• Genomics & Informatics
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• 제11권4호
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• pp.263-271
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• 2013

We investigated the contribution of genetic variations of KLF5 to basal metabolic rate (BMR) and resting metabolic rate (RMR) and the inhibition of obesity in Korean children. A variation of KLF5 (rs3782933) was genotyped in 62 Korean children. Using multiple linear regression analysis, we developed a model to predict BMR in children. We divided them into several groups; normal versus overweight by body mass index (BMI) and low BMR versus high BMR by BMR. There were no differences in the distributions of alleles and genotypes between each group. The genetic variation of KLF5 gene showed a significant correlation with several clinical factors, such as BMR, muscle, low-density lipoprotein cholesterol, and insulin. Children with the TT had significantly higher BMR than those with CC (p=0.030). The highest muscle was observed in the children with TT compared with CC (p=0.032). The insulin and C-peptide values were higher in children with TT than those with CC (p=0.029 vs. p=0.004, respectively). In linear regression analysis, BMI and muscle mass were correlated with BMR, whereas insulin and C-peptide were not associated with BMR. In the high-BMR group, we observed that higher muscle, fat mass, and C-peptide affect the increase of BMR in children with TT (p < 0.001, p < 0.001, and p=0.018, respectively), while Rohrer's index could explain the usual decrease in BMR (adjust $r^2$=1.000, p < 0.001, respectively). We identified a novel association between TT of KLF5 rs3782933 and BMR in Korean children. We could make better use of the variation within KLF5 in a future clinical intervention study of obesity.

• Computers and Concrete
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• 제24권1호
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• pp.37-49
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• 2019

In this study, the shear behaviour of reinforced concrete (RC) beams that were retrofitted using precast panels of ultra-high performance fiber reinforced concrete (UHPFRC) is presented. The precast UHPFRC panels were glued to the side surfaces of RC beams using epoxy adhesive in two different configurations: (i) retrofitting two sides, and (ii) retrofitting three sides. Experimental tests on the adhesive bond were conducted to estimate the bond capacity between the UHPFRC and normal concrete. All the specimens were tested in shear under varying levels of shear span-to-depth ratio (a/d=1.0; 1.5). For both types of configuration, the retrofitted specimens exhibited a significant improvement in terms of stiffness, load carrying capacity and failure mode. In addition, the UHPFRC retrofitting panels glued in three-sides shifted the failure from brittle shear to a more ductile flexural failure with enhancing the shear capacity up to 70%. This was more noticeable in beams that were tested with a/d=1.5. An approach for the approximation of the failure capacity of the retrofitted RC beams was evolved using a multi-level regression of the data obtained from the experimental work. The predicted values of strength have been validated by comparing them with the available test data. In addition, a 3-D finite element model (FEM) was developed to estimate the failure load and overall behaviour of the retrofitted beams. The FEM of the retrofitted beams was conducted using the non-linear finite element software ABAQUS.

• 한국환경보건학회지
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• 제38권4호
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• pp.323-331
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• 2012

Objectives: The objective of this study was to investigate the possible effects of environmental cadmium (Cd) exposure on of bone mineral density (BMD) levels. Methods: A total of 171 residents around abandoned mines in Chungcheongnam-do were surveyed in 2008-2011. Urinary Cd and BMD were analyzed by atomic absorption spectrometry and Dual-Energy X-ray absorptionmetry, respectively. Osteoporosis and osteopenia were defined by T-scores set by the WHO; Tscore ${\geq}$ -1.0, normal; -1.0 > T-score > -2.5, osteopenia; and T-score ${\leq}$ -2.5, osteoporosis. Logistic and multiple linear regressions were applied to estimate the association between U-Cd levels and BMD. Results: The U-Cd geometric mean of 171 Koreans was 2.79 ${\mu}g/g{\cdot}cr$. The U-Cd concentration was significantly higher among women (2.98 ${\mu}g/g{\cdot}cr$) than men (2.39 ${\mu}g/g{\cdot}cr$). With the multiple regression model, the BMD was influenced by U-Cd, BMI, and monthly income. With the logistic regression model, osteoporosis was associated with U-Cd levels (OR = 3.239, 95% CI = 1.770-5.927). Conclusions: We conclude that exposure to cadmium is associated with an increased risk of osteoporosis.

• Clinical and Experimental Pediatrics
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• 제62권2호
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• pp.48-54
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• 2019

Purpose: Liver metabolism plays a pivotal role in the development of metabolic disorders. We aimed to investigate the clinical and laboratory risk factors associated with alanine aminotransferase (ALT) levels in young adolescents from an urban population in Korea. Methods: A population of 120 apparently healthy adolescents aged 12-13 years was included in the cross-sectional design study; 58 were overweight or obese and 62 were of normal weight. We estimated anthropometric and laboratory measurements, including waist-to-height ratio, blood pressure, insulin sensitivity, aspartate aminotransferases (AST), ALT, and lipid profiles. Results: The mean ages of the overweight or obese and normal weight participants were $12.9{\pm}0.3$ and $13.0{\pm}0.3years$, respectively. Height, weight, body mass index, waist circumference, waist-to-height ratio, systolic and diastolic blood pressure, AST, ALT, total cholesterol, low-density lipoprotein-cholesterol, triglyceride, insulin, and the homeostatic model assessment of insulin resistance (HOMA-IR) score were significantly higher and the high-density lipoprotein-cholesterol and quantitative insulin-sensitivity check index were significantly lower in the overweight/obese participants in comparison to the normal-weight participants (all P<0.05). In multivariate linear regression analysis, waist-to-height ratio, systolic blood pressure, and HOMA-IR score were independently and positively associated with serum ALT levels. Conclusion: Screening for ALT levels in adolescents may help to differentiate those at risk of metabolic abnormalities and thus prevent disease progression at an early age.

• 통합자연과학논문집
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• 제13권1호
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• pp.27-33
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• 2020

The unsustainable human activities like increased use of automobiles, heavy industrialization and the use of large volumes of fertilizers, chemicals and pesticides in the agricultural land cause climate change problems in one way or another. Under normal circumstances, the heat radiations from the sun will be reflected back. An excessive volume of GHGs in the atmosphere would prevent these radiations from reflecting back. East Asia is facing severe climate change issues in recent times. A lot of climate change problems such as hurricanes and floods have been reported from this region in the last couple of decades. The study aimed at investigating the climate change in East Asia with changing Sea Surface Temperature (SST). The study adopted a quantitative research method with a case study research design where a deliberate focus was made on the East Asia Region. Secondary data was gathered and analyzed to yield both descriptive and inferential statistics. The study concluded that the impact of East Asia Climate variability was significant mainly for some extreme events. Also, the study concluded that there was a significant link between the change of the East Asia climate variability and that of the sea surface temperature. Further, the study concluded that a linear relationship existed between the sea surface temperature and the climate of East Asia. Hence, a linear regression was a significant predictor of the East Asia Climate (EAC) based on changing sea surface temperature. The model revealed that 37.4% of the variations in the climate change index were explained by the changes in the sea surface temperature. The climate was expected to change with a value of 49.48 for a unit change in the sea surface temperature.

• 한국대기환경학회지
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• 제22권4호
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• pp.440-450
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• 2006

PM10, NOx, and $O_3$ were measured at six locations, of which each three is horizontally and vertically distributed respectively, in an apartment complex around the heavily traffic road. Those were measured seven times a day with two hours interval starting from 8 o'clock in the morning for 15 days during May 2005 $\sim$ September 2005. PM10 and NOx showed high concentrations in rush hours while low concentrations in midday due to the direct emissions from automobiles in operation. Temporal variations of 01 showed very much similar trend appeared in normal urban atmospheres. The spatial distributions of PM10, NOx and $O_3$ showed that almost all of concentrations were higher in a row of Roadside > Surface at 130 m apart from the road > Surface at 230 m apart from the road > 3rd floor of apartment building > 15th floor of apartment building > 27th floor of apartment building. Model equations, which can project spatial concentration distributions, were constructed by combining the horizontal and the vertical linear regression equations derived from six mean values corresponding to six measuring locations. According to inter-comparison of PM10, NOx, and $O_3$ with the constructed model equations, concentration gradients were higher in a row of Vertical direction of NOx > Vertical direction of PM10 > Horizontal direction of NOx > Horizontal direction of PMIO > Vertical direction of $O_3$ > Horizontal direction of $O_3$. Why concentration gradient of particulate PM10 is lower than that of gaseous NOx is in question, and should be studied.

• 한국산학기술학회논문지
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• 제16권5호
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• pp.3633-3642
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• 2015

단기추진제는 Nitrocellulose를 주요 에너지원으로 사용하는 추진제이다. 추진제의 정확한 저장 수명 예측은 인적, 물적 자원의 비용 절감 효과를 기대할 수 있다. 본 연구에서는 안정제 함량 변화모사에 대해 n차 반응속도 모델을 적용하여 최적의 반응차수를 도출하고, 이에 따른 저장 수명을 예측하였다. 고온가속노화시험 결과로부터 최적의 반응차수는 1.15481로 도출되었으며, 이때의 추정표준오차(${\times}100$ 기준)는 16.284로 나타났다. 일반 저장온도 범위를 $21^{\circ}C$에서 $30^{\circ}C$로 가정하면, 본 시험에 사용된 단기추진제는 약 35년에서 최대 140년까지 저장 수명이 예측되었다. 정확한 저장 수명을 예측하기 위해서는 탄약 저장고내 온도 분포를 데이터화하여 적용하는 것이 타당할 것으로 판단된다.

• 인간식물환경학회지
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• 제24권6호
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• pp.629-638
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• 2021

Background and objective: This study was conducted to develop diameter growth models for thinned Quercus glauca Thunb. (QGT) stands to inform production goals for treatment and provide the information necessary for the systematic management of this stands. Methods: This study was conducted on QGT stands, of which initial thinning was completed in 2013 to develop a treatment system. To analyze the tree growth and trait response for each thinning treatment, forestry surveys were conducted in 2014 and 2021, and a one-way analysis of variance (ANOVA) was executed. In addition, non-linear least squares regression of the PROC NLIN procedure was used to develop an optimal diameter growth model. Results: Based on growth and trait analyses, the height and height-to-diameter (H/D) ratio were not different according to treatment plot (p > .05). For the diameter of basal height (DBH), the heavy thinning (HT) treatment plot was significantly larger than the control plot (p < .05). As a result of the development of diameter growth models by treatment plot, the mean squared error (MSE) of the Gompertz polymorphic equation (control: 2.2381, light thinning: 0.8478, and heavy thinning: 0.8679) was the lowest in all treatment plots, and the Shapiro-Wilk statistic was found to follow a normal distribution (p > .95), so it was selected as an equation fit for the diameter growth model. Conclusion: The findings of this study provide basic data for the systematic management of Quercus glauca Thunb. stands. It is necessary to construct permanent sample plots (PSP) that consider stand status, location conditions, and climatic environments.

• 지능정보연구
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• 제23권3호
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• pp.139-153
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• 2017

기업의 부도는 이해관계자들뿐 아니라 사회에도 경제적으로 큰 손실을 야기한다. 따라서 기업부도예측은 경영학 연구에 있어 중요한 연구주제 중 하나로 다뤄져 왔다. 기존의 연구에서는 부도 예측을 위해 다변량판별분석, 로짓분석, 신경망분석 등 다양한 방법론을 이용하여 모형의 부도 예측력을 높이고 과적합의 문제를 해결하고자 시도하였다. 하지만 기존의 연구들이 시간적 요소를 고려하지 않아 발생할 수 있는 문제점들을 갖고 있음에도 불구하고 부도 예측에 있어서 동적 모형을 이용한 연구는 활발히 진행되고 있지 않으며 따라서 동적 모형을 이용하여 부도예측모형이 더욱 개선될 여지가 있다는 점을 확인할 수 있었다. 이에 본 연구에서는 RNN(Recurrent Neural Network)을 이용하여 시계열 재무 데이터의 동적 변화를 반영한 모형을 만들었으며 기존의 부도예측모형들과의 비교분석을 통해 부도 예측력의 향상에 도움이 된다는 것을 확인할 수 있었다. 모형의 유용성을 검증하기 위해 KIS Value의 재무 데이터를 이용하여 실험을 수행하였고 비교모형으로는 다변량판별분석, 로짓분석, SVM, 인공신경망을 선정하였다. 실험 결과 제안된 모형이 비교 모형에 비해 우수한 예측력을 보이는 것으로 나타났다. 따라서 본 연구는 변수들의 변화를 포착하는 동적 모형을 부도예측에 새롭게 제안하여 부도예측 연구의 발전에 기여할 수 있을 것으로 기대된다.

• 한국산학기술학회논문지
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• 제20권9호
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• pp.56-65
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• 2019

물리적 환경이 보행에 미치는 영향에 관한 연구들은 지속적으로 이루어져 왔다. 그러나 도시공간에서의 보행량에 날씨가 미치는 영향에 대한 연구는 부족하다. 이에 본 연구는 도시공간에서 날씨가 보행량에 미치는 영향을 실증 분석하는 것을 목적으로 한다. 본 연구는 2009년 서울시 유동인구 조사자료를 활용하였으며, 지점별 보행량을 종속변수, 날씨와 물리적 환경을 독립변수로 하는 모형을 구축하였다. 날씨가 보행량에 미치는 영향을 계절별, 토지이용별, 시간대별로 파악하고자 계절-토지이용-시간대로 구분된 28개의 모형을 작성하여 결과를 비교 해석하였다. 본 연구의 종속변수가 정규성을 만족하지 못하기 때문에 음이항 회귀모형을 활용하였다. 분석결과를 정리하면 다음과 같다. 첫째, 날씨요인들은 보행량에 영향을 미친다. "비"는 대부분의 모형에서 보행량을 감소시키는 효과가 나타났으며, "눈"과 "천둥번개"는 소수의 모형에서 매우 큰 보행량 감소효과를 나타냈다. 둘째, 날씨가 보행량에 미치는 영향은 계절과 토지이용에 따라 다르게 나타났다. 예를 들어 "비"의 보행량 감소효과는 주거지역보다는 상업지역에서 크게 나타났으며, 동절기 보다는 하절기에 그 효과가 크게 나타났다. 셋째, 환경요인들의 영향도 계절에 따라 다르게 나타났다. 차로 수는 하절기에는 보행량에 정(+)의 영향을, 동절기에는 부(-)의 영향을 미치는 것으로 나타났다. 지하철역 여부 또한 하절기에는 보행량에 강한 정의 영향을 미치지만 동절기에는 그 효과가 작거나 음의 영향을 미쳤다. 본 연구의 정책적 시사점은 다음과 같다. 첫째, 보행량을 감소시키는 효과가 있는 눈이나 비에 대응할 수 있는 반옥외 도시공간의 조성이 필요하다. 둘째 계절별로 특화된 보행활성화 정책이 필요하다.