• Biomolecules & Therapeutics
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• v.31 no.3
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• pp.285-297
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• 2023

Alzheimer's disease (AD) is a neurodegenerative disease with progressive memory loss and the cognitive decline. AD is mainly caused by abnormal accumulation of misfolded amyloid β (Aβ), which leads to neurodegeneration via a number of possible mechanisms such as down-regulation of brain-derived neurotrophic factor-tropomyosin-related kinase B (BDNF-TRKB) signaling pathway. 7,8-Dihydroxyflavone (7,8-DHF), a TRKB agonist, has demonstrated potential to enhance BDNF-TRKB pathway in various neurodegenerative diseases. To expand the capacity of flavones as TRKB agonists, two natural flavones quercetin and apigenin, were evaluated. With tryptophan fluorescence quenching assay, we illustrated the direct interaction between quercetin/apigenin and TRKB extracellular domain. Employing Aβ folding reporter SH-SY5Y cells, we showed that quercetin and apigenin reduced Aβ-aggregation, oxidative stress, caspase-1 and acetylcholinesterase activities, as well as improved the neurite outgrowth. Treatments with quercetin and apigenin increased TRKB Tyr516 and Tyr817 and downstream cAMP-response-element binding protein (CREB) Ser133 to activate transcription of BDNF and BCL2 apoptosis regulator (BCL2), as well as reduced the expression of pro-apoptotic BCL2 associated X protein (BAX). Knockdown of TRKB counteracted the improvement of neurite outgrowth by quercetin and apigenin. Our results demonstrate that quercetin and apigenin are to work likely as a direct agonist on TRKB for their neuroprotective action, strengthening the therapeutic potential of quercetin and apigenin in treating AD.

• Structural Engineering and Mechanics
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• v.33 no.1
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• pp.67-77
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• 2009

The soil response calculation is described, by which, threw the fictive path of stress, the stress-deformation diagrams are determined, considering the nonlinear soil behavior. The calculation are lead incrementally, by which is shown that in the presented soil model (modified Cam Clay), considering the influence of overconsolidated soil pressure OCR, the number of calculation steps may, but not necessarily, have a sufficient influence on the value of failure load and definite soil deformation. The simplicity and the practicalness of the procedure, the enables modeling the complex relations in soil.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2009.11a
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• pp.187-187
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• 2009

The PVA(patterned vertical alignment) mode has a excellent dark state at normal direction. but they has a disclination area at divided domain region at voltage on state. so this disclination make a slow response time and decrease transmittance. To overcome this problem, we research about polymer stabilized vertical alignment (PS-VA) method which was using the UV curable reactive mesogen. According to our research, UV exposure condition which was UV dosage condition effected to rising time and decay time and also threshold voltage.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.1398-1403
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• 2003

In this paper, a simple method to design an MIMO sound field control system was proposed. The control system was designed to achieve 1) noise attenuation and 2) sound equalization by utilizing feedback and feedforward controllers. The method was based on partial model matching on frequency domain which only required measured frequency response data, or impulse response data in order to tune parameters of the controller. The proposed method was applied to a normal office room and results of experiment showed effectiveness of the proposed method.

• Transactions of the Korean Society of Mechanical Engineers
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• v.12 no.2
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• pp.193-199
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• 1988

The forced vibrations of nondissipative nonlinear two-degree-of-freedom system, subjected to periodic forcing functions, are investigated by use of the method of slowly changing phase and amplitude. The first order differential equations are derived for nonrationally solutions and the coupled nonlinear algebraic equations for stationary solutions. Through investigating the response curves of the system, which are obtained numerically by using Newton-Raphson method, it is found that the resonances can occur at more than the number of degree-of-freedom of the system depending on the relation between the nonlinear spring parameters, which has no counterpart in linear systems.

• Journal of Sensor Science and Technology
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• v.22 no.3
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• pp.227-232
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• 2013

In this research, fiber-optic pressure sensors were fabricated with rugate-structured porous silicon (RPS) diaphragms coated with PMMA (Polymethyl-Methacrylate). The reflectance spectrum of the PMMA/RPS diaphragm was almost the same as that of uncoated RPS diaphragm. However the mechanical strength of the PMMA/RPS diaphragm increased more than that of the uncoated diaphragm. As a result, the fiber-optic sensor fabricated with PMMA/RPS diaphragm could successfully detect more high pressure difference without diaphragm damage than the highest detectable pressure difference of the sensor with normal RPS diaphragm. The response data of the fiber-optic sensor recorded as a function of pressure difference were fitted by theoretical curves. During this process, elastic moduli of the used PMMA/RPS diaphragms were obtained numerically. The dynamic response properties of the fiber-optic sensor were also investigated under continuous variation of the pressure difference conditions.

• The Journal of the Korea institute of electronic communication sciences
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• v.9 no.4
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• pp.499-508
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• 2014

In this paper, we implemented a LED sensitivity illumination system, being driven in response to changes in the biological signals of GSR and PPG signal. After measuring biological signals of a human body from GSR and PPG sensor modules, MCU decided the state of relaxation or arousal of the subject, being based on the wake relaxation identifying map proposed in this paper. A developed LED sensitivity illumination system makes the subject to reach a normal state by giving a change of the LED illumination color, corresponding to a state of the subject.

• Journal of the Korean Mathematical Society
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• v.55 no.1
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• pp.43-58
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• 2018

In this paper, we study a delayed predator-prey system with Holling type IV functional response incorporating the effect of habitat complexity. The results show that there exist stability switches and Hopf bifurcation occurs while the delay crosses a set of critical values. The explicit formulas which determine the direction and stability of Hopf bifurcation are obtained by the normal form theory and the center manifold theorem.

• Proceedings of the KIPE Conference
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• 2000.07a
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• pp.620-623
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• 2000

A very simple control approach using neural network for the robust position control of a Permanent Magnet Synchronous Motor(PMSM) is presented The linear quadratic controller plus feedforward neural network is employed to obtain the robust PMSM system approximately linearized using field-orientation method for an AC servo. The neural network is trained in on-line phases and this neural network is composed by a fedforward recall and error back-propagation training. Since the total number of nodes are only eight this system can be easily realized by the general microprocessor. During the normal operation the input-output response is sampled and the weighting value is trained multi-times by error back-propagation method at each sample period to accommodate the possible variations in the parameters or load torque. And the state space analysis is performed to obtain the state feedback gains systematically. IN addition the robustness is also obtained without affecting overall system response. This method is realized by a floating-point Digital Singal Processor DS1102 Board (TMS320C31) The basic DSP software is used to write C program which is compiled by using ANSI-C style function prototypes.

• Journal of Korean Society for Quality Management
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• v.30 no.3
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• pp.38-52
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• 2002

This paper is concerned with the analysis of structural equation model(SEM) with the ordinal data such as Likert scale. The SEM is misused when the arbitrary scores allocated to the Likert scale are treated as quantitative data. The underlying distribution approaches have been studied to solve this problem, and the partial least squares(PLS) Is also tried. In this paper the quantification methods for the Likert scale are proposed to analyze the SEM. We assume that the Likert scale is an observation of the interval of the continuous underlying distribution, and the respondents have their own patterns in the response of some questions. Normal and beta distributions as the response patterns are considered to quantify the Likert scale. To compare the efficiency of the proposed method the bootstrap simulations are tried.