• International journal of steel structures
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• v.18 no.4
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• pp.1397-1409
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• 2018

Stiffened plates with high slenderness parameters show large out-of-plane deflections, due to elastic buckling, which may occur before the plates reach their ultimate strength. From a serviceability point of view, restriction of out-of-plane deflections exceeding the fabrication tolerance is of primary importance. Compressive strength at the serviceability limit state (SLS) for slender stiffened plates under uniaxial stress was investigated through nonlinear elasto-plastic finite element analysis, considering both geometric and material nonlinearity. Both normal and high-performance steel were considered in the study. The SLS was defined based on a deflection limit and an elastic buckling strength. Probabilistic distributions of the SLS strengths were obtained through Monte Carlo simulations, in association with the response surface method. On the basis of the obtained statistical distributions, partial safety factors were proposed for SLS. Comparisons with the ultimate strength of different design codes e.g. Japanese Code, AASHTO, and Canadian Code indicate that AASHTO and Canadian Code provide significantly conservative design, while Japanese Code matches well with a 5% non-exceedance probability for compressive strength at SLS.

• Structural Engineering and Mechanics
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• v.83 no.2
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• pp.259-272
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• 2022

The branch of electronics that uses an organic solar cell or conductive organic polymers in order to yield electricity from sunlight is called photovoltaic. Regarding this crucial issue, an artificial intelligence-based predictor is presented to investigate the vibrational behavior of the organic solar cell. In addition, the generalized differential quadrature method (GDQM) is utilized to extract the results. The validation examination is done to confirm the credibility of the results. Then, the deep neural network with fully connected layers (DNN-FCL) is trained by means of Adam optimization on the dataset whose members are the vibration response of the design-points. By determining the optimum values for the biases along with weights of DNN-FCL, one can predict the vibrational characteristics of any organic solar cell by knowing the properties defined as the inputs of the mentioned DNN. To assess the ability of the proposed artificial intelligence-based model in prediction of the vibrational response of the organic solar cell, the authors monitored the mean squared error in different steps of the training the DNN-FCL and they observed that the convergency of the results is excellent.

• IMMUNE NETWORK
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• v.7 no.4
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• pp.173-178
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• 2007

Background: We studied the role for expression of CD40 and CD40L by CD4 and CD8 T cells in the generation of CD8 T cell response to minor histocompatibility antigen, H60. H60 is a cellular antigen to which CD8 responses require CD4 T cell help. Methods: CD40- or CD40L-deficient mice were adoptively transferred with normal CD4 or CD8 T cells or with memory CD4 or CD8 T cells, and were immunized with male H60 congenic splenocytes to induce CD8 T cell response to H60. Peripheral blood CD8 T cell from the immunized mice were stained with the H60 tetramer. Results: CD8 T cell response to H60 was not induced in both CD40- and CD40L-deficient mice. Adoptive transfer of $CD40^{+/+}$ CD8 T cells into CD40-deficient mice did not compensate the defect in inducing CD8 T cell response to H60, while the H60-specific CD8 T cells were activated in the CD40-deficient mice that were adoptively transferred with $CD40^{+/+}$ CD4 T cells. Adoptive transfer of $CD40L^{+/+}$ CD4 T cells into CD40L-deficient mice induced primary CD8 T cell response for H60 and the presence of $CD40L^{+/+}$ CD4 T cells was required even for memory CD8 T cells response to H60. Conclusion: Our results suggest that the CD40-CD40L interaction mediates the delivery of CD4 T cell help to naive and memory H60-specific CD8 T cells. While the expression of CD40L by CD4 T cells is essential, signaling through CD40 on CD8 T cells is not required for the induction of CD8 T cell response to H60.

• BMB Reports
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• v.34 no.2
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• pp.123-129
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• 2001

Cellular response to ionizing radiation is affected by cell types, radiation doses, and post-irradiation time. Based on the trypan blue dye exclusion assay in normal oral mucosal cells (OM cells), a 48 h post-irradiation was sufffcient and an adequate time point for the evaluation of radiation sensitivity Its $LD_{50}$ was approximately 1.83 Gy To investigate possible biomarkers useful for the biological radiodosimetry of normal epithelial cells (p53, c-fos, cyclin D1, cdc-2, pRb) EGF receptor phosphorylation and Erk activation were evaluated at different radiation doses and different post-irradiation times. From 0.5 Gy, p53 was accumulated in the nucleus of basal cells of the OM raft culture at 4 h post-irradiation and sustained up to 24 h post-irradiation, which suggests that radiation-induced apoptosis or damage repair was not yet completed. The number of p53 positive cells and biosynthesis of p53 were correlated with radiation doses. Both cyclin D1 and c-fos were only transiently induced within 1 h post-irradiation. Cyclin D1 was induced at all radiation doses. However, cfos induction was highest at 0.1 Gy, approximately 7.3 fold more induction than the control, whose induction was reduced in a reverse correlation with radiation dose. The phosphorylation pattern of cdc-2 and pRb were unaffected by radiation. In contrast to A431 tails overexpressing the EGF receptor approximately 8.5 fold higher than normal epithelial, the OM cells reduced the basal level of the EGF receptor phosphorylation in a radiation dose dependent fashion. In conclusion, among radiation-induced biomolecules, the p53 nuclear accumulation may be considered for the future development of a useful marker far biological radiodosimetry in normal epithelial tissue since it was sustained for a longer period and showed a dose response relationship. Specific c-fos induction at a low dose may also be an important finding in this study It needs to be studied further for the elucidation of its possible connection with the low dose radio-adaptive response.

• The Journal of the Korea Contents Association
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• v.12 no.9
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• pp.357-368
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• 2012

The purpose of this study is to empirically examine the impact of enterprise R&D investment on international trade in Korea under the new Normal Era. In order to test whether the time series data of trade variables are stationary or not, we put in operation unit root test and cointegration test. Based on VECM (Vector Error Correction Model), we also apply impulse response functions and variance decomposition to estimate the dynamic effects in the short-run and long-run. The results show that the relationship between enterprise R&D investment and international trade (export and import) exists in the long-run as well as in the short-run. The results of applying impulse response functions and variance decomposition also indicate that the impact of enterprise R&D investment on international trade is positive, and a significant portion of fluctuations in the trade variable is explained by enterprise R&D investment. Therefore, enterprise R&D investment must be continuously increased to improve economic growth with promoting trading competition power in Korea under the new Normal Era.

• The Journal of the Korea Contents Association
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• v.13 no.12
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• pp.321-327
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• 2013

Impaired naming difficulty is common in normal elderly as well as in patients with neurological impairment. The 60-item Korean version-Boston Naming Test(K-BNT) is one of the most commonly used test for measuring confrontational naming ability. However, age-related cognitive decline may make the elderly difficult concentrating during the 60-item test, therefore, item reduction of the K-BNT would improve test validity and reliability. Thus, the purpose of this study was to develop a short form of the K-BNT based on Item Response Theory(IRT). Considering item-fit index, sex factor, and item difficulty through Rasch analysis, the 15-item K-BNT(i.e., K-BNT-15) was developed. Via administration of the K-BNT-15, we observed age-related decline in naming ability and significantly different performance between the normal elderly and patients with mild cognitive impairment. This study demonstrates the utility of IRT for developing a short-form language evaluation tool. The K-BNT-15 can be effective as a language screening tool to differentiate between normal aging and pathological diseases.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.9
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• pp.1305-1310
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• 2010

In a practical design process, the method of extracting the design space information of the complex system for verifying, improving, and optimizing the design process by taking into account the design variables and their shape tolerance is very important. Finite element analysis has been successfully implemented and integrated with design of experiment such as D-Optimal array; thus, a response surface model and optimization tools have been obtained, and design variables can be optimized by using the model and these tools. Then, to guarantee the robustness of the design variables, a robust design should be additionally performed by taking into account the statistical variation of the shape tolerance of the optimized design variables. In this study, a new approach based on the use of the response surface model is proposed; in this approach, the standard normal distribution of the shape tolerance is considered. By adopting this approach, it is possible to simultaneously optimize variables and perform a robust design. This approach can serve as a means of efficiently modeling the trade-off among many conflicting goals in the applications of finite element analysis. A case study on the robust optimal design of disc brakes under thermal loadings was carried out to solve multiple objective functions and determine the constraints of the design variables, such as a thermal deformation and weight.

• The Journal of the Korea Contents Association
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• v.20 no.3
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• pp.59-72
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• 2020

Previous crisis management research has mainly focused on business organizations' responsibility for crises, and yet research on CEOs in crisis still lacks. This research examined the influences of crisis responsibility and response strategies on attitudes toward a CEO, attitudes toward a corporate, and purchase intentions in the case of CEOs in crisis. In addition, this study explored how a CEO's SNS interactivity during normal times moderates the influences of crisis responsibility and response strategies. A 2(responsibility: high vs. low)X2(strategy: defensive vs. apology)X2(interactivity: high vs. low) experimental design was conducted with 200 Chinese students in Seoul. According to the analysis results from effects of response strategies by CEO's crisis responsibility levels, regardless of the crisis responsibility levels, the apology strategy was more effective than the defensive strategy in terms of CEO attitudes, corporate attitudes, and purchasing intentions. The analysis results about the moderating role of SNS interactivity during normal times show that under the CEO's high responsibility condition, keeping high SNS interactivity during normal times and using the apology after crisis brought out most favorable responses. Under the CEO's low responsibility condition, regardless of the SNS interactivity levels, the apology strategy brought out more favorable responses than the defensive strategy.

• Korean Journal of Soil Science and Fertilizer
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• v.10 no.1
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• pp.39-48
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• 1977

The results of the determination of the optimum level of nitrogen fertilizer experiment for rice paddy at 21 locations over the country in 1975 year are as follows. 1. The yields of control and N-fertilized plots of ordinary variety (Japonica type) were normal paddy soil>sandy paddy soil>poorly drained paddy soil. Control plots of Tongil variety, (Indica type) however, were sandy poorly drained soil>sandy normal paddy soil=clay poorly drained soil, and N-fertilized plots were normal paddy soil>sandy poorly drained soil>sandy soil>clay poorly drained soil. In other words Tongil variety has higher adaptability to sandy soil under no nitrogen. 2. The yield response to N-fertilizer was higher in normal paddy soil than sandy soil. The productivity per 1kg of nitrogen was 16.6kg in normal paddy soil, 10.5 in sandy soil, and 8.6-11.4 in poorly drained soil for Tongil variety. For ordinary variety, they were 12.6, 6.3, 6.6-9.3kg respectively. 3. Ripening ratio for ordinary variety and ripening ratio and grain weight for Togil variety were higher in sandy soil than normal paddy soil. The main reason why the N-response in mormal paddy soil is higher was appeared to be higher number of effective tillers in normal paddy soil. 4. The optimum rates of N-fertilizer in average were 19.4 in normal paddy soil, 14.6 in sandy soil, and 11.6-13.4kg/10a in poorly drained soil for Tongil variety. For ordinary variety they were 15.9, 10.2, and 8.7-12.7kg/10a respectively. 5. The optimum rate of nitrogen was increased with the increase of productivity in normal paddy soils. In sandy soils and poorly drained soils it was not proved. 6. The optimum rates of N-fertilizer calculated from field experiment were somewhat different from the optimum rates calculated from $SiO_2/OM$ ratio. However, the values calculated both ways showed high correlation. It would be recommendable, therefore, to use $SiO_2/OM$ ratio to calculate the optimum rates of N-fertilizer after revising this equation considering different rice varieties and soil types or water management and climate.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.12 no.1
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• pp.25-50
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• 2001

Using Fourier transformation and wavelet analysis, we compared the auditory event-related potentials of the patients with attention deficit-hyperactivity disorders(abbr. ADHD, 13 boys) and normal control children(8 boys). Amplitudes of the event-related potentials which were calculated via Fourier transformation were compared between the groups and between conditions(non-target versus target) in each group. To the non-target stimuli, the patients with ADHD showed significantly greater amplitudes across almost all of the electrode sites and frequencies. To the target stimuli, the incidents which ADHD patients showed much higher amplitudes than normal controls significantly decreased, while those of the reverse results increased significantly. These results were consistent with the comparison results about negative difference wave(abbr. Nd wave) using Fourier transformation. In summary, it was proved that non-target stimulus which should be ignored elicited more robust electrical response from the patients with ADHD than normal children, but the target stimulus which reguired active processing did much less electrical activity in the patients. For the patients, they showed much inhibited electrical response to the target stimuli in some electrodes and frequency ranges. Normal children were more strongly stimulated by the target stimuli in almost all electrodes and frequency ranges than the patients, but less in prefrontal leads and frontal leads. Wavelet analysis results proved that early responses(0-300msec) to the nontarget stimuli of the patients were significantly greater than the normal controls in prefrontal, anterior frontal, some parts of temporal, and occipital lobes and that late response(300-370msec) were significantly lesser than normal children in parietal and central electrodes. Target stimuli elicited significantly higher electrical activity in both group than non-target stimuli did. Prefrontal and frontal lobes showed stronger responses in the patients than normal children irrespective of stimulus condition, but parietal and temporal lobes did higher activities in normal children than the patients only to the target stimuli. In conclusion, the patients with ADHD showed much greater responses to the stimuli which should be ignored, but failed to activated the necessary processes to the target stimuli. Also, we found that the frequency-dimension analysis and wavelet analysis were useful for the signal processing such as event related potentials.