• The Journal of the Acoustical Society of Korea
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• v.29 no.2E
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• pp.55-63
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• 2010

High Intensity Focused Ultrasound (HIFU) is a noninvasive surgical method mainly targeting deeply located cancer tissue. Ultrasound is generated from an extemally located transducer and the beam is focused at the target volume, so that selective damage can be achieved without harm to overlying or surrounding tissues. The mechanism for cell killing can be combination of thermal and cavitational damage. Although cavitation can be an effective means of tissue destruction, the possibility of massive hemorrhage and the unpredictable nature of cavitational events prevent clinical application of cavitation. Hence, thermal damage has been a main focus related to HIFU research. 2D phased array transducer systems allow electronic scanning of focus, multi-foci, and anti-focus with multi-foci, so that HIFU becomes more applicable in clinical use. Currently, lack of noninvasive monitoring means of HIFU is the main factor to limit clinical applications, but development in MRI and Ultrasound Imaging techniques may be able to provide solutions to overcome this problem. With the development of advanced focusing algorithm and monitoring means, complete noninvasive surgery is expected to be implemented in the near future.

• Journal of Biomedical Engineering Research
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• v.16 no.2
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• pp.167-174
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• 1995

Development of a noninvasive intensive care system calls for the use of evoked potentials (EPs) as a means of diagnosing traumatic head-injured patients. The experiment entails surgically placing two subarachnoid bolts and a subdural balloon through the skull to simulate a subdural hematoma. Using various levels of intracranial pressure (ICP) and/or different sizes of balloons, auditory evoked potentials (AEPs) were recorded from a rabbit. Six positive peak latencies ($P_1 - P_6$) and five negative peak latencies ($N_l- N_5$) were extracted from an averaged AEP waveform. Multiple regression analyses were performed for determining. a relationship between the ICP and AEP peak latencies. The results indicate that a major correlation of ch, mges on AEP peak latencies is due to mechanical forces of a mass (inflated balloon simulating a hematoma) in the distortion of the brain matter rather than increased ICP itself.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1998.06a
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• pp.762-766
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• 1998

Mechanical valve is one of the most widely used implantable artificial organs, Since its failure (mechanical failures and thrombosis to name two representative example) means the death of patient, its reliability is very important and early noninvasive detection is essential requirement . This paper will explain the method to detect the thrombosis formation by spectral analysis and neural network. In order quantitatively to distinguish peak of a normal valve from that of a thrombotic valve, a 3 layer backpropagation neural network, which contains 7,000 input nodes, 20 hidden layer and 1output , was employed. The trained neural network can distinguish normal and thrombotic valve with a probability that is higher than 90% . In conclusion, the acoustical spectrum analysis coupled with a neural network algorithm lent itself to the noninvasive monitoring of implanted mechanical valves. This method will be applied to be applied to the performance evaluation of other implantable rtificial organs.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.129-130
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• 1998

In this paper, We designed the ECG-NIBP-$SpO_2$ patient monitor. This production can measure Electrocardiograph, Heart Rate, Noninvasive Blood Pressure, and Oxygen Saturation for Noninvasive Mehod and can display each information. These informations were implemented by the electrodes of ECG part, the cuff of NIBP module and the finger probe with light sensor of $SpO_2$ without injection of needle or catheter. In addition, We developed a new analysis algorithm and measurement technique for NIBP and $SpO_2$ to observe patient's conditions correctly.

• Journal of Sensor Science and Technology
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• v.15 no.6
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• pp.449-456
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• 2006

The purpose of urodynamic investigation is to obtain the information on the function of the urinary system. The aim of this study is to acquire the useful information of lower urinary tract symptom (LUTS) diagnosis through void force signal as noninvasive method. The system which could evaluate the function of compensatory hypertrophy with noninvasive and comfortable method was implemented to measure uroflow and void force during urination. The implemented system composes of the sensor parts, signal conditioning parts and PC monitoring program. For the evaluation of the implemented system, the simulation of control part of the system was performed and the model system for the lower urinary system was designed. The superiority of a measuring characteristic of the implemented system was verified using the model system. From the evaluation of the model system, we have found out that the void force was dependent on the occlusion degree and compensatory hypertrophy significantly.

• Proceedings of the KIEE Conference
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• 2005.07c
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• pp.2069-2071
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• 2005

본 연구에서는 플라즈마 식각 공정 시 식자률, 선택비, wafer 손상등과 중요한 관련이 있는 이온 에너지 분포(IED)를 측정하기 위해서 챔버 내에 직접적으로 분석기를 설치하지 않고 챔버 외부에서 비 침투적(noninvasive)인 방법을 사용하여 측정하였다. 이 방범은 신호선 중 한 곳에 측정 점을 잡기 위한 연결 장치만 필요하며 그곳에서의 전안 신호와 전류 신호를 오실로스코프에서 측정한 후 미리 얻어진 챔버 구조 모델링 계수 등을 통해 실제 바이어스 전극에 걸리는 전압 및 전극에서 플라즈마로 흐르는 전류를 유추한다. 전압 및 전류측정값과 power balance와 particle balance를 적용하여 얻은 플라즈마 특성 상태 변수들을 사용하여 oscillating step sheath model을 기반으로 한 분석 프로그램을 통해 실시간 이온에너지 분포 결과를 얻었다. 실제 공정 시 바이어스 주파수 변화, 바이어스 파워 변화, 소스 파워변화 조건 등에 따른 이온 에너지 분포 측정 및 분석을 통해 비 침투적측정방법 적용의 가능성과 장점을 확인하였다.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.251-253
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• 1996

Noninvasive monitoring of total Hemoglobin value is feasible with the use of spectroscopic measurements. As a step toward tile final goal of the development of a noninvasive monitor, the spectra$(400{\sim}800mm)$of EDTA whole blood were obtained along with reference total Hemoglobin values. Under the same condition water spectrum was generated. It was subtracted from each blood sample, and then tile first derivative of each subtracted data was taken by 'approximated first derivative algorithm' with gap (1,6,10,20nm). The correlation was obtained between total Hemoglobin and first valley wavelength of first derivative spectrum (sample number: 93).

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2007.04a
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• pp.9-10
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• 2007

본 논문에서는 비접촉식 이온에너지 해석 방법(Noninvasive Ion Energy Analysis, NIEA)을 이용하여 이온에너지 분포함수를 계산하고, 이 분포의 정보를 몇 가지 양으로써 특성지을 수 있는 모니터링 인자를 제안 하였다. 이온 에너지 분포에 영향을 미치는 외부 조건들인 rf 전력, 압력, 전극 간격을 변화시키며 해당 에너지 분포함수의 형태 변화 및 모니터링 인자들의 변화 양상을 관찰 하였다. NIEA 방법으로 측정한 이온 에너지와 공정과의 연관성을 알아보기 위해 poly silicon etching을 수행하며 이온 에너지 분포를 측정하였으며, 이온 에너지와 etch rate이 같은 경향을 나타내는 것을 확인 하였다.

• Clinical and Experimental Pediatrics
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• v.61 no.10
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• pp.307-314
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• 2018

The incidence of type 1 diabetes mellitus (T1DM) in children and adolescents is increasing worldwide. Combined effects of genetic and environmental factors cause T1DM, which make it difficult to predict whether an individual will inherit the disease. Due to the level of self-care necessary in T1DM maintenance, it is crucial for pediatric settings to support achieving optimal glucose control, especially when adolescents are beginning to take more responsibility for their own health. Innovative insulin delivery systems, such as continuous subcutaneous insulin infusion (CSII), and noninvasive glucose monitoring systems, such as continuous glucose monitoring (CGM), allow patients with T1DM to achieve a normal and flexible lifestyle. However, there are still challenges in achieving optimal glucose control despite advanced technology in T1DM administration. In this article, disease prediction and current management of T1DM are reviewed with special emphasis on biomarkers of pancreatic ${\beta}-cell$ stress, CSII, glucose monitoring, and several other adjunctive therapies.

• Nuclear Medicine and Molecular Imaging
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• v.40 no.2
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• pp.96-105
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• 2006

Molecular imaging has its root in nuclear medicine and gene therapy monitoring. Therefore, recent progress in the development of non-invasive imaging technologies, particularly nuclear medicine, should allow molecular imaging to play a major role in the field of gene therapy. These tools have recently been validated in gene therapy models for continuous quantitative monitoring of the location, magnitude, and time-variation of gene delivery and/or expression. This article reviews the use of radionuclide imaging technologies as they have been used in imaging gene delivery and gene expression for gene therapy applications. The studios published to date lend support that noninvasive imaging tools will help to accelerate pre-clinical model validation as well as allow for clinical monitoring of human gene therapy.