• 한국식품영양과학회지
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• 제36권6호
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• pp.708-719
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• 2007

본 연구에서는 104명의 성인남녀를 대상으로 그들의 GSTT1, GSTM1, GSTP1의 유전적 다형성 분포도를 조사한 결과, 전체 대상자들 중 각각 60명(57.4%), 42명(40.6%)가 GSTT1 과 GSTM1의 유전자를 가지고 있었으며, GSTT1과 GSTM1 유전자가 둘 다를 가진 대상자는 27명(25.7%), 둘 중에 하나만 가지고 있는 사람은 47명(45.5%) 그리고 둘 다 없는 사람은 30명으로 28.7%에 해당되었다. GSTP1 유전자의 경우 homozygous(a/a) wild type은 79명(75.5%)으로 대부분의 대상자가 여기에 해당되었으며, heterozygous(a/b) heterozygous type은 22명(21.6%), 그리고 homozygous(b/b) wild type으로 나타난 대상자는 3명(2.9%)이었다. GSTT1 null type은 산화적 스트레스를 더 많이 받고 있는 것으로 알려진흡연자의 비율이 present 군에 비해 낮음에도 불구하고 적혈구 GSH의 농도는 유의적으로 낮고 임파구 DNA 손상정도는 유의적으로 높은 것으로 나타났다. GSTM1 유전자의 경우 적혈구 GSH-Px의 활성만이 GSTM1 null type이 presenttype에 비해 유의적으로 높은 것으로 나타났으며, 나머지 다른 지표에서는 GSTM1 null type과 present type 간의 유의적인 차이가 없었다. GSTP1 유전자 다형성에 따른 항산화 영양상태의 유의적인 차이는 없었다. 흡연과 GST 유전자 다형성의 상호작용결과, 혈장 ${\alpha}$-carotene 농도, 적혈구 GSH-Px와 GST 활성은 GSTT1 null type의 경우 흡연자에 비해 비흡연자가 유의적으로 높게 나타났으며, GSTT1 present type에서는 흡연자와 비흡연자간의 유의적인 차이가 없는 것으로 나타났다. GSTM1 유전자의 경우 GSTM1의 null type에서 흡연자의 경우 비흡연자에 비해 혈장 ${\gamma}$-tocopherol과 ${\beta}$-carotene 수준이 유의적으로 낮았다. GSTT1과 GSTM1 유전자가 둘 다 없는 경우(both null)에는 흡연자의 혈장 lycopene과 적혈구 GST 활성이 비흡연자에 비해 유의적으로 낮았다. GSTP1 유전자의 경우 혈장 ${\alpha}$-carotene과 적혈구 GSH-Px 활성은 a/a type의 흡연자가 비흡연자에 비해 유의적으로 낮았고, 적혈구 catalase의 활성은 a/b type에서 흡연자가 비흡연자에 비해 유의적으로 낮았으며, ${\beta}$-carotene 농도는 두 type 모두에서 유의적으로 흡연자가 낮았다. 이상의 연구 결과 GST 유전적 다형성에따라 산화, 항산화 관련 효소 활성 및 항산화 영양소 수준의상태가 차이가 있음을 알 수 있었으며, 특히 흡연자의 경우 GST 유전자 type에 따라 항산화 영양상태가 더 큰 영향을 받음을 알 수 있었다. 이러한 연구 결과는 유전적 다형성에따라 항산화 영양소의 권장수준을 책정하는데 기초연구자료로 활용될 수 있을 것이다. 즉, GSTT1 또는 GSTM1 null type의 경우 비흡연자에 비해 흡연자가 항산화 영양소 수준이 더 낮게 나타났으므로 그들의 체내 항산화 영양 상태를 증가시킬 수 있는 여러 방안들, 즉 항산화 비타민의 보충투여 및 야채와 과일의 섭취 권장 등이 고려될 수 있을 것이다. 또한 GST 유전자 다형성에 따라 항산화 영양상태의 차이가 있으므로 항산화 관련 in vitro 실험, 동물 및 인체 실험의 결과 해석 시 나타나는 개인 간의 변이차이는 GST 유전자 다형성으로 일부분 설명될 수 있으리라 기대된다. 향후대상자의 범위를 좀 더 넓혀서 GST 유전자 다형성과 항산화 영양상태의 관계를 규명하고자 하며 더불어 산화물질 해독에 관여하는 다른 유전자(CYP 450, SULT 등)의 역할에 대해서도 계속적인 연구가 필요하다고 사료된다.

• 보건행정학회지
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• 제30권4호
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• pp.505-512
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• 2020

Background: In monitoring exposure to environmental smoke (ETS), biomarkers can overcome the subjectivity and inaccuracy of self-reporting measurements, and have the advantage of reflecting ETS exposure in all places. This study aims to evaluate the effectiveness of ETS exposure measurement using biomarkers such as urine cotinine. Methods: This study used the Korea National Health and Nutrition Survey data from 2009 to 2018. A total of 28,574 non-smokers with urine cotinine data were selected for the study. The cotinine concentration and ETS exposure rate using urine cotinine was estimated and then compared with the self-reporting measurements. The degree of agreement among measurements of ETS exposure was confirmed. Results: As a result of measuring ETS exposure with urine cotinine, 23,594 (83.8%) out of 28,574 subjects were classified as to exposure groups. This estimate differs significantly from measurements made by self-reporting. In addition, the average concentration of cotinine in non-smokers has decreased to a 10th level over the past 10 years. Based on the biomarker, the sensitivity of the self-reporting was 8.5%-29.0%, the specificity was 16.4%-19.5%, and the kappa value was 2.0%-5.8%. Conclusion: The findings of our study show that self-reporting measurement does not well reflect the extent to which non-smoker's exposure to smoking materials. Whereas cotinine concentration has decreased significantly over the past 10 years, the ETS exposure rate has not reduced. It strongly suggests the need for intervention in the group of non-smokers exposed to low concentrations of smoke. Therefore, an assessment using biomarkers such as cotinine-based measurement should be made in the Health Plan 2030.

• Tuberculosis and Respiratory Diseases
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• 제69권3호
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• pp.177-183
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• 2010

Background: Smoking reduces pulmonary function and induces various lung diseases. Recently, the rate of emphysema detection has increased due to lung cancer screening with low-dose chest computed tomography (CT). The purpose of this study was to evaluate changes in lung function associated with emphysema in healthy smokers. Methods: One hundred and ninety one healthy smokers, who had undergone a low-dose chest CT (LDCT) scan as part of lung cancer screening and had revisited the health center after a median 23.9 months' time, were recruited into this study. The severity of emphysema was calculated by the direct observation of a radiologist and a pulmonologist indipendently. Longitudinal changes in lung function according to emphysema based on LDCT and type of smoker was analyzed. Results: Of the participants in this study, 25% of healthy smokers had emphysema, which was mild in severity, in older patients (p=0.003) and in heavy smokers (p<0.001). $FEV_1/FVC$ and FEF25-75% were decreased in current smokers with emphysema (p=0.001 and p=0.009, respectively) and without emphysema (p=0.001 and p=0.042). Although lung function was not decreased in ex-smokers without emphysema, $FEV_1/FVC$ and FEF25-75% were decreased in ex-smoker with emphysema (p=0.020 and p=0.010). Conclusion: Upon examination with LDCT, the prevalence of emphysema was higher in healthy smokers was than in non-smokers. Lung function was diminished in smokers with emphysema, in spite of former smoker.

• The Journal of Asian Finance, Economics and Business
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• 제1권2호
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• pp.25-30
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• 2014

The small number of fusion research that addresses fear-appeal and self-efficacy in the effectiveness of warning labels cause the label is not clear, then the purpose of the study is the first to examine the effect of the combination of the message. With the experimental method, a total of 240 participants were smokers consist of Indonesian university students in the age range 18-23 years. Data obtained then processed with ANOVA statistical methods and Test T. The results are consistent with previous studies that the visual warning labels more effective than the textual warning labels alone. Results also suggest that a warning label should be both visual and textual messages combined with self-efficacy. Limitations, this study does not differentiate among smokers and non-smokers, in addition to the images are used only one type of disease, so that the research needs to be done to distinguish these factors.

• 한국학교보건학회지
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• 제32권2호
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• pp.88-95
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• 2019

Purpose: The prevalence of binge drinking has increased among Korean adolescents in recent years. The purpose of this study was to determine the influencing factors of adolescent binge drinking. Methods: This was a secondary analysis of data from the 14th Korea Youth Risk Behavior Survey. For the present analysis, 5,203 binge drinkers (girls who drank 3 or more glasses of soju and boys who drank 5 or more in average on one occasion in the last 30 days) and 4,464 non-binge drinkers were selected. Results: Compared with the adolescents who had no experience buying alcoholic beverages, the adolescents who responded that it was easy or uneasy to buy alcoholic drinks were more likely to be a binge drinker. Also, compared with never smokers, ex-smokers and current smokers were more likely to be a binge drinker. Binge drinking was positively associated with skipping breakfast, subjective health, and feelings of sadness or hopeless. Conclusion: The findings of this study may be useful in developing binge drinking prevention programs for adolescents.

• 대한의생명과학회지
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• 제29권1호
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• pp.34-40
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• 2023

Smoking is one of the three major risk factors for vascular disease along with hypertension and hyperlipidemia. It is true that smoking has a negative effect on the circulatory system, and the frequency of coronary artery disease and peripheral vascular disease is significantly increased in smokers. Many epidemiological studies report that smokers have an approximately two-fold increased risk of coronary artery disease compared to non-smokers. This study was designed to investigate the relationship between cerebral blood flow change and depression index after acute smoking. Cerebral blood flow tests were performed before and after smoking in 8 subjects. Changes in blood flow after smoking were correlated with the depression score and negatively correlated with the depression score. In particular, there was a strong correlation with changes in blood flow in anterior cerebral artery. It is well known that changes in blood flow after smoking have a negative effect. In addition, considering the study that smoking aggravates the symptoms of depression, it was found that smoking and depression are factors that negatively affect each other.

• Journal of Nutrition and Health
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• 제26권3호
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• pp.313-324
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• 1993

Sister chromatid exchange(SCE) has recently become a common cytogenic assay system for detecting exposure to chemical mutagens and carcinogens. One application of SCE is the monitoring of populations believed to be exposed to such agents. A cross-sectional study of SCE frequency in peripheral blood lymphocytes from 40 college students aged 18 to 26 years was conducted. The effects of cigarette smoking alcohol and coffee consumption, dietary and environmental factors on SCE were assessed. A mean spontaneous SCE per cell for the smokers(4.88$\pm$0.17). The SCE levels of the smokers were associated with the personal smoking amount ; the observed increase in the SCE frequency correlated with the number of cigarettes smoked per day (P<0.05). There was no effect of age on SCE. There were positive linear relationship between SCE and food frequency score of meat and fish group (P<0.05) or instant food group(P<0.01) in non-smokers. But in smokers, a significant inverse association between SCE and food frequency score of green and yellow vegetable group(P<0.05). Alcohol intake produced a significant increase(P<0.01) of SCE in comparison with the mean SCE for those not drinking alcohol in combine subjects. Other dietary parameters, including coffee intake, use of artificial sweetners and processed foods, did not show any increase in SCE. SCEs were inversely related to blood glucose and serum cholesterol levels of the combine subjects. No significant correlations were found between SCE frequencise and any other hematological parameters of the subjects.

• 한국치위생학회지
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• 제15권5호
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• pp.889-898
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• 2015

Objectives: The purpose of the study is to investigate the oral health-related quality of life (OHIP-14) according to smoking in the male workers in Gunsan. Methods: A self-reported questionnaire was completed by 460 male workers in Gunsan from April 13 to 30, 2015. Among 460 workers, smokers were 205 and nonsmokers were 255. The questionnaire included three questions of general characteristics of the subjects, four questions of subjective oral health, fourteen questions of OHIP, ten questions of sobriety test (AUDIT), and eight questions of smoking (Fagerstrom Test for Nicotine Dependence, FTND). Data were analyzed by frequency analysis, t-test, ANOVA, Pearson's correlation, and multiple regression analysis using IBM SPSS(Statistical Package for the Social Science) for Windows 20.0 program. Results: In the nonsmokers, there was a negative correlation between the alcohol consumption, dental health condition, tooth pain, gum bleeding, and halitosis. The higher OHIP in the smokers had the negative correlation with nicotine dependence, alcohol consumption, tooth pain, gum bleeding, and halitosis. In order to improve OHIP, smokers are encouraged to manage gum bleeding, and non-smokers to halitosis. Conclusions: In order to improve OHIP, cessation of smoking and alcohol consumption is very important and it can lead to improve the quality of life in the workers.

• Journal of Multimedia Information System
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• 제9권2호
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• pp.137-144
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• 2022

This research aims to identify the relationship between visual perception and emotion by the types of fear responses elicited from warning images on cigarette packages as well as the effectiveness of the size of such images through questionnaires and eye-tracking experiments with twenty university students from the colleges based in Busan. The research distinguished and analyzed the warning images as rational appeals and emotional appeals by the degree of fear and disgust and the result concurred with the research conclusions of Maynard that people would naturally avoid eye contact when presented with a warning image on cigarette packages. Also, eye avoidance was highly identified with larger (75%) warning images. While the previous research mostly adopted the self-rated validation method, this research tried to make the methodology more objective by adopting both questionnaires and eye-tracking experiments. Through this research, authors contribute to finding effective warning images on cigarette packages in a way to increase public awareness of the dangers of smoking and discourage smoking. Further research is recommended to explore the effectiveness of using explicit images on cigarette packages by the types of smokers such as heavy smokers, normal smokers, and non-smokers.

• 치위생과학회지
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• 제8권3호
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• pp.139-146
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• 2008

본 연구는 구강질환의 국소적인 원인 인자 중 하나인 흡연과 구강건강의 관련성을 연구하기 위하여 치위생과 실습 수업에 참여한 환자 중 흡연 경험자 51명, 흡연 비경험자 51명을 대상으로 설문 조사한 자료를 분석하여 다음과 같은 결론을 얻었다. 1. 음주 시에 흡연을 더 많이 하는 환자가 78.4%로 여전히 높은 수준에 있어 구강건강을 위협하는 것으로 나타났다. 2. 최근 1년 이내 치석제거를 받은 경험이 있는 환자는 22.5%로 여전히 낮은 수준이다. 3. 흡연 경험자는 흡연의 유해성에 대한 인식을 하고 있으며, 잇솔질 시 잇몸 출혈과, 구취에 대한 자각정도가 비경험자에 비하여 높게 나타났다. 4. 1일 평균 잇솔질 횟수는 비흡연자보다 흡연자가 낮았다. 5. 간이구강위생지수는 남자가 4.58로 여자 4.00보다 높았으며, 흡연 경험자가 4.59로 비경험자 4.18보다 높게 나타났다. 이는 흡연경험자이고 남자일수록 구강환경상태가 좋지 못한 것을 의미한다.