• Transactions of the Korean hydrogen and new energy society
• /
• v.20 no.4
• /
• pp.337-343
• /
• 2009

Noncatalytic partial oxidation of methane for producing synthesis gas was studied in a lab-scale experimental apparatus. Partial oxidation developed for high-temperature, fuel-rich combustion and it is exothermic process. but Steam reforming and Caron reforming is highly endothermic process to need much energy. Noncatalytic partial oxidation of methane is affected by temperature and equivalent ratio, so we studied effect about composition of synthesis gas at lab scale reactor. We used electronic heater to control the temperature of reactor. The quality of synthesis gas is improved and reduced heat value to require at Noncatalytic partial oxidation because the reacting temperature is lower at oxy condition.

• Elastomers and Composites
• /
• v.34 no.4
• /
• pp.332-340
• /
• 1999

Hydrogenations of BR and NR performed by a noncatalytic method using p-toluenesulphonylhydrazide were carried out by reactive processing. The experimental procedures for carrying out the reaction were established. Two steps comprising premixing of the rubber with TSH followed by hydrogenation in compression mould were proved to be suitable. The percentages of hydrogenation attained by reactive processing were higher than those of the reaction carried out in solution at the same [TSH]/[C=C] ratio, reaction temperature and time. In-creasing the reaction temperature and reaction time resulted in increases of the percentage of hydrogenation. For BR, the maximum percentage of hydrogenation obtained was 36% at [TSH]/[C=C]=1/1.5. For NR, the highest percentage of hydrogenation was 34% at [TSH]/[C=C]=1/1.5. Cis-trans isomerisation was also observed to occur during hydrogenation of both BR and NR. Thermal stabilities of the hydrogenated BR and NR were shown to improve over those or the unhydrogenated counterparts.

• 한국전산유체공학회:학술대회논문집
• /
• 1999.05a
• /
• pp.162-170
• /
• 1999

Numerical study has been peformed to develop a computer code for the design & optimal operating condition of SNCR(Selective Noncatalytic Reactor) for NOx reduction together with the analysis of the performance of vortex tube. Especially for the SNCR of the scale of industrial boiler, the required mixing and residence time of $NH_3$ solution was successfully tested numerically by the implementation of some baffle setups in a combustor. The introduction of interesting phenomena of vortex tube and similar system is made together with a theoretical hypothesis and simple cold flow simulation for the flow field analysis.

• Korean Journal of Pharmacognosy
• /
• v.30 no.4
• /
• pp.404-408
• /
• 1999

SH2 domains and their associated catalytic or noncatalytic proteins constitute critical signal transduction targets for drug discovery. Grb2 associates with phosphotyrosine sites of the activated receptors or Shc via their SH2 domain to link receptor tyrosine kinases to ras signalling. Blocking of the Grb2-Shc complex may be to intervene the oncogenic signal transduction pathways and to develop a new antitumor drug. In the search for blockers of Grb2 SH2-Shc interaction, Lutein, a family of carotenoids, was isolated from the extract of the leaf of Agastache rugosa O. Kuntze as SH2 domain antagonists. The $IC_{50}$ of Lutein against Grb2-Shc binding was $6.8\;{\mu}M$.

• Molecules and Cells
• /
• v.26 no.3
• /
• pp.228-235
• /
• 2008

Thiol-dependent redox systems are involved in regulation of diverse biological processes, such as response to stress, signal transduction, and protein folding. The thiol-based redox control is provided by mechanistically similar, but structurally distinct families of enzymes known as thiol oxidoreductases. Many such enzymes have been characterized, but identities and functions of the entire sets of thiol oxidoreductases in organisms are not known. Extreme sequence and structural divergence makes identification of these proteins difficult. Thiol oxidoreductases contain a redox-active cysteine residue, or its functional analog selenocysteine, in their active sites. Here, we describe computational methods for in silico prediction of thiol oxidoreductases in nucleotide and protein sequence databases and identification of their redox-active cysteines. We discuss different functional categories of cysteine residues, describe methods for discrimination between catalytic and noncatalytic and between redox and non-redox cysteine residues and highlight unique properties of the redox-active cysteines based on evolutionary conservation, secondary and three-dimensional structures, and sporadic replacement of cysteines with catalytically superior selenocysteine residues.

• Molecules and Cells
• /
• v.37 no.4
• /
• pp.286-294
• /
• 2014

Mammalian polo-like kinase 1 (Plk1) has been studied intensively as a key regulator of various cell cycle events that are critical for proper M-phase progression. The polobox domain (PBD) present in Plk1's C-terminal noncatalytic region has been shown to play a central role in targeting the N-terminal kinase domain of Plk1 to specific subcellular locations. Subsequent studies reveal that PBD binds to a phosphorylated motif generated by one of the two mechanisms - self-priming by Plk1 itself or non-self-priming by a Pro-directed kinase, such as Cdc2. Here, we comparatively review the differences in the biochemical steps of these mechanisms and discuss their physiological significance. Considering the diverse functions of Plk1 during the cell cycle, a better understanding of how the catalytic activity of Plk1 functions in concert with its cisacting PBD and how this coordinated process is intricately regulated to promote Plk1 functions will be important for providing new insights into different mechanisms underlying various Plk1-mediated biological events that occur at the multiple stages of the cell cycle.