• Toxicological Research
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• v.23 no.1
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• pp.1-9
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• 2007

Transporters are membrane proteins that mediate the transfer of substrate across the cellular membrane. In this overview, the characteristics and the toxicological relevance were discussed for various types of transporters. For drug transporters, the overview focused on ATP-binding cassette transporters and solute carrier family 21A/22A member transporters. Except for OCTN transporters and OATP transporters, drug transporters tend to have broad substrate specificity, suggesting drug-drug interaction at the level of transport processes (e.g., interaction between methotrexate and non-steroidal anti-inflammatory agents) is likely. For metal transporters, transporters for zinc, copper and multiple metals were discussed in this overview. These metal transporters have comparatively narrow substrate specificity, except for multiple metal transporters, suggesting that inter-substrate interaction at the level of transport is less likely. In contrast, the expressions of the transporters are often regulated by their substrates, suggesting cellular adaptation mechanism exists for these transporters. The drug-drug interactions in drug transporters and the cellular adaptation mechanisms for metal transporters are likely to lead to alterations in pharmacokinetics and cellular metal homeostasis, which may be linked to the development of toxicity. Therefore, the transporter-mediated alterations may have toxicological relevance.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.7
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• pp.1517-1524
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• 2011

In this paper, a new document summarization method, which uses the semantic features and the pseudo relevance feedback (PRF) by using WordNet, is introduced to extract meaningful sentences relevant to a user query. The proposed method can improve the quality of document summaries because the inherent semantic of the documents are well reflected by the semantic feature from NMF. In addition, it uses the PRF by the semantic features and WordNet to reduce the semantic gap between the high level user's requirement and the low level vector representation. The experimental results demonstrate that the proposed method achieves better performance that the other methods.

• Journal of the Korean Society for information Management
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• v.23 no.2
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• pp.97-111
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• 2006

The purpose of this study is to investigate what level of difference in precision would be significantly perceived by a human user of an information retrieval system. Not many researches have been conducted with regards to this issue in information retrieval field. Despite the non-significant results, there were several interesting findings in recognizing different levels of precision rates. The correctness of relevance task had little to do with the taken time for the task. In addition, the strong relationship between the subjects' topic familiarity and rate of correct judgments is one of the most interesting results in this study. It turned out that the subjects have more difficulty in a situation they have to judge between the two lists having more non-relevant documents than in a situation they do between the lists haying more relevant documents. Finally, the serious influence from the first top N documents in a list for relevance judgment task has been confirmed.

• Journal of the Korean Society for information Management
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• v.16 no.2
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• pp.49-80
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• 1999

This study analyses the researches on automatic query modification, expansion and combination based on search results of natural language queries and gives a conceptual framework for the factors affecting the effectiveness of the relevance feedback. The operating and experimental systems based on the vector space model, the binary independence model and the inference net model are reviewed, and it is found that the effectiveness of query expansion is affected by conceptual models, algorithms for weighting terms and documents and selecting query terms to be added, size of relevant and non-relevant documents to be used and size of terms to be added in relevance feedback, query length, type and size of DBs, etc.

• East Asian Journal of Business Economics (EAJBE)
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• v.6 no.4
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• pp.47-57
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• 2018

Purpose - This paper aims to analyze the determinants of licensing behaviors of manufacturing firms empirically in non-advanced exporting countries. Research design and methodology - We try to approach licensing behavior from the perspective of innovation strategy and open innovation, and deal with two activities composing licensing, i.e. licensing-in and licensing-out using the result of Korean Innovation Survey Results - Firstly, Organizational characteristic factors, particularly the size and size related factors influence the firm behavior of licensing-out, but not in case of licensing-in. Secondly, innovation strategy influences the firm behavior of licensing-in, but not in case of licensing-out. Lastly, the determinants of licensing-in and that of licensing-out are different. Conclusions - In general, firms doing licensing-out have many complementary assets and orientation for global markets. Meanwhile, firms doing licensing-in are innovative firms utilizing patent as an appropriation mechanism. Licensing-out have relevance with product market-related factors and licensing-in have more relevance with technology market-related factors

• Journal of Korean Dental Science
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• v.6 no.2
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• pp.78-86
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• 2013

Purpose: The purpose of this study was to assess the effects of lip anteroposterior position based on esthetic line on the perceived attractiveness. Materials and Methods: We selected a 20s female standard lateral photograph which was within average range of cephalometric analysis, modified lips anteroposterior position based on esthetic line into 5 pictures. This study investigated and compared the preference of facial profile among the groups; male : female and dental relevance: non-dental relevance. Total 255 judges (male : female=138 : 117, relevant : non-relevant=159 : 96) who were 20s to 30s were asked to rate these photographs based in lip attractiveness using visual analogue scale (VAS). Result: All groups had similarity the average of VAS of moved backward lips 2 mm were highest and moved forward lips 4 mm were lowest. Comparing between male group and female group, there were significant differences in all pictures except for original which was not modified. In the dental groups, moved forward lips 2 mm had significant difference and the average in dental relevant group were lower than non-relevant group in lip protrusion. Conclusion: The preference about lip protrusion was similar irrespective of dental knowledge or gender. All groups preferred retrusion of lips to protrusion of lips. In female group, they had higher the average of VAS. In relevant group, they disliked protrusion rather than retrusion of lips significantly.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.49 no.2
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• pp.53-60
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• 2012

In this paper, we proposes a new document summarization method using the expanded query by wikipedia and the semantic feature representing inherent structure of document set. The proposed method can expand the query from user's initial query using the relevance feedback based on wikipedia in order to reflect the user require. It can well represent the inherent structure of documents using the semantic feature by the non-negative matrix factorization (NMF). In addition, it can reduce the semantic gap between the user require and the result of document summarization to extract the meaningful sentences using the expanded query and semantic features. The experimental results demonstrate that the proposed method achieves better performance than the other methods to summary document.

• Tuberculosis and Respiratory Diseases
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• v.77 no.3
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• pp.124-131
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• 2014

Background: Bronchial anthracofibrosis (BAF), which is associated with exposure to biomass smoke in inefficiently ventilated indoor areas, can take the form of obstructive lung disease. Patients with BAF can mimic or present with an exacerbation of chronic obstructive pulmonary disease (COPD). The purpose of the current study was to investigate the prevalence of BAF in Korean patients with COPD exacerbation as well as to examine the clinical features of these patients in order to determine its clinical relevance. Methods: A total of 206 patients with COPD exacerbation were divided into BAF and non-BAF groups, according to computed tomography findings. We compared both clinical and radiologic variables between the two groups. Results: Patients with BAF (51 [25%]) were older, with a preponderance of nonsmoking women; moreover, they showed a more frequent association with exposure to wood smoke compared to those without BAF. However, no differences in the severity of illness and clinical course between the two groups were observed. Patients in the BAF group had less severe airflow obstruction, but more common and severe pulmonary hypertension signs than those in the non-BAF group. Conclusion: Compared with non-BAF COPD, BAF may be associated with milder airflow limitation and more frequent signs of pulmonary hypertension with a more severe grade in patients presenting with COPD exacerbation.

• Journal of the Korean Chemical Society
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• v.54 no.4
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• pp.471-478
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• 2010

This study analyzed the vocabulary level in the 'Water' unit of chemistry I textbook. It also analyzed its relevance to the 11th graders' vocabulary level. The main tool for analyzing vocabulary level was SWA(Science Word Analysis) program which was referenced the Standard Korean Dictionary and Graduated Vocabulary of Korean Language Education. The results in this study turned out to be as follows: The distribution of scientific vocabulary level increased from Level-1 to Level-3 and showed a tendency to decrease from Level-3 until Level-5. The average percentage of Out of level is the largest as 37%. The highest percentage of non-scientific vocabulary was Level-1. The distribution of non-scientific vocabulary level decreased progressively. The Level-5 and Out of level are used 18% averagely. So, there are 6 vocabularies of Level-5 and 82 vocabularies of extra-level inappropriate in scientific vocabularies. And there are 53 vocabularies of Level-5 and 145 vocabularies of Out of level inappropriate in non-scientific vocabularies. Therefore, the overall state of textbooks for grade 11 students are reasonable. But there are a great many vocabularies inappropriate for them. Those should be used minimum, and to be changed to the 1-4 of level vocabulary as stated in the student's level of understanding of appropriate vocabulary.

• Journal of Contemporary Eastern Asia
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• v.19 no.1
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• pp.31-42
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• 2020

There is great confusion over what constitutes public diplomacy (PD), who its actors are, and the relevance of non-state actors. In the Korean context, in addition to the general fuzziness of the concept, linguistic peculiarities of the terms gonggong and gongjung both of which refer to public, waegyo, which is interchangeably used for international affairs, foreign policy and diplomacy, and juche which is simultaneously used for actor and agent, add more layers of confusion. While the term PD in Korea is based almost entirely on Western conceptualization, these linguistic peculiarities prevent fruitful conversations among scholars and practitioners on PD. Against this background, this research note explores and addresses conceptual ambiguities that pertains to PD and the policy discourse on the topic, particularly on non-state PD in Korea. The paper draws on Korean government's PD-related policy documents and Diplomatic White Papers and all relevant academic articles found in Korean-language journals registered in the Korean Citation Index (KCI), which are analysed to gain an understanding of the PD-related policy discourse in Korea.