• Molecules and Cells
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• 제23권1호
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• pp.30-38
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• 2007

Dipyrithione (2, 2'-dithiobispyridine-1, 1'-dioxide, PTS2), a pyrithione derivate, is highly bactericidal and fungicidal. In this study we examined its apoptotic effect on HeLa cells. PTS2 induced HeLa cell death in a dose and time dependent manner. ERK1/2 and p38 were markedly activated, but little JNK1/2 activation was detected. Suppression of p38 activation by SB203580 reduced the extent of apoptosis of the HeLa cells and also prevented induction of p21, release of cytochrome c, and cleavage of caspase-3 and PARP. Inhibition of ERK1/2 with PD98059 increased apoptosis, indicating that ERK1/2 activation has an anti-apoptotic effect on PTS2-induced HeLa cell apoptosis. PTS2 also inhibited murine sarcoma 180 and hepatoma 22 tumor growth in an animal tumor model. Our findings indicate that PTS2 possesses anti-tumor activity, that caspase-3 and poly (ADP-ribose) polymerase (PARP) are involved in PTS2-induced HeLa cell apoptosis and that ERK1/2 and p38 have opposing effects on this apoptosis.

• Journal of muscle and joint health
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• 제6권1호
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• pp.51-72
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• 1999

The purpose of this study is to compar self-reported fatigue and fatigue-regulating behaviors of rheumatoid arthritic patients and normal persons. This study collected the data from 75 rheumatoid arthritic patents visited the departments of internal medicine or orthopedics of four general hospitals T-city and K-city by means of direct interview and questionnaires. in this study also collected data from 75 normal persons who had not been exposed to any other disease in T-city and K-city by means of direct interviews anti questionnaires which were conducted by two trained nurses. This experiment was conducted from August 1, 1998 to October 15, 1998. This study used both MAP(Multi-Dimentional Assessment of Fatigue) developed by Belza(1995) to measure fatigue and the measurement developed by Kwon, Young-Eun to investigate fatigue regulating behaviors. The collected materials were analyzed by means of descriptive statistics, t-test, and the ANCOVA according to the SPSS PC+ program. The findings are as follows : 1. There was the statistically significant difference(t =5.07, p=.000), between rheumatoid arthritic patients(32.76 points) and normal persons(25.81 points) in t-test comparison by group about fatigue. A fatigue degree of rheumatoid arthritic patient group was high in five kinds of lower realms such as common fatigue degree, fatigue severity to be experienced, distress due to fatigue, daily fatigue degree, and fatigue timing at the last week by dimension. 2. There was the significant difference in the number of fatigue-regulating behaviors between rheumatoid of fatigue arthritic patients(9.37 times) and normal persons (8.15 times), but there wasn't any significant difference in the efficiency between rheumatoid arthritic patients(2.85 points) and normal persons (2.78 points) This research suggests two kinds of things as follows : 1. It is necessary to develop an educational program for improving efficiency of fatigue-regulating behaviors as well as some nursing arbitration measures for reducing fatigue of rheumatoid arthritic patients. 2. It is necessary for the future studies to continuously grasp characteristics of fatigue by gender variable by selecting more rheumatoid arthritic male patients.

• 한국해양학회지
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• 제28권2호
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• pp.114-120
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• 1993

Numerical method of nonlinear regression was introduced to characterize grain-size distribution more effectively than using the traditional textural parameters. This technique proved critical particularly to multimodal size distributions, as exemplified by samples from Cheju strait continental shelf. Grain-size analysis of samples collected from the Cheju Strait continental shelf reveals that 86% of the grain-size distributions are multimodal. As multimodal grain-size distribution deviates from the statistical (log) normal distribution, the grain-size parameters traditionally used in sediment studies do not describe the distribution efficiently. Therefore, the use of grain-size curves into elementary normal component curves was used. Means and standard deviations of 387 decomposed normal components were decided by a decomposition method (nonlinear least square regression) from 167 size curves of the Cheju Strait sediments. The mean values of decomposed normal components show peaks at 1-3 phi and 8-9 phi size classes. The plot of mean values of the coarse fraction normal components on the map shows a characteristic and complex areal distribution. On the basis of the areal distribution of the mean values of the components and that of isopach of total Plenipotence sediment, the areal distribution of layers composing a transgressive sand of Late Plenipotence age were revealed.

• Journal of the Korea Institute of Information and Communication Engineering
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• 제11권2호
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• pp.430-435
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• 2007

In this paper, we propose an intelligent deployment of sensor network for reliable communication. The proposed method determines optimal transmission range based on the wireless channel characteristics, and searches the optimal number of sensor nodes, and optimal locations with SOFM. We calculate PRR against a distance uses the log-normal path loss model, and decide the communication range of sensor node from PRR. In order to verify the effectiveness of the proposed method, we performed simulations on the searching for intelligent deployment and checking for link condition of sensor network.

• The Journal of Korean Institute of Communications and Information Sciences
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• 제40권9호
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• pp.1856-1864
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• 2015

In this paper, the localization algorithm for improving the accuracy of the positioning using the Wi-Fi fingerprint using the normal distribution probability and the built-in typed accelerometer sensor, the gyroscope sensor of smartphone in the indoor environment is proposed. The experiments for analyzing the performance of the proposed algorithm were carried out at the region of the horizontal and vertical 20m * 10m in the engineering school building of our university, and the performance of the proposed algorithm is compared with the fingerprint and the DR (dead reckoning) while user is moving according to the assigned region. As a result, the maximum error distance in the proposed algorithm was decreased to 2cm and 36cm compared with two algorithms, respectively. In addition to this, the maximum error distance was also less than compared with two algorithms as 16.64cm and 36.25cm, respectively. It can be seen that the fingerprint map searching time of the proposed algorithm was also reduced to 0.15 seconds compared with two algorithms.

• The Transactions of the Korean Institute of Electrical Engineers D
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• 제54권11호
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• pp.680-688
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• 2005

The electrical current generated by heart creates not only electric potential but also a magnetic field. We have observed electrophysiological phenomena of the heart by measuring components of magnetocardiogram(MCG) using 61 channel superconducting quantum interference device(SQUD) system. We have analyzed the possibility and characteristics of MCG parameters for diagnosis of ischemic heart disease. A technique for automatic analysis of MCG signals in time domain was developed. The methods for detecting the position, the interval, the amplitude ratio, and the direction of single current dipole were examined in the MCG wave. The position and interval parameters were obtained by calculating the gradients of a envelope curve which could be formed by the difference between the maximum and minimum envelope of multi-channel MCG signals. We show some differences of the frequency contour map between the normal MCG and the abnormal (ischemic heart disease) MCG. The direction of single current dipole can be defined by rotating the magnetic field according to Biot-Savart's law at each point of MCG signals. In this study, we have examined the direction of single current dipole from searching for the centroids of positive and negative magnetic fields. The amplitude ratio parameters for measuring 57 deviation consisted of A$_{T}$/A$_{R}$ and other ratios. and We developed a new analysis method, which is based on the frequency contour map of electromagnetic field. Using theses parameters, we founded significant differences between normal subjects and ischemic patients in some parameters.

• Journal of the Korea Academia-Industrial cooperation Society
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• 제12권11호
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• pp.5150-5155
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• 2011

Alzheimer's disease (AD) and vascular dementia (VD) are the most common dementia. In this paper, we proposed a region selection for classification of AD, VD and normal (NOR) based on micro-Raman spectra from platelet. The preprocessing step is a smoothing followed by background elimination to the original spectra. Then we applied the minmax method for normalization. After the inspection of the preprocessed spectra, we found that 725-777, 1504-1592 and 1632-1700 $cm^{-1}$ regions are the most discriminative features in AD, VD and NOR spectra. We applied the feature transformation using PCA (principal component analysis) and NMF (nonnegative matrix factorization). The classification result of MAP(maximum a posteriori probability) involving 327 spectra transformed features using proposed local region showed about 92.8 % true classification average rate.

• Journal of the Korea Society of Computer and Information
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• 제13권5호
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• pp.77-84
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• 2008

This paper proposes a new approach to eliminate the reflectance component for the localization of text in natural scene images. Natural scene images normally have an illumination component as well as a reflectance component. It is well known that a reflectance component usually obstructs the task of detecting and recognizing objects like texts in the scene, since it blurs out an overall image. We have developed an approach that efficiently removes reflectance components while Preserving illumination components. We decided whether an input image hits Normal or Polarized for determining the light environment, using the histogram which consisted of a red component. In the normal image, we acquired the text region without additional processing. Otherwise we removed light reflecting from the object using homomorphic filtering in the polarized image. And then this decided the each text region based on the color merging technique and the Saliency Map. Finally, we localized text region on these two candidate regions.

• Investigative Magnetic Resonance Imaging
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• 제6권2호
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• pp.166-172
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• 2002

Purpose : To evaluate the usefulness of diffusion-weighted imaging(DWI) and quantitative apparent diffusion coefficient (ADC) maps in the patients with spinal cord infarction. Materials and methods : We studied 6 patients presented symptoms with spinal cord infarction, retrospectively (3 men and 3 women). We obtained multi-shot echo planar-based, DWI using 1.5T MR scanner at 5.4 mean days after the onset of ischemic symptoms. In six patients, signal intensity was acquired at conventional b value $1000s/\textrm{mm}^2$). The ADC value for the normal spinal cord and for infarcted lesions was measured from the trace ADC maps by using regions of interest positioned over the spinal cord. We analyzed signal intensity of lesion on MRI and DWI, and compared with ADC values in infarcted lesions and normal site. Results : T1-weighted MR image showed isosignal intensity in four of six patients and low signal intensity in two of six. T2-weighted MR image demonstrated high signal intensity in all of six. All DWI were considered to be diagnostic. All of six depicted a bright signal intensity on DWI. ADC values of infarcted lesion were measured lower than that of normal spinal cord on ADC map. The differences in ADC values between infarcted and normal spinal cord were significantly different (p＜0.05). Conclusion : It is possible to obtain DWI and ADC map of the spinal cord and DWI may be useful in the early diagnosis and localization of lesion site in patients with spinal cord infarction.

• Journal of KIISE:Computer Systems and Theory
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• 제37권3호
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• pp.184-193
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• 2010

This paper proposes a biological iridescence BRDF(Bidirectional Reflectance Distribution Function) compression and rendering method. In the graphics technology, iridescence sometimes is named structure colors. The main features of these symptoms are shown transform of color and brightness by varying viewpoint. Graphics technology to render this is the BRDF technology. The BRDF methods enable realistic representation of varying view direction, but it requires a lot of computing power because of large data. In this paper, we obtain reflection map from iridescence BRDF, analyze color of reflection map and propose representation method by several colorfully concentric circle. The one concentric circle represents beam width of reflection ray by one normal vector. In this paper, we synthesize rough concentric by using several virtually optical normal vectors. And we obtain spectrum information from concentric circles passing through the center point. The proposed method enables IBR(image based rendering) technique which results is realistic illuminance and spectrum distribution by one texture from reduced BRDF data within spectrum.