dismutase(SOD) and catalase in brain were lowered by the pretreatment of CSHDJ, whereas increased level of glutathione and increased activity of gluthathione peroxidase in brain were not changed significantly. Conclusions : Above results suggest that CSHDJ has anticonvulsant, antioxidant effect. That seems to be strongly related with the levels of GABA, glutamate, lipid peroxide and the activities of GABA-T, XOD, aldehyde oxidase, SOD, catalase in brain tissue. From these results, CSHDJ could be applied to various convulsive disorders.

  • PDF

원형탈모증 환자의 정서상태와 성격특성에 관한 임상적 연구 (Clinical Study of Emotional State and Personality Characteristics in Patients with Alopecia Aerata)

  • 이경규;백기청
    • 정신신체의학
    • /
    • 제5권2호
    • /
    • pp.158-167
    • /
    • 1997
  • Objectives: This study was aimed to investigate the emotional state and personality characteristics of alopecia aerata patient and to determine whether these characteristics are similar with those of neurotic patient. Methods : 20 alopecia aerata patients, 20 neurotic patients, and 20 normal healthy controls were studied. Beck Depression Inventory(BDI), State and Trait Anxiety Inventory(STAI) and Korean standardized edition of Catell's 16 Personality factors Questionnaire(16PF) were used for assessment. Results: 1) Total score of BDI was higher in neurosis group than alopecia aerata group and normal control group(p<0.05). Inspire of statistical non-significance, total score of in alopecia aerata group was higher than normal control group. 2) Total scores of state anxiety and trait anxiety in alopecia aerata and neurosis group were significantly higher than normal control group(p<0.001). 3) In first-stratum source traits of 16PF, normal control group was significantly higher than alopecia aerata group and neurosis group in B-factor(intelligence) and C-factor(ego-strength)(p<0.05). Alopecia aerata group and neurosis group were significantly higher than normal control group in O-factor(guilt-proneness) and $Q_4-factor(tension,\;anxiety)$(p<0.001). 4) In second-stratum source traits of 16PF, alopecia aerata group and neurosis group were significantly higher than normal control group in ANX-factor(anxiety)(p<0.05). Conclusions : These results suggest that emotional state and personality characterstics of patients with alopecia aerata are a distinguishable different to compare with normal control, and are very similar with those of neurotic patients. The authors propose that psychiatric management in patient with alopecia aerata will be more benificial.

  • PDF

Transcranial Doppler를 利用한 腦硬塞 患者의 血流速度와 血管 反應性에 대한 臨床的 考察 (Clinical study of the vasocreactivity and blood flow velocity of t he cerebral infarctions using Transcranial Doppler Sonography)

  • 안탁원;김병탁
    • 한방안이비인후피부과학회지
    • /
    • 제11권1호
    • /
    • pp.300-318
    • /
    • 1998
  • Background : The vasoreactivity of cerebral artery is currently the subject of increasing interest. Transcranial Doppler Sonography(TCD) is an accurate method of monitoring the blood flow velocities of the cerebral artery. We wished to assess the vasoreactivity between age-matched normal and cerebral infarction group. Method : We performed TCD findings in 40 normals and 20 cb-inf. subjects who arrived at hospital during 48 hours after attack. The former were devided into twenties normal group and fifties normal group. Result : 1. Fibrinogen levels showed significant changes between age-matched normal and cb-inf. group. 2. $V^{MEAN}$ of the both side Carotid Siphon during rest state increased significantly in cb-inf. group as compared with the age-matched normal group. 3. $V^{MEAN}and\;V^{MAX}$ of the both side carotid siphon during breath-hold state increased significantly in cb-inf. group as compared with the age-matched normal group. 4. Vasoreactivity of cerebral artery increased significantly in cb-inf. group as compared with the age-matched normal group. 5. $V^{MEAN}and\;V^{MAX}$ of the both side Radial artery during heat-stimuration state increased significantly in cb-inf. group as compared with the age-matched normal group. 6. Vasoreactivity of Radial artery increased significantly in cb-inf. group as compared with the age-matched normal group.

  • PDF

NG-SDH 망에서 다양한 클럭상태 하에서의 동기클럭 성능분석에 관한 연구 (A study on performance analysis of synchronization clock with various clock states in NG-SDH networks)

  • 이창기
    • 정보처리학회논문지C
    • /
    • 제13C권3호
    • /
    • pp.303-310
    • /
    • 2006
  • 본 논문은 NG-SDH망에서 정상상태와 SPT상태 및 LPT상태 등 다양한 클럭상태에 따른 동기클럭 특성분석과 최대 망노드수 도출을 위한 연구를 수행하는 것이다. 시뮬레이션을 통해서 정상상태일 경우 NG-SDH 최대 망노드수는 42개에서 38개로 나타났다. SPT상태에서 최종단 NE망을 SPT상태로 적용할 때 최대 망노드수는 19개에서 4개까지로 정상상태에 비하여 많이 감소하였고, 모든 NE망에서 SPT상태가 발생하면 규격만족 노드수가 크게 감소하였다. LPT상태에서 최종단 NE망을 LPT상태로 적용할 경우 최대 노드수는 모두 50개 이상까지로 나타났고, 모든 NE망을 LPT상태로 적용하더라도 동일한 결과를 얻었다. 그러나 모든 DOTS를 LPT상태로 적용하였을 경우 규격만족 전송망 노드수는 SPT상태나 정상상태에 비해 차이가 크지 않았다.

비정상임산부(非正常妊産婦)의 혈청중(血淸中) H.P.L.의 혈구응집조지반응(球凝集阻止反應)에 의한 측정(測定)에 관(關)한 연구(硏究) (H.P.L. Value in Abnormal Pregnancy by Hemagglutination-Inhibition Reaction)

  • 김동진;신면우
    • Clinical and Experimental Reproductive Medicine
    • /
    • 제4권1호
    • /
    • pp.27-32
    • /
    • 1977
  • Serum levels of human placental lactogen were measured by hemagglutination inhibition reaction in 26 normal pregnant state and in patients with 16 toxemia and 6 F.D.I.U. beyond their thirtieth week of gestation to evaluate their clinical usefulness. It was realized that HPL-HAIR Test Kit was easy to use and produced reliable results. The general conclusion were as follows: 1) HPL value was $6{\sim}8$ug/ml in normal pregnancy. 2) The levels in mild toxemia were similar in the normal state. 3) The levels in severe toxemia were similar or slightly lower than in the normal and mild toxemia. 4) The levels in F.D.I.U. were lower than in the normal state.

  • PDF