• 한국임상수의학회지
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• 제27권1호
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• pp.66-70
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• 2010

Reference interval is critical for interpreting laboratory results, monitoring response to therapy and predicting the prognosis of the patients in clinical settings. The aim of the present study was to update established reference intervals for routine hematologic and serum chemistry values for a population of clinically healthy dogs (range, 1-8 years) seen in an animal hospital. Blood was obtained by venipuncture while animals were physically restrained, and samples were analyzed for 9 chemistries on MS9-5H (Melot Schloesing Lab, France) and 6 hematology on Vet Test 8008 (IDEXX, USA). Data from 105 dogs (52 males and 53 females) for hematology and 113 dogs (37 males and 76 females) for chemistry were used to determine reference intervals using the parametric, nonparametric and bootstrap methods. Prior to analysis, all parameters were tested for normal distribution using Anderson-Darling criterion. Of the 9 biochemical analytes, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, creatinine, total protein, and glucose concentrations did not fit normal distribution for both original and transformed data. All but eosinophil count satisfied normal distribution for either original or transformed data. Parametric method can be used for original cholesterol concentrations, RBC, WBC, and neutrophil counts. This technique can also be used for power-transformed values of blood urea nitrogen concentrations and for logarithm of lymphocyte and monocyte counts. Non-parametric or bootstrap method was the preferred choice for the remaining 7 biochemical parameters and eosinophil count as they did not follow normal distributions. All three statistical techniques performed in similar reference intervals. When establishing reference intervals for clinical laboratory data, it is essential to assess the distribution of the original data to increase the accuracy of the interval, and non-parametric or bootstrap methods are of alternative for the data that do not fit normal distribution.

• Korean Journal of Acupuncture
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• 제30권1호
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• pp.1-8
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• 2013

Objectives : The purpose of the present study was to examine statistical methods used in articles published on the Korean Journal of Acupuncture from 2007 through 2012. Methods : Statistical methods and statistical packages used in original articles applied with descriptive statistics or inferential statistics were organized. Results : Out of a total of 195 original articles, 18 articles used descriptive statistics only and 177 articles used inferential statistics. 142 articles used 12 types of statistical packages. SPSS was used most at 97 times(63.4%). The number of descriptive statistical methods used was a total of 417 and among them 193 were presented as tables(46.3%) and 224 were presented as graphs(53.7%). The number of inferential statistics applied was a total of 256 and analysis of variance was used most at 90 times(35.2%). The number of parametric statistical methods used was a total of 170(75.6%) and that of nonparametric statistical methods used was a total of 55(24.4%). Analysis of variance and two sample t-test were most employed in both clinical and non-clinical research. The number of multiple comparison methods applied was a total of 67 and the number of Scheffe methods among them was most at 26 times(37.7%). Conclusions : In the present study, statistical methods used in the journal over the last six years were examined. The result of this study is considered to be a basic material to be referred to when evaluating the quality of the medical journal.

• 한국산학기술학회논문지
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• 제15권5호
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• pp.3007-3013
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• 2014

본 연구의 목적은 블루 LED 기반의 치과용 스캐너를 이용하여 제작된 3차원 디지털 모형의 정확도를 평가하는 것이다. 본 연구를 위하여 20개의 동일한 석고 모형 제작 후 블루 LED기반의 치과용 스캐너를 이용하여 석고 모형과 동일한 20개의 3차원 디지털 모형을 제작하였다. 정확도를 평가하기 위해 두 집단의 모형을 대상으로 6개의 계측 거리를 지정한 후 측정하였다. 통계분석은 비모수 검정법인 윌콕슨 순위 합 검정법을 이용하여 비교 분석하였다(제1종 오류수준=0.05). 비록 모든 부위에서 디지털 모형이 석고 모형보다 작은 것으로 분석되었으나(p<0.05), 임상적 허용 수치를 벗어나지 않았다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2019년도 학술발표회
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• pp.17-17
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• 2019

IPCC (Intergovernmental Panel on Climate Change) 기후변화 전망보고서에 따르면 RCP 4.5 시나리오 기준, 21세기 전 지구 평균기온은 $2.5^{\circ}C$ 상승(한반도 $+3.0^{\circ}C$)하며, 전 지구 평균강수량은 4.1% 증가(한반도 +16.0%)할 것이라 전망하고 있다(기상청, 2012). 최근 기후변화와 기상이변에 따른 도심지 폭우특성이 변화하고 있음을 많은 연구결과에서 말해주고 있으며, 그 발생 빈도와 강도가 점차 증가하고 있는 추세이다. 특히, 서울시의 경우 인구와 재산이 밀집해 있어 폭우 발생에 의한 시민의 인명과 재산 피해 우려가 크다. 따라서 본 연구에서는 서울시를 대상으로 근미래(~2050년) 기후변화 하에서의 재현기간에 따른 확률강우량 변화 특성을 분석하여 비교 평가한 후 설계 강우량 산정에 활용하고자 하였다. 관측자료 기반 강수량의 변동 특성 분석과 Non-stationary GEV방법을 이용한 비정상성 빈도해석을 수행하였으며, 근미래 폭우특성 변화분석을 위하여 CMIP5 (Coupled Model Intercomparison Project 5)에 참여한 GCMs(General Circulation Models)을 활용한 강우빈도해석을 수행하였다. Mann-Kendall Test와 Quantile Regression을 통한 서울지점 여름철 강수량(June to September)과 기준강수량 초과 강수(30, 50, 80, 100mm/hr), 연간 10th 최대 강수량(Annual Top 10th Precipitation) 등을 분석한 결과 최근 증가 경향이 뚜렷하게 나타났으며, 비정상성 빈도해석에 의한 확률강우량 분석의 가능성과 신뢰성을 확인하였다. 또한 19-GCMs을 통하여 모의된 일(Daily) 단위 강수량자료를 비모수통계적 상세화(Nonparametric Temporal Downscaling) 기법을 적용하여 시간(Hourly) 강우로 다운스케일링하였으며, 서울시 미래 확률강우량에 대한 IDF 곡선(Intensity-Duration-Frequency Curve)을 작성하여 비교?분석한 결과 지속시간 1시간 강우에 대하여 재현기간 30년, 100년 조건에서 확률강우량이 약 4%~11% 수준에서 증가하고 있음을 확인하였다. 본 연구의 결과는 도심지 수공구조물의 설계빈도 영향을 진단하고, 근미래 발생가능한 확률강우량 변화에 따른 시간당 목표 강우량설정의 방법론을 제시하였다는데 의의가 있으며, 서울시의 방재성능목표 설정과 침수취약지역 해소를 위한 기후변화에 따른 수공구조물 설계 시 활용이 가능할 것으로 기대된다.

• 한방안이비인후피부과학회지
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• 제31권1호
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• pp.42-51
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• 2018

Objectives : This study was aimed to evaluate the correlation between changes in disease severity and serum total IgE or eosinophil count in individual patients of atopic dermatitis depending on the change of severity. Methods : We performed a retrospective chart review of 8 cases of atopic dermatitis who underwent blood tests more than five times. Disease severity was assessed by objective SCORing of Atopic Dermatitis index (OSI). Blood tests include serum total IgE, eosinophil counts, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN) and serum creatinine (SCr). In each subject, on the day that the blood test was performed, OSI was also assesed by a same physician. Correlation between OSI and total IgE or eosinophil count was analysed by nonparametric correlation analysis. Results : There was a statistically significant positive correlation between OSI and total IgE in three cases and a positive correlation between OSI and eosinophil count in two cases. In other three cases, there were no significant correlation. There were no cases that OSI correlated with total IgE and eosinophil count at the same time. In all cases, AST, ALT, BUN and SCr were stable. Conclusions : We suggest that total IgE and eosinophil count may reflect the severity of atopic dermatitis differently in individual patients. We also suggest that total IgE and eosinophil counts may be used as biomarkers to predict the severity of atopic dermatitis in some patients depending on the underlying pathology.

• Journal of Veterinary Science
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• 제22권5호
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• pp.64.1-64.12
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• 2021

Background: Pituitary pars intermedia dysfunction (PPID), a neurodegenerative disease leading to reduced dopamine production, is a common disease in aged horses. The treatment is based on administration of the dopamine agonist pergolide. This drug has been related to valvular fibrosis in humans, but the cardiovascular effect of this drug has not yet been investigated in horses. Objectives: To determine whether pergolide induces valvular disease in horses or affects the cardiac function. Methods: Standard, tissue Doppler (TDE) and two-dimensional speckle tracking (STE) echocardiography were performed in horses with diagnosed PPID based on adrenocorticotropic hormone dosage. Measurements taken in horses treated with pergolide were compared with those from untreated horses with nonparametric t-tests. Furthermore, measurements from follow-up examinations performed at least three months after the initial exam were compared with a Wilcoxon signed rank test for repeated measurements in each group. Results: Twenty-three horses were included. None of the 12 horses under treatment developed valvular regurgitation. Furthermore, no differences in the measurements of the left ventricular systolic or diastolic function could be seen between the group of horses with treatment and those without treatment. Measurements taken in the follow-up exam did not differ compared to those taken in the initial exam in both groups. Conclusions: No changes of the left ventricular function assessed by TDE and STE could be shown in a small population of horses with confirmed PPID. Treatment with pergolide did not affect the ventricular function nor induce valvular disease.

• Nutrition Research and Practice
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• 제15권3호
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• pp.309-318
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• 2021

BACKGROUD/OBJECTIVES: Data regarding the effects of poly-γ-glutamic acid (γ-PGA) on sleep status are limited. This study aimed to test whether γ-PGA and vitamin B₆ (VitB6) supplements improve sleep duration and quality. SUBJECTS/METHODS: A factorial randomized, double-blinded, placebo-controlled crossover study included 47 adults (25 men and 22 women) who were free of chronic disease. Stratified randomized allocation considered age and gender for three interventions, group A (supplementation with γ-PGA 600 mg; n = 16), group B (supplementation with VitB6 100 mg; n = 14), and group C (dual supplementation of both γ-PGA 600 mg and VitB6 100 mg; n = 17). Participants underwent a 1-mon intervention period, followed by a 1-mon washout period, and then a second 1-mon intervention period. Differences (mean ± SD) in nighttime sleep status before and after supplementation were compared between the placebo and intervention groups using nonparametric tests. RESULTS: Significant changes in sleep duration (0.27 ± 0.98 h, P < 0.05) and the Pittsburgh Sleep Quality Index global score (-0.52 ± 1.58, P < 0.05) indicating improved sleep status were observed in the intervention compared with the placebo of group C while no significant changes were observed in groups A and B. No statistical significance was detected between the intervention and the placebo; however, there was a greater increase in the group C intervention (4.59 ± 38.5 ng/mL) in serum serotonin concentrations than the groups A and B interventions. No side effects were observed. CONCLUSIONS: On the basis of these findings, the dual supplementation of γ-PGA and VitB6 may be effective as functional food components to improve nighttime sleep status.

• 가정간호학회지
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• 제27권3호
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• pp.294-305
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• 2020

Purpose: The aim of this study was to examine the preliminary effects of applying a developed web-based video education program in patients with cancer receiving chemotherapy. Methods: A one-group pre-post test design was used. The web-based video education program to prevent infection consisted of 5 subjects. The program was confirmed to be valid by an expert group of doctors and nurses. Convenience sampling of 23 subjects was performed to evaluate the effectiveness of the web-based video education program. Data were analyzed based on nonparametric statistics using SPSS 25.0 software. Results: Per the results of the study, knowledge and self-management behavior of infection prevention significantly improved after application of the program; however, there was no significant difference in self-efficacy. Conclusion: It was confirmed that the web-based video education program is effective to improve the knowledge and self-management behavior of infection prevention. However, as a preliminary study, this study did not have external validity. Therefore, it is necessary to verify the effectiveness of the program through randomized controlled trials and confirm the true infection prevention effect that was not considered in this research design.

• The Journal of Advanced Prosthodontics
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• 제13권1호
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• pp.24-35
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• 2021

PURPOSE. This study was to evaluate the effect of rinsing time on the accuracy of interim crowns fabricated by digital light processing. MATERIALS AND METHODS. The maxillary right first molar master die was duplicated using a silicone material, while a study die was produced using epoxy resin. Scans of the epoxy resin die were used in combination with CAD software to design a maxillary right first molar interim crown. Based on this design, 24 interim crowns were fabricated with digital light processing. This study examined the trueness and precision of products that were processed with one of the three different postprocessing rinsing times (1 min, 5 min, and 10 min). Trueness was measured by superimposing reference data with scanned data from external, intaglio, and marginal surfaces. Precision was measured by superimposing the scan data within the group. The trueness and precision data were analyzed using Kruskal-Wallis, nonparametric, and post-hoc tests, and were compared using a Mann-Whitney U test with Bonferroni correction (α=.05). RESULTS. The trueness of the external and intaglio surfaces of crowns varied significantly among the different rinsing times (P=.004, P=.003), but there was no statistically significant difference in terms of trueness measurements of the marginal surfaces (P=.605). In terms of precision, statistically significant differences were found among the external, intaglio, and marginal surfaces (P=.001). CONCLUSION. Interim crowns rinsed for 10 minutes showed high accuracy.

• 치위생과학회지
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• 제21권2호
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• pp.127-132
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• 2021

Background: Obesity and dental caries have common risk factors such as food intake, eating habits, and lifestyle. Nevertheless, there has been no consensus on the significant association between obesity and dental caries, and additional studies are needed. We investigated the relationship between obesity and dental caries in some college students in this pilot study. Methods: Forty-two obese college students (body mass index [BMI]≥25) registered at a University Obesity Clinic and 19 normal students (18.5≤BMI<25) were recruited. Oral examinations were conducted, and anthropometric data and blood samples were collected. The blood concentrations of low-density lipoprotein (LDL), high-density lipoprotein, and triglyceride were also measured. After controlling for dental plaque index, a univariate analysis of dental caries indicators related to obesity was performed; partial correlation analysis was also conducted. A nonparametric test was used for the analysis of gender-related trends due to the limited number of participants. Results: The obese group had significantly fewer missing teeth (p=0.014), missing surfaces (p=0.035), filled surfaces (p=0.038), and decayed-missing-filled surfaces (p=0.020) than the normal group. There was no difference between the males in the normal and obese groups. The females in the obese group had significantly fewer missing teeth (p=0.003), missing surfaces (p=0.003), and decayed-missing-filled surfaces (p=0.046). Partial correlation analysis showed a weak negative correlation (r=-0.256) between the blood LDL concentration and decayed-missing-filled teeth. The other obesity and dental caries indicators were not correlated. Conclusion:The blood cholesterol concentration had a negative relationship with dental caries, and there were fewer cases of dental caries in the obese group in this study. However, it is important to clarify the relationship between obesity and dental caries through a dietary survey or additional investigations considering other confounding factors.