• 제목/요약/키워드: Normal Aging

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Caffeine Treatment during Oocyte Aging Improves the Developmental Rate and Quality in Bovine Embryos Developing In Vitro

  • Choi, Hyun-Yong;Lee, Sung-Hyun;Xu, Yong-Nan;Lee, Seung-Eun;Kim, Nam-Hyung
    • Reproductive and Developmental Biology
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    • 제37권4호
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    • pp.281-287
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    • 2013
  • In mammal, unfertilized oocytes remain in the oviduct or under in vitro culture, which is called "oocyte aging". This asynchrony negatively affects fertilization in pre- and post-implantation embryo development. Caffeine a phosphodiesterase inhibitor is known to rescue oocyte aging in several species. The objective of this study is to determine the cytoskeleton distribution in aged oocytes and the embryo developmental ability of aged oocytes in the present or absence of caffeine during maturation. Caffeine treatment increased the incidence of normal spindle assembly of aged oocytes (treatment, $67.57{\pm}4.11%$ aging, $44.61{\pm}6.4%$) and no significant differences compared to control group. Fluorescence values were compared using ROS (Reactive oxidation species) stain. Fluorescence values appear of control group intensity rate ($51.53.{\pm}3.80$), aging group ($68.10{\pm}5.54$) and treatment of caffeine ($45.04{\pm}2.98$). Aged oocytes that were derived from addition of caffeine to the IVM (in vitro maturation) medium had significantly increased 2-cell that developed to the blastocyst stage compared to the aging group. Blastocysts, derived from caffeine treatment group, significantly increased the total cell number compare aging ($90.44{\pm}10.18$ VS $67.88{\pm}7.72$). Apoptotic fragments of genomic DNA were measured in individual embryo using TUNEL assay. Blastocyst derived from caffeine treatment group decreased significantly the apoptotic index compared to blastocyst derived from aging group. In conclusion, we inferred that the caffeine treatment during oocyte aging can improve the developmental rate and quality in bovine embryos developing in vitro.

Dr. Speech Science를 이용한 정상 및 후두질환 환자의 음향분석 (Acoustic Analysis of Normal and Vocal Pathologic Voice Using Dr. Speech Science)

  • 이형석;태경;장경진;김경우;김경래;박철원
    • 대한후두음성언어의학회지
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    • 제8권2호
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    • pp.166-172
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    • 1997
  • Background : For example, aerodynamic study, vibratory study, acoustic study, neuro-muscular test and psychoacoustic evaluation, a number of objective methods are now available for assessing pathologic voice change. They help to differentiate pathologic condition from normal condition and to monitor pathologic and aging change. These laboratory analyses are used commonly to monitor speech therapy and to follow a patient's recovery after surgery. Objectives : We investigated the values of jitter, shimmer and NNE of normal person and hoarseness patients in Korea. The values of Jitter and shimmer might be meaningful parameters distinguishing pathologic vibration from normal and recovery after surgery. Materials and Methods : Statistical significance between normal control and 48 subjects taken microlaryngeal surgery were compared with Dr. speech science program that is computerized system for acoustic analysis of voice production employed to determine vocal characteristics of pitch perturbation(jitter) and amplitude perturbation(shimmer). Results : The mean normal values of jitter and shimmer were 0.226${\pm}$0.110(%), 2.200${\pm}$0.421(%) in male and 0.164${\pm}$0.060(%), 2.063 ${\pm}$0.575(%) in female. In patients with vocal nodule, the preoperative and postoperative values of jitter and shimmer were valueless. In patients with vocal polyps, the preoperative and postoperative values of jitter and shimmer were valuable. Conclusion : Dr. speech science program was effective to monitor laryngeal disease and aging changes.

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3온스 물 삼킴검사 이후 정상 노년층의 음질 변화: 음향학적 분석 (Voice quality of normal elderly people after a 3oz water-swallow test: An acoustic analysis)

  • 이솔희;최홍식;최성희;김향희
    • 말소리와 음성과학
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    • 제10권2호
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    • pp.69-76
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    • 2018
  • The elderly are at increased risk of developing dysphagia due to aging and illnesses. The aim of the current study was to analyze, via an acoustic study, the change in the voice quality of normal elderly people after a 3oz water-swallow test. Subjects included a group of 60 normal elderly people (age: $mean{\pm}SD=76.9{\pm}6.66$) and 60 healthy young adults (age: $mean{\pm}SD=25.1{\pm}2.36$). Every participant produced a five-second /a/ phonation pre- and post-swallowing, and the fractioned two-second sections were analyzed using the MDVP (multi dimensional voice program) analysis. The elderly group demonstrated a post-swallowing increase in the following related acoustic parameters: fundamental frequency, fundamental frequency variation, amplitude-variation, and noise in both two-second sections. However, the younger group showed an increase only in frequency related acoustic parameters (i.e., STD ) in the first two-second section. The significant changes in values in the post-swallowing parameters might indicate temporary irregularities in pitch and amplitude along with higher amounts of noise in the voice. The results could be attributed to water residues in the vocal fold and vocal tract, as well as a deterioration of the motor and sensory functions caused by anatomical and physiological changes that result from aging.

A Study on the Regional Gap Analysis and Management of the Elderly Health in an Aging Society

  • YOO, Chae-Hyun;SHIN, Seung-Jung
    • International journal of advanced smart convergence
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    • 제10권2호
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    • pp.168-174
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    • 2021
  • Korea is ranked as the world's No. 1 country in its aging rate. While the interest and demand for health is rapidly increasing, the health status of the elderly is in the lowest among OECD members. Increased chronic diseases, the burden of medical costs and digital/untact changes of societies after COVID-19 have caused the direction of healthcare to be changed from treatment oriented to health care and prevention oriented, along with increased income levels and a desire for a healthy life. Amid this paradigm of change, the gap in health standards and health inequality for the elderly according to local structure and social conditions affects not only socio-economic but also the quality of life for individual senior citizen. Utilizing prior data of Aging Research Panel Survey, this study aims to compare and analyze health conditions and regional gaps which are significant influences on the satisfaction of the life of the elderly, and to suggest direction of studies for health care to provide solutions for health inequalities. The findings are intended to be a basic data for researching models of the New Normal Smart Healthcare System that bridge the health gap between the elderly and enhance life satisfaction with health care models suitable for regional characteristics in aging society.

노년기의 마음이론: 신경인지적 접근 (Theory of Mind in Old Age: A Review from a Neurocognitive Perspective)

  • 박민
    • 한국노년학
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    • 제30권3호
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    • pp.743-757
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    • 2010
  • 마음이론이란 자기 자신과 타인의 믿음, 바람, 의도와 같은 마음 상태를 추론하는 능력을 가리킨다. 마음이론에 대한 대다수의 연구는 아동과 자폐증 환자에 초점을 맞춘 것이었으나 정상적인 노화 과정을 겪고 있는 노인과 치매 노인을 대상으로 한 연구도 이루어지고 있다. 본 논문에서는 마음이론의 노화에 대한 기존 연구 결과들을 개관하고 신경영상 기법의 활용과 실생활에 근거한 마음이론 측정 과제의 적용과 같은 향후 연구 방향을 제안한다. 아직까지 마음이론 능력의 노화가 다른 인지적 측면과 어떻게 관련되어 있는가와 같은 문제에 대해 논쟁이 이루어지고 있기는 하지만 마음이론의 관점에 근거한 노화 연구는 노인의 인지적 기능과 사회적 기능에 대한 이해를 증진시킬 것으로 기대된다.

Breakdown Characteristics and Lifetime Estimation of Rubber Insulating Gloves Using Statistical Models

  • Kim, Doo Hyun;Kang, Dong Kyu
    • International Journal of Safety
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    • 제1권1호
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    • pp.36-42
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    • 2002
  • This paper is aimed at predicting the life of rubber insulating gloves under normal operating stresses from relatively rapid test performed at higher stresses. Specimens of rubber insulating gloves are subject to multiple stress conditions, i.e. combined electrical and thermal stresses. Two modes of electrical stress, step voltage stress and constant voltage stress are used in specimen aging. There are two types of test for electrical stress in this experiment: the one is Breakdown Voltage (BDV) test under step voltage stress and thermal stress and the other is lifetime test under constant voltage stress and temperature stress. The ac breakdown voltage defined as the break-down point of insulation that leakage current excesses a limit value, l0mA in this experiment, is determined. Because the very high variability of aging data requires the application of statistical model, Weibull distribution is used to represent the failure times as the straight line on Weibull probability paper. Weibull parameters are deter-mined by three statistical methods i.e. maximum likelihood method, graphical method and least squares method, which employ SAS package, Weibull probability paper and FORTRAN, respectively. Two chosen models for predicting the life under simultaneous electrical and thermal stresses are inverse power model and exponential model. And the constants of life equation for multistress aging are calculated using numerical method, such as Gauss Jordan method etc.. The completion of life equation enables to estimate the life at normal stress based on the data collected from accelerated aging test. Also the comparison of the calculated lifetimes between the inverse power model and the exponential model is carried out. And the lifetimes calculated by three statistical methods with lower voltage than test voltage are compared. The results obtained from the suggested experimental method are presented and discussed.

워너 증후군에 발생하는 근골격계 종양 (The Musculoskeletal Tumors of Werner's Syndrome)

  • 이상훈;서성욱;유광현;김한수
    • 대한골관절종양학회지
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    • 제8권3호
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    • pp.69-75
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    • 2002
  • 워너 증후군은 상염색체 열성 유전을 하는 희귀한 성인 조로 질환이다. 이 질환은 조기 노화를 보일 뿐만 아니라, 악성 종양의 발생 빈도도 증가하게 되는데, 골연부 조직의 종양이 많이 발생하게 된다. 그러나 악성 종양의 발생 원인은 단순한 조기 노화 현상으로만 보기보다는 하나의 종양 증후군으로 보는 경향이 있으며, 그 이유는 워너 증후군 환자에서 발생하는 종양의 위치, 병리적 소견, 나이 등에서 정상인과는 많은 차이를 보였기 때문이다. 최근의 분자 유전학적 연구들에 의해서 워너 증후군은 DNA의 복제, 복구, 재생에 관여하는 Werner helicase의 유전자 변이와 관련이 있음이 밝혀졌다. 워너 증후군의 유전자 이상은 이러한 DNA 복구과정에 문제를 일으키고, 유전자의 불안정성을 증가시켜 종양의 발생 가능성을 높이게 된다. 육종의 발생과 워너 증후군의 연관성에 관한 향후의 연구들은 정상적인 노화의 과정과 육종의 발생 기전에 관한 많은 정보를 제공할 수 있을 것으로 사료된다.

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경계 스캔 기반 온-라인 회로 성능 모니터링 기법 (A Boundary-Scan Based On-Line Circuit Performance Monitoring Scheme)

  • 박정석;강태근;이현빈
    • 전자공학회논문지
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    • 제53권1호
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    • pp.51-58
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    • 2016
  • 반도체 제조공정의 발달로 칩의 성능은 더욱 향상되었으나 회로가 미세해지고 복잡해져 동작 환경에 의한 회로의 노화가 가속화 될 수 있다. 회로의 노화는 성능 저하로 나타나며, 결과적으로 시스템 오류를 발생 시킬 수 있다. 고신뢰 시스템에서는, 노화로 인한 오류가 큰 재난으로 이어질 수 있으므로, 사고를 예방하기 위한 오류 발생 예측 기술이 필수적이다. 본 논문에서는 회로의 정상동작 중에 성능 저하를 감지하여 오류를 예측 할 수 있는 모니터링 기법을 제시한다. 모니터링을 위한 별도의 회로를 추가하지 않고 경계 스캔 셀과 TAP 제어기를 재활용한 IEEE 1149.1 경계 스캔 기반의 온-라인 성능 저하 모니터링 방법을 제시한다. 시뮬레이션을 통하여 제안하는 성능 저하 모니터링 기법을 검증한다.

전라도 농촌장수지역 거주 70대 노인의 건강상태에 영향을 미치는 환경적 요인에 대한 탐색 연구 (Investigation on Influencing Environmental Factors on Health Status of Korean Septuagenarians Dwelling in Longevity Region in Jeonla Province)

  • 곽충실;연미영;이미숙;오세인;박상철
    • 대한지역사회영양학회지
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    • 제19권2호
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    • pp.142-162
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    • 2014
  • Objectives: To evaluate the critical environmental factors on healthy-aging of Korean people, we investigated the significant factors influencing health status of septuagenarians living in rural area of Jeonla province, known to be one of the representative longevity regions in Korea. Methods: We divided subjects into healthy group (36M/25F) or poor-health group (26M/73F) based on self-reported health status, body mass index, a number of prescription, and blood test data. General characteristics, physical measurements, lifestyle, dietary behavior and nutrient intake, physical health and mental health data were statistically compared between the two groups. Results: Average age was not different between healthy group and poor-health group in men and women, respectively. In men, significantly favorable factors to health were observed to be higher education, regular exercise, higher grip strength and walking function, body mass index (${\geq}18.5kg/m^2$), moderate frequency of drinking and eating-out, non-smoking, normal red blood cell (RBC) count, higher serum dehydroepiandrosterone-sulfate (DHEAS) level, good digestive function and appetite, normal hearing function, regular meals, adequate vegetable and fruit intake, diverse food intake, adequate energy and nutrients (protein, vitamin $B_1$, $B_6$, C and E, folate, niacin, P, Zn and K) intake, higher mini-nutrient status assessment (MNA) score and low level of depression. On the other hand, in women, those were literacy, living arrangement, moderate frequency of drinking, healthy teeth, higher grip strength and walking function, bone mineral density, normal RBC and white blood cell (WBC) count, higher DHEAS concentration, higher MNA score, normal cognition and memory function, having snack and adequate fruit intake. Conclusions: These results could be useful to plan effective strategies to increase health-life expectancy of Korean old people living in rural areas.

공진흑원단(拱辰黑元丹)이 초기노화(初期老化) 흰 쥐의 항노화(抗老化) 및 항산화(抗酸化)에 미치는 영향 (Anti-aging and Anti-oxidative Effect of Gongjinhugwon-dan in Early Stages of Aging Rats)

  • 이화섭;안택원
    • 사상체질의학회지
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    • 제19권3호
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    • pp.242-256
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    • 2007
  • 1. Objectives Purpose of this study is to prove anti-aging and anti-oxidative effects of Gongjinhugwon-dan decoction. 2. Methods The SD rats used in this experiment were 6, 18, and 36 weeks old. Each age group was again divided into three groups. These nine groups consisted of 8 rats each. One group was given no treatment, another group was dosed $200{\mu}l$ of normal saline daily, and the last group was dosed $200{\mu}l$ of 1 % Gongjinhugwon-dan and saline mixture. At the conclusion of the experiment, the age groups were relabelled accordingly (10 weeks, 22 weeks, and 40 weeks). After 4 weeks, change of weight and liver markers were measured. Serum LDL cholesterol, total bilirubin, albumin, glucose, GOT and GPT levels were observed in order to check the hematological modification. Also, each organ tissue was biopsied in order to measure the SOD activity and the glutathione content change. 3. Results & Conclusions Aging did not cause any significant change in GOT and LDH, but GPT and albumin levels showed increase after GHD intake. Serum GPT was lower in the experimental group. Serum total bilirubin of the 40 w GHD group was significantly increased. The populations of dendritic cells in the spleens of the GHD groups were significantly increased. The levels of GSH in the liver of the 40 w GHD group and in the kidney of 22w-GSD were significantly increased in comparison with those of the normal groups. The degenerative change of brain tissue was decreased in the 40 w GHD group compared with those of the 40w normal group and the 40 w saline group. These results suggest that anti-oxidative GSH concentration of liver and kidney in rats treated with GHD showed significant increase in the 40 w GHD group. GHD was effective on increasing anti-oxidative substance in liver and dendritic cells in spleen, thus helping immune system and preventing cell mutation and degenerative change of brain tissues. Further studies and clinical investigation with GHD is needed.

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